JP2015532923A5 - - Google Patents
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- JP2015532923A5 JP2015532923A5 JP2015533048A JP2015533048A JP2015532923A5 JP 2015532923 A5 JP2015532923 A5 JP 2015532923A5 JP 2015533048 A JP2015533048 A JP 2015533048A JP 2015533048 A JP2015533048 A JP 2015533048A JP 2015532923 A5 JP2015532923 A5 JP 2015532923A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tissue
- antibiotic
- ecm
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001519 tissues Anatomy 0.000 claims 4
- 210000002744 Extracellular Matrix Anatomy 0.000 claims 3
- 230000003115 biocidal Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 claims 1
- 229960005091 Chloramphenicol Drugs 0.000 claims 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N Chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N Clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 1
- 229960000282 Metronidazole Drugs 0.000 claims 1
- 229940049954 Penicillin Drugs 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 229960002180 Tetracycline Drugs 0.000 claims 1
- OFVLGDICTFRJMM-WESIUVDSSA-N Tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N VANCOMYCIN Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
- 229960003165 Vancomycin Drugs 0.000 claims 1
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229960000626 benzylpenicillin Drugs 0.000 claims 1
- 230000000975 bioactive Effects 0.000 claims 1
- 230000000271 cardiovascular Effects 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 229960002227 clindamycin Drugs 0.000 claims 1
- 229960003276 erythromycin Drugs 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
Claims (2)
- 損傷した心血管組織を治療するための注射可能な組成物であって、
細胞外マトリックス（ＥＣＭ）足場成分と生物活性剤成分とを有してなり、前記ＥＣＭ足場成分は哺乳動物の組織を含み、該哺乳動物の組織は脱細胞化された心臓組織を含み、前記生物活性剤成分は抗生物質を含む、組成物。 - 前記抗生物質が、アミノグリコシド、セファロスポリン、クロラムフェニコール、クリンダマイシン、エリスロマイシン、フルオロキノロン、マクロライド、アゾリド、メトロニダゾール、ペニシリン、テトラサイクリン、トリメトプリム−スルファメトキサゾールおよびバンコマイシンからなる群から選択される、請求項1に記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/573,569 | 2012-09-24 | ||
| US13/573,569 US9072816B2 (en) | 2006-01-18 | 2012-09-24 | Composition for modulating inflammation of cardiovascular tissue |
| PCT/US2013/046039 WO2014046752A1 (en) | 2012-09-24 | 2013-06-15 | Method and system for treatment of biological tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015532923A JP2015532923A (ja) | 2015-11-16 |
| JP2015532923A5 true JP2015532923A5 (ja) | 2016-07-28 |
Family
ID=50342519
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533045A Pending JP2015532922A (ja) | 2012-09-24 | 2013-05-29 | 生体組織の治療のための方法及びシステム |
| JP2015533049A Pending JP2015531664A (ja) | 2012-09-24 | 2013-06-14 | 生体組織の治療のための方法及びシステム |
| JP2015533048A Pending JP2015532923A (ja) | 2012-09-24 | 2013-06-15 | 生体組織の治療のための方法及びシステム |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533045A Pending JP2015532922A (ja) | 2012-09-24 | 2013-05-29 | 生体組織の治療のための方法及びシステム |
| JP2015533049A Pending JP2015531664A (ja) | 2012-09-24 | 2013-06-14 | 生体組織の治療のための方法及びシステム |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9072816B2 (ja) |
| EP (3) | EP2887948A4 (ja) |
| JP (3) | JP2015532922A (ja) |
| CN (1) | CN104703614A (ja) |
| AU (3) | AU2013318632A1 (ja) |
| BR (2) | BR112014031796A2 (ja) |
| CA (3) | CA2875302A1 (ja) |
| IL (2) | IL236021A0 (ja) |
| IN (1) | IN2015DN01780A (ja) |
| SG (2) | SG11201408808WA (ja) |
| WO (3) | WO2014046744A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9283302B2 (en) | 2011-12-16 | 2016-03-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
| US20080279833A1 (en) | 2007-05-10 | 2008-11-13 | Matheny Robert G | Laminate sheet articles for tissue regeneration |
| MX2011008735A (es) * | 2009-02-18 | 2012-01-12 | Cormatrix Cardiovascular Inc | Composiciones y metodos para prevenir la arritmia cardiaca. |
| US20160143738A1 (en) * | 2014-11-26 | 2016-05-26 | Cormatrix Cardiovascular, Inc. | Biological Constructs for Treating Damaged Organs and Tissue |
| US20160143720A1 (en) * | 2014-11-26 | 2016-05-26 | Cormatrix Cardiovascular, Inc. | Mesh Fiber Members and Methods for Forming and Using Same for Treating Damaged Biological Tissue |
| WO2016093863A1 (en) * | 2014-12-10 | 2016-06-16 | Cormatrix Cardiovascular, Inc. | Method and system for treatment of damaged biological tissue |
| KR20180015187A (ko) * | 2015-06-03 | 2018-02-12 | 위스콘신 얼럼나이 리서어치 화운데이션 | 심장 섬유모세포-유래된 세포외 기질 및 허혈성 질환 또는 손상의 치료를 위한 이의 주사 가능한 제형 |
| US11331348B2 (en) | 2016-04-28 | 2022-05-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compositions comprising extracellular matrix of primitive animal species and related methods |
| CA3010717A1 (en) | 2016-07-11 | 2018-01-18 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
| KR101710615B1 (ko) | 2016-09-07 | 2017-02-27 | 주식회사 파마리서치프로덕트 | 생착률을 증가시킨 이식용 진피층 및 이의 제조 방법 |
| JP6825182B2 (ja) * | 2018-06-19 | 2021-02-03 | フーワイ ホスピタル， チャイニーズ アカデミー オブ メディカル サイエンシズ アンド ペキン ユニオン メディカル カレッジ | 薬剤前処理による間葉系幹細胞由来エクソソームの調製方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5275826A (en) * | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
| US6485723B1 (en) * | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| EP0936930B1 (en) * | 1996-11-05 | 2004-07-28 | Purdue Research Foundation | Myocardial graft constructs |
| WO1998025637A1 (en) * | 1996-12-10 | 1998-06-18 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| EP0944647B1 (en) * | 1996-12-10 | 2008-11-12 | Purdue Research Foundation | Submucosa extracts |
| IL139708A0 (en) * | 2000-11-15 | 2002-02-10 | Amiel Gilad | Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering |
| WO2003007790A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
| US20040078090A1 (en) * | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
| US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
| EP1638548B1 (en) * | 2003-06-18 | 2010-09-29 | Institut de Cardiologie de Montreal / Montréal Heart Institute | Preventing atrial fibrillation (af) with the use of statin drugs |
| AU2004253508A1 (en) * | 2003-06-25 | 2005-01-13 | Acell, Inc. | Conditioned matrix compositions for tissue restoration |
| FI20045223A (fi) * | 2004-06-15 | 2005-12-16 | Bioretec Oy | Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin |
| US20050013870A1 (en) * | 2003-07-17 | 2005-01-20 | Toby Freyman | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
| GB2423934B (en) * | 2003-09-04 | 2007-11-28 | Cook Biotech Inc | Extracellular matrix composite materials, and manufacture and use thereof |
| EP1863545B1 (en) * | 2005-03-19 | 2015-11-18 | Cook Biotech, Inc. | Prosthetic implants including ECM composite material |
| US20060293760A1 (en) * | 2005-06-24 | 2006-12-28 | Dedeyne Patrick G | Soft tissue implants with improved interfaces |
| US8568761B2 (en) * | 2005-07-15 | 2013-10-29 | Cormatrix Cardiovascular, Inc. | Compositions for regenerating defective or absent myocardium |
| US9532943B2 (en) * | 2010-12-20 | 2017-01-03 | Cormatrix Cardiovascular, Inc. | Drug eluting patch for the treatment of localized tissue disease or defect |
| WO2008021127A2 (en) * | 2006-08-08 | 2008-02-21 | Howmedica Osteonics Corp. | Expandable cartilage implant |
| WO2008109407A2 (en) * | 2007-03-02 | 2008-09-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix-derived gels and related methods |
| CA2711001A1 (en) * | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein-based particles and methods thereof |
| WO2009086499A2 (en) | 2007-12-28 | 2009-07-09 | Cook Biotech Incorporated | Medical composition including an extracellular matrix particulate |
| JP2010059235A (ja) * | 2008-09-01 | 2010-03-18 | Fujifilm Corp | 紫外線吸収剤組成物 |
| DK2349292T3 (en) * | 2008-09-30 | 2017-06-26 | Univ California | COMPOSITIONS comprising decellularized extracellular matrix obtained from cardiac tissue |
| MX2011008735A (es) | 2009-02-18 | 2012-01-12 | Cormatrix Cardiovascular Inc | Composiciones y metodos para prevenir la arritmia cardiaca. |
-
2012
- 2012-09-24 US US13/573,569 patent/US9072816B2/en active Active
-
2013
- 2013-05-01 US US13/874,942 patent/US20140087000A1/en not_active Abandoned
- 2013-05-29 WO PCT/US2013/043087 patent/WO2014046744A1/en active Application Filing
- 2013-05-29 JP JP2015533045A patent/JP2015532922A/ja active Pending
- 2013-05-29 SG SG11201408808WA patent/SG11201408808WA/en unknown
- 2013-05-29 BR BR112014031796A patent/BR112014031796A2/pt not_active IP Right Cessation
- 2013-05-29 CN CN201380049450.3A patent/CN104703614A/zh active Pending
- 2013-05-29 AU AU2013318632A patent/AU2013318632A1/en not_active Abandoned
- 2013-05-29 EP EP13838953.1A patent/EP2887948A4/en not_active Withdrawn
- 2013-05-29 CA CA2875302A patent/CA2875302A1/en not_active Abandoned
- 2013-06-14 WO PCT/US2013/046041 patent/WO2014046753A2/en active Application Filing
- 2013-06-14 AU AU2013318552A patent/AU2013318552A1/en not_active Abandoned
- 2013-06-14 JP JP2015533049A patent/JP2015531664A/ja active Pending
- 2013-06-14 EP EP13839300.4A patent/EP2897623A4/en not_active Withdrawn
- 2013-06-14 BR BR112015006512A patent/BR112015006512A2/pt not_active IP Right Cessation
- 2013-06-14 SG SG11201501649TA patent/SG11201501649TA/en unknown
- 2013-06-14 CA CA2883885A patent/CA2883885A1/en not_active Abandoned
- 2013-06-15 EP EP13839811.0A patent/EP2897624A4/en not_active Withdrawn
- 2013-06-15 AU AU2013318551A patent/AU2013318551B2/en not_active Ceased
- 2013-06-15 WO PCT/US2013/046039 patent/WO2014046752A1/en active Application Filing
- 2013-06-15 CA CA2884959A patent/CA2884959C/en not_active Expired - Fee Related
- 2013-06-15 JP JP2015533048A patent/JP2015532923A/ja active Pending
-
2014
- 2014-12-01 IL IL236021A patent/IL236021A0/en unknown
- 2014-12-17 US US14/573,017 patent/US20150099007A1/en not_active Abandoned
-
2015
- 2015-03-04 IL IL237568A patent/IL237568A0/en unknown
- 2015-03-04 IN IN1780DEN2015 patent/IN2015DN01780A/en unknown
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