JP2015528811A5 - - Google Patents
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- Publication number
- JP2015528811A5 JP2015528811A5 JP2015524472A JP2015524472A JP2015528811A5 JP 2015528811 A5 JP2015528811 A5 JP 2015528811A5 JP 2015524472 A JP2015524472 A JP 2015524472A JP 2015524472 A JP2015524472 A JP 2015524472A JP 2015528811 A5 JP2015528811 A5 JP 2015528811A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- oxy
- naphthalen
- cis
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC*(C)*1n[s]nc1O Chemical compound CCC*(C)*1n[s]nc1O 0.000 description 16
- VMAQYKGITHDWKL-UHFFFAOYSA-N CC(C(N1)=O)NC1=O Chemical compound CC(C(N1)=O)NC1=O VMAQYKGITHDWKL-UHFFFAOYSA-N 0.000 description 1
- HWLLBFXGMGCOKR-UHFFFAOYSA-N CC(C)C1N=C(O)SC1 Chemical compound CC(C)C1N=C(O)SC1 HWLLBFXGMGCOKR-UHFFFAOYSA-N 0.000 description 1
- WJNAXMGXAKYXMB-UHFFFAOYSA-N CC(c([nH]c(O)n1)c1O)I Chemical compound CC(c([nH]c(O)n1)c1O)I WJNAXMGXAKYXMB-UHFFFAOYSA-N 0.000 description 1
- OZRMKPSTHNJIFQ-UHFFFAOYSA-N C[I](C(C(N1)=O)SC1=O)I Chemical compound C[I](C(C(N1)=O)SC1=O)I OZRMKPSTHNJIFQ-UHFFFAOYSA-N 0.000 description 1
- HUTNXAYRNHOZHL-UHFFFAOYSA-N Cc1c[o]c(O)n1 Chemical compound Cc1c[o]c(O)n1 HUTNXAYRNHOZHL-UHFFFAOYSA-N 0.000 description 1
- CPRNCHPETPGSFH-UHFFFAOYSA-N NC(C(O)=C1O)OC1O Chemical compound NC(C(O)=C1O)OC1O CPRNCHPETPGSFH-UHFFFAOYSA-N 0.000 description 1
- SNIUAQOVVXVIPV-UHFFFAOYSA-N OC(C1)N=C(O)SC1[Tm] Chemical compound OC(C1)N=C(O)SC1[Tm] SNIUAQOVVXVIPV-UHFFFAOYSA-N 0.000 description 1
- XWAXUDRSPKIROW-UHFFFAOYSA-N Oc1cc([IH]I)n[o]1 Chemical compound Oc1cc([IH]I)n[o]1 XWAXUDRSPKIROW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261676692P | 2012-07-27 | 2012-07-27 | |
| US61/676,692 | 2012-07-27 | ||
| PCT/US2013/052329 WO2014018891A1 (en) | 2012-07-27 | 2013-07-26 | Compounds that are s1p modulating agents and/or atx modulating agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528811A JP2015528811A (ja) | 2015-10-01 |
| JP2015528811A5 true JP2015528811A5 (https=) | 2016-09-08 |
| JP6324380B2 JP6324380B2 (ja) | 2018-05-16 |
Family
ID=49997868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524472A Expired - Fee Related JP6324380B2 (ja) | 2012-07-27 | 2013-07-26 | Ｓ１ｐ調節剤および／またはａｔｘ調節剤である化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9550798B2 (https=) |
| EP (1) | EP2877180B1 (https=) |
| JP (1) | JP6324380B2 (https=) |
| KR (1) | KR102127025B1 (https=) |
| CN (1) | CN104684560B (https=) |
| AR (1) | AR091929A1 (https=) |
| AU (1) | AU2013295594B2 (https=) |
| BR (1) | BR112015001613B1 (https=) |
| CA (1) | CA2879589C (https=) |
| CL (1) | CL2015000210A1 (https=) |
| EA (1) | EA027809B1 (https=) |
| ES (1) | ES2671194T3 (https=) |
| IL (1) | IL236694B (https=) |
| MX (1) | MX362346B (https=) |
| NZ (1) | NZ703851A (https=) |
| PH (1) | PH12015500180B1 (https=) |
| SG (1) | SG11201500342PA (https=) |
| TW (1) | TWI631097B (https=) |
| WO (1) | WO2014018891A1 (https=) |
| ZA (1) | ZA201500439B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| US9555050B2 (en) | 2012-07-27 | 2017-01-31 | Biogen Ma Inc. | ATX modulating agents |
| TWI616430B (zh) * | 2012-07-27 | 2018-03-01 | 百健Ｍａ公司 | Ａｔｘ調節劑 |
| US9499485B2 (en) | 2012-08-06 | 2016-11-22 | Biogen Ma Inc. | Compounds that are S1P modulating agents and/or ATX modulating agents |
| EP2879674B1 (en) | 2012-08-06 | 2017-11-22 | Biogen MA Inc. | Compounds that are s1p modulating agents and/or atx modulating agents |
| MX368615B (es) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos. |
| US9115054B2 (en) | 2013-02-21 | 2015-08-25 | Bristol-Myers Squibb Company | Tetrahydronaphthalenyl compounds useful as sipi agonists |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| MA40082B1 (fr) | 2014-08-20 | 2019-09-30 | Bristol Myers Squibb Co | Nouveau compose de substitution sphingosine phosphate utile traitement maladie rhumatisme |
| MA41139B1 (fr) | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| KR20200013086A (ko) | 2014-12-11 | 2020-02-05 | 액테리온 파마슈티칼 리미티드 | 선택적 s1p1 수용체 효능제에 대한 투약 섭생 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| JPWO2016208237A1 (ja) * | 2015-06-24 | 2018-04-12 | コニカミノルタ株式会社 | ガスバリアフィルム、透明導電部材、及び、有機エレクトロルミネッセンス素子、並びに、ガスバリアフィルムの製造方法、透明導電部材の製造方法、及び、有機エレクトロルミネッセンス素子の製造方法。 |
| EP3317278B1 (en) | 2015-07-01 | 2021-04-14 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| AU2016328436B2 (en) | 2015-09-24 | 2020-05-14 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| EP3596091B1 (en) | 2017-03-16 | 2021-08-25 | Waters Technologies Corporation | Chromatographic compositions |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| TW201908311A (zh) | 2017-06-13 | 2019-03-01 | 英商葛蘭素史克智慧財產發展有限公司 | 化合物 |
| EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
| TW201938517A (zh) * | 2017-12-01 | 2019-10-01 | 景凱生物科技股份有限公司 | 苯並雜環化合物及其用途 |
| KR102623218B1 (ko) * | 2018-08-23 | 2024-01-11 | 가천대학교 산학협력단 | 페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
| KR102558308B1 (ko) * | 2018-09-27 | 2023-07-24 | 주식회사 엘지화학 | 3-아자바이사이클로[3,1,1]헵탄 유도체 및 이를 포함하는 약제학적 조성물 |
| US12479830B2 (en) | 2019-10-10 | 2025-11-25 | Esteve Pharmaceuticals, S.A. | Homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having multimodal activity against pain |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| CR20230057A (es) | 2020-07-02 | 2023-08-15 | Incyte Corp | Compuestos tríciclicos de urea como inhibidores de jak2 v617f |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| US20230390270A1 (en) * | 2020-08-19 | 2023-12-07 | Biogen Ma Inc. | Methods for treating remitting multiple sclerosis |
| US12472171B2 (en) | 2020-08-19 | 2025-11-18 | Biogen Ma Inc. | Methods for treating hypercholesterolemia |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| AU2023235313A1 (en) | 2022-03-17 | 2024-10-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901379A (fr) * | 1943-09-10 | 1945-07-25 | Télégraphie par variations de fréquence | |
| US4016281A (en) | 1975-02-22 | 1977-04-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetralone and indanone compounds |
| EP0486011A3 (en) | 1990-11-16 | 1992-07-15 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical composition against pneumocystis carinii |
| US6048877A (en) * | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| WO2003053941A2 (en) * | 2001-12-20 | 2003-07-03 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases |
| US6908939B2 (en) * | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
| US7544699B2 (en) * | 2003-08-08 | 2009-06-09 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| KR20110140139A (ko) * | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
| US7825109B2 (en) | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| DE602005004404T2 (de) * | 2004-06-02 | 2009-01-15 | F. Hoffmann-La Roche Ag | Als histamin-3-rezeptorliganden einsetzbare naphthalene-derivate |
| JP5315611B2 (ja) | 2004-06-23 | 2013-10-16 | 小野薬品工業株式会社 | Ｓ１ｐ受容体結合能を有する化合物およびその用途 |
| WO2010043000A1 (en) * | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators and their use thereof |
| UA107360C2 (en) * | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| EP2670245B1 (en) * | 2011-02-04 | 2015-09-09 | The Scripps Research Institute | Alpha-ketoheterocycles and methods of making and using |
| EA034451B1 (ru) * | 2011-02-07 | 2020-02-10 | Байоджен Ма Инк. | Модуляторы s1p |
| KR20150023223A (ko) * | 2012-02-02 | 2015-03-05 | 세넥스 바이오테크놀러지 인코포레이티드 | Ｃｄｋ8/ｃｄｋ19 선택성 억제제 및 암에 대한 항-전이 및 화학예방 방법에서 이들의 용도 |
| US9555050B2 (en) | 2012-07-27 | 2017-01-31 | Biogen Ma Inc. | ATX modulating agents |
| TWI616430B (zh) | 2012-07-27 | 2018-03-01 | 百健Ｍａ公司 | Ａｔｘ調節劑 |
| EP2879674B1 (en) | 2012-08-06 | 2017-11-22 | Biogen MA Inc. | Compounds that are s1p modulating agents and/or atx modulating agents |
| US9499485B2 (en) | 2012-08-06 | 2016-11-22 | Biogen Ma Inc. | Compounds that are S1P modulating agents and/or ATX modulating agents |
| CA2899322A1 (en) | 2013-01-29 | 2014-08-07 | Biogen Ma Inc. | S1p modulating agents |
-
2013
- 2013-07-26 JP JP2015524472A patent/JP6324380B2/ja not_active Expired - Fee Related
- 2013-07-26 KR KR1020157004652A patent/KR102127025B1/ko not_active Expired - Fee Related
- 2013-07-26 MX MX2015001211A patent/MX362346B/es active IP Right Grant
- 2013-07-26 ES ES13822929.9T patent/ES2671194T3/es active Active
- 2013-07-26 CN CN201380050753.7A patent/CN104684560B/zh not_active Expired - Fee Related
- 2013-07-26 CA CA2879589A patent/CA2879589C/en not_active Expired - Fee Related
- 2013-07-26 NZ NZ703851A patent/NZ703851A/en not_active IP Right Cessation
- 2013-07-26 US US14/417,293 patent/US9550798B2/en active Active
- 2013-07-26 SG SG11201500342PA patent/SG11201500342PA/en unknown
- 2013-07-26 EP EP13822929.9A patent/EP2877180B1/en active Active
- 2013-07-26 WO PCT/US2013/052329 patent/WO2014018891A1/en not_active Ceased
- 2013-07-26 EA EA201590292A patent/EA027809B1/ru unknown
- 2013-07-26 BR BR112015001613-8A patent/BR112015001613B1/pt not_active IP Right Cessation
- 2013-07-26 TW TW102126998A patent/TWI631097B/zh not_active IP Right Cessation
- 2013-07-26 AU AU2013295594A patent/AU2013295594B2/en not_active Ceased
- 2013-07-29 AR ARP130102687A patent/AR091929A1/es not_active Application Discontinuation
-
2015
- 2015-01-13 IL IL236694A patent/IL236694B/en active IP Right Grant
- 2015-01-21 ZA ZA2015/00439A patent/ZA201500439B/en unknown
- 2015-01-27 PH PH12015500180A patent/PH12015500180B1/en unknown
- 2015-01-27 CL CL2015000210A patent/CL2015000210A1/es unknown
-
2016
- 2016-12-02 US US15/368,454 patent/US9944666B2/en active Active
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