JP2015528447A5 - - Google Patents
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- Publication number
- JP2015528447A5 JP2015528447A5 JP2015528547A JP2015528547A JP2015528447A5 JP 2015528447 A5 JP2015528447 A5 JP 2015528447A5 JP 2015528547 A JP2015528547 A JP 2015528547A JP 2015528547 A JP2015528547 A JP 2015528547A JP 2015528447 A5 JP2015528447 A5 JP 2015528447A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- compound
- therapeutic agent
- condition
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 238000000034 method Methods 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 2
- 206010021263 IgA nephropathy Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000002534 radiation-sensitizing agent Substances 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261692429P | 2012-08-23 | 2012-08-23 | |
| US61/692,429 | 2012-08-23 | ||
| PCT/US2013/055384 WO2014031487A1 (en) | 2012-08-23 | 2013-08-16 | Bivalent inhibitors of iap proteins and therapeutic methods using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528447A JP2015528447A (ja) | 2015-09-28 |
| JP2015528447A5 true JP2015528447A5 (enExample) | 2016-10-06 |
| JP6247298B2 JP6247298B2 (ja) | 2017-12-13 |
Family
ID=50148520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528547A Active JP6247298B2 (ja) | 2012-08-23 | 2013-08-16 | Ｉａｐタンパク質の二価阻害薬およびそれを用いた治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8883771B2 (enExample) |
| EP (1) | EP2888265B1 (enExample) |
| JP (1) | JP6247298B2 (enExample) |
| KR (2) | KR102237888B1 (enExample) |
| CN (3) | CN109485662B (enExample) |
| AU (1) | AU2013306087B2 (enExample) |
| CA (1) | CA2882496C (enExample) |
| ES (1) | ES2654623T3 (enExample) |
| HK (1) | HK1211030A1 (enExample) |
| MX (1) | MX366130B (enExample) |
| RU (1) | RU2649975C2 (enExample) |
| WO (1) | WO2014031487A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| US9969753B2 (en) * | 2014-04-16 | 2018-05-15 | Shenzhen Yongze Pharmaceutical Co., Ltd. | BCR-ABL diploid inhibitor, synthesizing method therefor, and uses thereof |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN109311867A (zh) | 2016-04-20 | 2019-02-05 | 葛兰素史克知识产权开发有限公司 | 包含ripk2抑制剂的共轭物 |
| CN109071525B (zh) * | 2016-05-09 | 2022-08-19 | 豪夫迈·罗氏有限公司 | 二聚化合物 |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| GB201610147D0 (en) | 2016-06-10 | 2016-07-27 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB2567126A (en) * | 2017-06-23 | 2019-04-10 | Femtogenix Ltd | PBC compounds |
| CN107987083A (zh) * | 2017-11-24 | 2018-05-04 | 江苏亚盛医药开发有限公司 | 用于治疗和/或预防与肝炎病毒相关的疾病或病症的双二氮杂双环化合物 |
| BR112021001796A2 (pt) | 2018-07-31 | 2021-05-18 | Ascentage Pharma (Suzhou) Co., Ltd. | método para tratar câncer por combinação de inibidor de iap e modulador de molécula de ponto de verificação imunológico |
| JP7515175B2 (ja) * | 2018-07-31 | 2024-07-12 | ファイメクス株式会社 | 複素環化合物 |
| WO2020109328A1 (en) | 2018-11-26 | 2020-06-04 | Debiopharm International S.A. | Combination treatment of hiv infections |
| US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
| CA3148504A1 (en) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Combination therapy for treatment of cancer |
| EP4034102A1 (en) | 2019-09-25 | 2022-08-03 | Debiopharm International SA | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
| WO2021098771A1 (en) * | 2019-11-19 | 2021-05-27 | Ascentage Pharma (Suzhou) Co., Ltd. | Treatment method with iap inhibitor |
| US20230029259A1 (en) * | 2019-12-02 | 2023-01-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents |
| CN112891353B (zh) * | 2019-12-04 | 2024-01-30 | 苏州亚盛药业有限公司 | 药物组合及其用途 |
| MX2022007909A (es) | 2019-12-24 | 2022-07-21 | Hoffmann La Roche | Combinacion farmaceutica de agentes antivirales que actuan sobre hbv y/o un inmunomodulador para el tratamiento de hbv. |
| US20230078120A1 (en) * | 2020-05-04 | 2023-03-16 | Ascentage Pharma (Suzhou) Co.,Ltd. | Methods for Treating Coronavirus Infections |
| TWI794895B (zh) * | 2020-07-16 | 2023-03-01 | 大陸商蘇州亞盛藥業有限公司 | 雙二氮雜雙環化合物或其鹽的結晶形式或無定形形式 |
| CN116963732A (zh) * | 2021-02-23 | 2023-10-27 | 苏州亚盛药业有限公司 | 药物组合物及其制备方法 |
| EP4382126A4 (en) | 2021-08-02 | 2025-07-30 | Ascentage Pharma Suzhou Co Ltd | PHARMACEUTICAL COMBINATION AND ITS USE |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| AU2023275703A1 (en) | 2022-05-23 | 2024-11-21 | Inhibrx Biosciences, Inc. | Dr5 agonist and iap antagonist combination therapy |
| WO2025090605A1 (en) * | 2023-10-24 | 2025-05-01 | University Of Houston System | Combination of iap inhibitors and cellular kinase inhibitors, such as ponatinib, for use in the treatment of cancer or pulmonary diseases, such as copd, cystic fibrosis, pulmonary fibrosis and covid-19 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040072831A1 (en) * | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| CA2582734C (en) | 2004-03-01 | 2011-05-03 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
| CN101128425B (zh) * | 2005-02-25 | 2012-12-26 | 泰特拉洛吉克药业公司 | Iap二聚体抑制剂 |
| PL2019671T3 (pl) * | 2006-05-05 | 2015-02-27 | Univ Michigan Regents | Związki pośrednie do wytwarzania dwuwartościowych mimetyków Smac |
| EA017797B1 (ru) * | 2007-04-13 | 2013-03-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Бициклические диазомиметики smac, способы их получения, их применения, содержащие их фармацевтические композиции и набор, содержащий указанные композиции |
| WO2011050068A2 (en) * | 2009-10-23 | 2011-04-28 | The Regents Of The University Of Michigan | Bivalent diazo bicyclic smac mimetics and the uses thereof |
-
2013
- 2013-08-16 US US13/969,030 patent/US8883771B2/en active Active
- 2013-08-16 WO PCT/US2013/055384 patent/WO2014031487A1/en not_active Ceased
- 2013-08-16 ES ES13831176.6T patent/ES2654623T3/es active Active
- 2013-08-16 CN CN201811229886.1A patent/CN109485662B/zh active Active
- 2013-08-16 KR KR1020207013450A patent/KR102237888B1/ko active Active
- 2013-08-16 CN CN201380055219.5A patent/CN104718209A/zh active Pending
- 2013-08-16 RU RU2015107552A patent/RU2649975C2/ru active
- 2013-08-16 KR KR1020157006767A patent/KR102111704B1/ko active Active
- 2013-08-16 MX MX2015002371A patent/MX366130B/es active IP Right Grant
- 2013-08-16 JP JP2015528547A patent/JP6247298B2/ja active Active
- 2013-08-16 HK HK15111880.3A patent/HK1211030A1/xx unknown
- 2013-08-16 AU AU2013306087A patent/AU2013306087B2/en active Active
- 2013-08-16 EP EP13831176.6A patent/EP2888265B1/en active Active
- 2013-08-16 CN CN201811229870.0A patent/CN109575049B/zh active Active
- 2013-08-16 CA CA2882496A patent/CA2882496C/en active Active
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