CN109485662B - Iap蛋白的二价抑制剂和使用其的治疗方法 - Google Patents

Iap蛋白的二价抑制剂和使用其的治疗方法 Download PDF

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CN109485662B
CN109485662B CN201811229886.1A CN201811229886A CN109485662B CN 109485662 B CN109485662 B CN 109485662B CN 201811229886 A CN201811229886 A CN 201811229886A CN 109485662 B CN109485662 B CN 109485662B
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compound
cancer
pharmaceutically acceptable
iap
disease
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CN109485662A (zh
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S·王
R·盛
H·孙
L·刘
J·卢
D·麦凯克恩
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University of Michigan Ann Arbor
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CN201811229886.1A 2012-08-23 2013-08-16 Iap蛋白的二价抑制剂和使用其的治疗方法 Active CN109485662B (zh)

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WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
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CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
GB2567126A (en) * 2017-06-23 2019-04-10 Femtogenix Ltd PBC compounds
CN107987083A (zh) * 2017-11-24 2018-05-04 江苏亚盛医药开发有限公司 用于治疗和/或预防与肝炎病毒相关的疾病或病症的双二氮杂双环化合物
AU2019300324A1 (en) 2018-07-13 2021-01-21 F. Hoffmann-La Roche Ag Oligonucleotides for modulating RTEL1 expression
JP7515175B2 (ja) * 2018-07-31 2024-07-12 ファイメクス株式会社 複素環化合物
US12186304B2 (en) 2018-07-31 2025-01-07 Ascentage Pharma (Suzhou) Co., Ltd. Method for treating cancer by combination of IAP inhibitor and modulator of immune checkpoint molecule
US20220016079A1 (en) 2018-11-26 2022-01-20 Debiopharm International S.A. Combination treatment of hiv infections
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
CA3148504A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
US20250268863A1 (en) 2019-09-25 2025-08-28 Debiopharm International Sa Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma
EP4061361A4 (en) * 2019-11-19 2023-11-29 Ascentage Pharma (Suzhou) Co., Ltd. TREATMENT METHODS WITH IAP INHIBITOR
WO2021110011A1 (en) * 2019-12-02 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents
CN112891353B (zh) * 2019-12-04 2024-01-30 苏州亚盛药业有限公司 药物组合及其用途
MX2022007909A (es) 2019-12-24 2022-07-21 Hoffmann La Roche Combinacion farmaceutica de agentes antivirales que actuan sobre hbv y/o un inmunomodulador para el tratamiento de hbv.
EP4146218A4 (en) * 2020-05-04 2024-08-28 Ascentage Pharma (Suzhou) Co., Ltd. METHODS OF TREATING CORONAVIRUS INFECTIONS
US20230257384A1 (en) * 2020-07-16 2023-08-17 Ascentage Pharma (Suzhou) Co., Ltd. The crystalline forms or amorphous forms of bisdiazabicyclic compounds or salts thereof
WO2022179490A1 (en) * 2021-02-23 2022-09-01 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical compositions and preparation methods thereof
JP2024528174A (ja) 2021-08-02 2024-07-26 アセンテージ ファーマ(スーチョウ)カンパニー,リミティド 医薬組合せおよびその使用
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CN101484151A (zh) * 2006-05-05 2009-07-15 密执安州立大学董事会 二价smac模拟物及其应用
WO2011050068A2 (en) * 2009-10-23 2011-04-28 The Regents Of The University Of Michigan Bivalent diazo bicyclic smac mimetics and the uses thereof

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RU2649975C2 (ru) 2018-04-06
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US8883771B2 (en) 2014-11-11
JP6247298B2 (ja) 2017-12-13
KR102111704B1 (ko) 2020-05-15
HK1211030A1 (en) 2016-05-13
MX366130B (es) 2019-06-28
JP2015528447A (ja) 2015-09-28
CN109485662A (zh) 2019-03-19
EP2888265B1 (en) 2017-10-11
CN104718209A (zh) 2015-06-17
WO2014031487A8 (en) 2014-05-30
KR102237888B1 (ko) 2021-04-07
AU2013306087A1 (en) 2015-03-12
AU2013306087B2 (en) 2017-08-10
EP2888265A4 (en) 2016-01-27
KR20150044937A (ko) 2015-04-27
WO2014031487A1 (en) 2014-02-27
CN109575049B (zh) 2021-07-30
MX2015002371A (es) 2015-10-05
US20140057924A1 (en) 2014-02-27
CA2882496C (en) 2020-07-14
EP2888265A1 (en) 2015-07-01
KR20200054334A (ko) 2020-05-19
RU2015107552A (ru) 2016-10-10
CA2882496A1 (en) 2014-02-27

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