AU2013306087B2 - Bivalent inhibitors of IAP proteins and therapeutic methods using the same - Google Patents

Bivalent inhibitors of IAP proteins and therapeutic methods using the same Download PDF

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AU2013306087B2
AU2013306087B2 AU2013306087A AU2013306087A AU2013306087B2 AU 2013306087 B2 AU2013306087 B2 AU 2013306087B2 AU 2013306087 A AU2013306087 A AU 2013306087A AU 2013306087 A AU2013306087 A AU 2013306087A AU 2013306087 B2 AU2013306087 B2 AU 2013306087B2
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cancer
compound
disease
cell
therapeutic agent
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AU2013306087A1 (en
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Liu Liu
Jianfeng Lu
Donna Mceachern
Rong SHENG
Haiying Sun
Shaomeng Wang
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University of Michigan System
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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AU2013306087A 2012-08-23 2013-08-16 Bivalent inhibitors of IAP proteins and therapeutic methods using the same Active AU2013306087B2 (en)

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US201261692429P 2012-08-23 2012-08-23
US61/692,429 2012-08-23
PCT/US2013/055384 WO2014031487A1 (en) 2012-08-23 2013-08-16 Bivalent inhibitors of iap proteins and therapeutic methods using the same

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AU2013306087A1 AU2013306087A1 (en) 2015-03-12
AU2013306087B2 true AU2013306087B2 (en) 2017-08-10

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EP (1) EP2888265B1 (enExample)
JP (1) JP6247298B2 (enExample)
KR (2) KR102111704B1 (enExample)
CN (3) CN104718209A (enExample)
AU (1) AU2013306087B2 (enExample)
CA (1) CA2882496C (enExample)
ES (1) ES2654623T3 (enExample)
HK (1) HK1211030A1 (enExample)
MX (1) MX366130B (enExample)
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WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
GB201506871D0 (en) * 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
JP2019514878A (ja) 2016-04-20 2019-06-06 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｒｉｐｋ２阻害剤を含むコンジュゲート
WO2017194390A1 (en) * 2016-05-09 2017-11-16 F. Hoffmann-La Roche Ag Dimeric compounds
ES2858151T3 (es) 2016-05-20 2021-09-29 Hoffmann La Roche Conjugados de PROTAC-anticuerpo y procedimientos de uso
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
GB2567126A (en) * 2017-06-23 2019-04-10 Femtogenix Ltd PBC compounds
CN107987083A (zh) * 2017-11-24 2018-05-04 江苏亚盛医药开发有限公司 用于治疗和/或预防与肝炎病毒相关的疾病或病症的双二氮杂双环化合物
CR20210015A (es) 2018-07-13 2021-03-22 Hoffmann La Roche Oligonucleótidos para modular la expresión de rtel 1
AU2019314728A1 (en) * 2018-07-31 2020-12-17 Ascentage Pharma (Suzhou) Co., Ltd. Method for treating cancer by combination of IAP inhibitor and modulator of immune checkpoint molecule
JP7515175B2 (ja) * 2018-07-31 2024-07-12 ファイメクス株式会社 複素環化合物
CN113453678A (zh) 2018-11-26 2021-09-28 德彪药业国际股份公司 Hiv感染的联合治疗
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
WO2021026349A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
CA3151770A1 (en) 2019-09-25 2021-04-01 Silvano BRIENZA Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma
WO2021098771A1 (en) * 2019-11-19 2021-05-27 Ascentage Pharma (Suzhou) Co., Ltd. Treatment method with iap inhibitor
TW202133842A (zh) * 2019-12-02 2021-09-16 大陸商蘇州亞盛藥業有限公司 Iap抑制劑與parp或mek抑制劑或其他化學治療劑的組合
WO2021110136A1 (en) * 2019-12-04 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical combination and use thereof
AU2020415322A1 (en) 2019-12-24 2022-06-16 F. Hoffmann-La Roche Ag Pharmaceutical combination of antiviral agents targeting HBV and/or an immune modulator for treatment of HBV
CN114728006A (zh) * 2020-05-04 2022-07-08 苏州亚盛药业有限公司 治疗冠状病毒感染的方法
CN113943342A (zh) * 2020-07-16 2022-01-18 苏州亚盛药业有限公司 双二氮杂双环化合物或其盐的结晶形式或无定形形式
WO2022179490A1 (en) * 2021-02-23 2022-09-01 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical compositions and preparation methods thereof
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MX366130B (es) 2019-06-28
CN109575049A (zh) 2019-04-05
JP2015528447A (ja) 2015-09-28
EP2888265A1 (en) 2015-07-01
RU2649975C2 (ru) 2018-04-06
CA2882496A1 (en) 2014-02-27
CN109575049B (zh) 2021-07-30
CN109485662B (zh) 2021-12-21
ES2654623T3 (es) 2018-02-14
CN109485662A (zh) 2019-03-19
EP2888265B1 (en) 2017-10-11
KR102237888B1 (ko) 2021-04-07
CA2882496C (en) 2020-07-14
US8883771B2 (en) 2014-11-11
MX2015002371A (es) 2015-10-05
HK1211030A1 (en) 2016-05-13
RU2015107552A (ru) 2016-10-10
KR102111704B1 (ko) 2020-05-15
KR20200054334A (ko) 2020-05-19
US20140057924A1 (en) 2014-02-27
CN104718209A (zh) 2015-06-17
KR20150044937A (ko) 2015-04-27
WO2014031487A1 (en) 2014-02-27
JP6247298B2 (ja) 2017-12-13
WO2014031487A8 (en) 2014-05-30
AU2013306087A1 (en) 2015-03-12

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