CA2882496C - Bivalent inhibitors of iap proteins and therapeutic methods using the same - Google Patents

Bivalent inhibitors of iap proteins and therapeutic methods using the same Download PDF

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CA2882496C
CA2882496C CA2882496A CA2882496A CA2882496C CA 2882496 C CA2882496 C CA 2882496C CA 2882496 A CA2882496 A CA 2882496A CA 2882496 A CA2882496 A CA 2882496A CA 2882496 C CA2882496 C CA 2882496C
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compound
cancer
structural formula
apoptosis
compounds
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French (fr)
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CA2882496A1 (en
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Shaomeng Wang
Rong SHENG
Haiying Sun
Liu Liu
Jianfeng Lu
Donna Mceachern
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University of Michigan System
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University of Michigan System
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P31/14—Antivirals for RNA viruses
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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CA2882496A 2012-08-23 2013-08-16 Bivalent inhibitors of iap proteins and therapeutic methods using the same Active CA2882496C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261692429P 2012-08-23 2012-08-23
US61/692,429 2012-08-23
PCT/US2013/055384 WO2014031487A1 (en) 2012-08-23 2013-08-16 Bivalent inhibitors of iap proteins and therapeutic methods using the same

Publications (2)

Publication Number Publication Date
CA2882496A1 CA2882496A1 (en) 2014-02-27
CA2882496C true CA2882496C (en) 2020-07-14

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CA2882496A Active CA2882496C (en) 2012-08-23 2013-08-16 Bivalent inhibitors of iap proteins and therapeutic methods using the same

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US (1) US8883771B2 (enExample)
EP (1) EP2888265B1 (enExample)
JP (1) JP6247298B2 (enExample)
KR (2) KR102237888B1 (enExample)
CN (3) CN109485662B (enExample)
AU (1) AU2013306087B2 (enExample)
CA (1) CA2882496C (enExample)
ES (1) ES2654623T3 (enExample)
HK (1) HK1211030A1 (enExample)
MX (1) MX366130B (enExample)
RU (1) RU2649975C2 (enExample)
WO (1) WO2014031487A1 (enExample)

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CA2974651A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
US9969753B2 (en) * 2014-04-16 2018-05-15 Shenzhen Yongze Pharmaceutical Co., Ltd. BCR-ABL diploid inhibitor, synthesizing method therefor, and uses thereof
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
CN109311867A (zh) 2016-04-20 2019-02-05 葛兰素史克知识产权开发有限公司 包含ripk2抑制剂的共轭物
CN109071525B (zh) * 2016-05-09 2022-08-19 豪夫迈·罗氏有限公司 二聚化合物
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
GB2567126A (en) * 2017-06-23 2019-04-10 Femtogenix Ltd PBC compounds
CN107987083A (zh) * 2017-11-24 2018-05-04 江苏亚盛医药开发有限公司 用于治疗和/或预防与肝炎病毒相关的疾病或病症的双二氮杂双环化合物
BR112021001796A2 (pt) 2018-07-31 2021-05-18 Ascentage Pharma (Suzhou) Co., Ltd. método para tratar câncer por combinação de inibidor de iap e modulador de molécula de ponto de verificação imunológico
JP7515175B2 (ja) * 2018-07-31 2024-07-12 ファイメクス株式会社 複素環化合物
WO2020109328A1 (en) 2018-11-26 2020-06-04 Debiopharm International S.A. Combination treatment of hiv infections
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
CA3148504A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
EP4034102A1 (en) 2019-09-25 2022-08-03 Debiopharm International SA Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma
WO2021098771A1 (en) * 2019-11-19 2021-05-27 Ascentage Pharma (Suzhou) Co., Ltd. Treatment method with iap inhibitor
US20230029259A1 (en) * 2019-12-02 2023-01-26 Ascentage Pharma (Suzhou) Co., Ltd. Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents
CN112891353B (zh) * 2019-12-04 2024-01-30 苏州亚盛药业有限公司 药物组合及其用途
MX2022007909A (es) 2019-12-24 2022-07-21 Hoffmann La Roche Combinacion farmaceutica de agentes antivirales que actuan sobre hbv y/o un inmunomodulador para el tratamiento de hbv.
US20230078120A1 (en) * 2020-05-04 2023-03-16 Ascentage Pharma (Suzhou) Co.,Ltd. Methods for Treating Coronavirus Infections
TWI794895B (zh) * 2020-07-16 2023-03-01 大陸商蘇州亞盛藥業有限公司 雙二氮雜雙環化合物或其鹽的結晶形式或無定形形式
CN116963732A (zh) * 2021-02-23 2023-10-27 苏州亚盛药业有限公司 药物组合物及其制备方法
EP4382126A4 (en) 2021-08-02 2025-07-30 Ascentage Pharma Suzhou Co Ltd PHARMACEUTICAL COMBINATION AND ITS USE
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
AU2023275703A1 (en) 2022-05-23 2024-11-21 Inhibrx Biosciences, Inc. Dr5 agonist and iap antagonist combination therapy
WO2025090605A1 (en) * 2023-10-24 2025-05-01 University Of Houston System Combination of iap inhibitors and cellular kinase inhibitors, such as ponatinib, for use in the treatment of cancer or pulmonary diseases, such as copd, cystic fibrosis, pulmonary fibrosis and covid-19

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US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
CA2582734C (en) 2004-03-01 2011-05-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
CN101128425B (zh) * 2005-02-25 2012-12-26 泰特拉洛吉克药业公司 Iap二聚体抑制剂
PL2019671T3 (pl) * 2006-05-05 2015-02-27 Univ Michigan Regents Związki pośrednie do wytwarzania dwuwartościowych mimetyków Smac
EA017797B1 (ru) * 2007-04-13 2013-03-29 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Бициклические диазомиметики smac, способы их получения, их применения, содержащие их фармацевтические композиции и набор, содержащий указанные композиции
WO2011050068A2 (en) * 2009-10-23 2011-04-28 The Regents Of The University Of Michigan Bivalent diazo bicyclic smac mimetics and the uses thereof

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Publication number Publication date
KR102111704B1 (ko) 2020-05-15
CA2882496A1 (en) 2014-02-27
EP2888265B1 (en) 2017-10-11
CN109575049B (zh) 2021-07-30
EP2888265A1 (en) 2015-07-01
ES2654623T3 (es) 2018-02-14
JP2015528447A (ja) 2015-09-28
AU2013306087A1 (en) 2015-03-12
EP2888265A4 (en) 2016-01-27
US20140057924A1 (en) 2014-02-27
MX366130B (es) 2019-06-28
RU2649975C2 (ru) 2018-04-06
CN109485662A (zh) 2019-03-19
MX2015002371A (es) 2015-10-05
US8883771B2 (en) 2014-11-11
KR20200054334A (ko) 2020-05-19
AU2013306087B2 (en) 2017-08-10
HK1211030A1 (en) 2016-05-13
CN104718209A (zh) 2015-06-17
CN109575049A (zh) 2019-04-05
KR102237888B1 (ko) 2021-04-07
JP6247298B2 (ja) 2017-12-13
WO2014031487A8 (en) 2014-05-30
WO2014031487A1 (en) 2014-02-27
KR20150044937A (ko) 2015-04-27
CN109485662B (zh) 2021-12-21
RU2015107552A (ru) 2016-10-10

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