RU2649975C2 - Бивалентные ингибиторы ингибиторов белков апоптоза и терапевтические способы их применения - Google Patents

Бивалентные ингибиторы ингибиторов белков апоптоза и терапевтические способы их применения Download PDF

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RU2649975C2
RU2649975C2 RU2015107552A RU2015107552A RU2649975C2 RU 2649975 C2 RU2649975 C2 RU 2649975C2 RU 2015107552 A RU2015107552 A RU 2015107552A RU 2015107552 A RU2015107552 A RU 2015107552A RU 2649975 C2 RU2649975 C2 RU 2649975C2
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cancer
present
iap
apoptosis
structural formula
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RU2015107552A
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RU2015107552A (ru
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Шаомэн Ван
Жун ШЭН
Хайин Сунь
Лю ЛЮ
Цзяньфэн Лу
Донна МАКИЧЕРН
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Дзе Реджентс Оф Дзе Юнивёрсити Оф Мичиган
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RU2015107552A 2012-08-23 2013-08-16 Бивалентные ингибиторы ингибиторов белков апоптоза и терапевтические способы их применения RU2649975C2 (ru)

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US201261692429P 2012-08-23 2012-08-23
US61/692,429 2012-08-23
PCT/US2013/055384 WO2014031487A1 (en) 2012-08-23 2013-08-16 Bivalent inhibitors of iap proteins and therapeutic methods using the same

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CN (3) CN109575049B (enExample)
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
JP2017511348A (ja) * 2014-04-16 2017-04-20 成都大学 Bcr−Abl二倍体の阻害剤、その調製方法及びその用途
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
GB201506871D0 (en) * 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
AU2017253560B2 (en) 2016-04-20 2019-03-21 Glaxosmithkline Intellectual Property Development Limited Conjugates comprising RIPK2 inhibitors
JP6953435B2 (ja) * 2016-05-09 2021-10-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 二量体化合物
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
GB2567126A (en) * 2017-06-23 2019-04-10 Femtogenix Ltd PBC compounds
CN107987083A (zh) * 2017-11-24 2018-05-04 江苏亚盛医药开发有限公司 用于治疗和/或预防与肝炎病毒相关的疾病或病症的双二氮杂双环化合物
BR112021000538A2 (pt) 2018-07-13 2021-04-06 F. Hoffmann-La Roche Ag Oligonucleotídeos para modular a expressão de rtel1
CA3101835A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Method for treating cancer by combination of iap inhibitor and modulator of immune checkpoint molecule
WO2020027225A1 (ja) 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
JP2022511437A (ja) 2018-11-26 2022-01-31 デバイオファーム インターナショナル エス.エー. Hiv感染の組み合わせ治療
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
US12636370B2 (en) 2019-08-08 2026-05-26 Institute For Cancer Research Combination therapy for treatment of cancer
AU2020356356A1 (en) 2019-09-25 2022-05-12 Debiopharm International S.A. Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma
US12678509B2 (en) * 2019-11-08 2026-07-14 Sanford Burnham Prebys Medical Discovery Institute Inhibitor of apoptosis (IAP) protein antagonists
WO2021098771A1 (en) * 2019-11-19 2021-05-27 Ascentage Pharma (Suzhou) Co., Ltd. Treatment method with iap inhibitor
CN112972684B (zh) * 2019-12-02 2024-05-31 苏州亚盛药业有限公司 Iap抑制剂与parp或mek抑制剂或其他化学治疗剂的组合
CN118542872A (zh) * 2019-12-04 2024-08-27 苏州亚盛药业有限公司 药物组合及其用途
EP4081217A1 (en) 2019-12-24 2022-11-02 F. Hoffmann-La Roche AG Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
WO2021223664A1 (en) * 2020-05-04 2021-11-11 Ascentage Pharma (Suzhou) Co., Ltd. Methods for treating coronavirus infections
TWI794895B (zh) * 2020-07-16 2023-03-01 大陸商蘇州亞盛藥業有限公司 雙二氮雜雙環化合物或其鹽的結晶形式或無定形形式
CN116963732A (zh) * 2021-02-23 2023-10-27 苏州亚盛药业有限公司 药物组合物及其制备方法
JP2024528174A (ja) 2021-08-02 2024-07-26 アセンテージ ファーマ(スーチョウ)カンパニー,リミティド 医薬組合せおよびその使用
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
EP4529455A1 (en) 2022-05-23 2025-04-02 Inhibrx Biosciences, Inc. Dr5 agonist and iap antagonist combination therapy
US12508320B2 (en) 2023-06-29 2025-12-30 SeeCure Taiwan Co., Ltd. Drug conjugate, pharmaceutical composition and method of treating hepatitis
AU2024367811A1 (en) * 2023-10-24 2026-05-07 Tract Pharmaceuticals, Inc. Combination of iap inhibitors and cellular kinase inhibitors, such as ponatinib, for use in the treatment of cancer or pulmonary diseases, such as copd, cystic fibrosis, pulmonary fibrosis and covid-19
WO2025261398A1 (en) * 2024-06-19 2025-12-26 Ascentage Pharma (Suzhou) Co., Ltd. Methods for treating diseases caused by hiv infection
CN119100970B (zh) * 2024-08-30 2025-09-30 中国药科大学 基于热休克蛋白90的二价抑制剂及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007130626A2 (en) * 2006-05-05 2007-11-15 The Regents Of The University Of Michigan Bivalent smac mimetics and the uses thereof
RU2342387C2 (ru) * 2003-04-09 2008-12-27 Чоонгвае Фарма Корпорейшн Миметики с обратной конфигурацией и способы их применения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1723122B1 (en) 2004-03-01 2014-11-19 Board of Regents, The University of Texas System Dimeric small molecule potentiators of apoptosis
CN101128425B (zh) * 2005-02-25 2012-12-26 泰特拉洛吉克药业公司 Iap二聚体抑制剂
WO2008128171A2 (en) * 2007-04-13 2008-10-23 The Regents Of The University Of Michigan Diazo bicyclic smac mimetics and the uses thereof
ES2643233T3 (es) * 2009-10-23 2017-11-21 The Regents Of The University Of Michigan Miméticos de SMAC bicíclicos diazo bivalentes y los usos de los mismos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2342387C2 (ru) * 2003-04-09 2008-12-27 Чоонгвае Фарма Корпорейшн Миметики с обратной конфигурацией и способы их применения
WO2007130626A2 (en) * 2006-05-05 2007-11-15 The Regents Of The University Of Michigan Bivalent smac mimetics and the uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Yuefeng Peng; Haiying Sun; Jianfeng Lu; Liu Liu; Qian Cai; Rong Shen; Chao-Yie Yang; Han Yi; Shaomeng Wang, Bivalent Smac Mimetics with a Diazabicyclic Core as Highly Potent Antagonists of XIAP and cIAP1/2 and Novel Anticancer Agents, Journal of Medicinal Chemistry, т. 55, n:1, стр.: 106 - 114, 2012. *

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ES2654623T3 (es) 2018-02-14
KR20200054334A (ko) 2020-05-19
WO2014031487A1 (en) 2014-02-27
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JP6247298B2 (ja) 2017-12-13
KR102237888B1 (ko) 2021-04-07
EP2888265B1 (en) 2017-10-11
CN104718209A (zh) 2015-06-17
RU2015107552A (ru) 2016-10-10
CN109485662A (zh) 2019-03-19
HK1211030A1 (en) 2016-05-13
AU2013306087B2 (en) 2017-08-10
MX2015002371A (es) 2015-10-05
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US20140057924A1 (en) 2014-02-27
JP2015528447A (ja) 2015-09-28
KR102111704B1 (ko) 2020-05-15
CN109575049B (zh) 2021-07-30

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