JP2015527978A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015527978A5 JP2015527978A5 JP2015518629A JP2015518629A JP2015527978A5 JP 2015527978 A5 JP2015527978 A5 JP 2015527978A5 JP 2015518629 A JP2015518629 A JP 2015518629A JP 2015518629 A JP2015518629 A JP 2015518629A JP 2015527978 A5 JP2015527978 A5 JP 2015527978A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence number
- cancer
- antibody
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261663496P | 2012-06-22 | 2012-06-22 | |
| US61/663,496 | 2012-06-22 | ||
| PCT/US2013/047192 WO2013192596A2 (en) | 2012-06-22 | 2013-06-21 | Antigen binding proteins that bind ccr2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018141655A Division JP2018199681A (ja) | 2012-06-22 | 2018-07-27 | Ｃｃｒ２に結合する抗原結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015527978A JP2015527978A (ja) | 2015-09-24 |
| JP2015527978A5 true JP2015527978A5 (https=) | 2016-08-12 |
| JP6438391B2 JP6438391B2 (ja) | 2018-12-12 |
Family
ID=49769736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518629A Expired - Fee Related JP6438391B2 (ja) | 2012-06-22 | 2013-06-21 | Ｃｃｒ２に結合する抗原結合タンパク質 |
| JP2018141655A Withdrawn JP2018199681A (ja) | 2012-06-22 | 2018-07-27 | Ｃｃｒ２に結合する抗原結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018141655A Withdrawn JP2018199681A (ja) | 2012-06-22 | 2018-07-27 | Ｃｃｒ２に結合する抗原結合タンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9315579B2 (https=) |
| EP (1) | EP2864358B1 (https=) |
| JP (2) | JP6438391B2 (https=) |
| CN (1) | CN105051065A (https=) |
| CA (1) | CA2877814A1 (https=) |
| HK (1) | HK1208236A1 (https=) |
| WO (1) | WO2013192596A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014013138B1 (pt) | 2011-12-01 | 2022-06-28 | Chemocentryx, Inc | Compostos de anilinas substituídas como antagonistas de ccr(4) e composição farmacêutica compreendendo os mesmos |
| CN105050618B (zh) * | 2012-06-21 | 2018-11-16 | 索伦托治疗有限公司 | 与c-Met结合的抗原结合蛋白 |
| WO2013192596A2 (en) * | 2012-06-22 | 2013-12-27 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind ccr2 |
| DK3297438T3 (da) | 2015-05-21 | 2022-01-17 | Chemocentryx Inc | Ccr2-modulatorer |
| WO2017165125A1 (en) * | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Use of a pd-1 antagonist and an anti-ccr2 antibody in the treatment of cancer |
| US20170348442A1 (en) | 2016-06-02 | 2017-12-07 | Washington University | Compositions and methods for detecting ccr2 receptors |
| WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| CN110709422B (zh) * | 2017-04-19 | 2023-12-26 | 马伦戈治疗公司 | 多特异性分子及其用途 |
| CA3293051A1 (en) | 2017-09-25 | 2026-03-02 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| EP3720881A1 (en) | 2017-12-08 | 2020-10-14 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
| CN112105353B (zh) * | 2018-01-08 | 2024-04-19 | 凯莫森特里克斯股份有限公司 | Ccr2拮抗剂治疗实体瘤的方法 |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| CN113164777B (zh) | 2018-09-27 | 2024-12-13 | 马伦戈治疗公司 | Csf1r/ccr2多特异性抗体 |
| EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| MX2024004447A (es) | 2021-10-27 | 2024-05-08 | Granite Bio Ag | Anticuerpos dirigidos a ccr2. |
| WO2024220548A2 (en) * | 2023-04-17 | 2024-10-24 | University Of Southern California | Molecular-mri using ccr2-targeted micelles for detection of lymph node metastases |
| CN121399160A (zh) | 2023-05-29 | 2026-01-23 | 花岗岩生物股份公司 | 靶向ccr2的抗体 |
| WO2025231346A1 (en) * | 2024-05-03 | 2025-11-06 | The Wistar Institute Of Anatomy And Biology | Anti-interferon-alpha and anti-interferon-beta antibodies, and methods of use thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3817827A (en) | 1972-03-30 | 1974-06-18 | Scott Paper Co | Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6010902A (en) | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| JP3051145B2 (ja) | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| JPH07509128A (ja) | 1992-07-13 | 1995-10-12 | バイオネブラスカ・インコーポレーテッド | 組換型ポリペプチドの修飾方法 |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6541208B1 (en) | 1998-03-17 | 2003-04-01 | University Of Maryland Biotechnology Institute | Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| GB0016138D0 (en) | 2000-06-30 | 2000-08-23 | Novartis Ag | Organic compounds |
| EP2295450B1 (en) | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Pegylated interleukin-10 |
| GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| US20070021466A1 (en) | 2002-11-18 | 2007-01-25 | Solomon Ungashe | CCR2 inhibitors and methods of use thereof |
| US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
| WO2004110376A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
| MXPA06000176A (es) * | 2003-12-10 | 2006-06-27 | Millennium Pharm Inc | Anticuerpos anti-ccr2 humanizados y sus metodos de uso. |
| US20050260139A1 (en) * | 2004-03-30 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on anticholinergics and CCR2 receptor antagonists |
| CA2665808A1 (en) * | 2006-10-05 | 2008-05-22 | Centocor Ortho Biotech Inc. | Ccr2 antagonists for treatment of fibrosis |
| RU2547595C2 (ru) * | 2008-08-18 | 2015-04-10 | Пфайзер Инк | Антитела против ccr2 |
| WO2013192596A2 (en) * | 2012-06-22 | 2013-12-27 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind ccr2 |
-
2013
- 2013-06-21 WO PCT/US2013/047192 patent/WO2013192596A2/en not_active Ceased
- 2013-06-21 HK HK15108907.8A patent/HK1208236A1/xx unknown
- 2013-06-21 CN CN201380043633.4A patent/CN105051065A/zh active Pending
- 2013-06-21 US US13/924,501 patent/US9315579B2/en active Active
- 2013-06-21 CA CA2877814A patent/CA2877814A1/en not_active Abandoned
- 2013-06-21 EP EP13807252.5A patent/EP2864358B1/en active Active
- 2013-06-21 JP JP2015518629A patent/JP6438391B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-13 US US15/097,955 patent/US9951138B2/en active Active
-
2018
- 2018-03-19 US US15/925,494 patent/US10696746B2/en active Active
- 2018-07-27 JP JP2018141655A patent/JP2018199681A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015527978A5 (https=) | ||
| CN105837688B (zh) | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 | |
| RU2016136639A (ru) | Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины | |
| HRP20200241T1 (hr) | Anti-c5a vezujuće skupine s visokom blokirajućom aktivnosti | |
| JP6681327B2 (ja) | 抗ｐｄ−１抗体およびその応用 | |
| JP2012501669A5 (https=) | ||
| JP2020500542A5 (https=) | ||
| JP2016515524A5 (https=) | ||
| JP2012500020A5 (https=) | ||
| RU2009128215A (ru) | Человеческие антитела, которые связываются с человеческим il-12, и способы получения | |
| TN2015000348A1 (en) | Antibodies that bind il-23 | |
| JP2014500009A5 (https=) | ||
| RU2011135422A (ru) | Человеческие анти-il-6 антитела с пролонгированным периодом выведения in vivo и их применение при лечении онкологических, аутоиммунных заболеваний и воспалительных заболеваний | |
| EA201370105A1 (ru) | Человеческие антитела против человеческого tnf-подобного лиганда-1а (tl1a) | |
| RU2020111737A (ru) | Антитело против il-6r и его антигенсвязывающий фрагмент и медицинское применение | |
| JP2012521191A5 (https=) | ||
| JP2019524730A5 (https=) | ||
| JP2017512838A5 (https=) | ||
| RU2015144033A (ru) | Антитела против cd25 и их применения | |
| EA201300418A1 (ru) | Антитела к человеческому tweak и варианты их применения | |
| JP2017523984A5 (https=) | ||
| RU2019126888A (ru) | Антитело к человеческому аннексину а1 | |
| JP2016520595A5 (https=) | ||
| Chan et al. | Affinity maturation: highlights in the application of in vitro strategies for the directed evolution of antibodies | |
| JP2020504078A5 (https=) |