JP2015525071A5 - - Google Patents

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Publication number
JP2015525071A5
JP2015525071A5 JP2015516160A JP2015516160A JP2015525071A5 JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5 JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5
Authority
JP
Japan
Prior art keywords
human
human immunoglobulin
chain variable
heavy chain
genetically engineered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015516160A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015525071A (ja
Filing date
Publication date
Priority claimed from US13/488,628 external-priority patent/US20130045492A1/en
Application filed filed Critical
Priority claimed from PCT/US2013/044257 external-priority patent/WO2013184761A1/fr
Publication of JP2015525071A publication Critical patent/JP2015525071A/ja
Publication of JP2015525071A5 publication Critical patent/JP2015525071A5/ja
Pending legal-status Critical Current

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JP2015516160A 2012-06-05 2013-06-05 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法 Pending JP2015525071A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/488,628 US20130045492A1 (en) 2010-02-08 2012-06-05 Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US13/488,628 2012-06-05
PCT/US2013/044257 WO2013184761A1 (fr) 2012-06-05 2013-06-05 Procédés pour préparer des anticorps bispécifiques entièrement humains en utilisant une chaîne légère commune

Publications (2)

Publication Number Publication Date
JP2015525071A JP2015525071A (ja) 2015-09-03
JP2015525071A5 true JP2015525071A5 (fr) 2016-07-21

Family

ID=48652344

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015516160A Pending JP2015525071A (ja) 2012-06-05 2013-06-05 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法

Country Status (12)

Country Link
EP (1) EP2854523A1 (fr)
JP (1) JP2015525071A (fr)
KR (1) KR20150023535A (fr)
CN (1) CN104582476B (fr)
AU (1) AU2013271737A1 (fr)
CA (1) CA2874846A1 (fr)
HK (1) HK1208994A1 (fr)
IL (1) IL235781A0 (fr)
MX (1) MX2014014891A (fr)
RU (1) RU2014153674A (fr)
SG (2) SG10201609535TA (fr)
WO (1) WO2013184761A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
PT2505654T (pt) 2010-02-08 2016-11-18 Regeneron Pharma Rato de cadeia leve comum
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
WO2013138681A1 (fr) 2012-03-16 2013-09-19 Regeneron Pharmaceuticals, Inc. Souris produisant des protéines de liaison à l'antigène ayant des caractéristiques de liaison dépendant du ph
NZ730271A (en) 2012-03-16 2022-09-30 Regeneron Pharma Non-human animals expressing ph-sensitive immunoglobulin sequences
LT2883449T (lt) 2012-03-16 2018-05-10 Regeneron Pharmaceuticals, Inc. Histidinu modifikuoti lengvosios grandinės antikūnai ir juos gaminantys genetiškai modifikuoti graužikai
NZ772318A (en) 2012-04-20 2023-06-30 Merus Nv Methods and means for the production of ig-like molecules
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
NL2012424C2 (en) * 2013-03-13 2014-12-08 Regeneron Pharma Common light chain mouse.
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
KR102614189B1 (ko) 2014-11-17 2023-12-18 리제너론 파아마슈티컬스, 인크. Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법
EP3023437A1 (fr) * 2014-11-20 2016-05-25 EngMab AG Anticorps bispécifiques contre la CD3epsilon et BCMA
CN107207609B (zh) * 2014-11-20 2022-07-19 豪夫迈·罗氏有限公司 共同轻链和使用方法
CA2981312C (fr) 2015-03-30 2023-09-26 Regeneron Pharmaceuticals, Inc. Regions constantes de chaines lourdes presentant une liaison reduite aux recepteurs fc gamma
MA56416A (fr) 2015-05-12 2022-05-04 Regeneron Pharma Détermination de la pureté de protéines multimériques
EP3353212B1 (fr) * 2015-09-23 2021-11-03 Regeneron Pharmaceuticals, Inc. Anticorps bispécifiques anti-cd3 optimisés et leurs utilisations
KR20230006929A (ko) 2016-01-13 2023-01-11 리제너론 파마슈티칼스 인코포레이티드 조작된 중쇄 다양성 영역을 갖는 설치류
US20190380316A1 (en) 2018-06-14 2019-12-19 Regeneron Pharmaceuticals, Inc. Non-human animals capable of engineered dh-dh rearrangement and uses thereof
CN112771077A (zh) 2018-08-31 2021-05-07 瑞泽恩制药公司 针对cd3/c20双特异性抗体的减轻细胞因子释放综合征的给药策略
JP2022520819A (ja) 2019-02-22 2022-04-01 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US20220090060A1 (en) 2020-09-11 2022-03-24 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
KR20230147048A (ko) 2020-12-16 2023-10-20 리제너론 파마슈티칼스 인코포레이티드 인간화 Fc 알파 수용체를 발현하는 마우스
US20220195014A1 (en) 2020-12-23 2022-06-23 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
MX2023007583A (es) 2020-12-23 2023-07-07 Regeneron Pharma Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen.

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Publication number Priority date Publication date Assignee Title
AU643189B2 (en) * 1988-09-06 1993-11-11 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0754225A4 (fr) * 1993-04-26 2001-01-31 Genpharm Int Animaux transgeniques capables de produire des anticorps heterologues
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP2298809A3 (fr) * 2001-07-12 2012-02-15 FOOTE, Jefferson Anticorps super humanisés
DE50115587D1 (de) * 2001-10-01 2010-09-16 Deutsches Krebsforsch Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus
WO2003061363A2 (fr) * 2002-01-17 2003-07-31 Albert Einstein College Of Medicine Of Yeshiva University Mutations provoquees par la cytidine-desaminase induite par activation
CN101824090B (zh) * 2002-06-14 2013-01-02 免疫医疗公司 人源化单克隆抗体hPAM4
CN101962408A (zh) * 2002-07-12 2011-02-02 杰斐逊·富特 超人源化抗体
SI3456190T1 (sl) * 2008-06-27 2022-06-30 Merus N.V. Transgena mišja živali, ki proizvaja protitelesa
PT2505654T (pt) * 2010-02-08 2016-11-18 Regeneron Pharma Rato de cadeia leve comum
EP3865581A1 (fr) * 2011-08-05 2021-08-18 Regeneron Pharmaceuticals, Inc. Souris à chaîne légère universelle humanisée

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