JP2015525071A5 - - Google Patents

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Publication number
JP2015525071A5
JP2015525071A5 JP2015516160A JP2015516160A JP2015525071A5 JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5 JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5
Authority
JP
Japan
Prior art keywords
human
human immunoglobulin
chain variable
heavy chain
genetically engineered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015516160A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015525071A (ja
Filing date
Publication date
Priority claimed from US13/488,628 external-priority patent/US20130045492A1/en
Application filed filed Critical
Priority claimed from PCT/US2013/044257 external-priority patent/WO2013184761A1/fr
Publication of JP2015525071A publication Critical patent/JP2015525071A/ja
Publication of JP2015525071A5 publication Critical patent/JP2015525071A5/ja
Pending legal-status Critical Current

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JP2015516160A 2012-06-05 2013-06-05 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法 Pending JP2015525071A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/488,628 US20130045492A1 (en) 2010-02-08 2012-06-05 Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US13/488,628 2012-06-05
PCT/US2013/044257 WO2013184761A1 (fr) 2012-06-05 2013-06-05 Procédés pour préparer des anticorps bispécifiques entièrement humains en utilisant une chaîne légère commune

Publications (2)

Publication Number Publication Date
JP2015525071A JP2015525071A (ja) 2015-09-03
JP2015525071A5 true JP2015525071A5 (fr) 2016-07-21

Family

ID=48652344

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015516160A Pending JP2015525071A (ja) 2012-06-05 2013-06-05 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法

Country Status (12)

Country Link
EP (1) EP2854523A1 (fr)
JP (1) JP2015525071A (fr)
KR (1) KR20150023535A (fr)
CN (1) CN104582476B (fr)
AU (1) AU2013271737A1 (fr)
CA (1) CA2874846A1 (fr)
HK (1) HK1208994A1 (fr)
IL (1) IL235781A0 (fr)
MX (1) MX2014014891A (fr)
RU (1) RU2014153674A (fr)
SG (2) SG10201609535TA (fr)
WO (1) WO2013184761A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
HUE026229T2 (en) 2010-02-08 2016-06-28 Regeneron Pharma Common light chain mouse
KR102228296B1 (ko) 2012-03-16 2021-03-17 리제너론 파마슈티칼스 인코포레이티드 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물
MY173376A (en) 2012-03-16 2020-01-21 Regeneron Pharma Mice that produce antigen?binding proteins with ph?dependent binding characteristics
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
MX355944B (es) 2012-03-16 2018-05-07 Regeneron Pharma Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph.
KR102382304B1 (ko) 2012-04-20 2022-04-04 메뤼스 엔.페. Ig-유사 분자의 제조방법 및 제조수단
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
CA2903696A1 (fr) * 2013-03-13 2014-10-02 Regeneron Pharmaceuticals, Inc. Souris a chaine legere classique
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
KR102614189B1 (ko) 2014-11-17 2023-12-18 리제너론 파아마슈티컬스, 인크. Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법
RU2747011C2 (ru) * 2014-11-20 2021-04-23 Ф.Хоффманн-Ля Рош Аг Общие легкие цепи и способы их применения
EP3023437A1 (fr) * 2014-11-20 2016-05-25 EngMab AG Anticorps bispécifiques contre la CD3epsilon et BCMA
EP3277725B1 (fr) 2015-03-30 2020-11-25 Regeneron Pharmaceuticals, Inc. Régions constantes de chaînes lourdes présentant une liaison réduite aux récepteurs fc gamma
PL3294775T3 (pl) 2015-05-12 2021-12-13 Regeneron Pharmaceuticals, Inc. Oznaczanie czystości białka multimerycznego
LT3353212T (lt) * 2015-09-23 2021-12-27 Regeneron Pharmaceuticals, Inc. Optimizuoti anti-cd3 bispecifiniai antikūnai ir jų naudojimas
RU2763320C2 (ru) 2016-01-13 2021-12-28 Регенерон Фармасьютикалз, Инк. Грызуны, имеющие сконструированный участок разнообразия тяжелой цепи
CN112312766A (zh) 2018-06-14 2021-02-02 瑞泽恩制药公司 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物
MX2021002190A (es) 2018-08-31 2021-05-14 Regeneron Pharma Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20.
CA3127153A1 (fr) 2019-02-22 2020-08-27 Regeneron Pharmaceuticals, Inc. Rongeurs ayant des canaux sodiques genetiquement modifies et leurs procedes d'utilisation
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
WO2022056276A1 (fr) 2020-09-11 2022-03-17 Regeneron Pharmaceuticals, Inc. Identification et production d'anticorps spécifiques à un antigène
KR20230147048A (ko) 2020-12-16 2023-10-20 리제너론 파마슈티칼스 인코포레이티드 인간화 Fc 알파 수용체를 발현하는 마우스
MX2023007401A (es) 2020-12-23 2023-07-06 Regeneron Pharma Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos.
TW202242114A (zh) 2020-12-23 2022-11-01 美商再生元醫藥公司 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0364096B1 (fr) * 1988-09-06 2000-03-08 Xoma Corporation Eléments d'expression de gènes et production d'anticorps souris-humains chimériques
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0754225A4 (fr) * 1993-04-26 2001-01-31 Genpharm Int Animaux transgeniques capables de produire des anticorps heterologues
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP2298809A3 (fr) * 2001-07-12 2012-02-15 FOOTE, Jefferson Anticorps super humanisés
DE50115587D1 (de) * 2001-10-01 2010-09-16 Deutsches Krebsforsch Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus
US20050095712A1 (en) * 2002-01-17 2005-05-05 Alberto Martin Mutations caused by activation-induced cytidine deaminase
BR0311799A (pt) * 2002-06-14 2005-05-10 Immunomedics Inc Anticorpo monoclonal hpam4
CN101962408A (zh) * 2002-07-12 2011-02-02 杰斐逊·富特 超人源化抗体
RU2731084C2 (ru) * 2008-06-27 2020-08-28 Мерюс Н.В. Продуцирующие антитела млекопитающие, не являющиеся человеком
HUE026229T2 (en) * 2010-02-08 2016-06-28 Regeneron Pharma Common light chain mouse
EP2739740B1 (fr) * 2011-08-05 2019-10-02 Regeneron Pharmaceuticals, Inc. Souris à chaîne légère universelle humanisée

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