JP2020501516A5 - - Google Patents
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- Publication number
- JP2020501516A5 JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene segments
- light chain
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000018358 Immunoglobulins Human genes 0.000 claims description 54
- 108060003951 Immunoglobulins Proteins 0.000 claims description 54
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 23
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 23
- 238000003780 insertion Methods 0.000 claims description 22
- 239000003623 enhancer Substances 0.000 claims description 19
- 230000002708 enhancing Effects 0.000 claims description 19
- 210000004602 germ cell Anatomy 0.000 claims description 14
- 229920002332 Noncoding DNA Polymers 0.000 claims description 10
- 108010002162 IGK Proteins 0.000 claims description 9
- 102100007034 Immunoglobulin kappa light chain Human genes 0.000 claims description 9
- 210000001671 Embryonic Stem Cells Anatomy 0.000 claims description 7
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 6
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 241000283984 Rodentia Species 0.000 description 81
- 210000004027 cells Anatomy 0.000 description 5
- 241000700159 Rattus Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000038129 antigens Human genes 0.000 description 3
- 108091007172 antigens Proteins 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 102000004965 antibodies Human genes 0.000 description 2
- 108090001123 antibodies Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417845P | 2016-11-04 | 2016-11-04 | |
| US62/417,845 | 2016-11-04 | ||
| US201762567932P | 2017-10-04 | 2017-10-04 | |
| US62/567,932 | 2017-10-04 | ||
| PCT/US2017/060006 WO2018128691A1 (fr) | 2016-11-04 | 2017-11-03 | Animaux non humains présentant un locus de chaîne légère d'immunoglobuline lambda modifié |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Division JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501516A JP2020501516A (ja) | 2020-01-23 |
| JP2020501516A5 true JP2020501516A5 (fr) | 2020-12-10 |
| JP6884860B2 JP6884860B2 (ja) | 2021-06-09 |
Family
ID=62025924
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522647A Active JP6884860B2 (ja) | 2016-11-04 | 2017-11-03 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Pending JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Pending JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10820582B2 (fr) |
| EP (3) | EP3766343B1 (fr) |
| JP (4) | JP6884860B2 (fr) |
| KR (4) | KR102319069B1 (fr) |
| CN (2) | CN109996441B (fr) |
| AU (2) | AU2017391167B2 (fr) |
| BR (1) | BR112019008675A2 (fr) |
| CA (1) | CA3038720A1 (fr) |
| CY (1) | CY1123491T1 (fr) |
| DK (2) | DK3407709T3 (fr) |
| ES (2) | ES2823305T3 (fr) |
| HR (2) | HRP20220888T1 (fr) |
| HU (2) | HUE061980T2 (fr) |
| IL (2) | IL266282B2 (fr) |
| LT (2) | LT3407709T (fr) |
| MA (2) | MA53935A (fr) |
| MX (2) | MX2019005256A (fr) |
| PL (2) | PL3407709T3 (fr) |
| PT (2) | PT3407709T (fr) |
| RS (2) | RS60886B1 (fr) |
| RU (2) | RU2757665C2 (fr) |
| SG (2) | SG10201913483XA (fr) |
| SI (2) | SI3407709T1 (fr) |
| WO (1) | WO2018128691A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62023B1 (sr) * | 2012-02-01 | 2021-07-30 | Regeneron Pharma | Humanizovani glodari koji eksprimiraju teške lance koji sadrže vl domene |
| US10813346B2 (en) | 2015-12-03 | 2020-10-27 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| HRP20220888T1 (hr) | 2016-11-04 | 2022-10-28 | Regeneron Pharmaceuticals, Inc. | Ne-humane životinje koje imaju konstruirani lokus imunoglobulinskog lamba lakog lanca |
| CN112040769B (zh) | 2018-03-24 | 2023-05-16 | 瑞泽恩制药公司 | 用于产生针对肽-mhc复合物的治疗抗体的经过基因修饰的非人动物、制造方法和用途 |
| JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
| US20190380316A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
| JP2022520819A (ja) | 2019-02-22 | 2022-04-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法 |
| CN114554841B (zh) * | 2019-07-01 | 2024-06-11 | 特里安尼公司 | 转基因哺乳动物及其使用方法 |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| MX2023007583A (es) | 2020-12-23 | 2023-07-07 | Regeneron Pharma | Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen. |
| US20220195014A1 (en) | 2020-12-23 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| GB202217978D0 (en) * | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2124967C (fr) * | 1991-12-17 | 2008-04-08 | Nils Lonberg | Animaux transgeniques non humains capables de produire des anticorps heterologues |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2003047336A2 (fr) | 2001-11-30 | 2003-06-12 | Abgenix, Inc. | Animaux transgeniques porteurs de genes a chaine legere $g(l) d'immunoglobuline humaine |
| WO2005007696A2 (fr) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Locus d'immunoglobuline humanises |
| CN102585002A (zh) | 2006-06-02 | 2012-07-18 | 瑞泽恩制药公司 | 人il-6受体的高亲和力抗体 |
| KR102362774B1 (ko) | 2008-09-30 | 2022-02-15 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| MX2011007660A (es) * | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
| DK3028564T5 (da) * | 2009-07-08 | 2024-04-29 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| US20120204278A1 (en) * | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011115476A1 (fr) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Nutrition du nourrisson destinée à améliorer la composition en acides gras des membranes cérébrales à un stade ultérieur de sa vie |
| PT2905338T (pt) | 2010-06-22 | 2017-11-10 | Regeneron Pharma | Ratinhos transgénicos com um locus de imunoglobulina lambda endógeno modificado |
| ES2748832T5 (es) | 2011-02-25 | 2023-06-08 | Regeneron Pharma | Ratones ADAM6 |
| EP2627773B1 (fr) | 2011-10-17 | 2017-06-14 | Regeneron Pharmaceuticals, Inc. | Souris à chaîne lourde d'immunoglobuline limitée |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| KR102081657B1 (ko) * | 2011-12-20 | 2020-02-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
| AU2014218915B2 (en) * | 2013-02-20 | 2017-01-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
| CN109913495B (zh) | 2013-02-20 | 2022-11-25 | 瑞泽恩制药公司 | 大鼠的遗传修饰 |
| US9788534B2 (en) * | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| EP3794941A1 (fr) * | 2013-10-01 | 2021-03-24 | Kymab Limited | Modèles d'animaux et molécules thérapeutiques |
| US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
| CN113215196A (zh) | 2014-06-06 | 2021-08-06 | 瑞泽恩制药公司 | 用于修饰所靶向基因座的方法和组合物 |
| SI3354732T1 (sl) | 2014-06-23 | 2020-07-31 | Regeneron Pharmaceuticals, Inc. | Z nukleazo posredovan DNA sklop |
| PT3221457T (pt) | 2014-11-21 | 2019-06-27 | Regeneron Pharma | Métodos e composições para modificação genética visada através da utilização de arn guia emparelhados |
| RU2707137C2 (ru) | 2014-12-19 | 2019-11-22 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для нацеленной генетической модификации посредством одноэтапного множественного нацеливания |
| HRP20220888T1 (hr) | 2016-11-04 | 2022-10-28 | Regeneron Pharmaceuticals, Inc. | Ne-humane životinje koje imaju konstruirani lokus imunoglobulinskog lamba lakog lanca |
-
2017
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active IP Right Grant
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/fr active Application Filing
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 CA CA3038720A patent/CA3038720A1/fr active Pending
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active IP Right Grant
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 MX MX2019005256A patent/MX2019005256A/es unknown
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/fr active Active
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active IP Right Grant
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Search and Examination
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/fr active Active
- 2017-11-03 EP EP22164751.4A patent/EP4082334A1/fr active Pending
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
-
2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
-
2020
- 2020-09-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2020-09-24 US US17/031,367 patent/US20210029978A1/en active Pending
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
-
2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
-
2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
-
2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja active Pending
-
2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending
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