CA2874846A1 - Procedes pour preparer des anticorps bispecifiques entierement humains en utilisant une chaine legere commune - Google Patents
Procedes pour preparer des anticorps bispecifiques entierement humains en utilisant une chaine legere commune Download PDFInfo
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- CA2874846A1 CA2874846A1 CA2874846A CA2874846A CA2874846A1 CA 2874846 A1 CA2874846 A1 CA 2874846A1 CA 2874846 A CA2874846 A CA 2874846A CA 2874846 A CA2874846 A CA 2874846A CA 2874846 A1 CA2874846 A1 CA 2874846A1
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-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/488,628 US20130045492A1 (en) | 2010-02-08 | 2012-06-05 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US13/488,628 | 2012-06-05 | ||
| PCT/US2013/044257 WO2013184761A1 (fr) | 2012-06-05 | 2013-06-05 | Procédés pour préparer des anticorps bispécifiques entièrement humains en utilisant une chaîne légère commune |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2874846A1 true CA2874846A1 (fr) | 2013-12-12 |
Family
ID=48652344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2874846A Abandoned CA2874846A1 (fr) | 2012-06-05 | 2013-06-05 | Procedes pour preparer des anticorps bispecifiques entierement humains en utilisant une chaine legere commune |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2854523A1 (fr) |
| JP (1) | JP2015525071A (fr) |
| KR (1) | KR20150023535A (fr) |
| CN (1) | CN104582476B (fr) |
| AU (1) | AU2013271737A1 (fr) |
| CA (1) | CA2874846A1 (fr) |
| HK (1) | HK1208994A1 (fr) |
| IL (1) | IL235781A0 (fr) |
| MX (1) | MX2014014891A (fr) |
| RU (1) | RU2014153674A (fr) |
| SG (2) | SG10201609535TA (fr) |
| WO (1) | WO2013184761A1 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| HUE026229T2 (en) | 2010-02-08 | 2016-06-28 | Regeneron Pharma | Common light chain mouse |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| MY173376A (en) | 2012-03-16 | 2020-01-21 | Regeneron Pharma | Mice that produce antigen?binding proteins with ph?dependent binding characteristics |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| MX355944B (es) | 2012-03-16 | 2018-05-07 | Regeneron Pharma | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
| KR102382304B1 (ko) | 2012-04-20 | 2022-04-04 | 메뤼스 엔.페. | Ig-유사 분자의 제조방법 및 제조수단 |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| CA2903696A1 (fr) * | 2013-03-13 | 2014-10-02 | Regeneron Pharmaceuticals, Inc. | Souris a chaine legere classique |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
| RU2747011C2 (ru) * | 2014-11-20 | 2021-04-23 | Ф.Хоффманн-Ля Рош Аг | Общие легкие цепи и способы их применения |
| EP3023437A1 (fr) * | 2014-11-20 | 2016-05-25 | EngMab AG | Anticorps bispécifiques contre la CD3epsilon et BCMA |
| EP3277725B1 (fr) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Régions constantes de chaînes lourdes présentant une liaison réduite aux récepteurs fc gamma |
| PL3294775T3 (pl) | 2015-05-12 | 2021-12-13 | Regeneron Pharmaceuticals, Inc. | Oznaczanie czystości białka multimerycznego |
| LT3353212T (lt) * | 2015-09-23 | 2021-12-27 | Regeneron Pharmaceuticals, Inc. | Optimizuoti anti-cd3 bispecifiniai antikūnai ir jų naudojimas |
| RU2763320C2 (ru) | 2016-01-13 | 2021-12-28 | Регенерон Фармасьютикалз, Инк. | Грызуны, имеющие сконструированный участок разнообразия тяжелой цепи |
| CN112312766A (zh) | 2018-06-14 | 2021-02-02 | 瑞泽恩制药公司 | 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物 |
| MX2021002190A (es) | 2018-08-31 | 2021-05-14 | Regeneron Pharma | Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20. |
| CA3127153A1 (fr) | 2019-02-22 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Rongeurs ayant des canaux sodiques genetiquement modifies et leurs procedes d'utilisation |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| WO2022056276A1 (fr) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification et production d'anticorps spécifiques à un antigène |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
| TW202242114A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0364096B1 (fr) * | 1988-09-06 | 2000-03-08 | Xoma Corporation | Eléments d'expression de gènes et production d'anticorps souris-humains chimériques |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0754225A4 (fr) * | 1993-04-26 | 2001-01-31 | Genpharm Int | Animaux transgeniques capables de produire des anticorps heterologues |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP2298809A3 (fr) * | 2001-07-12 | 2012-02-15 | FOOTE, Jefferson | Anticorps super humanisés |
| DE50115587D1 (de) * | 2001-10-01 | 2010-09-16 | Deutsches Krebsforsch | Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus |
| US20050095712A1 (en) * | 2002-01-17 | 2005-05-05 | Alberto Martin | Mutations caused by activation-induced cytidine deaminase |
| BR0311799A (pt) * | 2002-06-14 | 2005-05-10 | Immunomedics Inc | Anticorpo monoclonal hpam4 |
| CN101962408A (zh) * | 2002-07-12 | 2011-02-02 | 杰斐逊·富特 | 超人源化抗体 |
| RU2731084C2 (ru) * | 2008-06-27 | 2020-08-28 | Мерюс Н.В. | Продуцирующие антитела млекопитающие, не являющиеся человеком |
| HUE026229T2 (en) * | 2010-02-08 | 2016-06-28 | Regeneron Pharma | Common light chain mouse |
| EP2739740B1 (fr) * | 2011-08-05 | 2019-10-02 | Regeneron Pharmaceuticals, Inc. | Souris à chaîne légère universelle humanisée |
-
2013
- 2013-06-05 CN CN201380030014.1A patent/CN104582476B/zh active Active
- 2013-06-05 KR KR20147036869A patent/KR20150023535A/ko not_active Application Discontinuation
- 2013-06-05 CA CA2874846A patent/CA2874846A1/fr not_active Abandoned
- 2013-06-05 WO PCT/US2013/044257 patent/WO2013184761A1/fr active Application Filing
- 2013-06-05 SG SG10201609535TA patent/SG10201609535TA/en unknown
- 2013-06-05 EP EP13729875.8A patent/EP2854523A1/fr not_active Ceased
- 2013-06-05 SG SG11201407644UA patent/SG11201407644UA/en unknown
- 2013-06-05 JP JP2015516160A patent/JP2015525071A/ja active Pending
- 2013-06-05 MX MX2014014891A patent/MX2014014891A/es unknown
- 2013-06-05 AU AU2013271737A patent/AU2013271737A1/en not_active Abandoned
- 2013-06-05 RU RU2014153674A patent/RU2014153674A/ru not_active Application Discontinuation
-
2014
- 2014-11-18 IL IL235781A patent/IL235781A0/en unknown
-
2015
- 2015-10-06 HK HK15109745.2A patent/HK1208994A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201609535TA (en) | 2017-01-27 |
| JP2015525071A (ja) | 2015-09-03 |
| HK1208994A1 (en) | 2016-03-24 |
| CN104582476A (zh) | 2015-04-29 |
| KR20150023535A (ko) | 2015-03-05 |
| CN104582476B (zh) | 2017-03-08 |
| AU2013271737A1 (en) | 2015-01-22 |
| MX2014014891A (es) | 2015-06-17 |
| IL235781A0 (en) | 2015-01-29 |
| EP2854523A1 (fr) | 2015-04-08 |
| WO2013184761A1 (fr) | 2013-12-12 |
| SG11201407644UA (en) | 2014-12-30 |
| RU2014153674A (ru) | 2016-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20190605 |