JP2015524456A5 - - Google Patents
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- Publication number
- JP2015524456A5 JP2015524456A5 JP2015525846A JP2015525846A JP2015524456A5 JP 2015524456 A5 JP2015524456 A5 JP 2015524456A5 JP 2015525846 A JP2015525846 A JP 2015525846A JP 2015525846 A JP2015525846 A JP 2015525846A JP 2015524456 A5 JP2015524456 A5 JP 2015524456A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- compound represented
- pharmaceutically acceptable
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
Description
本発明の式Ｉの化合物及びその薬学的に許容しうる塩は、当技術分野において公知の方法、例えば、以下に記載のプロセスによって調製することでき、当該プロセスは、以下を含む：
式：
で表される化合物を、式：
で表される化合物と反応させて、式：
［式中、置換基は、上述したとおりである］
で表される化合物にすること
及び所望であれば、得られた化合物を薬学的に許容しうる酸付加塩に変換すること。
式：
で表される化合物を、式：
で表される化合物と反応させて、式：
［式中、置換基は、上述したとおりである］
で表される化合物にすること
及び所望であれば、得られた化合物を薬学的に許容しうる酸付加塩に変換すること。
Claims (1)
- 請求項１〜１３のいずれか一項に定義される式Ｉの化合物の製造プロセスであって、以下を含むプロセス：
式：
で表される化合物を、
式：
で表される化合物と反応させて、式：
［式中、置換基は、上述したとおりである］
で表される化合物にすること
及び所望であれば、得られた化合物を薬学的に許容しうる酸付加塩に変換すること。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179381 | 2012-08-06 | ||
| EP12179381.4 | 2012-08-06 | ||
| PCT/EP2013/066344 WO2014023674A1 (en) | 2012-08-06 | 2013-08-05 | Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524456A JP2015524456A (ja) | 2015-08-24 |
| JP2015524456A5 true JP2015524456A5 (ja) | 2016-08-04 |
| JP5974177B2 JP5974177B2 (ja) | 2016-08-23 |
Family
ID=48918402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525846A Active JP5974177B2 (ja) | 2012-08-06 | 2013-08-05 | ピペラジノ［１，２−ａ］インドール−１−オン類及び［１，４］ジアゼピノ［１，２−ａ］インドール−１−オン |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9284321B2 (ja) |
| EP (1) | EP2880036B1 (ja) |
| JP (1) | JP5974177B2 (ja) |
| KR (1) | KR101716062B1 (ja) |
| CN (1) | CN104540829B (ja) |
| AR (1) | AR092041A1 (ja) |
| AU (1) | AU2013301577B2 (ja) |
| BR (1) | BR112015000313A2 (ja) |
| CA (1) | CA2880682A1 (ja) |
| CL (1) | CL2015000143A1 (ja) |
| CO (1) | CO7141435A2 (ja) |
| CR (1) | CR20140545A (ja) |
| EA (1) | EA025884B1 (ja) |
| HK (1) | HK1206355A1 (ja) |
| IL (1) | IL236808B (ja) |
| MA (1) | MA37791B1 (ja) |
| MX (1) | MX362184B (ja) |
| MY (1) | MY185216A (ja) |
| NZ (1) | NZ703192A (ja) |
| PE (1) | PE20150341A1 (ja) |
| PH (1) | PH12015500059A1 (ja) |
| SG (1) | SG11201408529VA (ja) |
| TW (1) | TWI506027B (ja) |
| UA (1) | UA113013C2 (ja) |
| WO (1) | WO2014023674A1 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4089397A1 (en) * | 2013-02-18 | 2022-11-16 | Labrador Diagnostics LLC | System for optically analyzing a sample |
| WO2014161801A1 (en) * | 2013-04-02 | 2014-10-09 | F. Hoffmann-La Roche Ag | Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one |
| CN105555763B (zh) * | 2013-09-12 | 2018-04-17 | 豪夫迈·罗氏有限公司 | 吲哚‑甲酰胺衍生物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1965981C3 (de) * | 1968-02-13 | 1978-08-31 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 9-Phenyl-lO-oxopiperazino [l,2-a]-indole und Verfahren zu ihrer Herstellung |
| GB0106177D0 (en) * | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| JP2009518351A (ja) * | 2005-12-09 | 2009-05-07 | エフ．ホフマン−ラ ロシュ アーゲー | 肥満症の処置に有用な三環性アミド誘導体 |
| WO2008046072A2 (en) | 2006-10-13 | 2008-04-17 | The Board Of Regents Of The University Of Texas System | Chemical inducers of neurogenesis |
| BRPI0718776A2 (pt) * | 2006-11-09 | 2013-12-03 | Hoffmann La Roche | Derivados de indol e benzofurano 2-carboxamida |
| CN103415289B (zh) | 2010-07-07 | 2017-04-12 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
| WO2014161801A1 (en) * | 2013-04-02 | 2014-10-09 | F. Hoffmann-La Roche Ag | Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one |
-
2013
- 2013-08-05 AU AU2013301577A patent/AU2013301577B2/en not_active Ceased
- 2013-08-05 EP EP13745648.9A patent/EP2880036B1/en active Active
- 2013-08-05 WO PCT/EP2013/066344 patent/WO2014023674A1/en active Application Filing
- 2013-08-05 PE PE2015000024A patent/PE20150341A1/es active IP Right Grant
- 2013-08-05 MY MYPI2014003519A patent/MY185216A/en unknown
- 2013-08-05 CA CA2880682A patent/CA2880682A1/en not_active Abandoned
- 2013-08-05 SG SG11201408529VA patent/SG11201408529VA/en unknown
- 2013-08-05 MX MX2015001318A patent/MX362184B/es active IP Right Grant
- 2013-08-05 BR BR112015000313A patent/BR112015000313A2/pt not_active Application Discontinuation
- 2013-08-05 KR KR1020157003112A patent/KR101716062B1/ko active IP Right Grant
- 2013-08-05 NZ NZ703192A patent/NZ703192A/en not_active IP Right Cessation
- 2013-08-05 UA UAA201501071A patent/UA113013C2/uk unknown
- 2013-08-05 CN CN201380041546.5A patent/CN104540829B/zh active Active
- 2013-08-05 EA EA201590125A patent/EA025884B1/ru not_active IP Right Cessation
- 2013-08-05 AR ARP130102771A patent/AR092041A1/es unknown
- 2013-08-05 TW TW102128001A patent/TWI506027B/zh not_active IP Right Cessation
- 2013-08-05 JP JP2015525846A patent/JP5974177B2/ja active Active
-
2014
- 2014-11-27 CR CR20140545A patent/CR20140545A/es unknown
- 2014-11-28 CO CO14262433A patent/CO7141435A2/es unknown
-
2015
- 2015-01-09 PH PH12015500059A patent/PH12015500059A1/en unknown
- 2015-01-19 IL IL236808A patent/IL236808B/en not_active IP Right Cessation
- 2015-01-20 MA MA37791A patent/MA37791B1/fr unknown
- 2015-01-21 CL CL2015000143A patent/CL2015000143A1/es unknown
- 2015-02-04 US US14/614,232 patent/US9284321B2/en active Active
- 2015-07-24 HK HK15107077.4A patent/HK1206355A1/xx unknown
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