MA37791B1 - Pipérazino[1,2-a]indol-1-ones et [1,4]diazépino[1,2-a]indol-1-one - Google Patents
Pipérazino[1,2-a]indol-1-ones et [1,4]diazépino[1,2-a]indol-1-oneInfo
- Publication number
- MA37791B1 MA37791B1 MA37791A MA37791A MA37791B1 MA 37791 B1 MA37791 B1 MA 37791B1 MA 37791 A MA37791 A MA 37791A MA 37791 A MA37791 A MA 37791A MA 37791 B1 MA37791 B1 MA 37791B1
- Authority
- MA
- Morocco
- Prior art keywords
- lower alkyl
- halogen
- substituted
- disorder
- disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Abstract
La présente invention concerne des composés de formule générale (i), dans laquelle r1 représente hydrogène, halogène, alkyle inférieur, alcoxy inférieur, alcoxy inférieur substitué par halogène ou cyano ; r2 représente hydrogène, alkyle inférieur ou alkyle inférieur substitué par halogène ; r3 représente phényle, benzo[1,3]dioxolyle, 2,3-dihydro-benzofuran-5-yle ou un hétéroaryle à 5 et 6 chaînons, phényle et les groupes hétéroaryle à 5 et 6 chaînons pouvant être substitués par un ou plusieurs substituants choisis parmi cyano, nitro, amino et di-alkyl inférieur-amino, alkyl inférieur sulfonyle, alcoxy inférieur, alcoxy inférieur substitué par halogène, halogène, alkyle inférieur, alkyle inférieur substitué par halogène ou alkyle inférieur substitué par hydroxyle ; x représente -ch(alkyl inférieur)-, -ch2-, -ch2ch2- ou -ch(alkyl inférieur)ch2- ; r représente hydrogène ou alkyle inférieur ; n est 1 ou 2 ; ou un sel d'addition acide, pharmaceutiquement acceptable, un mélange racémique ou son énantiomère correspondant et/ou leurs isomères optiques. Les composés peuvent être utilisés pour le traitement de la schizophrénie, du trouble de la personnalité obsessionnelle-compulsive, de la dépression majeure, des troubles bipolaires, des troubles de l'anxiété, du vieillissement normal, de l'épilepsie, de la dégénescence rétinienne, du traumatisme cérébral, du traumatisme médullaire, du trouble de stress post-traumatique, du trouble panique, de la maladie de parkinson, de la démence, de la maladie d'alzheimer, du trouble cognitif léger, du dysfonctionnement cognitif induit par chimiothérapie, du syndrome de down, des troubles du spectre de l'autisme, de la perte auditive, de l'acouphène, de l'ataxie spinocérébelleuse, de la sclérose latérale amyotrophique, de la sclérose en plaques, de la maladie de huntington, de l'accident vasculaire cérébral, de la radiothérapie, du stress chronique, de l'abus de drogues neuro-actives, tels que l'alcool, les opiacés, la méthamphétamine, la phencyclidine et la cocaïne.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179381 | 2012-08-06 | ||
| PCT/EP2013/066344 WO2014023674A1 (fr) | 2012-08-06 | 2013-08-05 | Pipérazino[1,2-a]indol-1-ones et [1,4]diazépino[1,2-a]indol-1-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37791A1 MA37791A1 (fr) | 2016-05-31 |
| MA37791B1 true MA37791B1 (fr) | 2016-12-30 |
Family
ID=48918402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37791A MA37791B1 (fr) | 2012-08-06 | 2015-01-20 | Pipérazino[1,2-a]indol-1-ones et [1,4]diazépino[1,2-a]indol-1-one |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9284321B2 (fr) |
| EP (1) | EP2880036B1 (fr) |
| JP (1) | JP5974177B2 (fr) |
| KR (1) | KR101716062B1 (fr) |
| CN (1) | CN104540829B (fr) |
| AR (1) | AR092041A1 (fr) |
| AU (1) | AU2013301577B2 (fr) |
| BR (1) | BR112015000313A2 (fr) |
| CA (1) | CA2880682A1 (fr) |
| CL (1) | CL2015000143A1 (fr) |
| CO (1) | CO7141435A2 (fr) |
| CR (1) | CR20140545A (fr) |
| EA (1) | EA025884B1 (fr) |
| HK (1) | HK1206355A1 (fr) |
| IL (1) | IL236808B (fr) |
| MA (1) | MA37791B1 (fr) |
| MX (1) | MX362184B (fr) |
| MY (1) | MY185216A (fr) |
| NZ (1) | NZ703192A (fr) |
| PE (1) | PE20150341A1 (fr) |
| PH (1) | PH12015500059B1 (fr) |
| SG (1) | SG11201408529VA (fr) |
| TW (1) | TWI506027B (fr) |
| UA (1) | UA113013C2 (fr) |
| WO (1) | WO2014023674A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201506420WA (en) * | 2013-02-18 | 2015-09-29 | Theranos Inc | Image analysis and measurement of biological samples |
| KR101767329B1 (ko) * | 2013-04-02 | 2017-08-10 | 에프. 호프만-라 로슈 아게 | 피페라지노[1,2-a]인돌-1-온 및 [1,4]다이아제피노[1,2-a]인돌-1-온 |
| CA2917628A1 (fr) * | 2013-09-12 | 2015-03-19 | F. Hoffmann-La Roche Ag | Derives d'indole-carboxamide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1965981C3 (de) * | 1968-02-13 | 1978-08-31 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 9-Phenyl-lO-oxopiperazino [l,2-a]-indole und Verfahren zu ihrer Herstellung |
| GB0106177D0 (en) * | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| AU2006324089A1 (en) * | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| WO2008046072A2 (fr) | 2006-10-13 | 2008-04-17 | The Board Of Regents Of The University Of Texas System | Inducteurs chimiques de la neurogénèse |
| MX2009004898A (es) * | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
| BR112013000414A2 (pt) | 2010-07-07 | 2016-05-17 | Univ Texas | compostos proneurogênicos |
| KR101767329B1 (ko) * | 2013-04-02 | 2017-08-10 | 에프. 호프만-라 로슈 아게 | 피페라지노[1,2-a]인돌-1-온 및 [1,4]다이아제피노[1,2-a]인돌-1-온 |
-
2013
- 2013-08-05 TW TW102128001A patent/TWI506027B/zh not_active IP Right Cessation
- 2013-08-05 BR BR112015000313A patent/BR112015000313A2/pt not_active Application Discontinuation
- 2013-08-05 PE PE2015000024A patent/PE20150341A1/es active IP Right Grant
- 2013-08-05 MX MX2015001318A patent/MX362184B/es active IP Right Grant
- 2013-08-05 SG SG11201408529VA patent/SG11201408529VA/en unknown
- 2013-08-05 KR KR1020157003112A patent/KR101716062B1/ko active IP Right Grant
- 2013-08-05 CN CN201380041546.5A patent/CN104540829B/zh active Active
- 2013-08-05 CA CA2880682A patent/CA2880682A1/fr not_active Abandoned
- 2013-08-05 EP EP13745648.9A patent/EP2880036B1/fr active Active
- 2013-08-05 NZ NZ703192A patent/NZ703192A/en not_active IP Right Cessation
- 2013-08-05 EA EA201590125A patent/EA025884B1/ru not_active IP Right Cessation
- 2013-08-05 AU AU2013301577A patent/AU2013301577B2/en not_active Ceased
- 2013-08-05 AR ARP130102771A patent/AR092041A1/es unknown
- 2013-08-05 MY MYPI2014003519A patent/MY185216A/en unknown
- 2013-08-05 UA UAA201501071A patent/UA113013C2/uk unknown
- 2013-08-05 WO PCT/EP2013/066344 patent/WO2014023674A1/fr active Application Filing
- 2013-08-05 JP JP2015525846A patent/JP5974177B2/ja active Active
-
2014
- 2014-11-27 CR CR20140545A patent/CR20140545A/es unknown
- 2014-11-28 CO CO14262433A patent/CO7141435A2/es unknown
-
2015
- 2015-01-09 PH PH12015500059A patent/PH12015500059B1/en unknown
- 2015-01-19 IL IL236808A patent/IL236808B/en not_active IP Right Cessation
- 2015-01-20 MA MA37791A patent/MA37791B1/fr unknown
- 2015-01-21 CL CL2015000143A patent/CL2015000143A1/es unknown
- 2015-02-04 US US14/614,232 patent/US9284321B2/en active Active
- 2015-07-24 HK HK15107077.4A patent/HK1206355A1/xx unknown
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