MA34251B1 - Derives amido-tropane - Google Patents

Derives amido-tropane

Info

Publication number
MA34251B1
MA34251B1 MA35398A MA35398A MA34251B1 MA 34251 B1 MA34251 B1 MA 34251B1 MA 35398 A MA35398 A MA 35398A MA 35398 A MA35398 A MA 35398A MA 34251 B1 MA34251 B1 MA 34251B1
Authority
MA
Morocco
Prior art keywords
glyt
compound
general formula
compounds
inhibitors
Prior art date
Application number
MA35398A
Other languages
English (en)
Inventor
Sabine Kolczewski
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA34251B1 publication Critical patent/MA34251B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE GÉNÉRALE (I), DANS LAQUELLE R1, R2 ET R3 REPRÉSENTENT CHACUN INDÉPENDAMMENT UN ATOME D'HYDROGÈNE, UN ALKYLE INFÉRIEUR, UN ALKOXY INFÉRIEUR, UN CYCLOALKYLE, UN ALKYLE INFÉRIEUR SUBSTITUÉ PAR UN ATOME D'HALOGÈNE OU UN GROUPE S-(ALKYLE INFÉRIEUR) ; OU BIEN UN SEL D'ADDITION ACIDE PHARMACEUTIQUEMENT ACCEPTABLE, UN MÉLANGE RACÉMIQUE, OU L'ÉNANTIOMÈRE ET/OU L'ISOMÈRE OPTIQUE CORRESPONDANT DUDIT COMPOSÉ. LES COMPOSÉS DE FORMULE GÉNÉRALE (I) SE SONT AVÉRÉS ÊTRE DE BONS INHIBITEURS DU TRANSPORTEUR DE TYPE 1 DE LA GLYCINE (GLYT-1), ET PRÉSENTER UNE BONNE SÉLECTIVITÉ ENVERS LES INHIBITEURS DU TRANSPORTEUR DE TYPE 2 DE LA GLYCINE (GLYT-2). DE TELS COMPOSÉS PEUVENT ÊTRE UTILISÉS DANS LE CADRE DU TRAITEMENT DE TROUBLES NEUROLOGIQUES ET NEUROPSYCHIATRIQUES.
MA35398A 2010-06-22 2011-06-17 Derives amido-tropane MA34251B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10166757 2010-06-22
PCT/EP2011/060073 WO2011161006A1 (fr) 2010-06-22 2011-06-17 Dérivés amido-tropane

Publications (1)

Publication Number Publication Date
MA34251B1 true MA34251B1 (fr) 2013-05-02

Family

ID=44310862

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35398A MA34251B1 (fr) 2010-06-22 2011-06-17 Derives amido-tropane

Country Status (24)

Country Link
US (1) US8153653B2 (fr)
EP (1) EP2585456B1 (fr)
JP (1) JP5546684B2 (fr)
KR (1) KR101445016B1 (fr)
CN (1) CN102947297B (fr)
AR (1) AR081961A1 (fr)
AU (1) AU2011269145A1 (fr)
BR (1) BR112012032576A2 (fr)
CA (1) CA2801458C (fr)
CL (1) CL2012003552A1 (fr)
CO (1) CO6630160A2 (fr)
CR (1) CR20120614A (fr)
EA (1) EA201291374A1 (fr)
EC (1) ECSP12012347A (fr)
ES (1) ES2550831T3 (fr)
HK (1) HK1179606A1 (fr)
IL (1) IL222998A0 (fr)
MA (1) MA34251B1 (fr)
MX (1) MX2012013820A (fr)
PE (1) PE20130317A1 (fr)
SG (1) SG186329A1 (fr)
TW (1) TWI417097B (fr)
WO (1) WO2011161006A1 (fr)
ZA (1) ZA201209248B (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT885220E (pt) * 1996-02-22 2001-11-30 Neurosearch As Derivados de tropano a sua preparacao e utilizacao
US5834484A (en) * 1997-03-12 1998-11-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Cocaine analogs
JP4563386B2 (ja) * 2003-09-09 2010-10-13 エフ.ホフマン−ラ ロシュ アーゲー 精神病の処置のためのグリシン取り込み阻害剤としての1−(2−アミノ−ベンゾール)−ピペラジン誘導体
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
EP1745018A1 (fr) * 2004-04-29 2007-01-24 Merck & Co., Inc. Inhibiteurs de transporteur de glycine à base d'azétidine
FR2873693B1 (fr) * 2004-07-29 2006-09-15 Sanofi Synthelabo Derives d'amino-tropane, leur preparation et leur application en therapeutique
GB0428231D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
EP1836178A1 (fr) * 2005-01-06 2007-09-26 F. Hoffmann-Roche AG Phenyl methanones sulfanyl substituees utilisees comme inhibiteurs du transporteur de glycine 1 (glyt-1) pour le traitement de troubles neurologiques et neuropsychiatriques
JP2010517959A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド GlyT1トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用
WO2010020548A1 (fr) * 2008-08-20 2010-02-25 F. Hoffmann-La Roche Ag Antagonistes de glyt1

Also Published As

Publication number Publication date
EP2585456B1 (fr) 2015-09-16
CR20120614A (es) 2013-01-11
WO2011161006A1 (fr) 2011-12-29
IL222998A0 (en) 2013-02-03
US20110312993A1 (en) 2011-12-22
SG186329A1 (en) 2013-01-30
ZA201209248B (en) 2013-08-28
KR101445016B1 (ko) 2014-09-26
US8153653B2 (en) 2012-04-10
PE20130317A1 (es) 2013-03-11
AU2011269145A1 (en) 2012-11-08
AR081961A1 (es) 2012-10-31
EP2585456A1 (fr) 2013-05-01
JP2013529607A (ja) 2013-07-22
CA2801458C (fr) 2018-10-30
CL2012003552A1 (es) 2013-04-12
KR20130029414A (ko) 2013-03-22
ECSP12012347A (es) 2013-01-31
JP5546684B2 (ja) 2014-07-09
CA2801458A1 (fr) 2011-12-29
HK1179606A1 (zh) 2013-10-04
CN102947297B (zh) 2015-12-16
TWI417097B (zh) 2013-12-01
MX2012013820A (es) 2013-01-28
EA201291374A1 (ru) 2013-06-28
ES2550831T3 (es) 2015-11-12
CN102947297A (zh) 2013-02-27
TW201206438A (en) 2012-02-16
BR112012032576A2 (pt) 2016-11-22
CO6630160A2 (es) 2013-03-01

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