CO6630160A2 - Derivados de amino-tropano - Google Patents
Derivados de amino-tropanoInfo
- Publication number
- CO6630160A2 CO6630160A2 CO12192372A CO12192372A CO6630160A2 CO 6630160 A2 CO6630160 A2 CO 6630160A2 CO 12192372 A CO12192372 A CO 12192372A CO 12192372 A CO12192372 A CO 12192372A CO 6630160 A2 CO6630160 A2 CO 6630160A2
- Authority
- CO
- Colombia
- Prior art keywords
- lower alkyl
- compounds
- inhibitors
- glycine transporter
- tropane derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención, se refiere a compuestos de la fórmula general Ien donde, R1, R2 y R3 son, de una forma independiente la una con respecto a la otra, hidrógeno, alquilo inferior, alcoxi inferior, cicloalquilo, alquilo inferior sustituido por halógeno, ó S-alquilo inferior;o a sales de adición de ácidos, farmacéuticamente aceptables, a una mezcla racémica, o sus correspondientes enantiómeros y / o isómeros ópticos de ésta.Se ha encontrado el hecho de que, los compuestos de las fórmulas generales 1, son buenos inhibidores del transportador de glicina 1 (GlyT-1), y que éstos tienen una buena selectividad a los inhibidores del transportador de glicina 2 (GIyT-2), apropiados en el tratamiento de los trastornos neurológicos y neuropsiquiátricos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10166757 | 2010-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6630160A2 true CO6630160A2 (es) | 2013-03-01 |
Family
ID=44310862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12192372A CO6630160A2 (es) | 2010-06-22 | 2012-10-26 | Derivados de amino-tropano |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8153653B2 (es) |
| EP (1) | EP2585456B1 (es) |
| JP (1) | JP5546684B2 (es) |
| KR (1) | KR101445016B1 (es) |
| CN (1) | CN102947297B (es) |
| AR (1) | AR081961A1 (es) |
| AU (1) | AU2011269145A1 (es) |
| BR (1) | BR112012032576A2 (es) |
| CA (1) | CA2801458C (es) |
| CL (1) | CL2012003552A1 (es) |
| CO (1) | CO6630160A2 (es) |
| CR (1) | CR20120614A (es) |
| EA (1) | EA201291374A1 (es) |
| EC (1) | ECSP12012347A (es) |
| ES (1) | ES2550831T3 (es) |
| HK (1) | HK1179606A1 (es) |
| IL (1) | IL222998A0 (es) |
| MA (1) | MA34251B1 (es) |
| MX (1) | MX2012013820A (es) |
| PE (1) | PE20130317A1 (es) |
| SG (1) | SG186329A1 (es) |
| TW (1) | TWI417097B (es) |
| WO (1) | WO2011161006A1 (es) |
| ZA (1) | ZA201209248B (es) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU720358B2 (en) * | 1996-02-22 | 2000-06-01 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| US5834484A (en) * | 1997-03-12 | 1998-11-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Cocaine analogs |
| BRPI0414209B8 (pt) * | 2003-09-09 | 2021-05-25 | Hoffmann La Roche | derivados de 1-(2-amino-benzol)-piperazina, seus processos de preparação e seu uso, e medicamento |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| CA2564501A1 (en) * | 2004-04-29 | 2005-11-24 | Merck Sharp & Dohme Limited | Azetidine glycine transporter inhibitors |
| FR2873693B1 (fr) * | 2004-07-29 | 2006-09-15 | Sanofi Synthelabo | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
| GB0428231D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| JP2008526795A (ja) * | 2005-01-06 | 2008-07-24 | エフ．ホフマン−ラ ロシュ アーゲー | 神経障害および神経精神疾患を処置するためのグリシントランスポータ１（ｇｌｙｔ−１）阻害物質としての、スルファニル置換フェニルメタノン |
| US20100113545A1 (en) * | 2007-02-01 | 2010-05-06 | Steven Coulton | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| WO2010020548A1 (en) * | 2008-08-20 | 2010-02-25 | F. Hoffmann-La Roche Ag | Glyt1 receptor antagonists |
-
2011
- 2011-06-15 US US13/160,559 patent/US8153653B2/en not_active Expired - Fee Related
- 2011-06-17 ES ES11728224.4T patent/ES2550831T3/es active Active
- 2011-06-17 PE PE2012002444A patent/PE20130317A1/es not_active Application Discontinuation
- 2011-06-17 WO PCT/EP2011/060073 patent/WO2011161006A1/en active Application Filing
- 2011-06-17 JP JP2013515816A patent/JP5546684B2/ja not_active Expired - Fee Related
- 2011-06-17 CA CA2801458A patent/CA2801458C/en not_active Expired - Fee Related
- 2011-06-17 MA MA35398A patent/MA34251B1/fr unknown
- 2011-06-17 CN CN201180030703.3A patent/CN102947297B/zh not_active Expired - Fee Related
- 2011-06-17 KR KR1020127033182A patent/KR101445016B1/ko active IP Right Grant
- 2011-06-17 AU AU2011269145A patent/AU2011269145A1/en not_active Abandoned
- 2011-06-17 MX MX2012013820A patent/MX2012013820A/es active IP Right Grant
- 2011-06-17 EP EP11728224.4A patent/EP2585456B1/en active Active
- 2011-06-17 SG SG2012091708A patent/SG186329A1/en unknown
- 2011-06-17 EA EA201291374A patent/EA201291374A1/ru unknown
- 2011-06-17 BR BR112012032576A patent/BR112012032576A2/pt active Search and Examination
- 2011-06-20 TW TW100121503A patent/TWI417097B/zh not_active IP Right Cessation
- 2011-06-21 AR ARP110102138A patent/AR081961A1/es unknown
-
2012
- 2012-10-26 CO CO12192372A patent/CO6630160A2/es active IP Right Grant
- 2012-11-12 IL IL222998A patent/IL222998A0/en unknown
- 2012-12-05 CR CR20120614A patent/CR20120614A/es unknown
- 2012-12-06 ZA ZA2012/09248A patent/ZA201209248B/en unknown
- 2012-12-17 CL CL2012003552A patent/CL2012003552A1/es unknown
- 2012-12-20 EC ECSP12012347 patent/ECSP12012347A/es unknown
-
2013
- 2013-06-05 HK HK13106598.8A patent/HK1179606A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA201291374A1 (ru) | 2013-06-28 |
| TWI417097B (zh) | 2013-12-01 |
| AU2011269145A1 (en) | 2012-11-08 |
| CN102947297B (zh) | 2015-12-16 |
| KR101445016B1 (ko) | 2014-09-26 |
| JP2013529607A (ja) | 2013-07-22 |
| CA2801458A1 (en) | 2011-12-29 |
| MX2012013820A (es) | 2013-01-28 |
| JP5546684B2 (ja) | 2014-07-09 |
| WO2011161006A1 (en) | 2011-12-29 |
| US8153653B2 (en) | 2012-04-10 |
| CA2801458C (en) | 2018-10-30 |
| ZA201209248B (en) | 2013-08-28 |
| TW201206438A (en) | 2012-02-16 |
| EP2585456A1 (en) | 2013-05-01 |
| BR112012032576A2 (pt) | 2016-11-22 |
| IL222998A0 (en) | 2013-02-03 |
| SG186329A1 (en) | 2013-01-30 |
| CR20120614A (es) | 2013-01-11 |
| ECSP12012347A (es) | 2013-01-31 |
| CN102947297A (zh) | 2013-02-27 |
| KR20130029414A (ko) | 2013-03-22 |
| EP2585456B1 (en) | 2015-09-16 |
| PE20130317A1 (es) | 2013-03-11 |
| CL2012003552A1 (es) | 2013-04-12 |
| AR081961A1 (es) | 2012-10-31 |
| MA34251B1 (fr) | 2013-05-02 |
| HK1179606A1 (zh) | 2013-10-04 |
| US20110312993A1 (en) | 2011-12-22 |
| ES2550831T3 (es) | 2015-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |