HK1179606A1 - 酰胺基-托烷衍生物 - Google Patents

酰胺基-托烷衍生物

Info

Publication number
HK1179606A1
HK1179606A1 HK13106598.8A HK13106598A HK1179606A1 HK 1179606 A1 HK1179606 A1 HK 1179606A1 HK 13106598 A HK13106598 A HK 13106598A HK 1179606 A1 HK1179606 A1 HK 1179606A1
Authority
HK
Hong Kong
Prior art keywords
amido
tropane derivatives
tropane
derivatives
amido tropane
Prior art date
Application number
HK13106598.8A
Other languages
English (en)
Inventor
薩賓．克爾茨維斯基
伊曼紐爾．皮納德
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1179606A1 publication Critical patent/HK1179606A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK13106598.8A 2010-06-22 2013-06-05 酰胺基-托烷衍生物 HK1179606A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10166757 2010-06-22
PCT/EP2011/060073 WO2011161006A1 (en) 2010-06-22 2011-06-17 Amido-tropane derivatives

Publications (1)

Publication Number Publication Date
HK1179606A1 true HK1179606A1 (zh) 2013-10-04

Family

ID=44310862

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13106598.8A HK1179606A1 (zh) 2010-06-22 2013-06-05 酰胺基-托烷衍生物

Country Status (24)

Country Link
US (1) US8153653B2 (zh)
EP (1) EP2585456B1 (zh)
JP (1) JP5546684B2 (zh)
KR (1) KR101445016B1 (zh)
CN (1) CN102947297B (zh)
AR (1) AR081961A1 (zh)
AU (1) AU2011269145A1 (zh)
BR (1) BR112012032576A2 (zh)
CA (1) CA2801458C (zh)
CL (1) CL2012003552A1 (zh)
CO (1) CO6630160A2 (zh)
CR (1) CR20120614A (zh)
EA (1) EA201291374A1 (zh)
EC (1) ECSP12012347A (zh)
ES (1) ES2550831T3 (zh)
HK (1) HK1179606A1 (zh)
IL (1) IL222998A0 (zh)
MA (1) MA34251B1 (zh)
MX (1) MX2012013820A (zh)
PE (1) PE20130317A1 (zh)
SG (1) SG186329A1 (zh)
TW (1) TWI417097B (zh)
WO (1) WO2011161006A1 (zh)
ZA (1) ZA201209248B (zh)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT885220E (pt) * 1996-02-22 2001-11-30 Neurosearch As Derivados de tropano a sua preparacao e utilizacao
US5834484A (en) * 1997-03-12 1998-11-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Cocaine analogs
JP4563386B2 (ja) * 2003-09-09 2010-10-13 エフ．ホフマン−ラ ロシュ アーゲー 精神病の処置のためのグリシン取り込み阻害剤としての１−（２−アミノ−ベンゾール）−ピペラジン誘導体
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
EP1745018A1 (en) * 2004-04-29 2007-01-24 Merck & Co., Inc. Azetidine glycine transporter inhibitors
FR2873693B1 (fr) * 2004-07-29 2006-09-15 Sanofi Synthelabo Derives d'amino-tropane, leur preparation et leur application en therapeutique
GB0428231D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
EP1836178A1 (en) * 2005-01-06 2007-09-26 F. Hoffmann-Roche AG Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
JP2010517959A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド ＧｌｙＴ１トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用
WO2010020548A1 (en) * 2008-08-20 2010-02-25 F. Hoffmann-La Roche Ag Glyt1 receptor antagonists

Also Published As

Publication number Publication date
EP2585456B1 (en) 2015-09-16
CR20120614A (es) 2013-01-11
WO2011161006A1 (en) 2011-12-29
IL222998A0 (en) 2013-02-03
US20110312993A1 (en) 2011-12-22
SG186329A1 (en) 2013-01-30
ZA201209248B (en) 2013-08-28
KR101445016B1 (ko) 2014-09-26
MA34251B1 (fr) 2013-05-02
US8153653B2 (en) 2012-04-10
PE20130317A1 (es) 2013-03-11
AU2011269145A1 (en) 2012-11-08
AR081961A1 (es) 2012-10-31
EP2585456A1 (en) 2013-05-01
JP2013529607A (ja) 2013-07-22
CA2801458C (en) 2018-10-30
CL2012003552A1 (es) 2013-04-12
KR20130029414A (ko) 2013-03-22
ECSP12012347A (es) 2013-01-31
JP5546684B2 (ja) 2014-07-09
CA2801458A1 (en) 2011-12-29
CN102947297B (zh) 2015-12-16
TWI417097B (zh) 2013-12-01
MX2012013820A (es) 2013-01-28
EA201291374A1 (ru) 2013-06-28
ES2550831T3 (es) 2015-11-12
CN102947297A (zh) 2013-02-27
TW201206438A (en) 2012-02-16
BR112012032576A2 (pt) 2016-11-22
CO6630160A2 (es) 2013-03-01

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230615