AR081961A1 - Derivados de amino-tropano - Google Patents

Derivados de amino-tropano

Info

Publication number
AR081961A1
AR081961A1 ARP110102138A ARP110102138A AR081961A1 AR 081961 A1 AR081961 A1 AR 081961A1 AR P110102138 A ARP110102138 A AR P110102138A AR P110102138 A ARP110102138 A AR P110102138A AR 081961 A1 AR081961 A1 AR 081961A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
compounds
inhibitors
amino
glycine transporter
Prior art date
Application number
ARP110102138A
Other languages
English (en)
Inventor
Sabine Kolczewski
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR081961A1 publication Critical patent/AR081961A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Se refiere a compuestos de la fórmula general (1) en donde: R1, R2 y R3, son, de una forma independiente la una con respecto a la otra, hidrógeno, alquilo inferior, alcoxi inferior, cicloalquilo, alquilo inferior sustituido por halógeno, ó S-alquilo inferior; o a sales de adición de ácidos, farmacéuticamente aceptables, a una mezcla racémica, o sus correspondientes enantiómeros y/o isómeros ópticos de ésta. Se ha encontrado el hecho de que, los compuestos de las fórmulas generales (1), son buenos inhibidores del transportador de glicina 1 (GlyT-1), y que éstos tienen una buena selectividad a los inhibidores del transportador de glicina 2 (GIyT-2), apropiados en el tratamiento de los trastornos neurológicos y neuropsiquiátricos.
ARP110102138A 2010-06-22 2011-06-21 Derivados de amino-tropano AR081961A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10166757 2010-06-22

Publications (1)

Publication Number Publication Date
AR081961A1 true AR081961A1 (es) 2012-10-31

Family

ID=44310862

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102138A AR081961A1 (es) 2010-06-22 2011-06-21 Derivados de amino-tropano

Country Status (24)

Country Link
US (1) US8153653B2 (es)
EP (1) EP2585456B1 (es)
JP (1) JP5546684B2 (es)
KR (1) KR101445016B1 (es)
CN (1) CN102947297B (es)
AR (1) AR081961A1 (es)
AU (1) AU2011269145A1 (es)
BR (1) BR112012032576A2 (es)
CA (1) CA2801458C (es)
CL (1) CL2012003552A1 (es)
CO (1) CO6630160A2 (es)
CR (1) CR20120614A (es)
EA (1) EA201291374A1 (es)
EC (1) ECSP12012347A (es)
ES (1) ES2550831T3 (es)
HK (1) HK1179606A1 (es)
IL (1) IL222998A0 (es)
MA (1) MA34251B1 (es)
MX (1) MX2012013820A (es)
PE (1) PE20130317A1 (es)
SG (1) SG186329A1 (es)
TW (1) TWI417097B (es)
WO (1) WO2011161006A1 (es)
ZA (1) ZA201209248B (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0885220B1 (en) * 1996-02-22 2001-07-11 Neurosearch A/S Tropane-derivatives, their preparation and use
US5834484A (en) * 1997-03-12 1998-11-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Cocaine analogs
PT1663232E (pt) * 2003-09-09 2007-12-12 Hoffmann La Roche Derivados de 1- (2-amino-benzol) -piperazina como inibidores de absorção de glicina para o tratamento de psicoses
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
AU2005243192A1 (en) * 2004-04-29 2005-11-24 Merck & Co., Inc. Azetidine glycine transporter inhibitors
FR2873693B1 (fr) * 2004-07-29 2006-09-15 Sanofi Synthelabo Derives d'amino-tropane, leur preparation et leur application en therapeutique
GB0428231D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
CN101356163A (zh) * 2005-01-06 2009-01-28 弗·哈夫曼-拉罗切有限公司 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的硫烷基取代的苯甲酮化合物
TW200846328A (en) * 2007-02-01 2008-12-01 Glaxo Group Ltd GlyT1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
WO2010020548A1 (en) * 2008-08-20 2010-02-25 F. Hoffmann-La Roche Ag Glyt1 receptor antagonists

Also Published As

Publication number Publication date
BR112012032576A2 (pt) 2016-11-22
HK1179606A1 (zh) 2013-10-04
ES2550831T3 (es) 2015-11-12
JP2013529607A (ja) 2013-07-22
US8153653B2 (en) 2012-04-10
EA201291374A1 (ru) 2013-06-28
CA2801458C (en) 2018-10-30
WO2011161006A1 (en) 2011-12-29
KR101445016B1 (ko) 2014-09-26
TW201206438A (en) 2012-02-16
PE20130317A1 (es) 2013-03-11
CN102947297B (zh) 2015-12-16
MX2012013820A (es) 2013-01-28
EP2585456A1 (en) 2013-05-01
TWI417097B (zh) 2013-12-01
ZA201209248B (en) 2013-08-28
MA34251B1 (fr) 2013-05-02
CL2012003552A1 (es) 2013-04-12
CO6630160A2 (es) 2013-03-01
EP2585456B1 (en) 2015-09-16
US20110312993A1 (en) 2011-12-22
SG186329A1 (en) 2013-01-30
IL222998A0 (en) 2013-02-03
KR20130029414A (ko) 2013-03-22
JP5546684B2 (ja) 2014-07-09
CN102947297A (zh) 2013-02-27
AU2011269145A1 (en) 2012-11-08
ECSP12012347A (es) 2013-01-31
CR20120614A (es) 2013-01-11
CA2801458A1 (en) 2011-12-29

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