JP2015523083A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523083A5 JP2015523083A5 JP2015521809A JP2015521809A JP2015523083A5 JP 2015523083 A5 JP2015523083 A5 JP 2015523083A5 JP 2015521809 A JP2015521809 A JP 2015521809A JP 2015521809 A JP2015521809 A JP 2015521809A JP 2015523083 A5 JP2015523083 A5 JP 2015523083A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- msc
- trophoblast
- group
- markers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 13
- 210000002993 trophoblast Anatomy 0.000 claims 12
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 9
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 6
- 102100022464 5'-nucleotidase Human genes 0.000 claims 5
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 5
- 230000004069 differentiation Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 102100037241 Endoglin Human genes 0.000 claims 3
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 108010082117 matrigel Proteins 0.000 claims 3
- 102100022749 Aminopeptidase N Human genes 0.000 claims 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 2
- 102100024210 CD166 antigen Human genes 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 2
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 2
- 101000980840 Homo sapiens CD166 antigen Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 2
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 2
- 102100025304 Integrin beta-1 Human genes 0.000 claims 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 2
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
- -1 CD31 Proteins 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100037362 Fibronectin Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 1
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000622304 Homo sapiens Vascular cell adhesion protein 1 Proteins 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 102000007547 Laminin Human genes 0.000 claims 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 101100482117 Saimiri sciureus THBD gene Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 210000003098 myoblast Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000000963 osteoblast Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670192P | 2012-07-11 | 2012-07-11 | |
| US61/670,192 | 2012-07-11 | ||
| US201261684509P | 2012-08-17 | 2012-08-17 | |
| US61/684,509 | 2012-08-17 | ||
| PCT/US2013/050077 WO2014011881A2 (en) | 2012-07-11 | 2013-07-11 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523083A JP2015523083A (ja) | 2015-08-13 |
| JP2015523083A5 true JP2015523083A5 (OSRAM) | 2016-09-01 |
| JP6277187B2 JP6277187B2 (ja) | 2018-02-07 |
Family
ID=49916687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521809A Active JP6277187B2 (ja) | 2012-07-11 | 2013-07-11 | ヒト胚性幹細胞由来の間葉系様幹細胞、方法およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9725698B2 (OSRAM) |
| EP (1) | EP2872619B1 (OSRAM) |
| JP (1) | JP6277187B2 (OSRAM) |
| CN (1) | CN104487568B (OSRAM) |
| AU (1) | AU2013290146B2 (OSRAM) |
| CA (2) | CA2876512C (OSRAM) |
| WO (1) | WO2014011881A2 (OSRAM) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3712258B1 (en) | 2006-04-14 | 2025-01-01 | Astellas Institute for Regenerative Medicine | Hemangio-colony forming cells |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US20160095885A1 (en) * | 2014-10-01 | 2016-04-07 | WibiWorks Therapeutics, Inc. | Induction Medium & Methods for Stem Cell Culture & Therapy |
| CN108495930A (zh) * | 2015-08-07 | 2018-09-04 | 京都府公立大学法人 | 棕色脂肪细胞的制备方法 |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| CN105326864A (zh) * | 2015-11-30 | 2016-02-17 | 奥思达干细胞有限公司 | 一种治疗系统性红斑狼疮的干细胞制剂及其制备方法 |
| US11318167B2 (en) | 2015-12-11 | 2022-05-03 | The Johns Hopkins University | Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy |
| CN105754936B (zh) * | 2016-02-25 | 2018-06-08 | 付清玲 | 人诱导性多能干细胞诱导为间充质干细胞的方法 |
| CA3017772C (en) * | 2016-03-16 | 2023-02-21 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
| CN105769911A (zh) * | 2016-03-23 | 2016-07-20 | 中国人民解放军第二军医大学 | 间充质干细胞诱导斑秃处毛发再生的方法及应用 |
| US20200140851A1 (en) * | 2016-08-23 | 2020-05-07 | The Scripps Research Institute | Methods and Compositions Related to In Vivo Selection of Functional Molecules |
| KR101971322B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | Ｓｏｃｓ의 발현 또는 활성 억제를 이용한 고효능 줄기세포 선별방법 |
| KR101971323B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | 면역질환 치료를 위한 고효능 줄기세포 선별방법 |
| CN110452869A (zh) * | 2016-11-26 | 2019-11-15 | 中国科学院大连化学物理研究所 | 一种高通量形成拟胚体的微阵列芯片的制备方法与应用 |
| JP2020512296A (ja) * | 2016-12-23 | 2020-04-23 | ステムバイオス テクノロジーズ，インコーポレイテッド | Ｉｌ−６レベルを低減するための体性幹細胞の使用 |
| CN106754715A (zh) * | 2017-02-13 | 2017-05-31 | 四川新生命干细胞科技股份有限公司 | 一种用于造血干细胞培养的滋养层的制备方法 |
| EP3595684A1 (en) * | 2017-03-17 | 2020-01-22 | Senti Biosciences, Inc. | Immunomodulating cell circuits |
| KR20180112547A (ko) * | 2017-04-04 | 2018-10-12 | 경북대학교 산학협력단 | 역분화 줄기세포의 지속적인 계대배양을 통한 중간엽 줄기세포로의 분화방법 |
| SG10202111394XA (en) | 2017-04-13 | 2021-12-30 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| KR20230035710A (ko) * | 2017-05-26 | 2023-03-14 | 스테미넌트 바이오테라퓨틱스 인크. | 폴리글루타민(polyq) 질병에 대한 치료법 |
| KR20210118479A (ko) * | 2017-05-26 | 2021-09-30 | 카이트 파마 인코포레이티드 | 배아 중간엽 전구 세포를 제조하고 사용하는 방법 |
| EP3653700A4 (en) * | 2017-07-13 | 2021-04-14 | National University Corporation Tokyo Medical and Dental University | ARTIFICIAL TENDON OR TISSUE MADE WITH THE HELP OF A THREE-DIMENSIONAL MECHANICAL SIGNALING CELL CULTURE SYSTEM |
| CN107460169B (zh) * | 2017-07-14 | 2020-12-11 | 中国科学院广州生物医药与健康研究院 | 维生素c在制备培养基中的用途 |
| CN111793607B (zh) * | 2017-07-28 | 2022-05-17 | 杨涛 | 定向诱导hiPSC分化为神经细胞体系中培养神经元细胞的基础培养基 |
| CN109666630A (zh) * | 2017-10-17 | 2019-04-23 | 澳门大学 | 多能干细胞分化为间充质干细胞的方法及其培养基和应用 |
| RU2730864C1 (ru) * | 2017-11-10 | 2020-08-26 | Редженесис Сайенс Ко., Лтд. | Способ производства культивируемых клеток и лекарственного препарата для лечения спинномозговых травм |
| US20210403871A1 (en) * | 2017-11-28 | 2021-12-30 | Inno-Health Technology Co., Ltd. | Methods of producing populations of mesenchymal stem cells from peripheral blood and uses thereof |
| CN108324993B (zh) * | 2018-01-15 | 2020-11-03 | 朱剑虹 | 一种诱导毛发再生的干细胞复合体、其制备方法及应用 |
| CN108570448B (zh) * | 2018-01-26 | 2019-04-02 | 皓昇莱生物制药有限公司 | 一种高效的hPSCs向MSCs分化的方法 |
| CN108570447A (zh) * | 2018-01-26 | 2018-09-25 | 皓昇莱生物制药有限公司 | 一种筛选分化hPSCs向MSCs的方法 |
| WO2019173376A1 (en) * | 2018-03-06 | 2019-09-12 | Orig3N, Inc. | Ipsc-derived cell compositions, and related systems and methods for cartilage repair |
| CN110295145B (zh) * | 2018-03-22 | 2020-10-16 | 苏州麦迪耐斯医药科技有限公司 | 一种体外培养脑肿瘤细胞的培养液及培养方法 |
| CN108504627A (zh) * | 2018-04-02 | 2018-09-07 | 中国人民解放军陆军军医大学第二附属医院 | 人类黄韧带干细胞的提取方法 |
| CN108498452A (zh) * | 2018-04-10 | 2018-09-07 | 上海交通大学医学院附属仁济医院 | 一种用于治疗勃起功能障碍的含干细胞可注射水凝胶及其制备方法 |
| EP3801764A4 (en) * | 2018-06-06 | 2022-02-23 | The Regents of the University of California | NEURAL STEM CELL COMPOSITIONS AND METHODS OF TREATING NEURODEGENERATIVE DISORDERS |
| CN109055307B (zh) * | 2018-08-26 | 2021-06-11 | 杭州爱唯生命科技有限公司 | 一种bmp-2激活剂及在干细胞诱导分化方面的应用 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN110352951A (zh) * | 2018-11-15 | 2019-10-22 | 崔磊 | 一种无血清无dmso组织工程骨冻存液及其制备和冻存方法 |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| CN118634363A (zh) * | 2018-12-17 | 2024-09-13 | 哈佛学院院长等 | 用于调节免疫系统的生物工程化支架及其用途 |
| CN113544261B (zh) * | 2019-02-27 | 2024-10-01 | 武田药品工业株式会社 | 用于同种异体疗法的改良的干细胞群 |
| WO2020181130A2 (en) * | 2019-03-05 | 2020-09-10 | MiRagen Therapeutics, Inc. | Polynucleotide conjugates and uses thereof |
| WO2020243504A1 (en) * | 2019-05-31 | 2020-12-03 | Figene, Llc | Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis |
| CA3143332A1 (en) * | 2019-06-14 | 2020-12-17 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of multiple lineages from induced pluripotent stem cells using charged surfaces |
| CN112094804B (zh) * | 2019-06-18 | 2024-05-14 | 中国医学科学院基础医学研究所 | 一种异质性干细胞群、其制备方法及用途 |
| CN114787340B (zh) * | 2019-07-26 | 2025-02-25 | 布瑞克斯奥根株式会社 | 诱导多能干细胞来源间充质干细胞前体细胞及其制备方法 |
| CN110499282B (zh) * | 2019-09-03 | 2021-05-11 | 广州赛莱拉干细胞科技股份有限公司 | 一种培养基及其应用和诱导肌腱干细胞向脂肪细胞分化的方法 |
| CN110713973B (zh) * | 2019-09-30 | 2021-05-14 | 浙江大学 | 一种诱导多能干细胞分化为间充质干细胞的培养基组合及方法 |
| CN110862983B (zh) * | 2019-11-05 | 2021-04-06 | 桂林医学院 | 一种特异靶向小鼠Gdf5基因的sgRNA导向序列及其应用 |
| US20230167412A1 (en) * | 2019-11-28 | 2023-06-01 | The University Of Hong Kong | Mesenchymal stromal cells as a reprogramming source for ipsc induction |
| CN113018316A (zh) * | 2019-12-24 | 2021-06-25 | 厦门大学 | 多能干细胞来源的间充质干细胞在修复皮肤损伤中的应用 |
| CN111454892A (zh) * | 2020-03-12 | 2020-07-28 | 成都世联康健生物科技有限公司 | 牙间充质干细胞培养基及在牙髓干细胞内的活性验证方法 |
| CN111471648A (zh) * | 2020-04-10 | 2020-07-31 | 南京大学 | 一种预处理活化的间充质干细胞的制备方法及其在髓系白血病治疗中的应用 |
| TW202208613A (zh) * | 2020-05-05 | 2022-03-01 | 美商加速生物科學有限公司 | 非永生的多潛能幹細胞 |
| US20230242873A1 (en) * | 2020-05-13 | 2023-08-03 | Figene, Llc | Fibroblast based therapy for treatment of parkinson's disease |
| TWI806051B (zh) * | 2020-05-13 | 2023-06-21 | 長聖國際生技股份有限公司 | 生產類紅血球及/或紅血球之方法 |
| CN111557952A (zh) * | 2020-05-28 | 2020-08-21 | 澳门大学 | 间充质干细胞在制备用于促进脂肪移植的制剂中的应用 |
| WO2022016165A2 (en) * | 2020-06-02 | 2022-01-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differentiation of trophectoderm lineage cells from pluripotent stem cells |
| US20230250394A1 (en) * | 2020-06-24 | 2023-08-10 | Syracuse University | Generation of perinatal-like mesenchymal stem cells from human induced pluripotent stem cells |
| WO2022004938A1 (ko) * | 2020-06-30 | 2022-01-06 | 주식회사 미래셀바이오 | 유사 중간엽 줄기세포의 제조방법 |
| CN112359012B (zh) * | 2020-10-22 | 2022-11-25 | 中国科学院水生生物研究所 | 诱导多能干细胞分化制备心脏瓣膜内皮细胞的方法及其应用 |
| CN114504596A (zh) * | 2020-10-23 | 2022-05-17 | 厦门大学 | 多能干细胞来源的间充质干细胞在治疗银屑病中的应用 |
| CN113462642A (zh) * | 2021-08-12 | 2021-10-01 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 间充质干细胞的快速诱导分化方法、试剂盒及其应用 |
| WO2023090589A1 (ko) * | 2021-11-22 | 2023-05-25 | 주식회사 미래셀바이오 | 전분화능 줄기세포 기반 과민성 면역반응에 의한 피부질환의 예방 또는 치료용 조성물 |
| CN113975298A (zh) * | 2021-11-29 | 2022-01-28 | 海南康盾生物制药有限公司 | 一种用于小儿自闭症的细胞治疗药物及其制备方法 |
| CN114438037B (zh) * | 2022-01-25 | 2024-06-04 | 深圳市乐土生物医药有限公司 | 一种制备诱导性间充质干细胞的方法 |
| CN114574436A (zh) * | 2022-05-06 | 2022-06-03 | 深圳汉盛汇融再生医学科技有限公司 | 一种治疗膝关节退行性病变的干细胞制剂及其制备方法 |
| CN115785221B (zh) * | 2022-07-11 | 2023-07-04 | 北京大学 | 一种转录因子hoxb9磷酸化位点的特异性抗体及其制备方法和应用 |
| WO2024206943A2 (en) * | 2023-03-31 | 2024-10-03 | Pluristyx, Inc. | Conditionally immortalized stem cells and uses thereof |
| CN116376828B (zh) * | 2023-06-02 | 2023-08-11 | 成都云测医学生物技术有限公司 | 一种诱导CD4+T细胞生成Treg细胞的方法及应用 |
| WO2025221594A1 (en) * | 2024-04-16 | 2025-10-23 | The Regents Of The University Of California | Methods for generating dopaminergic neurons and organoids thereof |
| CN120009537A (zh) * | 2025-02-14 | 2025-05-16 | 上海安库生医生物科技有限公司 | Tacstd2蛋白在制备检测和鉴定人羊膜上皮细胞的产品中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| IL135593A (en) | 1997-10-14 | 2004-06-01 | Luminex Corp | Precisely fluorescently painted polymeric microspheres and methods for making and using them |
| CA2318779C (en) | 1998-01-22 | 2009-08-25 | Luminex Corporation | Microparticles with multiple fluorescent signals |
| JP4526186B2 (ja) | 1998-06-08 | 2010-08-18 | オシリス セラピューティクス，インコーポレイテッド | 造血幹細胞を試験管内で維持する方法と組成物 |
| EP1210379B1 (en) | 1999-04-16 | 2007-03-21 | Wm. MARSH RICE UNIVERSITY | Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US7148062B2 (en) * | 2002-03-15 | 2006-12-12 | Wicell Research Institute, Inc. | Method for generating primate trophoblasts |
| US7642091B2 (en) * | 2005-02-24 | 2010-01-05 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| BRPI0617084A2 (pt) | 2005-09-02 | 2011-07-12 | Agency Science Tech & Res | método, linhagem de célula progenitora, célula diferenciada e método para gerar uma célula diferenciada de uma célula-tronco (es) embrionária |
| US20090304647A1 (en) * | 2008-05-30 | 2009-12-10 | The Board Of Trustees Of The University Of Illinois | Production of Neural Stem Cells from Bone Marrow Tissue and Use Thereof |
| JP2010094062A (ja) * | 2008-10-15 | 2010-04-30 | Saitama Medical Univ | 間葉系幹細胞の多分化能維持用培地、培養方法、及び分化方法 |
| ES2645869T3 (es) * | 2008-12-17 | 2017-12-11 | The Scripps Research Institute | Generación y mantenimiento de células madre |
| US20110088107A1 (en) * | 2009-04-24 | 2011-04-14 | Yaqub Hanna | Compositions and methods for deriving or culturing pluripotent cells |
| CA2770753C (en) * | 2009-08-12 | 2019-01-15 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
| KR101193541B1 (ko) * | 2009-08-24 | 2012-10-22 | 한국과학기술원 | 인간 배아줄기세포에서 중간엽 줄기세포로 분화시키는 방법 |
| GB2502704B (en) * | 2010-11-15 | 2019-12-04 | Accelerated Biosciences Corp | Generation of neural stem cells from human trophoblast stem cells |
| KR102108245B1 (ko) | 2011-11-30 | 2020-05-08 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
-
2013
- 2013-07-11 EP EP13816490.0A patent/EP2872619B1/en not_active Not-in-force
- 2013-07-11 CN CN201380036985.7A patent/CN104487568B/zh active Active
- 2013-07-11 WO PCT/US2013/050077 patent/WO2014011881A2/en not_active Ceased
- 2013-07-11 US US14/413,297 patent/US9725698B2/en active Active
- 2013-07-11 JP JP2015521809A patent/JP6277187B2/ja active Active
- 2013-07-11 CA CA2876512A patent/CA2876512C/en active Active
- 2013-07-11 AU AU2013290146A patent/AU2013290146B2/en active Active
- 2013-07-11 CA CA3176706A patent/CA3176706A1/en active Pending
-
2017
- 2017-06-27 US US15/635,022 patent/US10226488B2/en active Active
-
2019
- 2019-01-23 US US16/254,986 patent/US10842826B2/en active Active
-
2020
- 2020-10-09 US US17/066,642 patent/US20210085725A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015523083A5 (OSRAM) | ||
| Mushahary et al. | Isolation, cultivation, and characterization of human mesenchymal stem cells | |
| Lodie et al. | Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction | |
| KR101532556B1 (ko) | 간엽줄기세포의 배양 방법 | |
| Gucciardo et al. | Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine | |
| Al-Saqi et al. | Defined serum-free media for in vitro expansion of adipose-derived mesenchymal stem cells | |
| Kmiecik et al. | Fetal membranes as a source of stem cells | |
| Nicoletti et al. | Methods and procedures in adipose stem cells: state of the art and perspective for translation medicine | |
| Vishnubalaji et al. | Skin-derived multipotent stromal cells–an archrival for mesenchymal stem cells | |
| WO2011108993A1 (en) | Culture additives to boost stem cell proliferation and differentiation response | |
| CN102618491A (zh) | 诱导间充质干细胞向胰岛样细胞分化的培养液及诱导方法和用途 | |
| Dissanayaka et al. | Characterization of dental pulp stem cells isolated from canine premolars | |
| US20060134781A1 (en) | Three-dimensional cell culture system | |
| KR20140038236A (ko) | 간엽줄기세포 응집체의 제조 방법 | |
| Cho et al. | Tonsil-derived stem cells as a new source of adult stem cells | |
| JP2019076112A (ja) | 成体心臓幹細胞集団 | |
| Takebe et al. | Cryopreservation method for the effective collection of dental pulp stem cells | |
| KR20140001900A (ko) | 인간 다분화능 배아 줄기 세포-유사 전구 세포 | |
| Jing et al. | Explant culture: an efficient method to isolate adipose‐derived stromal cells for tissue engineering | |
| Nel et al. | Determinants of dental pulp stem cell heterogeneity | |
| Indumathi et al. | Comparison of feto-maternal organ derived stem cells in facets of immunophenotype, proliferation and differentiation | |
| Yamachika et al. | Bone regeneration from mesenchymal stem cells (MSCs) and compact bone-derived MSCs as an animal model | |
| CN117802039A (zh) | 一种无血清间充质干细胞三维培养基及其应用 | |
| Roosens et al. | Complete static repopulation of decellularized porcine tissues for heart valve engineering: an in vitro study | |
| Esposito et al. | Culture conditions allow selection of different mesenchymal progenitors from adult mouse bone marrow |