JP2015520385A5 - - Google Patents
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- JP2015520385A5 JP2015520385A5 JP2015516253A JP2015516253A JP2015520385A5 JP 2015520385 A5 JP2015520385 A5 JP 2015520385A5 JP 2015516253 A JP2015516253 A JP 2015516253A JP 2015516253 A JP2015516253 A JP 2015516253A JP 2015520385 A5 JP2015520385 A5 JP 2015520385A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- solid support
- tag
- substrate
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 30
- 108091023037 Aptamer Proteins 0.000 claims 28
- 239000007787 solid Substances 0.000 claims 21
- 239000000758 substrate Substances 0.000 claims 12
- 239000011324 bead Substances 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000003196 chaotropic effect Effects 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000012360 testing method Methods 0.000 claims 5
- 239000007853 buffer solution Substances 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 108090001008 Avidin Proteins 0.000 claims 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 3
- 108010090804 Streptavidin Proteins 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 3
- 235000020958 biotin Nutrition 0.000 claims 3
- 239000011616 biotin Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 108010087904 neutravidin Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108010081020 traptavidin Proteins 0.000 claims 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- -1 Extravidin Proteins 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 2
- 230000003278 mimic effect Effects 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 claims 2
- 229910001488 sodium perchlorate Inorganic materials 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- KISUPFXQEHWGAR-RRKCRQDMSA-N 4-amino-5-bromo-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical group C1=C(Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 KISUPFXQEHWGAR-RRKCRQDMSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 claims 1
- LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical class BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 claims 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 238000001190 Q-PCR Methods 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 229950004398 broxuridine Drugs 0.000 claims 1
- 239000008366 buffered solution Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 150000001925 cycloalkenes Chemical class 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 230000000153 supplemental effect Effects 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656956P | 2012-06-07 | 2012-06-07 | |
| US61/656,956 | 2012-06-07 | ||
| PCT/US2013/044792 WO2013185078A1 (en) | 2012-06-07 | 2013-06-07 | Aptamer-based multiplexed assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520385A JP2015520385A (ja) | 2015-07-16 |
| JP2015520385A5 true JP2015520385A5 (https=) | 2016-07-07 |
| JP6298456B2 JP6298456B2 (ja) | 2018-03-20 |
Family
ID=49712701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516253A Active JP6298456B2 (ja) | 2012-06-07 | 2013-06-07 | アプタマーに基づく多重化アッセイ |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20150141259A1 (https=) |
| EP (1) | EP2859121B1 (https=) |
| JP (1) | JP6298456B2 (https=) |
| KR (1) | KR102088381B1 (https=) |
| CN (2) | CN104508150B (https=) |
| AU (1) | AU2013271401B2 (https=) |
| BR (1) | BR112014030298B1 (https=) |
| CA (1) | CA2873099C (https=) |
| CY (1) | CY1118748T1 (https=) |
| ES (1) | ES2617226T3 (https=) |
| HR (1) | HRP20170296T1 (https=) |
| IL (1) | IL235588B (https=) |
| IN (1) | IN2014KN02647A (https=) |
| MX (1) | MX356413B (https=) |
| MY (1) | MY170164A (https=) |
| NZ (1) | NZ701824A (https=) |
| PH (1) | PH12014502581B1 (https=) |
| RU (1) | RU2666989C2 (https=) |
| SG (2) | SG10201701361WA (https=) |
| WO (1) | WO2013185078A1 (https=) |
| ZA (1) | ZA201408409B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| WO2015109020A1 (en) * | 2014-01-14 | 2015-07-23 | Aptitude Medical Systems, Inc. | Use of nucleic acid agents for ultra-sensitive digital detection and quantification of target molecules |
| CA3152415A1 (en) | 2014-02-18 | 2015-08-27 | Somalogic Operating Co., Inc. | Compositions and methods for detecting microorganisms |
| CN106574925B (zh) * | 2014-05-23 | 2019-07-26 | 萤火虫生物股份有限公司 | 用于生物测定的底物介导的反应器 |
| GB2528643A (en) * | 2014-07-08 | 2016-02-03 | Adc Biotechnology Ltd | Method of synthesising ADCs |
| KR102003589B1 (ko) * | 2016-03-03 | 2019-07-24 | 성균관대학교산학협력단 | 생화학 분자 검출센서 및 다파장 형광을 이용한 생화학 분자 검출방법 |
| CN105779609A (zh) * | 2016-04-15 | 2016-07-20 | 上海伊丽萨生物科技有限公司 | 一种超敏免疫检测方法 |
| CA3039057A1 (en) * | 2016-10-13 | 2018-04-19 | Laboratory Corporation Of America Holdings | Devices and methods to reduce interfering compounds in biological samples |
| CN120992918A (zh) * | 2018-04-13 | 2025-11-21 | 富鲁达加拿大公司 | 用于元素分析的稳定细胞采集 |
| EP3810563A4 (en) * | 2018-06-22 | 2022-03-23 | Somalogic, Inc. | IMPROVED PROTEOMIC MULTIPLEX TESTS |
| US11181501B2 (en) | 2018-09-11 | 2021-11-23 | City University Of Hong Kong | Method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample |
| LU101073B1 (en) | 2018-12-21 | 2020-06-24 | Luxembourg Inst Science & Tech List | Dna aptamers specific of adenovirus types |
| KR102177672B1 (ko) * | 2019-02-01 | 2020-11-12 | 주식회사 압타머사이언스 | 압타머를 이용한 다중(multiplex) PCR 방법 |
| KR102113078B1 (ko) * | 2019-07-05 | 2020-05-20 | 광주과학기술원 | 압타머의 선별 방법 |
| CN110791551A (zh) * | 2019-09-17 | 2020-02-14 | 北京化工大学 | 一种无载体氯霉素适配体信号放大传感器的建立方法 |
| KR102403628B1 (ko) * | 2019-12-03 | 2022-05-30 | 주식회사 바이오이즈 | 시료의 표적분자 집단에 대한 프로파일을 얻는 방법 |
| CN113624724A (zh) * | 2020-05-07 | 2021-11-09 | 廖世奇 | 一种适配体分子信标对靶分子的多元检测分析方法 |
| CN111812313B (zh) * | 2020-06-22 | 2021-10-08 | 北京生物制品研究所有限责任公司 | 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法 |
| WO2022232308A1 (en) | 2021-04-27 | 2022-11-03 | Singular Genomics Systems, Inc. | High density sequencing and multiplexed priming |
| WO2022265362A1 (ko) * | 2021-06-14 | 2022-12-22 | 김성천 | 압타머를 이용하여 시료의 표적 단백질 분자 집단에 대한 프로파일을 얻는 방법 |
| EP4457358A1 (en) * | 2021-12-30 | 2024-11-06 | SomaLogic Operating Co., Inc. | Next-generation sequencing for protein measurement |
| CN116103367B (zh) * | 2022-11-11 | 2025-12-23 | 杭州佰辰医学检验所有限公司 | 一种检测靶标物的方法 |
| WO2025064457A1 (en) * | 2023-09-19 | 2025-03-27 | Somalogic Operating Co., Inc. | Methods of solid-phase nucleic acid hybridization |
| WO2025166038A1 (en) * | 2024-02-02 | 2025-08-07 | Illumina, Inc. | Improved aptamer detection techniques |
| CN121272015A (zh) * | 2024-07-03 | 2026-01-06 | 常州福洛森医疗科技有限公司 | 适配体在可寻址性检测中应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0786469B1 (en) | 1990-06-11 | 2006-03-01 | Gilead Sciences, Inc. | Methods of use of nucleic acid ligands |
| US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| PT1232502E (pt) * | 1999-11-17 | 2006-05-31 | Roche Diagnostics Gmbh | Particulas de vidro magneticas, metodo para a sua preparacao e suas utilizacoes |
| US7601497B2 (en) * | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| DE60326864D1 (de) * | 2002-07-24 | 2009-05-07 | Bio Rad Laboratories | Proteininteraktionsdifferenzabbildung |
| KR101168654B1 (ko) * | 2004-05-19 | 2012-07-25 | 브이피 호울딩 엘엘씨 | 표면 증강 라만 산란에 의한 화학기의 증강된 검출을 위한 층상의 플라즈몬 구조를 가진 광센서 |
| US7699979B2 (en) * | 2005-01-07 | 2010-04-20 | Board Of Trustees Of The University Of Arkansas | Separation system and efficient capture of contaminants using magnetic nanoparticles |
| US7285835B2 (en) * | 2005-02-24 | 2007-10-23 | Freescale Semiconductor, Inc. | Low power magnetoelectronic device structures utilizing enhanced permeability materials |
| US8637656B2 (en) * | 2005-07-05 | 2014-01-28 | Ribomic Inc. | Nucleic acid capable of binding to immunoglobulin G and use thereof |
| WO2007084886A2 (en) * | 2006-01-17 | 2007-07-26 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US7947447B2 (en) * | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7855054B2 (en) * | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| US7964356B2 (en) | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| DK2172566T4 (da) * | 2007-07-17 | 2022-06-13 | Somalogic Inc | Fremgangsmåde til generering af aptamerer med forbedrede off-rates |
| US8291501B2 (en) * | 2008-02-08 | 2012-10-16 | Cheng Holdings, Llc | Validation of protected intra-system interconnects for digital rights management in electrical computers and digital data processing systems |
| CN102046138A (zh) * | 2008-05-30 | 2011-05-04 | 欧莱雅 | 头发处理方法及成套用品 |
| AU2009273052B2 (en) * | 2008-07-14 | 2015-09-17 | The University Of Tokyo | Aptamer against IL-17 and use thereof |
| EP2418968B1 (en) * | 2009-04-13 | 2015-12-02 | Agriculture and Food Development Authority (TEAGASC) | Method of producing microbeads |
| GB0916700D0 (en) * | 2009-09-23 | 2009-11-04 | Nanoco Technologies Ltd | Semiconductor nanoparticle-based materials |
-
2013
- 2013-06-07 WO PCT/US2013/044792 patent/WO2013185078A1/en not_active Ceased
- 2013-06-07 CA CA2873099A patent/CA2873099C/en active Active
- 2013-06-07 CN CN201380040107.2A patent/CN104508150B/zh active Active
- 2013-06-07 US US14/401,791 patent/US20150141259A1/en not_active Abandoned
- 2013-06-07 KR KR1020147034387A patent/KR102088381B1/ko active Active
- 2013-06-07 ES ES13801106.9T patent/ES2617226T3/es active Active
- 2013-06-07 RU RU2014152698A patent/RU2666989C2/ru not_active Application Discontinuation
- 2013-06-07 MY MYPI2014703374A patent/MY170164A/en unknown
- 2013-06-07 NZ NZ701824A patent/NZ701824A/en not_active IP Right Cessation
- 2013-06-07 MX MX2014014784A patent/MX356413B/es active IP Right Grant
- 2013-06-07 SG SG10201701361WA patent/SG10201701361WA/en unknown
- 2013-06-07 JP JP2015516253A patent/JP6298456B2/ja active Active
- 2013-06-07 BR BR112014030298-7A patent/BR112014030298B1/pt not_active IP Right Cessation
- 2013-06-07 HR HRP20170296TT patent/HRP20170296T1/hr unknown
- 2013-06-07 CN CN201810446555.7A patent/CN108614102A/zh active Pending
- 2013-06-07 EP EP13801106.9A patent/EP2859121B1/en active Active
- 2013-06-07 IN IN2647KON2014 patent/IN2014KN02647A/en unknown
- 2013-06-07 SG SG11201407505XA patent/SG11201407505XA/en unknown
- 2013-06-07 AU AU2013271401A patent/AU2013271401B2/en active Active
-
2014
- 2014-11-09 IL IL235588A patent/IL235588B/en active IP Right Grant
- 2014-11-17 ZA ZA2014/08409A patent/ZA201408409B/en unknown
- 2014-11-19 PH PH12014502581A patent/PH12014502581B1/en unknown
-
2017
- 2017-02-22 CY CY20171100249T patent/CY1118748T1/el unknown
- 2017-03-09 US US15/454,080 patent/US20170176422A1/en not_active Abandoned
- 2017-11-30 US US15/827,441 patent/US20180224444A1/en not_active Abandoned
-
2021
- 2021-03-30 US US17/217,006 patent/US20210239692A1/en not_active Abandoned
-
2025
- 2025-01-10 US US19/015,991 patent/US20250147022A1/en active Pending
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