JP2015520182A5 - - Google Patents
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- Publication number
- JP2015520182A5 JP2015520182A5 JP2015515640A JP2015515640A JP2015520182A5 JP 2015520182 A5 JP2015520182 A5 JP 2015520182A5 JP 2015515640 A JP2015515640 A JP 2015515640A JP 2015515640 A JP2015515640 A JP 2015515640A JP 2015520182 A5 JP2015520182 A5 JP 2015520182A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- antibody
- fragment
- seq
- trka
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 101150111783 NTRK1 gene Proteins 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 208000004454 Hyperalgesia Diseases 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 101000961149 Homo sapiens Immunoglobulin heavy constant gamma 4 Proteins 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102100039347 Immunoglobulin heavy constant gamma 4 Human genes 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 206010053552 allodynia Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 201000010103 fibrous dysplasia Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 201000007094 prostatitis Diseases 0.000 claims 2
- 102220011641 rs201315884 Human genes 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000009935 visceral pain Diseases 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 208000014181 Bronchial disease Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010062746 Carditis Diseases 0.000 claims 1
- 206010064012 Central pain syndrome Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000029147 Collagen-vascular disease Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010011796 Cystitis interstitial Diseases 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010072132 Fracture pain Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000000913 Kidney Calculi Diseases 0.000 claims 1
- 206010024453 Ligament sprain Diseases 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 206010027452 Metastases to bone Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000010040 Sprains and Strains Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000035874 hyperreactivity Effects 0.000 claims 1
- 208000021646 inflammation of heart layer Diseases 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000017445 musculoskeletal system disease Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000025661 ovarian cyst Diseases 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 108010067988 prolactin-binding protein Proteins 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000009092 tissue dysfunction Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000001457 vasomotor Effects 0.000 claims 1
- 208000001319 vasomotor rhinitis Diseases 0.000 claims 1
- 230000009278 visceral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657184P | 2012-06-08 | 2012-06-08 | |
| US61/657,184 | 2012-06-08 | ||
| PCT/IB2013/054688 WO2013183032A2 (en) | 2012-06-08 | 2013-06-07 | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015520182A JP2015520182A (ja) | 2015-07-16 |
| JP2015520182A5 true JP2015520182A5 (enExample) | 2016-07-28 |
Family
ID=48906463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015515640A Pending JP2015520182A (ja) | 2012-06-08 | 2013-06-07 | アミノ酸置換を有するヒト化抗ＴｒｋＡ抗体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20130344064A1 (enExample) |
| EP (1) | EP2859019B1 (enExample) |
| JP (1) | JP2015520182A (enExample) |
| KR (1) | KR20150023679A (enExample) |
| CN (1) | CN104520330A (enExample) |
| AP (1) | AP2014008145A0 (enExample) |
| AU (1) | AU2013273115B2 (enExample) |
| CA (1) | CA2875703A1 (enExample) |
| CL (1) | CL2014003339A1 (enExample) |
| CO (1) | CO7240431A2 (enExample) |
| EA (1) | EA201492163A1 (enExample) |
| ES (1) | ES2666126T3 (enExample) |
| IL (1) | IL235994A0 (enExample) |
| IN (1) | IN2014MN02656A (enExample) |
| MX (1) | MX362394B (enExample) |
| PE (1) | PE20150212A1 (enExample) |
| PH (1) | PH12014502722A1 (enExample) |
| SG (1) | SG11201408037SA (enExample) |
| UA (1) | UA113879C2 (enExample) |
| WO (1) | WO2013183032A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| WO2012075340A2 (en) | 2010-12-01 | 2012-06-07 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
| BR112017025029A2 (pt) | 2015-05-22 | 2018-08-07 | Astellas Pharma Inc. | ?novo fragmento fab de anticorpo ngf anti- humano?. |
| BR112019013947A2 (pt) * | 2017-01-10 | 2020-02-11 | Yamaguchi University | Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. |
| JP7183268B2 (ja) | 2017-11-20 | 2022-12-05 | ジャスト－エヴォテック バイオロジックス、インコーポレイテッド | 等張化剤としてリジン塩を含有するアフリベルセプト製剤及びその使用 |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| AU2020281378B2 (en) * | 2019-05-30 | 2025-09-11 | Sunshine Lake Pharma Co., Ltd. | Anti-TrkA antibodies and uses thereof |
| CN116178541B (zh) * | 2020-08-06 | 2025-09-30 | 熙源安健医药(北京)有限公司 | 抗ngf抗体及其抗原结合片段、其制备方法和应用 |
| CN114516917B (zh) * | 2020-11-20 | 2022-11-18 | 广东东阳光药业有限公司 | 人源化抗TrkA的抗体及其应用 |
| CN117264068A (zh) * | 2021-02-28 | 2023-12-22 | 熙源安健医药（上海）有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
| WO2024240164A1 (en) * | 2023-05-23 | 2024-11-28 | 4B Technologies (Suzhou) Limited | TrkA ANTIBODY AND USE THEREOF |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| US5844092A (en) | 1994-03-18 | 1998-12-01 | Genentech, Inc. | Human TRK receptors and neurotrophic factor inhibitors |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| BR0008758A (pt) | 1999-01-15 | 2001-12-04 | Genentech Inc | Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante |
| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| US6548062B2 (en) | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| CN101213214B (zh) * | 2005-05-20 | 2014-06-25 | 埃博灵克斯股份有限公司 | 针对冯威勒布兰特因子的单一结构域vhh抗体 |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| FI118245B (fi) | 2005-06-08 | 2007-08-31 | Iprbox Oy | Kamera |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| AU2008234248C1 (en) * | 2007-03-29 | 2015-01-22 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| PT2252633E (pt) * | 2008-02-04 | 2013-11-19 | Lay Line Genomics Spa | Anticorpos anti-trka e seus derivados |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2013
- 2013-06-07 EP EP13742750.6A patent/EP2859019B1/en active Active
- 2013-06-07 PE PE2014002388A patent/PE20150212A1/es not_active Application Discontinuation
- 2013-06-07 AU AU2013273115A patent/AU2013273115B2/en not_active Ceased
- 2013-06-07 WO PCT/IB2013/054688 patent/WO2013183032A2/en not_active Ceased
- 2013-06-07 ES ES13742750.6T patent/ES2666126T3/es active Active
- 2013-06-07 KR KR20157000453A patent/KR20150023679A/ko not_active Ceased
- 2013-06-07 US US13/913,057 patent/US20130344064A1/en not_active Abandoned
- 2013-06-07 IN IN2656MUN2014 patent/IN2014MN02656A/en unknown
- 2013-06-07 SG SG11201408037SA patent/SG11201408037SA/en unknown
- 2013-06-07 CN CN201380042359.9A patent/CN104520330A/zh active Pending
- 2013-06-07 MX MX2014015043A patent/MX362394B/es active IP Right Grant
- 2013-06-07 CA CA2875703A patent/CA2875703A1/en not_active Abandoned
- 2013-06-07 UA UAA201413515A patent/UA113879C2/uk unknown
- 2013-06-07 EA EA201492163A patent/EA201492163A1/ru unknown
- 2013-06-07 JP JP2015515640A patent/JP2015520182A/ja active Pending
- 2013-06-07 AP AP2014008145A patent/AP2014008145A0/xx unknown
-
2014
- 2014-11-30 IL IL235994A patent/IL235994A0/en unknown
- 2014-12-04 PH PH12014502722A patent/PH12014502722A1/en unknown
- 2014-12-05 CL CL2014003339A patent/CL2014003339A1/es unknown
- 2014-12-30 CO CO14285848A patent/CO7240431A2/es unknown
-
2016
- 2016-09-14 US US15/265,331 patent/US20170218087A1/en not_active Abandoned
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