AR104721A1 - Fragmento fab anti-ngf humano - Google Patents
Fragmento fab anti-ngf humanoInfo
- Publication number
- AR104721A1 AR104721A1 ARP160101483A ARP160101483A AR104721A1 AR 104721 A1 AR104721 A1 AR 104721A1 AR P160101483 A ARP160101483 A AR P160101483A AR P160101483 A ARP160101483 A AR P160101483A AR 104721 A1 AR104721 A1 AR 104721A1
- Authority
- AR
- Argentina
- Prior art keywords
- human fab
- seq
- amino acid
- acid sequence
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se provee un fragmento de anticuerpo Fab anti-NGF humano superior, que conservara una actividad de neutralización elevada, que presentara menos efectos secundarios como resultado de una exposición sistémica y que pudiera ejercer un efecto farmacológico local. El objetivo se logra mediante un fragmento de anticuerpo Fab-anti-NGF humano que comprende un fragmento de la cadena pesada que consiste en la secuencia de aminoácidos que se representa en SEQ ID Nº 5 y una cadena liviana que consiste en la secuencia de aminoácidos que se representa en SEQ ID Nº 8. Reivindicación 12: La composición farmacéutica de acuerdo con la reivindicación 11, caracterizada porque es una composición farmacéutica que puede ser administrada de manera local para tratar el dolor postoperatorio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015104806 | 2015-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104721A1 true AR104721A1 (es) | 2017-08-09 |
Family
ID=57393503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101483A AR104721A1 (es) | 2015-05-22 | 2016-05-20 | Fragmento fab anti-ngf humano |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11260124B2 (es) |
| EP (1) | EP3299461B1 (es) |
| JP (1) | JP6700620B2 (es) |
| KR (1) | KR102440054B1 (es) |
| CN (1) | CN107614683B (es) |
| AR (1) | AR104721A1 (es) |
| AU (1) | AU2016268625B2 (es) |
| BR (1) | BR112017025029A2 (es) |
| CA (1) | CA2986210C (es) |
| CO (1) | CO2017012397A2 (es) |
| HK (1) | HK1246349A1 (es) |
| IL (1) | IL255832B (es) |
| MA (1) | MA42138A (es) |
| MX (1) | MX2017014911A (es) |
| MY (1) | MY184164A (es) |
| PH (1) | PH12017502126A1 (es) |
| RU (1) | RU2729825C2 (es) |
| SG (1) | SG11201709589XA (es) |
| TW (1) | TWI706959B (es) |
| UA (1) | UA123209C2 (es) |
| WO (1) | WO2016190263A1 (es) |
| ZA (1) | ZA201708169B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10725059B2 (en) * | 2015-04-06 | 2020-07-28 | Meso Scale Technologies, Llc. | High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus |
| NL2017890B1 (nl) * | 2016-11-29 | 2018-06-11 | Josh Ip Iii B V | Medische transportinrichting, hulpaandrijving, en werkwijze voor het transporteren van een dergelijke transportinrichting |
| US20210147529A1 (en) * | 2018-05-15 | 2021-05-20 | Astellas Pharma Inc. | Pharmaceutical composition for suppressing atrial fibrillation having as active ingredient anti-human ngf antibody or antigen-binding fragment thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527358A (en) | 1994-01-21 | 1996-06-18 | Medtronic, Inc. | Temporary medical electrical lead |
| WO2004032852A2 (en) | 2002-10-04 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists |
| PL215171B1 (pl) | 2002-12-24 | 2013-10-31 | Rinat Neuroscience Corp | Przeciwcialo przeciw czynnikowi wzrostu nerwów (NGF) lub jego fragment, kompozycja farmaceutyczna, zestaw, sposób wytwarzania przeciwciala lub jego fragmentu, zastosowanie skutecznej ilosci antagonistycznego przeciwciala anty-NGF lub jego fragmentu, zastosowanie antagonistycznego przeciwciala anty-NGF lub jego fragmentu, izolowany polinukleotyd zawierajacy sekwencje nukleotydowa kodujaca przeciwcialo lub jego fragment, wektor oraz komórka gospodarza zawierajaca polinukleotyd |
| TWI385180B (zh) | 2003-07-15 | 2013-02-11 | Amgen Inc | 作為選擇性神經生長因子（ｎｇｆ）通道抑制劑之人類抗-ｎｇｆ中和抗體 |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| CA2562024C (en) * | 2004-04-07 | 2014-05-27 | Rinat Neuroscience Corp. | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| ES2435691T3 (es) | 2005-01-24 | 2013-12-23 | Medimmune Limited | Anticuerpos humanos contra NGF humano |
| US9532943B2 (en) | 2010-12-20 | 2017-01-03 | Cormatrix Cardiovascular, Inc. | Drug eluting patch for the treatment of localized tissue disease or defect |
| JP2007244601A (ja) | 2006-03-15 | 2007-09-27 | Kanazawa Univ | 心筋用パッド |
| EP2572729A3 (en) | 2007-08-10 | 2013-06-05 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human nerve growth factor |
| SG10201703707YA (en) * | 2009-03-19 | 2017-06-29 | Chugai Pharmaceutical Co Ltd | Pharmaceutical formulation containing improved antibody molecules |
| PE20121540A1 (es) | 2009-05-04 | 2012-12-22 | Abbott Res Bv | Anticuerpos contra el factor de crecimiento nervioso (ngf) con estabilidad in vivo mejorada |
| BR112013015308A2 (pt) | 2010-12-20 | 2016-09-20 | Cormatrix Cardiovascular Inc | dispositivo para administrar um inibidor de hmg coa reductase ao tecido cardiovascular para tratar uma doença cardiovascular |
| EP3498732B1 (en) * | 2011-05-06 | 2021-11-17 | Zoetis Services LLC | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| EP3502136A1 (en) * | 2011-05-06 | 2019-06-26 | Nexvet Australia Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB201114858D0 (en) * | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| DK2743348T3 (en) * | 2011-08-11 | 2018-02-26 | Astellas Pharma Inc | Hitherto UNKNOWN ANTI-HUMAN NGF ANTIBODY |
| PE20150212A1 (es) | 2012-06-08 | 2015-02-27 | Glenmark Pharmaceuticals Sa | Anticuerpos anti-trka con propiedades inhibitorias mejoradas y sus derivados |
| JP6135161B2 (ja) * | 2013-02-08 | 2017-05-31 | アステラス製薬株式会社 | 新規抗ヒトｎｇｆ抗体 |
| US9127055B2 (en) * | 2013-02-08 | 2015-09-08 | Astellas Pharma Inc. | Method of treating pain with anti-human NGF antibody |
| AU2015362775B2 (en) | 2014-12-17 | 2019-07-04 | Dow Global Technologies Llc | Viscoelastic polyurethane foam with aqueous polymer dispersion |
-
2016
- 2016-05-20 US US15/575,969 patent/US11260124B2/en active Active
- 2016-05-20 BR BR112017025029-2A patent/BR112017025029A2/pt active Search and Examination
- 2016-05-20 JP JP2017520694A patent/JP6700620B2/ja active Active
- 2016-05-20 SG SG11201709589XA patent/SG11201709589XA/en unknown
- 2016-05-20 MY MYPI2017704449A patent/MY184164A/en unknown
- 2016-05-20 EP EP16799968.9A patent/EP3299461B1/en active Active
- 2016-05-20 AR ARP160101483A patent/AR104721A1/es unknown
- 2016-05-20 AU AU2016268625A patent/AU2016268625B2/en active Active
- 2016-05-20 TW TW105115796A patent/TWI706959B/zh active
- 2016-05-20 RU RU2017145071A patent/RU2729825C2/ru active
- 2016-05-20 MX MX2017014911A patent/MX2017014911A/es unknown
- 2016-05-20 MA MA042138A patent/MA42138A/fr unknown
- 2016-05-20 KR KR1020177034038A patent/KR102440054B1/ko active IP Right Grant
- 2016-05-20 CA CA2986210A patent/CA2986210C/en active Active
- 2016-05-20 UA UAA201712706A patent/UA123209C2/uk unknown
- 2016-05-20 CN CN201680029680.7A patent/CN107614683B/zh active Active
- 2016-05-20 WO PCT/JP2016/065099 patent/WO2016190263A1/ja active Application Filing
-
2017
- 2017-11-21 IL IL255832A patent/IL255832B/en unknown
- 2017-11-22 PH PH12017502126A patent/PH12017502126A1/en unknown
- 2017-11-30 ZA ZA2017/08169A patent/ZA201708169B/en unknown
- 2017-11-30 CO CONC2017/0012397A patent/CO2017012397A2/es unknown
-
2018
- 2018-05-03 HK HK18105725.1A patent/HK1246349A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2016190263A1 (ja) | 2018-04-12 |
| RU2017145071A (ru) | 2019-06-24 |
| TW201713691A (zh) | 2017-04-16 |
| CA2986210C (en) | 2022-04-26 |
| ZA201708169B (en) | 2019-06-26 |
| CN107614683B (zh) | 2020-12-22 |
| HK1246349A1 (zh) | 2018-09-07 |
| MX2017014911A (es) | 2018-03-23 |
| UA123209C2 (uk) | 2021-03-03 |
| IL255832B (en) | 2021-07-29 |
| IL255832A (en) | 2018-01-31 |
| AU2016268625A1 (en) | 2017-12-07 |
| KR102440054B1 (ko) | 2022-09-06 |
| US11260124B2 (en) | 2022-03-01 |
| EP3299461A1 (en) | 2018-03-28 |
| EP3299461B1 (en) | 2023-03-29 |
| MA42138A (fr) | 2018-03-28 |
| AU2016268625B2 (en) | 2022-01-27 |
| CA2986210A1 (en) | 2016-12-01 |
| KR20180006391A (ko) | 2018-01-17 |
| US20180147281A1 (en) | 2018-05-31 |
| RU2017145071A3 (es) | 2019-10-17 |
| SG11201709589XA (en) | 2017-12-28 |
| CN107614683A (zh) | 2018-01-19 |
| MY184164A (en) | 2021-03-24 |
| WO2016190263A1 (ja) | 2016-12-01 |
| CO2017012397A2 (es) | 2018-02-28 |
| BR112017025029A2 (pt) | 2018-08-07 |
| TWI706959B (zh) | 2020-10-11 |
| PH12017502126A1 (en) | 2018-05-07 |
| RU2729825C2 (ru) | 2020-08-12 |
| EP3299461A4 (en) | 2018-12-19 |
| JP6700620B2 (ja) | 2020-05-27 |
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