JP2015519404A5 - - Google Patents
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- Publication number
- JP2015519404A5 JP2015519404A5 JP2015517469A JP2015517469A JP2015519404A5 JP 2015519404 A5 JP2015519404 A5 JP 2015519404A5 JP 2015517469 A JP2015517469 A JP 2015517469A JP 2015517469 A JP2015517469 A JP 2015517469A JP 2015519404 A5 JP2015519404 A5 JP 2015519404A5
- Authority
- JP
- Japan
- Prior art keywords
- administration
- dnc
- cyclobenzaprine
- composition
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 169
- JURKNVYFZMSNLP-UHFFFAOYSA-N cyclobenzaprine Chemical compound C1=CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 JURKNVYFZMSNLP-UHFFFAOYSA-N 0.000 claims description 151
- 229960003572 cyclobenzaprine Drugs 0.000 claims description 151
- 238000000034 method Methods 0.000 claims description 89
- 238000010521 absorption reaction Methods 0.000 claims description 82
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 claims description 81
- 229960000836 amitriptyline Drugs 0.000 claims description 81
- 230000036470 plasma concentration Effects 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 239000002610 basifying agent Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 6
- 208000001640 Fibromyalgia Diseases 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- 239000007983 Tris buffer Substances 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 3
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 3
- UZLGHNUASUZUOR-UHFFFAOYSA-L dipotassium;3-carboxy-3-hydroxypentanedioate Chemical compound [K+].[K+].OC(=O)CC(O)(C([O-])=O)CC([O-])=O UZLGHNUASUZUOR-UHFFFAOYSA-L 0.000 claims description 3
- 239000002526 disodium citrate Substances 0.000 claims description 3
- 235000019262 disodium citrate Nutrition 0.000 claims description 3
- -1 disodium hydrogen Chemical class 0.000 claims description 3
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical group [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- 235000011056 potassium acetate Nutrition 0.000 claims description 3
- 239000011736 potassium bicarbonate Substances 0.000 claims description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- 235000011181 potassium carbonates Nutrition 0.000 claims description 3
- 239000001508 potassium citrate Substances 0.000 claims description 3
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000006190 sub-lingual tablet Substances 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 235000015870 tripotassium citrate Nutrition 0.000 claims description 3
- 229910000404 tripotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019798 tripotassium phosphate Nutrition 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 3
- 235000019263 trisodium citrate Nutrition 0.000 claims description 3
- 229940038773 trisodium citrate Drugs 0.000 claims description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 3
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 3
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 208000008238 Muscle Spasticity Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 239000007935 oral tablet Substances 0.000 description 4
- 230000000472 traumatic effect Effects 0.000 description 4
- 239000007937 lozenge Substances 0.000 description 2
- 239000007922 nasal spray Substances 0.000 description 2
- 229940097496 nasal spray Drugs 0.000 description 2
- 239000000668 oral spray Substances 0.000 description 2
- 229940041678 oral spray Drugs 0.000 description 2
- 229940096978 oral tablet Drugs 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660593P | 2012-06-15 | 2012-06-15 | |
| US61/660,593 | 2012-06-15 | ||
| US201261667774P | 2012-07-03 | 2012-07-03 | |
| US61/667,774 | 2012-07-03 | ||
| US201261725402P | 2012-11-12 | 2012-11-12 | |
| US61/725,402 | 2012-11-12 | ||
| US201361792900P | 2013-03-15 | 2013-03-15 | |
| US61/792,900 | 2013-03-15 | ||
| PCT/US2013/046023 WO2013188847A1 (en) | 2012-06-15 | 2013-06-14 | Compositions and methods for transmucosal absorption |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017192713A Division JP2017222726A (ja) | 2012-06-15 | 2017-10-02 | 経粘膜吸収のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519404A JP2015519404A (ja) | 2015-07-09 |
| JP2015519404A5 true JP2015519404A5 (https=) | 2016-07-28 |
| JP6259452B2 JP6259452B2 (ja) | 2018-01-10 |
Family
ID=49758769
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517469A Active JP6259452B2 (ja) | 2012-06-15 | 2013-06-14 | 経粘膜吸収のための組成物および方法 |
| JP2017192713A Withdrawn JP2017222726A (ja) | 2012-06-15 | 2017-10-02 | 経粘膜吸収のための組成物および方法 |
| JP2019091262A Withdrawn JP2019123757A (ja) | 2012-06-15 | 2019-05-14 | 経粘膜吸収のための組成物および方法 |
| JP2021100154A Withdrawn JP2021138765A (ja) | 2012-06-15 | 2021-06-16 | 経粘膜吸収のための組成物および方法 |
| JP2024014696A Pending JP2024032964A (ja) | 2012-06-15 | 2024-02-02 | 経粘膜吸収のための組成物および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017192713A Withdrawn JP2017222726A (ja) | 2012-06-15 | 2017-10-02 | 経粘膜吸収のための組成物および方法 |
| JP2019091262A Withdrawn JP2019123757A (ja) | 2012-06-15 | 2019-05-14 | 経粘膜吸収のための組成物および方法 |
| JP2021100154A Withdrawn JP2021138765A (ja) | 2012-06-15 | 2021-06-16 | 経粘膜吸収のための組成物および方法 |
| JP2024014696A Pending JP2024032964A (ja) | 2012-06-15 | 2024-02-02 | 経粘膜吸収のための組成物および方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20140171515A1 (https=) |
| EP (1) | EP2861223B1 (https=) |
| JP (5) | JP6259452B2 (https=) |
| CN (2) | CN104684550A (https=) |
| AR (1) | AR092330A1 (https=) |
| AU (2) | AU2013274003B2 (https=) |
| BR (1) | BR112014031394B1 (https=) |
| CA (2) | CA3118913C (https=) |
| DK (1) | DK2861223T3 (https=) |
| ES (1) | ES2929133T3 (https=) |
| HR (1) | HRP20221325T1 (https=) |
| HU (1) | HUE060175T2 (https=) |
| IL (1) | IL236268B (https=) |
| LT (1) | LT2861223T (https=) |
| MX (2) | MX382516B (https=) |
| MY (1) | MY194495A (https=) |
| NZ (2) | NZ726488A (https=) |
| PL (1) | PL2861223T3 (https=) |
| PT (1) | PT2861223T (https=) |
| RS (1) | RS63822B1 (https=) |
| SG (2) | SG10201605407TA (https=) |
| SI (1) | SI2861223T1 (https=) |
| SM (1) | SMT202200436T1 (https=) |
| TW (3) | TWI642429B (https=) |
| WO (1) | WO2013188847A1 (https=) |
| ZA (1) | ZA201500288B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20171739T1 (hr) | 2009-11-20 | 2018-03-09 | Tonix Pharma Holdings Limited | Postupci i kompozicije za liječenje simptoma povezanih s posttraumatskim stresnim poremećajem korištenjem ciklobenzaprina |
| US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| JP6310542B2 (ja) | 2013-03-15 | 2018-04-11 | トニックス ファーマシューティカルズ， インコーポレイテッド | シクロベンザプリン塩酸塩およびアミトリプチリン塩酸塩の共融製剤 |
| SG11201701995PA (en) | 2014-09-18 | 2017-04-27 | Tonix Pharma Holdings Ltd | Eutectic formulations of cyclobenzaprine hydrochloride |
| MX386469B (es) * | 2015-07-15 | 2025-03-18 | Theranexus | Uso de amitriptilina para el bloqueo de hemicanales en el cerebro y metodo para la potenciacion de este efecto in vivo. |
| WO2018045367A1 (en) * | 2016-09-02 | 2018-03-08 | Nova Southeastern University | Atropine sulfate rapidly-disintegrating sublingual tablets for treatment of acute organophosphate toxicity |
| EP3651751A4 (en) | 2017-07-13 | 2021-03-31 | Tonix Pharmaceuticals Holding Corp. | CYCLOBENZAPRINE AND AMITRYPTILENE ANALOGUES |
| CN107496355B (zh) * | 2017-08-24 | 2021-04-30 | 正大制药（青岛）有限公司 | 一种盐酸环苯扎林舌下喷雾剂及其制备方法 |
| CN107519142B (zh) * | 2017-08-24 | 2021-02-26 | 正大制药（青岛）有限公司 | 一种盐酸环苯扎林舌下片及其制备方法 |
| KR102704497B1 (ko) * | 2017-12-08 | 2024-09-10 | 에프. 호프만-라 로슈 아게 | 약학 제형 |
| US11826321B2 (en) | 2017-12-11 | 2023-11-28 | Tonix Pharma Holdings Limited | Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions |
| CN108721240A (zh) * | 2018-06-08 | 2018-11-02 | 华益药业科技(安徽)有限公司 | 一种25mg阿米替林薄膜包衣片处方和工艺规程 |
| TW202019400A (zh) | 2018-08-20 | 2020-06-01 | 愛爾蘭商托尼克製藥控股有限公司 | 治療急性壓力症候群及創傷後壓力症候群之方法 |
| US20220339124A1 (en) * | 2019-09-30 | 2022-10-27 | Cadila Healthcare Limited | Intranasal pharmaceutical compositions of cyclobenzaprine |
| AU2021253592A1 (en) * | 2020-04-08 | 2022-11-10 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine treatment for sexual dysfunction |
| MX2023005899A (es) * | 2020-11-20 | 2023-08-16 | TONIX Pharmaceuticals Holding Corp | Tratamiento con ciclobenzaprina para el trastorno por consumo de alcohol. |
| AU2021396509A1 (en) | 2020-12-07 | 2023-06-29 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine treatment for fibromyalgia |
| WO2022170107A2 (en) | 2021-02-04 | 2022-08-11 | Tonix Pharmaceuticals Holding Corp. | An improved method of assessing clinical response in the treatment of ptsd symptoms |
| US20240415789A1 (en) | 2021-10-06 | 2024-12-19 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients |
| WO2023250036A1 (en) | 2022-06-21 | 2023-12-28 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine treatment for post-acute sequelae of (sars)-cov-2 infection (pasc) |
| JP2025067457A (ja) * | 2023-10-13 | 2025-04-24 | 株式会社島津製作所 | 液体クロマトグラフにおけるコストパフォーマンスの算出方法、プログラム、および、解析装置 |
| WO2025160302A1 (en) | 2024-01-25 | 2025-07-31 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine treatment for acute stress reaction or acute stress disorder |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968507A (en) * | 1984-06-20 | 1990-11-06 | Merck & Co., Inc. | Controlled porosity osmotic pump |
| US20030077227A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| WO1999018937A1 (en) * | 1997-10-16 | 1999-04-22 | Merck & Co., Inc. | New cyclobenzaprine composition |
| DK1077683T3 (da) * | 1998-05-14 | 2003-03-31 | Alza Corp | Antidepressiv behandling |
| WO2001012175A1 (en) | 1999-08-13 | 2001-02-22 | Vela Pharmaceuticals Inc. | Uses compositions for treating or preventing sleep disturbances using very low doses of cyclobenzaprine |
| BR0013122A (pt) | 1999-08-13 | 2002-04-30 | Vela Pharmaceuticals Inc | Ciclobenzaprina para tratamento de distúrbio de ansiedade generalizado e composições de ciclobenzaprina |
| WO2001089476A1 (en) * | 2000-05-19 | 2001-11-29 | Npd Llc | Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements |
| WO2002094229A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of muscle relaxants through an inhalation route |
| US7501113B2 (en) * | 2003-02-04 | 2009-03-10 | Philip Morris Usa Inc. | Aerosol formulations and aerosol delivery of buprenorphine |
| WO2006105205A1 (en) * | 2005-03-29 | 2006-10-05 | University Of Kentucky Research Foundation | Sublingual spray for the treatment of pain |
| US20090148532A1 (en) * | 2007-12-06 | 2009-06-11 | Venkatesh Gopi M | Preparation of controlled release skeletal muscle relaxant dosage forms |
| JP2009079060A (ja) * | 2008-10-15 | 2009-04-16 | Novadel Pharma Inc | 極性または非極性の、バッカルスプレーまたはカプセル |
| US20100266682A1 (en) * | 2008-12-10 | 2010-10-21 | Nipun Davar | Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same |
| US20100247586A1 (en) * | 2009-03-27 | 2010-09-30 | Andreas Hugerth | Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties |
| HRP20171739T1 (hr) * | 2009-11-20 | 2018-03-09 | Tonix Pharma Holdings Limited | Postupci i kompozicije za liječenje simptoma povezanih s posttraumatskim stresnim poremećajem korištenjem ciklobenzaprina |
| US20110319389A1 (en) * | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| ITMI20110558A1 (it) * | 2011-04-06 | 2012-10-07 | Campiglio Consulting Srl | Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale |
| JP6310542B2 (ja) * | 2013-03-15 | 2018-04-11 | トニックス ファーマシューティカルズ， インコーポレイテッド | シクロベンザプリン塩酸塩およびアミトリプチリン塩酸塩の共融製剤 |
-
2013
- 2013-06-14 SM SM20220436T patent/SMT202200436T1/it unknown
- 2013-06-14 SI SI201332010T patent/SI2861223T1/sl unknown
- 2013-06-14 NZ NZ726488A patent/NZ726488A/en unknown
- 2013-06-14 EP EP13804115.7A patent/EP2861223B1/en active Active
- 2013-06-14 TW TW106117185A patent/TWI642429B/zh active
- 2013-06-14 HR HRP20221325TT patent/HRP20221325T1/hr unknown
- 2013-06-14 CA CA3118913A patent/CA3118913C/en active Active
- 2013-06-14 JP JP2015517469A patent/JP6259452B2/ja active Active
- 2013-06-14 US US13/918,692 patent/US20140171515A1/en not_active Abandoned
- 2013-06-14 PL PL13804115.7T patent/PL2861223T3/pl unknown
- 2013-06-14 LT LTEPPCT/US2013/046023T patent/LT2861223T/lt unknown
- 2013-06-14 RS RS20221005A patent/RS63822B1/sr unknown
- 2013-06-14 PT PT138041157T patent/PT2861223T/pt unknown
- 2013-06-14 AU AU2013274003A patent/AU2013274003B2/en active Active
- 2013-06-14 AR ARP130102101A patent/AR092330A1/es not_active Application Discontinuation
- 2013-06-14 BR BR112014031394-6A patent/BR112014031394B1/pt active IP Right Grant
- 2013-06-14 ES ES13804115T patent/ES2929133T3/es active Active
- 2013-06-14 SG SG10201605407TA patent/SG10201605407TA/en unknown
- 2013-06-14 CA CA2876902A patent/CA2876902C/en active Active
- 2013-06-14 MX MX2014015436A patent/MX382516B/es unknown
- 2013-06-14 WO PCT/US2013/046023 patent/WO2013188847A1/en not_active Ceased
- 2013-06-14 HU HUE13804115A patent/HUE060175T2/hu unknown
- 2013-06-14 MY MYPI2014703784A patent/MY194495A/en unknown
- 2013-06-14 CN CN201380039522.6A patent/CN104684550A/zh active Pending
- 2013-06-14 MX MX2021005317A patent/MX2021005317A/es unknown
- 2013-06-14 TW TW107117266A patent/TWI683660B/zh active
- 2013-06-14 SG SG11201408318RA patent/SG11201408318RA/en unknown
- 2013-06-14 CN CN202010024102.2A patent/CN111388430A/zh active Pending
- 2013-06-14 NZ NZ631144A patent/NZ631144A/en unknown
- 2013-06-14 DK DK13804115.7T patent/DK2861223T3/da active
- 2013-06-14 TW TW102121267A patent/TWI590820B/zh active
-
2014
- 2014-12-15 IL IL236268A patent/IL236268B/en unknown
-
2015
- 2015-01-15 ZA ZA2015/00288A patent/ZA201500288B/en unknown
-
2017
- 2017-10-02 JP JP2017192713A patent/JP2017222726A/ja not_active Withdrawn
-
2018
- 2018-10-04 AU AU2018241128A patent/AU2018241128B2/en active Active
-
2019
- 2019-05-14 JP JP2019091262A patent/JP2019123757A/ja not_active Withdrawn
-
2021
- 2021-06-16 JP JP2021100154A patent/JP2021138765A/ja not_active Withdrawn
-
2024
- 2024-02-02 JP JP2024014696A patent/JP2024032964A/ja active Pending
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