TWI590820B - 供穿黏膜吸收之組合物及方法 - Google Patents

供穿黏膜吸收之組合物及方法 Download PDF

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Publication number
TWI590820B
TWI590820B TW102121267A TW102121267A TWI590820B TW I590820 B TWI590820 B TW I590820B TW 102121267 A TW102121267 A TW 102121267A TW 102121267 A TW102121267 A TW 102121267A TW I590820 B TWI590820 B TW I590820B
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TW
Taiwan
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equal
hours
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composition
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Application number
TW102121267A
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English (en)
Chinese (zh)
Other versions
TW201408281A (zh
Inventor
賽斯 雷德曼
賈吉歐 瑞納爾
哈瑞 布里瑞頓
Original Assignee
托尼克製藥有限公司
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Publication of TW201408281A publication Critical patent/TW201408281A/zh
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Publication of TWI590820B publication Critical patent/TWI590820B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
TW102121267A 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法 TWI590820B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261660593P 2012-06-15 2012-06-15
US201261667774P 2012-07-03 2012-07-03
US201261725402P 2012-11-12 2012-11-12
US201361792900P 2013-03-15 2013-03-15

Publications (2)

Publication Number Publication Date
TW201408281A TW201408281A (zh) 2014-03-01
TWI590820B true TWI590820B (zh) 2017-07-11

Family

ID=49758769

Family Applications (3)

Application Number Title Priority Date Filing Date
TW102121267A TWI590820B (zh) 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法
TW107117266A TWI683660B (zh) 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法
TW106117185A TWI642429B (zh) 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW107117266A TWI683660B (zh) 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法
TW106117185A TWI642429B (zh) 2012-06-15 2013-06-14 供穿黏膜吸收之組合物及方法

Country Status (26)

Country Link
US (1) US20140171515A1 (https=)
EP (1) EP2861223B1 (https=)
JP (5) JP6259452B2 (https=)
CN (2) CN104684550A (https=)
AR (1) AR092330A1 (https=)
AU (2) AU2013274003B2 (https=)
BR (1) BR112014031394B1 (https=)
CA (2) CA3118913C (https=)
DK (1) DK2861223T3 (https=)
ES (1) ES2929133T3 (https=)
HR (1) HRP20221325T1 (https=)
HU (1) HUE060175T2 (https=)
IL (1) IL236268B (https=)
LT (1) LT2861223T (https=)
MX (2) MX2021005317A (https=)
MY (1) MY194495A (https=)
NZ (2) NZ726488A (https=)
PL (1) PL2861223T3 (https=)
PT (1) PT2861223T (https=)
RS (1) RS63822B1 (https=)
SG (2) SG10201605407TA (https=)
SI (1) SI2861223T1 (https=)
SM (1) SMT202200436T1 (https=)
TW (3) TWI590820B (https=)
WO (1) WO2013188847A1 (https=)
ZA (1) ZA201500288B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201700578T1 (it) 2009-11-20 2018-01-11 Tonix Pharma Holdings Ltd Metodo e composizioni per trattare i sintomi associati al disturbo da stress post-traumatico usando ciclobenzaprina
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
SMT202400324T1 (it) 2013-03-15 2024-11-15 Tonix Pharma Ltd Formulazioni eutettiche di ciclobenzaprina cloridrato e mannitolo
MY186047A (en) * 2014-09-18 2021-06-17 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
CN108024976A (zh) * 2015-07-15 2018-05-11 特兰埃克斯公司 阿米替林用于阻断大脑半通道的用途和用于增强其体内作用的方法
US12337063B2 (en) * 2016-09-02 2025-06-24 University Of Sharjah Formulation for atropine sulfate rapidly-disintegrating sublingual tablets
WO2019014651A1 (en) 2017-07-13 2019-01-17 Tonix Pharmaceuticals Holding Corp. ANALOGUES OF CYCLOBENZAPRINE AND AMITRYPTILENE
CN107519142B (zh) * 2017-08-24 2021-02-26 正大制药(青岛)有限公司 一种盐酸环苯扎林舌下片及其制备方法
CN107496355B (zh) * 2017-08-24 2021-04-30 正大制药(青岛)有限公司 一种盐酸环苯扎林舌下喷雾剂及其制备方法
BR112020004035A2 (pt) * 2017-12-08 2020-09-01 F. Hoffmann-La Roche Ag formulação farmacêutica
MX2020006140A (es) 2017-12-11 2020-08-13 Tonix Pharma Holdings Ltd Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas.
CN108721240A (zh) * 2018-06-08 2018-11-02 华益药业科技(安徽)有限公司 一种25mg阿米替林薄膜包衣片处方和工艺规程
US20220117915A1 (en) * 2018-08-20 2022-04-21 Tonix Pharma Holdings Limited Methods of treating acute stress disorder and posttraumatic stress disorder
CA3156118A1 (en) * 2019-09-30 2021-04-08 Cadila Healthcare Limited INTRANASAL PHARMACEUTICAL COMPOSITIONS OF CYCLOBENZAPRINE
AU2021253592A1 (en) 2020-04-08 2022-11-10 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for sexual dysfunction
MX2023005899A (es) * 2020-11-20 2023-08-16 TONIX Pharmaceuticals Holding Corp Tratamiento con ciclobenzaprina para el trastorno por consumo de alcohol.
US20240024256A1 (en) 2020-12-07 2024-01-25 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for fibromyalgia
WO2022170107A2 (en) 2021-02-04 2022-08-11 Tonix Pharmaceuticals Holding Corp. An improved method of assessing clinical response in the treatment of ptsd symptoms
WO2023059728A1 (en) 2021-10-06 2023-04-13 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients
CA3260042A1 (en) 2022-06-21 2023-12-28 Tonix Pharmaceuticals Holding Corp. CYCLOBENZAPRINE TREATMENT FOR POST-ACUTE SEQUELAE OF A (SARS)-COV-2 (PASC) INFECTION
JP2025067457A (ja) * 2023-10-13 2025-04-24 株式会社島津製作所 液体クロマトグラフにおけるコストパフォーマンスの算出方法、プログラム、および、解析装置
WO2025160302A1 (en) 2024-01-25 2025-07-31 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for acute stress reaction or acute stress disorder

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968507A (en) * 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (en) * 1997-10-16 1999-04-22 Merck & Co., Inc. New cyclobenzaprine composition
PT1077683E (pt) * 1998-05-14 2003-04-30 Alza Corp Terapia anti-depressiva
AR025111A1 (es) 1999-08-13 2002-11-06 Janus Pharmaceuticals Inc Metodos y composiciones para tratar trastornos de ansiedad generalizada
BR0013017A (pt) 1999-08-13 2002-04-16 Vela Pharmaceuticals Inc Usos de composições para o tratamento ou prevenção dos distúrbios do sono usando doses muito baixas de ciclobenzaprina
WO2001089476A1 (en) * 2000-05-19 2001-11-29 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
WO2002094229A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of muscle relaxants through an inhalation route
AU2003297087B2 (en) * 2003-02-04 2009-06-11 Philip Morris Products S.A. Aerosol formulations and aerosol delivery of buspirone, buprenorphine, triazolam, cyclobenzaprine and zolpidem
WO2006105205A1 (en) * 2005-03-29 2006-10-05 University Of Kentucky Research Foundation Sublingual spray for the treatment of pain
US20090148532A1 (en) * 2007-12-06 2009-06-11 Venkatesh Gopi M Preparation of controlled release skeletal muscle relaxant dosage forms
JP2009079060A (ja) * 2008-10-15 2009-04-16 Novadel Pharma Inc 極性または非極性の、バッカルスプレーまたはカプセル
US20100266682A1 (en) * 2008-12-10 2010-10-21 Nipun Davar Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
SMT201700578T1 (it) * 2009-11-20 2018-01-11 Tonix Pharma Holdings Ltd Metodo e composizioni per trattare i sintomi associati al disturbo da stress post-traumatico usando ciclobenzaprina
US20110319389A1 (en) * 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
ITMI20110558A1 (it) * 2011-04-06 2012-10-07 Campiglio Consulting Srl Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale
SMT202400324T1 (it) * 2013-03-15 2024-11-15 Tonix Pharma Ltd Formulazioni eutettiche di ciclobenzaprina cloridrato e mannitolo

Also Published As

Publication number Publication date
MY194495A (en) 2022-11-30
CA2876902C (en) 2021-07-13
ES2929133T3 (es) 2022-11-25
AU2018241128B2 (en) 2020-05-21
MX2021005317A (es) 2022-12-16
BR112014031394A2 (pt) 2017-06-27
HUE060175T2 (hu) 2023-02-28
PL2861223T3 (pl) 2022-12-12
JP2015519404A (ja) 2015-07-09
HRP20221325T1 (hr) 2022-12-23
TWI683660B (zh) 2020-02-01
WO2013188847A1 (en) 2013-12-19
TWI642429B (zh) 2018-12-01
JP2019123757A (ja) 2019-07-25
SMT202200436T1 (it) 2023-01-13
PT2861223T (pt) 2022-11-07
TW201842903A (zh) 2018-12-16
MX382516B (es) 2025-03-13
NZ726488A (en) 2018-10-26
IL236268B (en) 2022-03-01
TW201731494A (zh) 2017-09-16
NZ631144A (en) 2016-12-23
AU2013274003B2 (en) 2018-07-05
JP6259452B2 (ja) 2018-01-10
AU2013274003A1 (en) 2015-02-05
CN104684550A (zh) 2015-06-03
EP2861223A4 (en) 2016-01-27
ZA201500288B (en) 2022-05-25
CN111388430A (zh) 2020-07-10
BR112014031394A8 (pt) 2021-11-03
AU2018241128A1 (en) 2018-10-25
RS63822B1 (sr) 2023-01-31
DK2861223T3 (da) 2022-11-07
MX2014015436A (es) 2015-07-14
CA3118913A1 (en) 2013-12-19
WO2013188847A8 (en) 2015-02-05
IL236268A0 (en) 2015-02-26
EP2861223A1 (en) 2015-04-22
LT2861223T (lt) 2022-12-12
JP2021138765A (ja) 2021-09-16
CA2876902A1 (en) 2013-12-19
HK1209361A1 (en) 2016-04-01
SG10201605407TA (en) 2016-08-30
TW201408281A (zh) 2014-03-01
US20140171515A1 (en) 2014-06-19
BR112014031394B1 (pt) 2022-10-18
AR092330A1 (es) 2015-04-15
JP2017222726A (ja) 2017-12-21
SI2861223T1 (sl) 2023-01-31
SG11201408318RA (en) 2015-01-29
CA3118913C (en) 2024-04-30
JP2024032964A (ja) 2024-03-12
EP2861223B1 (en) 2022-08-03

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