JP2015518837A5 - - Google Patents
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- Publication number
- JP2015518837A5 JP2015518837A5 JP2015512890A JP2015512890A JP2015518837A5 JP 2015518837 A5 JP2015518837 A5 JP 2015518837A5 JP 2015512890 A JP2015512890 A JP 2015512890A JP 2015512890 A JP2015512890 A JP 2015512890A JP 2015518837 A5 JP2015518837 A5 JP 2015518837A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- salt
- formula
- process according
- forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](C*)c(c(Cl)ncn1)c1Cl Chemical compound C[C@](C*)c(c(Cl)ncn1)c1Cl 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261648421P | 2012-05-17 | 2012-05-17 | |
| US61/648,421 | 2012-05-17 | ||
| US201361785281P | 2013-03-14 | 2013-03-14 | |
| US61/785,281 | 2013-03-14 | ||
| PCT/US2013/041624 WO2013173736A1 (en) | 2012-05-17 | 2013-05-17 | Process for making hydroxylated cyclopentylpyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518837A JP2015518837A (ja) | 2015-07-06 |
| JP2015518837A5 true JP2015518837A5 (enExample) | 2016-07-07 |
| JP6214636B2 JP6214636B2 (ja) | 2017-10-18 |
Family
ID=48534507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512890A Active JP6214636B2 (ja) | 2012-05-17 | 2013-05-17 | ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9309204B2 (enExample) |
| EP (1) | EP2861583B1 (enExample) |
| JP (1) | JP6214636B2 (enExample) |
| KR (1) | KR20150020211A (enExample) |
| CN (1) | CN104487430B (enExample) |
| AU (1) | AU2013262568B2 (enExample) |
| BR (1) | BR112014028570A2 (enExample) |
| CA (1) | CA2873653A1 (enExample) |
| DK (1) | DK2861583T3 (enExample) |
| ES (1) | ES2588878T3 (enExample) |
| IL (1) | IL235714A0 (enExample) |
| MA (1) | MA37649B1 (enExample) |
| MX (1) | MX2014013865A (enExample) |
| PL (1) | PL2861583T3 (enExample) |
| RU (1) | RU2014151017A (enExample) |
| SG (1) | SG11201407613RA (enExample) |
| SI (1) | SI2861583T1 (enExample) |
| WO (1) | WO2013173736A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2858989T (lt) | 2012-05-17 | 2020-08-10 | Genentech, Inc. | Akt inhibuojančio pirimidinil-ciklopentano junginio amorfinė forma, jo kompozicijos ir būdai |
| ES2582557T3 (es) | 2012-05-17 | 2016-09-13 | Array Biopharma, Inc. | Proceso para la preparación de compuestos hidroxilados de ciclopentilpirimidina |
| EP2850200A1 (en) | 2012-05-17 | 2015-03-25 | Genentech, Inc. | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| BR112014028585B1 (pt) | 2012-05-17 | 2020-12-22 | Genentech , Inc | processo para fabricação de aminoácidos, e seus intermediários |
| CN112898210B (zh) | 2013-11-15 | 2025-02-21 | 豪夫迈·罗氏有限公司 | 用于制备嘧啶基环戊烷化合物的方法 |
| KR102284944B1 (ko) * | 2013-11-27 | 2021-08-03 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법 |
| PL3197875T3 (pl) * | 2014-09-26 | 2020-03-31 | F. Hoffmann-La Roche Ag | Sposoby wytwarzania związków (cyklopentylo[d]pirymidyn-4-ylo)piperazynowych |
| CN120887837A (zh) | 2020-06-16 | 2025-11-04 | 豪夫迈·罗氏有限公司 | 用于制备羟基化环戊基嘧啶化合物的方法 |
| KR102689151B1 (ko) * | 2021-09-06 | 2024-07-29 | 연세대학교 산학협력단 | Akt 신호경로 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995015684A1 (en) | 1993-12-12 | 1995-06-15 | Agrogene, Ltd. | A novel method to protect plants from fungal infection |
| WO1998044797A1 (en) | 1997-04-07 | 1998-10-15 | Merck & Co., Inc. | A method of treating cancer |
| US6201023B1 (en) | 1997-06-10 | 2001-03-13 | Agrogene Ltd. | Methods and compositions to protect crops against plant parasitic nematodes |
| EP0982300A3 (en) | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| CA2363169A1 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| CN1281604C (zh) * | 1999-06-03 | 2006-10-25 | 帝国脏器制药株式会社 | 取代吡唑化合物 |
| WO2001022963A1 (en) | 1999-09-27 | 2001-04-05 | Merck & Co., Inc. | Method of preventing osteoporosis |
| CA2526506A1 (en) | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| AU2004293026B2 (en) | 2003-11-21 | 2012-01-19 | Array Biopharma Inc. | AKT protein kinase inhibitors |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| JP5157576B2 (ja) | 2007-05-14 | 2013-03-06 | 住友化学株式会社 | 光学活性２−アルキル−１，１，３−トリアルコキシカルボニルプロパンの製造方法 |
| MX2009014013A (es) * | 2007-07-05 | 2010-01-28 | Array Biopharma Inc | Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt. |
| WO2009047255A1 (en) | 2007-10-09 | 2009-04-16 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| US8835434B2 (en) * | 2008-01-09 | 2014-09-16 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| AU2009303475B2 (en) * | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| BR112012011328A2 (pt) | 2009-10-23 | 2016-11-22 | Lilly Co Eli | inibidores de akt |
| WO2012009649A1 (en) | 2010-07-16 | 2012-01-19 | Anderson Gaweco | Mif inhibitors and their uses |
| WO2012177925A1 (en) | 2011-06-21 | 2012-12-27 | The Board Institute, Inc. | Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene |
| ES2582557T3 (es) | 2012-05-17 | 2016-09-13 | Array Biopharma, Inc. | Proceso para la preparación de compuestos hidroxilados de ciclopentilpirimidina |
| EP2850200A1 (en) | 2012-05-17 | 2015-03-25 | Genentech, Inc. | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| BR112014028585B1 (pt) | 2012-05-17 | 2020-12-22 | Genentech , Inc | processo para fabricação de aminoácidos, e seus intermediários |
| WO2014071194A2 (en) | 2012-11-01 | 2014-05-08 | Katz Robert S | Methods for treating fibromyalgia |
| US20150376198A1 (en) | 2013-02-18 | 2015-12-31 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
| EP2968318A4 (en) | 2013-03-15 | 2016-12-14 | Shifa Biomedical Corp | ANTI-PCSK9 COMPOUNDS AND METHODS FOR TREATING AND / OR PREVENTING CARDIOVASCULAR DISEASES |
-
2013
- 2013-05-17 ES ES13725533.7T patent/ES2588878T3/es active Active
- 2013-05-17 AU AU2013262568A patent/AU2013262568B2/en not_active Ceased
- 2013-05-17 CN CN201380037994.8A patent/CN104487430B/zh active Active
- 2013-05-17 MX MX2014013865A patent/MX2014013865A/es unknown
- 2013-05-17 SI SI201330302A patent/SI2861583T1/sl unknown
- 2013-05-17 US US14/401,091 patent/US9309204B2/en active Active
- 2013-05-17 MA MA37649A patent/MA37649B1/fr unknown
- 2013-05-17 WO PCT/US2013/041624 patent/WO2013173736A1/en not_active Ceased
- 2013-05-17 RU RU2014151017A patent/RU2014151017A/ru not_active Application Discontinuation
- 2013-05-17 KR KR20147035262A patent/KR20150020211A/ko not_active Withdrawn
- 2013-05-17 PL PL13725533.7T patent/PL2861583T3/pl unknown
- 2013-05-17 DK DK13725533.7T patent/DK2861583T3/en active
- 2013-05-17 CA CA2873653A patent/CA2873653A1/en not_active Abandoned
- 2013-05-17 EP EP13725533.7A patent/EP2861583B1/en active Active
- 2013-05-17 JP JP2015512890A patent/JP6214636B2/ja active Active
- 2013-05-17 BR BR112014028570A patent/BR112014028570A2/pt not_active IP Right Cessation
- 2013-05-17 SG SG11201407613RA patent/SG11201407613RA/en unknown
-
2014
- 2014-11-13 IL IL235714A patent/IL235714A0/en unknown
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