SI2861583T1 - Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojin - Google Patents
Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojinInfo
- Publication number
- SI2861583T1 SI2861583T1 SI201330302A SI201330302A SI2861583T1 SI 2861583 T1 SI2861583 T1 SI 2861583T1 SI 201330302 A SI201330302 A SI 201330302A SI 201330302 A SI201330302 A SI 201330302A SI 2861583 T1 SI2861583 T1 SI 2861583T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compounds
- making
- making hydroxylated
- cyclopentylpyrimidine compounds
- hydroxylated cyclopentylpyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261648421P | 2012-05-17 | 2012-05-17 | |
US201361785281P | 2013-03-14 | 2013-03-14 | |
EP13725533.7A EP2861583B1 (en) | 2012-05-17 | 2013-05-17 | Process for making hydroxylated cyclopentylpyrimidine compounds |
PCT/US2013/041624 WO2013173736A1 (en) | 2012-05-17 | 2013-05-17 | Process for making hydroxylated cyclopentylpyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2861583T1 true SI2861583T1 (sl) | 2016-10-28 |
Family
ID=48534507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201330302A SI2861583T1 (sl) | 2012-05-17 | 2013-05-17 | Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojin |
Country Status (19)
Country | Link |
---|---|
US (1) | US9309204B2 (sl) |
EP (1) | EP2861583B1 (sl) |
JP (1) | JP6214636B2 (sl) |
KR (1) | KR20150020211A (sl) |
CN (1) | CN104487430B (sl) |
AU (1) | AU2013262568B2 (sl) |
BR (1) | BR112014028570A2 (sl) |
CA (1) | CA2873653A1 (sl) |
DK (1) | DK2861583T3 (sl) |
ES (1) | ES2588878T3 (sl) |
HK (1) | HK1208673A1 (sl) |
IL (1) | IL235714A0 (sl) |
MA (1) | MA37649B1 (sl) |
MX (1) | MX2014013865A (sl) |
PL (1) | PL2861583T3 (sl) |
RU (1) | RU2014151017A (sl) |
SG (1) | SG11201407613RA (sl) |
SI (1) | SI2861583T1 (sl) |
WO (1) | WO2013173736A1 (sl) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201407591PA (en) | 2012-05-17 | 2015-01-29 | Genentech Inc | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
BR112014028589B1 (pt) | 2012-05-17 | 2022-08-23 | Genentech, Inc. | Ciclopentilpirimidina hidroxilada, seu processo de fabricação e seus intermediários |
AU2013262548B2 (en) | 2012-05-17 | 2017-09-21 | Genentech, Inc. | Amorphous form of an AKT inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof |
SI2850054T1 (sl) | 2012-05-17 | 2018-06-29 | Genentech, Inc. | Postopek za izdelavo aminokislinskih spojin |
JP6374503B2 (ja) | 2013-11-15 | 2018-08-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピリミジニルシクロペンタン化合物の調製方法 |
RU2697707C9 (ru) * | 2013-11-27 | 2019-10-03 | Саншайн Лейк Фарма Ко., Лтд. | Процессы приготовления производных соединений дигидропиримидина и их промежуточных продуктов |
US10457648B2 (en) * | 2014-09-26 | 2019-10-29 | Genentech Inc. | Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
WO2021254920A1 (en) | 2020-06-16 | 2021-12-23 | F. Hoffmann-La Roche Ag | Process for making hydroxylated cyclopentylpyrimidine compounds |
KR20230035773A (ko) * | 2021-09-06 | 2023-03-14 | 연세대학교 산학협력단 | Akt 신호경로 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1134212C (zh) | 1993-12-12 | 2004-01-14 | 阿格罗吉恩有限公司 | 保护植物免受真菌侵染的新方法 |
JP2001524079A (ja) | 1997-04-07 | 2001-11-27 | メルク エンド カンパニー インコーポレーテッド | ガンの治療方法 |
US6201023B1 (en) | 1997-06-10 | 2001-03-13 | Agrogene Ltd. | Methods and compositions to protect crops against plant parasitic nematodes |
EP0982300A3 (en) | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
US6376496B1 (en) | 1999-03-03 | 2002-04-23 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
CN1281604C (zh) | 1999-06-03 | 2006-10-25 | 帝国脏器制药株式会社 | 取代吡唑化合物 |
AU7715300A (en) | 1999-09-27 | 2001-04-30 | Merck & Co., Inc. | Method of preventing osteoporosis |
WO2004108673A2 (en) | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
JP5157576B2 (ja) | 2007-05-14 | 2013-03-06 | 住友化学株式会社 | 光学活性2−アルキル−1,1,3−トリアルコキシカルボニルプロパンの製造方法 |
BRPI0813993A2 (pt) | 2007-07-05 | 2015-06-16 | Array Biopharma Inc | Ciclopentanos de pirimidila como inibidores de proteína quinase akt |
WO2009047255A1 (en) | 2007-10-09 | 2009-04-16 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
BRPI0906798A2 (pt) | 2008-01-09 | 2015-07-14 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt |
JP5551707B2 (ja) * | 2008-10-15 | 2014-07-16 | アムジエン・インコーポレーテツド | スピロ環gpr40調節因子 |
CA2758484A1 (en) | 2009-04-15 | 2010-10-21 | David A. Degoey | Anti-viral compounds |
JP5581390B2 (ja) * | 2009-10-23 | 2014-08-27 | イーライ リリー アンド カンパニー | Akt阻害剤 |
US9050334B2 (en) | 2010-07-16 | 2015-06-09 | Innov88 Llc | MIF inhibitors and their uses |
WO2012177925A1 (en) | 2011-06-21 | 2012-12-27 | The Board Institute, Inc. | Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene |
SI2850054T1 (sl) | 2012-05-17 | 2018-06-29 | Genentech, Inc. | Postopek za izdelavo aminokislinskih spojin |
BR112014028589B1 (pt) | 2012-05-17 | 2022-08-23 | Genentech, Inc. | Ciclopentilpirimidina hidroxilada, seu processo de fabricação e seus intermediários |
SG11201407591PA (en) | 2012-05-17 | 2015-01-29 | Genentech Inc | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
WO2014071194A2 (en) | 2012-11-01 | 2014-05-08 | Katz Robert S | Methods for treating fibromyalgia |
CA2901577A1 (en) | 2013-02-18 | 2014-08-21 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
WO2014150395A1 (en) | 2013-03-15 | 2014-09-25 | Shifa Biomedical Corporation | Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases |
-
2013
- 2013-05-17 DK DK13725533.7T patent/DK2861583T3/en active
- 2013-05-17 JP JP2015512890A patent/JP6214636B2/ja active Active
- 2013-05-17 PL PL13725533.7T patent/PL2861583T3/pl unknown
- 2013-05-17 AU AU2013262568A patent/AU2013262568B2/en not_active Ceased
- 2013-05-17 WO PCT/US2013/041624 patent/WO2013173736A1/en active Application Filing
- 2013-05-17 RU RU2014151017A patent/RU2014151017A/ru not_active Application Discontinuation
- 2013-05-17 KR KR20147035262A patent/KR20150020211A/ko not_active Application Discontinuation
- 2013-05-17 BR BR112014028570A patent/BR112014028570A2/pt not_active IP Right Cessation
- 2013-05-17 CN CN201380037994.8A patent/CN104487430B/zh active Active
- 2013-05-17 MA MA37649A patent/MA37649B1/fr unknown
- 2013-05-17 US US14/401,091 patent/US9309204B2/en active Active
- 2013-05-17 MX MX2014013865A patent/MX2014013865A/es unknown
- 2013-05-17 CA CA2873653A patent/CA2873653A1/en not_active Abandoned
- 2013-05-17 EP EP13725533.7A patent/EP2861583B1/en active Active
- 2013-05-17 ES ES13725533.7T patent/ES2588878T3/es active Active
- 2013-05-17 SG SG11201407613RA patent/SG11201407613RA/en unknown
- 2013-05-17 SI SI201330302A patent/SI2861583T1/sl unknown
-
2014
- 2014-11-13 IL IL235714A patent/IL235714A0/en unknown
-
2015
- 2015-09-23 HK HK15109328.7A patent/HK1208673A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2015518837A (ja) | 2015-07-06 |
PL2861583T3 (pl) | 2016-12-30 |
US20150099881A1 (en) | 2015-04-09 |
KR20150020211A (ko) | 2015-02-25 |
IL235714A0 (en) | 2015-02-01 |
EP2861583B1 (en) | 2016-06-29 |
EP2861583A1 (en) | 2015-04-22 |
AU2013262568A1 (en) | 2015-01-22 |
RU2014151017A (ru) | 2016-07-10 |
SG11201407613RA (en) | 2015-01-29 |
MA37649B1 (fr) | 2017-03-31 |
CN104487430A (zh) | 2015-04-01 |
MX2014013865A (es) | 2015-05-07 |
DK2861583T3 (en) | 2016-10-03 |
WO2013173736A1 (en) | 2013-11-21 |
HK1208673A1 (en) | 2016-03-11 |
CN104487430B (zh) | 2016-08-24 |
AU2013262568B2 (en) | 2017-08-31 |
BR112014028570A2 (pt) | 2018-04-24 |
MA37649A1 (fr) | 2016-06-30 |
JP6214636B2 (ja) | 2017-10-18 |
ES2588878T3 (es) | 2016-11-07 |
CA2873653A1 (en) | 2013-11-21 |
US9309204B2 (en) | 2016-04-12 |
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