JP2015516982A5 - - Google Patents
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- JP2015516982A5 JP2015516982A5 JP2015508890A JP2015508890A JP2015516982A5 JP 2015516982 A5 JP2015516982 A5 JP 2015516982A5 JP 2015508890 A JP2015508890 A JP 2015508890A JP 2015508890 A JP2015508890 A JP 2015508890A JP 2015516982 A5 JP2015516982 A5 JP 2015516982A5
- Authority
- JP
- Japan
- Prior art keywords
- sphingosine
- article
- composition
- compound
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 29
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 28
- 239000002253 acid Substances 0.000 claims description 26
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
- 230000003628 erosive effect Effects 0.000 claims description 17
- -1 sphingosine compound Chemical class 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 11
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 9
- 210000000988 bone and bone Anatomy 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 7
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 239000000606 toothpaste Substances 0.000 claims description 6
- 229940034610 toothpaste Drugs 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 230000032770 biofilm formation Effects 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229910052587 fluorapatite Inorganic materials 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229910052719 titanium Inorganic materials 0.000 claims description 2
- 239000010936 titanium Substances 0.000 claims description 2
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 claims 5
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 claims 5
- 229940033329 phytosphingosine Drugs 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 230000010065 bacterial adhesion Effects 0.000 claims 2
- 239000004568 cement Substances 0.000 claims 2
- 239000003599 detergent Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 208000004509 Tooth Discoloration Diseases 0.000 claims 1
- 206010044032 Tooth discolouration Diseases 0.000 claims 1
- 206010044038 Tooth erosion Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 claims 1
- 210000000959 ear middle Anatomy 0.000 claims 1
- 210000001105 femoral artery Anatomy 0.000 claims 1
- 229940077441 fluorapatite Drugs 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 229920000554 ionomer Polymers 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 claims 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000036367 tooth discoloration Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 238000009423 ventilation Methods 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 description 20
- 150000003410 sphingosines Chemical class 0.000 description 12
- 238000005115 demineralization Methods 0.000 description 11
- 230000002328 demineralizing effect Effects 0.000 description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 208000035475 disorder Diseases 0.000 description 9
- 210000003296 saliva Anatomy 0.000 description 9
- 206010072665 Tooth demineralisation Diseases 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 8
- 210000003298 dental enamel Anatomy 0.000 description 7
- 208000008617 Tooth Demineralization Diseases 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 210000004268 dentin Anatomy 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 201000002170 dentin sensitivity Diseases 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000006558 Dental Calculus Diseases 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 239000002562 thickening agent Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
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- 208000002064 Dental Plaque Diseases 0.000 description 2
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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| WO2017100580A1 (en) * | 2015-12-10 | 2017-06-15 | Aaron Seitz | Sphingolipid coatings and process for manufacturing sphingolipid coatings effective for inhibiting biofilm formation |
| JP2023033269A (ja) * | 2021-08-28 | 2023-03-10 | ブルネエズ株式会社 | 外用組成物 |
| CN115969738B (zh) * | 2022-02-25 | 2025-05-16 | 华熙生物科技股份有限公司 | 一种含植物鞘氨醇的组合物及口腔护理产品 |
| CN118217180B (zh) * | 2024-05-20 | 2024-09-17 | 广州舒客实业有限公司 | 一种缓释的植物蛋白酶组合物及其在牙膏上的应用 |
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| US3839796A (en) * | 1972-03-16 | 1974-10-08 | J Hazar | Prosthetic denture and method |
| US5128132A (en) | 1988-11-22 | 1992-07-07 | Parnell Pharmaceuticals, Inc. | Eriodictyon compositions and methods for treating internal mucous membranes |
| JPH03210271A (ja) * | 1990-01-12 | 1991-09-13 | Asahi Optical Co Ltd | リン酸カルシウム系生体材料の製造方法 |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5405836A (en) | 1993-03-02 | 1995-04-11 | Nabisco, Inc. | Pet foods with water-soluble zinc compound coating for controlling malodorous breath |
| EP0689465A1 (en) * | 1993-03-18 | 1996-01-03 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
| US5541165A (en) | 1994-09-27 | 1996-07-30 | Turgeon; Jean A. | Saliva substitute |
| JP3414008B2 (ja) * | 1994-11-18 | 2003-06-09 | 花王株式会社 | 複合粉体及び複合粉体含有化粧料 |
| KR100541271B1 (ko) * | 1997-05-02 | 2006-04-21 | 코스모페름 베.파우 | 국소적 사용을 위한 항균조성물 |
| US6379725B1 (en) | 1998-05-05 | 2002-04-30 | Natural Polymer International Corporation | Protein-based chewable pet toy |
| KR100557925B1 (ko) | 1999-06-29 | 2006-03-10 | 주식회사 하이닉스반도체 | 리프레시 카운터 회로 |
| EP1221997B1 (en) * | 1999-10-06 | 2007-11-28 | The Penn State Research Foundation | System and device for preventing restenosis in body vessels |
| KR100314789B1 (ko) * | 1999-11-05 | 2001-11-17 | 김현준 | 충치 예방 및 구강내 염증 치료용 치약 조성물 |
| US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| JP2001158735A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 歯周病の予防及び改善剤 |
| CN100475060C (zh) | 2000-07-19 | 2009-04-08 | 尤尼蒂卡株式会社 | 含有鞘糖脂的功能性食品或化妆品及其制造方法 |
| US20020119241A1 (en) | 2001-02-28 | 2002-08-29 | Speck Donald R. | Method and composition for extruded pet food product |
| US9827314B2 (en) | 2003-12-08 | 2017-11-28 | Mars, Incorporated | Edible compositions which are adapted for use by a companion animal |
| JP4965063B2 (ja) | 2004-05-07 | 2012-07-04 | 雪印メグミルク株式会社 | 口腔内細菌叢改善剤、抗菌剤及び生育促進剤。 |
| US7118732B2 (en) * | 2004-05-10 | 2006-10-10 | Colgate-Palmolive Company | Tooth-whitening compositions comprising silicone polymer and methods therefor |
| US8691273B2 (en) * | 2005-07-21 | 2014-04-08 | Lisopharm Ag | Method for producing hydroxyapatite particles |
| JP4788903B2 (ja) * | 2006-04-19 | 2011-10-05 | ライオン株式会社 | 共重合体及びこれを含有する組成物 |
| GB0625678D0 (en) | 2006-12-21 | 2007-01-31 | Lux Biotechnology Ltd | Composition and method for detection of demineralisation |
| EP2127647A4 (en) | 2007-01-16 | 2011-05-04 | Mizkan Group Corp | COMPOSITION FOR INHIBITING MUSCLE DAMAGE |
| JP5241249B2 (ja) * | 2008-01-17 | 2013-07-17 | 正治 加藤 | 齲蝕治療用キット |
| EP2092834A1 (en) | 2008-02-19 | 2009-08-26 | Innopact B.V. | Methods and compositions of sphingolipid for preventing treating microbial infections |
| US8632843B2 (en) | 2008-11-24 | 2014-01-21 | Promimic Ab | Methods and systems of controlled coating of nanoparticles onto micro-rough implant surfaces and associated implants |
| FR2940092B1 (fr) | 2008-12-19 | 2011-02-18 | Oreal | Composition de teinture d'oxydation des fibres keratiniques comprenant un corps gras amide ou ester |
| IT1396436B1 (it) * | 2009-11-16 | 2012-11-23 | Icf Srl | Composizione per la prevenzione ed il trattamento delle patologie odontostomatologiche degli animali e relativi usi. |
| JP2011207825A (ja) * | 2010-03-30 | 2011-10-20 | Toyobo Co Ltd | 皮膚外用剤 |
| JP2011140527A (ja) * | 2011-04-20 | 2011-07-21 | Acusphere Inc | 超音波造影剤の投薬処方物 |
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- 2013-04-26 WO PCT/NL2013/050314 patent/WO2013162366A1/en not_active Ceased
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2022
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