JP2015514779A5 - - Google Patents
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- Publication number
- JP2015514779A5 JP2015514779A5 JP2015507175A JP2015507175A JP2015514779A5 JP 2015514779 A5 JP2015514779 A5 JP 2015514779A5 JP 2015507175 A JP2015507175 A JP 2015507175A JP 2015507175 A JP2015507175 A JP 2015507175A JP 2015514779 A5 JP2015514779 A5 JP 2015514779A5
- Authority
- JP
- Japan
- Prior art keywords
- monohydrochloride
- aqueous phase
- anamorelin
- manufacturing
- anamorerin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636108P | 2012-04-20 | 2012-04-20 | |
| US61/636,108 | 2012-04-20 | ||
| PCT/US2013/037159 WO2013158874A1 (en) | 2012-04-20 | 2013-04-18 | Methods of producing anamorelin hydrochloride having controlled chloride content |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017043785A Division JP6284665B2 (ja) | 2012-04-20 | 2017-03-08 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514779A JP2015514779A (ja) | 2015-05-21 |
| JP2015514779A5 true JP2015514779A5 (https=) | 2016-09-08 |
| JP6109925B2 JP6109925B2 (ja) | 2017-04-05 |
Family
ID=48225135
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507175A Active JP6109925B2 (ja) | 2012-04-20 | 2013-04-18 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
| JP2017043785A Active JP6284665B2 (ja) | 2012-04-20 | 2017-03-08 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
| JP2018013782A Active JP6616853B2 (ja) | 2012-04-20 | 2018-01-30 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017043785A Active JP6284665B2 (ja) | 2012-04-20 | 2017-03-08 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
| JP2018013782A Active JP6616853B2 (ja) | 2012-04-20 | 2018-01-30 | 制御された塩化物含量を有するアナモレリン塩酸塩の製造方法 |
Country Status (48)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3353B1 (ar) | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
| GEAP201814459A (en) * | 2014-09-04 | 2018-09-10 | Helsinn Healthcare Sa | Medical treatments based on anamorelin |
| EP4659747A2 (en) | 2015-07-24 | 2025-12-10 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| CN108239141A (zh) * | 2016-12-23 | 2018-07-03 | 江苏先声药业有限公司 | 一种阿拉莫林的制备方法 |
| CN115569120A (zh) * | 2019-08-30 | 2023-01-06 | 赫尔森保健股份公司 | 具有改善稳定性的阿拉莫林片剂的生产方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| WO2005030698A1 (en) * | 2003-09-26 | 2005-04-07 | Ranbaxy Laboratories Limited | Process for the preparation of voglibose |
| US7825138B2 (en) | 2004-06-29 | 2010-11-02 | Helsinn Therapeutics (U.S.), Inc. | Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide |
| CA2677813A1 (en) * | 2007-02-13 | 2008-08-21 | Helsinn Therapeutics (U.S.), Inc. | Method of treating cell proliferative disorders using growth hormone secretagogues |
| UA105657C2 (uk) * | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| JO3353B1 (ar) | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
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2013
- 2013-04-15 JO JOP/2013/0101A patent/JO3353B1/ar active
- 2013-04-17 AR ARP130101264A patent/AR090725A1/es not_active Application Discontinuation
- 2013-04-18 AU AU2013249197A patent/AU2013249197B2/en active Active
- 2013-04-18 RS RS20180192A patent/RS56869B1/sr unknown
- 2013-04-18 CN CN201910323606.1A patent/CN110041398A/zh active Pending
- 2013-04-18 JP JP2015507175A patent/JP6109925B2/ja active Active
- 2013-04-18 BR BR112014025972A patent/BR112014025972A8/pt not_active Application Discontinuation
- 2013-04-18 UA UAA201412382A patent/UA116207C2/uk unknown
- 2013-04-18 NZ NZ700833A patent/NZ700833A/en unknown
- 2013-04-18 PT PT137193447T patent/PT2838892T/pt unknown
- 2013-04-18 KR KR1020147018116A patent/KR101972998B1/ko active Active
- 2013-04-18 HR HRP20180316TT patent/HRP20180316T1/hr unknown
- 2013-04-18 CA CA2869893A patent/CA2869893C/en active Active
- 2013-04-18 HU HUE17192651A patent/HUE050865T2/hu unknown
- 2013-04-18 TW TW106105466A patent/TWI677494B/zh active
- 2013-04-18 CN CN201910323598.0A patent/CN110041304A/zh active Pending
- 2013-04-18 PL PL17192651T patent/PL3290410T3/pl unknown
- 2013-04-18 SI SI201331789T patent/SI3290410T1/sl unknown
- 2013-04-18 KR KR1020197011485A patent/KR102141323B1/ko active Active
- 2013-04-18 EA EA201401151A patent/EA031581B1/ru unknown
- 2013-04-18 MX MX2014012178A patent/MX354793B/es active IP Right Grant
- 2013-04-18 ES ES13719344.7T patent/ES2658862T3/es active Active
- 2013-04-18 HU HUE13719344A patent/HUE035697T2/en unknown
- 2013-04-18 DK DK13719344.7T patent/DK2838892T3/en active
- 2013-04-18 SI SI201330963T patent/SI2838892T1/en unknown
- 2013-04-18 EP EP19155007.8A patent/EP3517532B1/en active Active
- 2013-04-18 TW TW102113767A patent/TWI589572B/zh active
- 2013-04-18 WO PCT/US2013/037159 patent/WO2013158874A1/en not_active Ceased
- 2013-04-18 MA MA37524A patent/MA37524B1/fr unknown
- 2013-04-18 EP EP13719344.7A patent/EP2838892B1/en active Active
- 2013-04-18 EP EP17192651.2A patent/EP3290410B1/en active Active
- 2013-04-18 CN CN201380003026.5A patent/CN103857669B/zh active Active
- 2013-04-18 SG SG11201406478XA patent/SG11201406478XA/en unknown
- 2013-04-18 US US13/865,649 patent/US20140018391A1/en not_active Abandoned
- 2013-04-18 PT PT191550078T patent/PT3517532T/pt unknown
- 2013-04-18 CA CA3031652A patent/CA3031652C/en active Active
- 2013-04-18 AP AP2014008013A patent/AP2014008013A0/xx unknown
- 2013-04-18 ME MEP-2018-47A patent/ME02966B/me unknown
- 2013-04-18 GE GEAP201313634A patent/GEP20186902B/en unknown
- 2013-04-18 MD MDA20140122A patent/MD4615C1/ro active IP Right Grant
- 2013-04-18 PE PE2014001624A patent/PE20150084A1/es not_active Application Discontinuation
- 2013-04-18 GE GEAP201813634A patent/GEAP201813634A/en unknown
- 2013-04-18 LT LTEP13719344.7T patent/LT2838892T/lt unknown
- 2013-04-18 MY MYPI2014703092A patent/MY170068A/en unknown
- 2013-04-18 DK DK19155007.8T patent/DK3517532T3/da active
- 2013-04-18 PL PL13719344T patent/PL2838892T3/pl unknown
- 2013-04-18 SG SG10201608488RA patent/SG10201608488RA/en unknown
- 2013-04-18 ES ES17192651T patent/ES2820354T3/es active Active
- 2013-04-19 PY PY201301316881A patent/PY1316881A/es unknown
- 2013-04-19 UY UY0001034753A patent/UY34753A/es active IP Right Grant
- 2013-07-29 NO NO13823572A patent/NO2877697T3/no unknown
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2014
- 2014-10-07 IL IL235064A patent/IL235064B/en active IP Right Grant
- 2014-10-08 TN TN2014000421A patent/TN2014000421A1/fr unknown
- 2014-10-20 DO DO2014000235A patent/DOP2014000235A/es unknown
- 2014-10-20 NI NI201400124A patent/NI201400124A/es unknown
- 2014-10-20 PH PH12014502351A patent/PH12014502351B1/en unknown
- 2014-10-20 CL CL2014002817A patent/CL2014002817A1/es unknown
- 2014-11-12 US US14/539,318 patent/US9403867B2/en active Active
- 2014-11-18 EC ECIEPI201427739A patent/ECSP14027739A/es unknown
- 2014-11-19 ZA ZA2014/08508A patent/ZA201408508B/en unknown
- 2014-11-19 CR CR20140530A patent/CR20140530A/es unknown
- 2014-11-20 CO CO14255094A patent/CO7131356A2/es unknown
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2016
- 2016-04-21 US US15/135,051 patent/US9981002B2/en active Active
- 2016-04-21 US US15/135,107 patent/US9956261B2/en active Active
- 2016-04-21 US US15/135,147 patent/US9872883B2/en active Active
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2017
- 2017-03-08 JP JP2017043785A patent/JP6284665B2/ja active Active
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2018
- 2018-01-30 JP JP2018013782A patent/JP6616853B2/ja active Active
- 2018-03-05 CY CY20181100270T patent/CY1120276T1/el unknown
- 2018-04-26 US US15/963,284 patent/US10300105B2/en active Active
- 2018-06-28 HK HK18108293.7A patent/HK1248694A1/en unknown
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2019
- 2019-04-14 US US16/383,623 patent/US10576122B2/en active Active
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2020
- 2020-01-24 US US16/751,836 patent/US10905737B2/en active Active
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