JP2015514700A - 婦人科疾患の治療方法 - Google Patents

婦人科疾患の治療方法 Download PDF

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Publication number
JP2015514700A
JP2015514700A JP2015501044A JP2015501044A JP2015514700A JP 2015514700 A JP2015514700 A JP 2015514700A JP 2015501044 A JP2015501044 A JP 2015501044A JP 2015501044 A JP2015501044 A JP 2015501044A JP 2015514700 A JP2015514700 A JP 2015514700A
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JP
Japan
Prior art keywords
pharmaceutical composition
active metabolite
progesterone receptor
composition suitable
intravaginal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015501044A
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English (en)
Japanese (ja)
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JP2015514700A5 (https=
Inventor
ゴトラン，ジャン−ピエール
ボウヤ，ヴァレリエ
ルーマイエ，エルネス
Original Assignee
プレグレム ソシエテ アノニム
プレグレム ソシエテ アノニム
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Publication date
Application filed by プレグレム ソシエテ アノニム, プレグレム ソシエテ アノニム filed Critical プレグレム ソシエテ アノニム
Publication of JP2015514700A publication Critical patent/JP2015514700A/ja
Publication of JP2015514700A5 publication Critical patent/JP2015514700A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2015501044A 2012-03-23 2013-03-22 婦人科疾患の治療方法 Pending JP2015514700A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261614785P 2012-03-23 2012-03-23
US61/614,785 2012-03-23
EP12160956.4 2012-03-23
EP12160956.4A EP2641602A1 (en) 2012-03-23 2012-03-23 Method for treating gynecological diseases
PCT/IB2013/052274 WO2013140372A1 (en) 2012-03-23 2013-03-22 Method for treating gynecological diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018023604A Division JP2018109025A (ja) 2012-03-23 2018-02-13 婦人科疾患の治療方法

Publications (2)

Publication Number Publication Date
JP2015514700A true JP2015514700A (ja) 2015-05-21
JP2015514700A5 JP2015514700A5 (https=) 2016-05-19

Family

ID=45976689

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015501044A Pending JP2015514700A (ja) 2012-03-23 2013-03-22 婦人科疾患の治療方法
JP2018023604A Pending JP2018109025A (ja) 2012-03-23 2018-02-13 婦人科疾患の治療方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018023604A Pending JP2018109025A (ja) 2012-03-23 2018-02-13 婦人科疾患の治療方法

Country Status (18)

Country Link
US (1) US10441534B2 (https=)
EP (3) EP2641602A1 (https=)
JP (2) JP2015514700A (https=)
KR (1) KR20140138824A (https=)
CN (1) CN104203246A (https=)
AU (1) AU2013236960B2 (https=)
CA (1) CA2864073A1 (https=)
CO (1) CO7111317A2 (https=)
EA (1) EA031488B1 (https=)
GE (1) GEP201706696B (https=)
HK (1) HK1199827A1 (https=)
MX (1) MX369520B (https=)
MY (1) MY172530A (https=)
NZ (1) NZ630011A (https=)
SG (1) SG11201404921QA (https=)
TW (2) TW201832767A (https=)
WO (1) WO2013140372A1 (https=)
ZA (1) ZA201407575B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6995757B2 (ja) 2015-12-23 2022-01-17 オリック ファーマシューティカルズ，インク． グルココルチコイド受容体の阻害剤
WO2017112904A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
EP3394078A4 (en) 2015-12-23 2019-11-27 Oric Pharmaceuticals, Inc. INHIBITORS OF THE GLUCOCORTICIDE RECEPTOR
WO2017165707A1 (en) * 2016-03-24 2017-09-28 Juniper Pharmaceuticals, Inc. Vaginal administration of agents for treating and preventing pain associated with gynecological medical procedures
NZ753142A (en) 2016-10-07 2020-08-28 Oric Pharmaceuticals Inc Inhibitors of glucocorticoid receptor
WO2022174074A1 (en) * 2021-02-12 2022-08-18 The Regents Of The University Of California Endometriosis-related methods and compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510949A (ja) * 2008-01-29 2011-04-07 ラボラトワール・アシュエールア−ファルマ 子宮筋腫を治療するためのウリプリスタルの使用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3920805A (en) 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
US4155991A (en) 1974-10-18 1979-05-22 Schering Aktiengesellschaft Vaginal ring
IL48277A (en) 1974-10-18 1978-03-10 Schering Ag Vaginal ring
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US3991760A (en) 1975-12-02 1976-11-16 The Procter & Gamble Company Vaginal medicament dispensing means
US4286587A (en) 1978-10-11 1981-09-01 Alza Corporation Vaginal drug delivery system made from polymer
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
US4250611A (en) 1979-04-19 1981-02-17 Alza Corporation Process for making drug delivery device with reservoir
US4596576A (en) 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
NL8500470A (nl) 1985-02-19 1986-09-16 Achel Homesteel Pvba Intravaginaal orgaan.
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
FI95768C (fi) 1993-06-17 1996-03-25 Leiras Oy Emättimensisäinen antosysteemi
US5929262A (en) 1995-03-30 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
ES2212912B1 (es) 2003-01-22 2005-10-01 Crystal Pharma, S.A. Procedimiento para la obtencion de 17alfa-acetoxi-11beta-(4-n,n-dimetilaminofenil)-19-norpregna-4,9-dien-3,20-diona.
CA2516319C (en) 2003-02-28 2012-09-18 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
CA2573266C (en) 2004-07-09 2011-11-08 The Population Council, Inc. Sustained release compositions containing progesterone receptor modulators
SI2148681T1 (sl) * 2007-04-20 2016-07-29 Preglem S.A. Selektivni modulatorji progesterona v zdravljenju maternične krvavitve
EP2359807B1 (en) * 2008-02-04 2017-07-26 Ferring B.V. Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510949A (ja) * 2008-01-29 2011-04-07 ラボラトワール・アシュエールア−ファルマ 子宮筋腫を治療するためのウリプリスタルの使用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONTRACEPTION, vol. 85, JPN6017007695, 2011, pages 480 - 488, ISSN: 0003658709 *
FERTIL STERIL, vol. Vol.92, No.3, Supplement, JPN7017000783, 2009, pages 60 - 61, ISSN: 0003658711 *
J PEDIATR ADOLESE GYNECOL, vol. 12, JPN7017000784, 1999, pages 23 - 26, ISSN: 0003658712 *
TOMIC VLATKA: "ORAL MICRONIZED PROGESTERONE COMBINED WITH VAGINAL PROGESTERONE GEL FOR LUTEAL SUPPORT", JOURNAL OF THE INTERNATIONAL SOCIETY OF GYNECOLOGICAL ENDOCRINOLOGY, vol. V27 N12, JPN5015005888, December 2011 (2011-12-01), pages 1010 - 1013, ISSN: 0003658710 *

Also Published As

Publication number Publication date
AU2013236960A1 (en) 2014-09-25
WO2013140372A1 (en) 2013-09-26
GEP201706696B (en) 2017-07-10
EP2641602A1 (en) 2013-09-25
JP2018109025A (ja) 2018-07-12
EP2827873A1 (en) 2015-01-28
HK1199827A1 (en) 2015-07-24
CO7111317A2 (es) 2014-11-10
US10441534B2 (en) 2019-10-15
EA201491614A1 (ru) 2015-01-30
MX2014011487A (es) 2015-01-12
MX369520B (es) 2019-11-11
AU2013236960B2 (en) 2017-11-23
US20150038476A1 (en) 2015-02-05
TW201400121A (zh) 2014-01-01
TW201832767A (zh) 2018-09-16
EA031488B1 (ru) 2019-01-31
ZA201407575B (en) 2015-12-23
NZ630011A (en) 2016-12-23
MY172530A (en) 2019-11-29
KR20140138824A (ko) 2014-12-04
CN104203246A (zh) 2014-12-10
EP3363500A1 (en) 2018-08-22
CA2864073A1 (en) 2013-09-26
SG11201404921QA (en) 2014-10-30

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