JP2015514677A5 - - Google Patents
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- Publication number
- JP2015514677A5 JP2015514677A5 JP2014550214A JP2014550214A JP2015514677A5 JP 2015514677 A5 JP2015514677 A5 JP 2015514677A5 JP 2014550214 A JP2014550214 A JP 2014550214A JP 2014550214 A JP2014550214 A JP 2014550214A JP 2015514677 A5 JP2015514677 A5 JP 2015514677A5
- Authority
- JP
- Japan
- Prior art keywords
- ppm
- disorder
- dihydrate
- thiophen
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636920P | 2012-04-23 | 2012-04-23 | |
| US61/636,920 | 2012-04-23 | ||
| US201361791378P | 2013-03-15 | 2013-03-15 | |
| US61/791,378 | 2013-03-15 | ||
| PCT/JP2013/062681 WO2013162046A1 (en) | 2012-04-23 | 2013-04-23 | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514677A JP2015514677A (ja) | 2015-05-21 |
| JP2015514677A5 true JP2015514677A5 (https=) | 2016-04-07 |
| JP5952917B2 JP5952917B2 (ja) | 2016-07-13 |
Family
ID=48428584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550214A Active JP5952917B2 (ja) | 2012-04-23 | 2013-04-23 | ベンゾチオフェン化合物又はその塩の、二水和物、及びその製造方法 |
Country Status (36)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| EP2911670A1 (en) * | 2012-10-25 | 2015-09-02 | Otsuka Pharmaceutical Co., Ltd. | Prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease containing brexpiprazole or salt thereof |
| MX2016013889A (es) | 2014-04-22 | 2017-03-09 | Otsuka Pharma Co Ltd | Medicamento. |
| CN104447723A (zh) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法 |
| CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
| CN106883223B (zh) * | 2015-12-16 | 2021-11-23 | 北京福元医药股份有限公司 | 一种Brexpiprazole盐酸盐的纯化方法 |
| WO2017106641A1 (en) | 2015-12-17 | 2017-06-22 | Assia Chemical Industries Ltd. | Solid state forms of brexpiprazole |
| WO2017115287A1 (en) | 2015-12-28 | 2017-07-06 | Honour (R&D) | Process for the preparation of quinoline-2(1h)-one derivatives |
| JP2019059672A (ja) * | 2015-12-28 | 2019-04-18 | 大日本住友製薬株式会社 | 治療抵抗性うつ病等の治療薬 |
| WO2017134038A1 (en) | 2016-02-01 | 2017-08-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole dihydrate for use in intramuscular injectable sustained release formulations |
| US20170320862A1 (en) | 2016-05-03 | 2017-11-09 | Cadila Healthcare Limited | Process for the preparation of brexpiprazole and intermediates thereof |
| CN107365305A (zh) | 2016-05-12 | 2017-11-21 | 上海奥博生物医药技术有限公司 | 一种依匹哌唑新晶型及其制备方法 |
| WO2017208251A1 (en) * | 2016-05-31 | 2017-12-07 | Cipla Limited | A new stable polymorph of brexpiprazole and process for preparation thereof |
| CN106188023A (zh) * | 2016-07-04 | 2016-12-07 | 山东川成医药股份有限公司 | 一种依匹唑派的精制方法 |
| PL233778B1 (pl) | 2016-07-19 | 2019-11-29 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu |
| WO2018033484A1 (en) | 2016-08-16 | 2018-02-22 | Hexal Aktiengesellschaft | Pharmaceutical compositions of a benzothiophene compound |
| WO2018033481A1 (en) | 2016-08-16 | 2018-02-22 | H E X A L Aktiengesellschaft | Immediate release tablet of a benzothiophene compound |
| CN107936005A (zh) * | 2016-10-13 | 2018-04-20 | 上海科胜药物研发有限公司 | 一种依匹哌唑新晶型ii及其制备方法 |
| CN106699745A (zh) * | 2016-12-14 | 2017-05-24 | 上海博志研新药物技术有限公司 | 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用 |
| US11072605B2 (en) | 2017-02-02 | 2021-07-27 | Hexal Ag | Crystalline brexpiprazole |
| EP3501506B1 (en) | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
| CN111440158A (zh) * | 2020-03-24 | 2020-07-24 | 石药集团中奇制药技术（石家庄）有限公司 | 一种盐酸依匹哌唑新晶型及其制备方法 |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
| WO2023067664A1 (ja) * | 2021-10-18 | 2023-04-27 | 大塚製薬株式会社 | ベンゾチオフェン化合物の新規結晶形及びその製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| ATE411797T2 (de) | 2003-10-23 | 2008-11-15 | Otsuka Pharma Co Ltd | Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren |
| US20090198059A1 (en) | 2004-09-13 | 2009-08-06 | Chava Satyanarayana | Process for the preparation of polymorphs, solvates of aripiprazole using aripirazole acid salts |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| AR066677A1 (es) * | 2007-05-24 | 2009-09-02 | Novartis Ag | Formulacion de pasireotida. composicion farmaceutica para liberacion prolongada. microparticulas. |
| WO2009055675A1 (en) * | 2007-10-26 | 2009-04-30 | Repligen Corporation | Methods of identifying histone deacetylase inhibitors useful for neurological disorders |
| JP5791278B2 (ja) * | 2008-01-30 | 2015-10-07 | ノバルティス アーゲー | オクトレオチドおよび３種の線状ポリラクチド−コ−グリコリドポリマーを含む徐放性製剤 |
| EP2233471A1 (en) * | 2009-02-06 | 2010-09-29 | Adamed Sp. z o.o. | A salt of 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4.dihydro-2(1h)-quinolinone with 5-sulfosalicylic acid and its preparation process |
| CN103025318B (zh) | 2010-08-24 | 2016-07-06 | 大塚制药株式会社 | 含有喹啉酮衍生物、和硅油和/或硅油衍生物的悬浮液和块状组合物 |
| BR112013023847B1 (pt) * | 2011-03-18 | 2021-02-23 | Alkermes Pharma Ireland Limited | composições farmacêuticas compreendendo ésteres de sorbitano e uso das mesmas |
| JP2012232958A (ja) * | 2011-05-09 | 2012-11-29 | Otsuka Pharmaceut Co Ltd | 注射製剤 |
| US9206169B2 (en) * | 2011-07-28 | 2015-12-08 | Otsuka Pharmaceutical Co., Ltd. | Method for producing benzo[b]thiophene compound |
| JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| JOP20200109A1 (ar) * | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
-
2013
- 2013-04-19 TW TW102114005A patent/TWI562991B/zh active
- 2013-04-22 AR ARP130101319A patent/AR090774A1/es unknown
- 2013-04-23 CA CA2870000A patent/CA2870000C/en active Active
- 2013-04-23 ES ES13722129T patent/ES2617881T5/es active Active
- 2013-04-23 DK DK13722129.7T patent/DK2841431T4/da active
- 2013-04-23 IN IN8867DEN2014 patent/IN2014DN08867A/en unknown
- 2013-04-23 JO JOP/2013/0114A patent/JO3325B1/ar active
- 2013-04-23 SI SI201330538T patent/SI2841431T2/sl unknown
- 2013-04-23 AU AU2013253372A patent/AU2013253372B2/en active Active
- 2013-04-23 SG SG11201406790VA patent/SG11201406790VA/en unknown
- 2013-04-23 PT PT137221297T patent/PT2841431T/pt unknown
- 2013-04-23 KR KR1020147032745A patent/KR102160395B1/ko active Active
- 2013-04-23 MY MYPI2014703139A patent/MY170220A/en unknown
- 2013-04-23 ME MEP-2017-56A patent/ME02619B/me unknown
- 2013-04-23 NZ NZ630260A patent/NZ630260A/en unknown
- 2013-04-23 EA EA201491933A patent/EA026541B1/ru not_active IP Right Cessation
- 2013-04-23 HU HUE13722129A patent/HUE031997T2/en unknown
- 2013-04-23 FI FIEP13722129.7T patent/FI2841431T4/fi active
- 2013-04-23 UA UAA201412555A patent/UA117456C2/uk unknown
- 2013-04-23 WO PCT/JP2013/062681 patent/WO2013162046A1/en not_active Ceased
- 2013-04-23 RS RS20170214A patent/RS55742B2/sr unknown
- 2013-04-23 MX MX2014012527A patent/MX361723B/es active IP Right Grant
- 2013-04-23 EP EP13722129.7A patent/EP2841431B2/en active Active
- 2013-04-23 PL PL13722129.7T patent/PL2841431T5/pl unknown
- 2013-04-23 SM SM20170130T patent/SMT201700130T1/it unknown
- 2013-04-23 BR BR112014026424-4A patent/BR112014026424B1/pt active IP Right Grant
- 2013-04-23 JP JP2014550214A patent/JP5952917B2/ja active Active
- 2013-04-23 US US14/396,224 patent/US9499525B2/en active Active
- 2013-04-23 HR HRP20170242TT patent/HRP20170242T4/hr unknown
- 2013-04-23 CN CN201380021622.6A patent/CN104254530B/zh active Active
- 2013-04-23 LT LTEP13722129.7T patent/LT2841431T/lt unknown
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2014
- 2014-10-07 IL IL235044A patent/IL235044B/en active IP Right Grant
- 2014-10-14 CO CO14226629A patent/CO7111315A2/es unknown
- 2014-10-15 ZA ZA2014/07477A patent/ZA201407477B/en unknown
- 2014-10-17 PH PH12014502324A patent/PH12014502324A1/en unknown
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2016
- 2016-10-14 US US15/294,644 patent/US10407415B2/en active Active
-
2017
- 2017-02-28 SM SM201700130T patent/SMT201700130B/it unknown
- 2017-03-07 CY CY20171100293T patent/CY1119103T1/el unknown
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2019
- 2019-09-09 US US16/564,972 patent/US20200140424A1/en not_active Abandoned
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2020
- 2020-08-04 US US16/985,177 patent/US20210115030A1/en not_active Abandoned
-
2022
- 2022-02-14 US US17/651,042 patent/US20230049327A1/en not_active Abandoned
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