JP2015514072A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015514072A5 JP2015514072A5 JP2015501784A JP2015501784A JP2015514072A5 JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5 JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- phenyl
- indazol
- acrylic acid
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613442P | 2012-03-20 | 2012-03-20 | |
| US61/613,442 | 2012-03-20 | ||
| PCT/US2013/031507 WO2013142266A1 (en) | 2012-03-20 | 2013-03-14 | Estrogen receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514072A JP2015514072A (ja) | 2015-05-18 |
| JP2015514072A5 true JP2015514072A5 (https=) | 2017-02-09 |
| JP6154887B2 JP6154887B2 (ja) | 2017-06-28 |
Family
ID=49223229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501784A Active JP6154887B2 (ja) | 2012-03-20 | 2013-03-14 | エストロゲン受容体モジュレーターおよびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9499538B2 (https=) |
| EP (1) | EP2828243B1 (https=) |
| JP (1) | JP6154887B2 (https=) |
| KR (1) | KR20140138296A (https=) |
| CN (1) | CN104220426B (https=) |
| AU (1) | AU2013235499A1 (https=) |
| CA (1) | CA2866891A1 (https=) |
| CO (1) | CO7170179A2 (https=) |
| CR (1) | CR20140479A (https=) |
| EA (1) | EA201491530A1 (https=) |
| IL (1) | IL234487A0 (https=) |
| MX (1) | MX2014011217A (https=) |
| NZ (1) | NZ630124A (https=) |
| PE (1) | PE20142461A1 (https=) |
| PH (1) | PH12014502095A1 (https=) |
| SG (1) | SG11201405918XA (https=) |
| WO (1) | WO2013142266A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| MX2015011132A (es) | 2013-03-14 | 2015-11-30 | Seragon Pharmaceuticals Inc | Moduladores policiclicos del receptor de estrogenos y sus usos. |
| WO2014145873A2 (en) | 2013-03-15 | 2014-09-18 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| CA2915534A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
| EP3089747A1 (en) | 2013-12-06 | 2016-11-09 | F. Hoffmann-La Roche AG | Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer |
| SG11201607339VA (en) * | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Methods and compositions for modulating estrogen receptor mutants |
| WO2015136016A2 (en) | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
| CN106660969A (zh) | 2014-08-11 | 2017-05-10 | 豪夫迈·罗氏有限公司 | 雌激素受体调节剂的结晶形式 |
| US10053451B2 (en) | 2015-05-26 | 2018-08-21 | Genentech, Inc. | Heterocyclic estrogen receptor modulators and uses thereof |
| MD3302471T2 (ro) | 2015-05-29 | 2021-12-31 | Eisai R&D Man Co Ltd | Compuși de alchenă tetrasubstituiți și utilizarea acestora |
| CN105061316B (zh) * | 2015-07-17 | 2017-12-22 | 苏州大学 | 稠环类化合物、制备方法和用途 |
| CN106518768B (zh) * | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
| US9975856B2 (en) | 2015-10-07 | 2018-05-22 | Genentech, Inc. | Process for the preparation of (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
| LT3386500T (lt) | 2015-12-09 | 2022-12-27 | The Board Of Trustees Of The University Of Illinois | Selektyvūs estrogenų receptorių slopintojai benzotiofeno pagrindu |
| KR102111792B1 (ko) | 2016-03-25 | 2020-05-18 | 뤄신 바이오테크놀러지 (상하이) 컴퍼니 리미티드 | 에스트로겐 수용체 하향 조절제로서의 치환된 인돌 화합물 |
| KR20220071293A (ko) | 2016-04-01 | 2022-05-31 | 리커리엄 아이피 홀딩스, 엘엘씨 | 에스트로겐 수용체 조절제 |
| BR112019003557A2 (pt) | 2016-08-31 | 2019-05-21 | Jiangsu Hengrui Medicine Co., Ltd. | derivados de oxopicolinamida, método de preparação dos mesmos e uso farmacêutico dos mesmos |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| US20180141913A1 (en) * | 2016-11-24 | 2018-05-24 | Eisai R & D Management Co., Ltd. | Tetrasubstituted alkene compounds and their use |
| RU2747399C2 (ru) | 2016-11-28 | 2021-05-04 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Соли производного индазола и их кристаллы |
| MX2019008158A (es) | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
| CN108976187B (zh) * | 2017-06-02 | 2021-11-26 | 上海青东生物科技有限公司 | 一种取代苯并呋喃衍生物及其制备与在制备抗肿瘤药物中的应用 |
| WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| JP7571006B2 (ja) | 2018-08-17 | 2024-10-22 | ジェネンテック， インコーポレイテッド | 乳がんの処置のための診断的および治療的方法 |
| EP3889133B1 (en) | 2018-12-17 | 2026-01-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 4-[[2-[[5-[1-(1h-indol-2-yl)-2-(phenyl)-1-ethen-1-yl]-2-pyridinyl]oxy]ethyl]amino]-2-butenamide derivatives for the treatment of estrogen receptor positive breast cancer |
| CA3143367A1 (en) * | 2019-06-19 | 2020-12-24 | Jiangsu Hengrui Medicine Co., Ltd. | Indazole derivative, preparation method therefor, and pharmaceutical application thereof |
| KR20220044528A (ko) | 2019-08-06 | 2022-04-08 | 리커리엄 아이피 홀딩스, 엘엘씨 | 돌연변이체를 치료하기 위한 에스트로겐 수용체 조절제 |
| EP4267578A4 (en) | 2020-12-23 | 2024-11-20 | Recurium IP Holdings, LLC | ESTROGEN RECEPTOR MODULATORS |
| CN115745895A (zh) * | 2021-11-13 | 2023-03-07 | 温州奥洋科技有限公司 | 一种紫外线吸收剂二苯嘧啶乙烯的结构与合成路线 |
| CN116239562B (zh) * | 2021-12-07 | 2024-12-31 | 江苏师范大学 | 一种以苯并呋喃酮为原料合成盐酸多塞平的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860900D1 (en) | 1977-08-22 | 1981-11-05 | Ici Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
| US4229447A (en) | 1979-06-04 | 1980-10-21 | American Home Products Corporation | Intraoral methods of using benzodiazepines |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US5011692A (en) | 1985-12-28 | 1991-04-30 | Sumitomo Pharmaceuticals Company, Limited | Sustained pulsewise release pharmaceutical preparation |
| US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5739136A (en) | 1989-10-17 | 1998-04-14 | Ellinwood, Jr.; Everett H. | Intraoral dosing method of administering medicaments |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| US5229135A (en) | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| JP3409366B2 (ja) | 1993-06-18 | 2003-05-26 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス素子 |
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| DE19807760A1 (de) | 1997-02-27 | 1998-09-03 | Fuji Electric Co Ltd | Elektrofotografischer Fotoleiter |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| DE69840126D1 (de) | 1997-08-15 | 2008-11-27 | Univ Duke | Verfahren zur prophylaxis oder behandlung von östrogen-abhängigen krankheiten |
| DE19801598C2 (de) | 1998-01-17 | 2000-05-11 | Aventis Res & Tech Gmbh & Co | Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen |
| DE19801597C2 (de) | 1998-01-17 | 2001-05-03 | Aventis Res & Tech Gmbh & Co | Basenkatalysierte Synthese von 1-Aryl-4-(arylethyl)piperazinen aus aromatischen Olefinen und 1-Arylpiperazinen |
| TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
| GB9929988D0 (en) | 1999-12-17 | 2000-02-09 | Celltech Therapeutics Ltd | Chemical compounds |
| US6528681B2 (en) * | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
| PL374215A1 (en) * | 2001-08-11 | 2005-10-03 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
| WO2003103686A1 (en) | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| EP1692127B1 (en) * | 2003-10-08 | 2008-07-02 | Smithkline Beecham Corporation | Triphenylethylene compounds as selective estrogen receptor modulators |
| DE102004028862A1 (de) * | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-Aminoindazole |
| US20070292545A1 (en) | 2005-10-18 | 2007-12-20 | Aaron Monte | Anti-infective agents and methods of use |
| ATE451363T1 (de) * | 2005-01-26 | 2009-12-15 | Schering Corp | 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs |
| KR20080045705A (ko) | 2005-08-15 | 2008-05-23 | 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. | 인쇄가능 재료 |
| WO2008057857A1 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| JP2008156313A (ja) | 2006-12-26 | 2008-07-10 | Fyuuensu:Kk | アミロイド疾患の治療およびモニタリングのための薬剤 |
| GB0704407D0 (en) | 2007-03-07 | 2007-04-18 | Glaxo Group Ltd | Compounds |
| DE102007049451A1 (de) * | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| JP5223362B2 (ja) | 2008-02-07 | 2013-06-26 | コニカミノルタビジネステクノロジーズ株式会社 | 光電変換素子及び太陽電池 |
| WO2009131654A2 (en) | 2008-04-21 | 2009-10-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives |
| AR074199A1 (es) | 2008-11-20 | 2010-12-29 | Glaxosmithkline Llc | Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer. |
| WO2010077603A1 (en) | 2008-12-08 | 2010-07-08 | North Carolina State University | Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives |
| WO2010107474A1 (en) | 2009-03-16 | 2010-09-23 | The Research Foundation Of State University Of New York | Antiestrogens for breast cancer therapy |
| WO2010144959A1 (en) | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| JP6126562B2 (ja) * | 2014-08-27 | 2017-05-10 | 三星ダイヤモンド工業株式会社 | 光ファイバ装置 |
-
2013
- 2013-03-14 US US14/386,313 patent/US9499538B2/en active Active
- 2013-03-14 CA CA2866891A patent/CA2866891A1/en not_active Abandoned
- 2013-03-14 WO PCT/US2013/031507 patent/WO2013142266A1/en not_active Ceased
- 2013-03-14 MX MX2014011217A patent/MX2014011217A/es unknown
- 2013-03-14 AU AU2013235499A patent/AU2013235499A1/en not_active Abandoned
- 2013-03-14 EA EA201491530A patent/EA201491530A1/ru unknown
- 2013-03-14 SG SG11201405918XA patent/SG11201405918XA/en unknown
- 2013-03-14 KR KR1020147028984A patent/KR20140138296A/ko not_active Withdrawn
- 2013-03-14 JP JP2015501784A patent/JP6154887B2/ja active Active
- 2013-03-14 EP EP13763661.9A patent/EP2828243B1/en active Active
- 2013-03-14 PE PE2014001451A patent/PE20142461A1/es not_active Application Discontinuation
- 2013-03-14 CN CN201380019700.9A patent/CN104220426B/zh active Active
- 2013-03-14 NZ NZ630124A patent/NZ630124A/en not_active IP Right Cessation
-
2014
- 2014-09-07 IL IL234487A patent/IL234487A0/en unknown
- 2014-09-22 PH PH12014502095A patent/PH12014502095A1/en unknown
- 2014-10-15 CR CR20140479A patent/CR20140479A/es not_active Application Discontinuation
- 2014-10-17 CO CO14230728A patent/CO7170179A2/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015514072A5 (https=) | ||
| RU2015138964A (ru) | Полициклические модуляторы рецептора эстрогена и их применения | |
| JP2014531465A5 (https=) | ||
| JP2014528446A5 (https=) | ||
| RU2015132181A (ru) | Фтор-[1,3]-оксазины в качестве ингибиторов васе1 | |
| JP2014518214A5 (https=) | ||
| HRP20160539T1 (hr) | Antagonisti trpv4 | |
| JP2016512259A5 (https=) | ||
| JP2014525444A5 (https=) | ||
| RU2021129721A (ru) | Пирролопиримидины в качестве потенциаторов мвтр | |
| JP2017528519A5 (https=) | ||
| JP2009541311A5 (https=) | ||
| JP2012508223A5 (https=) | ||
| JP2018535999A5 (https=) | ||
| RU2021133444A (ru) | Производные бензимидазола в качестве модуляторов ror-гамма | |
| RU2012133475A (ru) | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения | |
| JP2016514718A5 (https=) | ||
| JP2013518046A5 (https=) | ||
| JP2020536116A5 (https=) | ||
| TW201917126A (zh) | 二氫二酮 | |
| JP2020529419A5 (https=) | ||
| JP2020510046A5 (https=) | ||
| JP2020503293A5 (https=) | ||
| JP2019508400A5 (https=) | ||
| JP7554492B2 (ja) | フェニルイミダゾール化合物 |