JP2015514070A - Ｔｆｐｉ阻害剤および使用方法 - Google Patents

Ｔｆｐｉ阻害剤および使用方法 Download PDF

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Publication number
JP2015514070A
JP2015514070A JP2015501673A JP2015501673A JP2015514070A JP 2015514070 A JP2015514070 A JP 2015514070A JP 2015501673 A JP2015501673 A JP 2015501673A JP 2015501673 A JP2015501673 A JP 2015501673A JP 2015514070 A JP2015514070 A JP 2015514070A
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JP
Japan
Prior art keywords
amino acid
group
acid selected
peptide
tfpi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015501673A
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English (en)
Japanese (ja)
Inventor
ミヒャエル ドカル，
ミヒャエル ドカル，
ルドルフ ハルトマン，
ルドルフ ハルトマン，
フリードリヒ シャイフリンガー，
フリードリヒ シャイフリンガー，
フランク オスターカンプ，
フランク オスターカンプ，
トーマス ポラコフスキ，
トーマス ポラコフスキ，
ウルリヒ ライネケ，
ウルリヒ ライネケ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of JP2015514070A publication Critical patent/JP2015514070A/ja
Priority to JP2019035095A priority Critical patent/JP7303640B2/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015501673A 2012-03-21 2013-01-31 Ｔｆｐｉ阻害剤および使用方法 Pending JP2015514070A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019035095A JP7303640B2 (ja) 2012-03-21 2019-02-28 Ｔｆｐｉ阻害剤および使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261613865P 2012-03-21 2012-03-21
US61/613,865 2012-03-21
PCT/US2013/024167 WO2013141965A1 (en) 2012-03-21 2013-01-31 Tfpi inhibitors and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019035095A Division JP7303640B2 (ja) 2012-03-21 2019-02-28 Ｔｆｐｉ阻害剤および使用方法

Publications (1)

Publication Number Publication Date
JP2015514070A true JP2015514070A (ja) 2015-05-18

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015501673A Pending JP2015514070A (ja) 2012-03-21 2013-01-31 Ｔｆｐｉ阻害剤および使用方法
JP2019035095A Active JP7303640B2 (ja) 2012-03-21 2019-02-28 Ｔｆｐｉ阻害剤および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019035095A Active JP7303640B2 (ja) 2012-03-21 2019-02-28 Ｔｆｐｉ阻害剤および使用方法

Country Status (16)

Country Link
US (3) US8962563B2 (enExample)
EP (1) EP2827883B1 (enExample)
JP (2) JP2015514070A (enExample)
KR (2) KR20140143191A (enExample)
CN (3) CN104302306B (enExample)
AU (2) AU2013235741C1 (enExample)
BR (1) BR112014022435B1 (enExample)
CA (1) CA2867363C (enExample)
DK (1) DK2827883T3 (enExample)
ES (1) ES2733958T3 (enExample)
HR (1) HRP20191160T1 (enExample)
HU (1) HUE046572T2 (enExample)
LT (1) LT2827883T (enExample)
NZ (3) NZ629130A (enExample)
SI (1) SI2827883T1 (enExample)
WO (1) WO2013141965A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019521324A (ja) * 2016-05-13 2019-07-25 ザ・スクリップス・リサーチ・インスティテュートＴｈｅ Ｓｃｒｉｐｐｓ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 抗血栓療法および止血療法のための組成物および方法

Families Citing this family (9)

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US9580758B2 (en) 2013-11-12 2017-02-28 Luc Montagnier System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
BR112016019484A2 (pt) 2014-02-28 2017-10-24 3B Pharmaceuticals Gmbh peptídeos e métodos de uso
ES2905085T3 (es) 2014-09-17 2022-04-07 Novo Nordisk As Anticuerpos que pueden unirse a dos epítopos en el inhibidor de la vía del factor tisular (1-161)
EP3997104A1 (en) * 2019-07-08 2022-05-18 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
IL289675B1 (en) 2019-07-08 2025-09-01 3B Pharmaceuticals Gmbh Compounds comprising a protein ligand for fibroblast activation and their use
JPWO2021167107A1 (enExample) * 2020-02-22 2021-08-26
US20240199703A1 (en) * 2021-04-18 2024-06-20 Rambam Med-Tech Ltd. Procoagulant peptides and use thereof
CA3244889A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM
US20240216504A1 (en) * 2022-12-30 2024-07-04 Dong Kyu Jin Method for preventing or treating of hemathrosis

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WO2011115712A2 (en) * 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use

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