AU2013235741C1 - TFPI inhibitors and methods of use - Google Patents

TFPI inhibitors and methods of use Download PDF

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Publication number
AU2013235741C1
AU2013235741C1 AU2013235741A AU2013235741A AU2013235741C1 AU 2013235741 C1 AU2013235741 C1 AU 2013235741C1 AU 2013235741 A AU2013235741 A AU 2013235741A AU 2013235741 A AU2013235741 A AU 2013235741A AU 2013235741 C1 AU2013235741 C1 AU 2013235741C1
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AU
Australia
Prior art keywords
amino acid
group
acid selected
peptide
tfpi
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AU2013235741A
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English (en)
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AU2013235741A1 (en
AU2013235741B2 (en
Inventor
Michael Dockal
Rudolf Hartmann
Frank Osterkamp
Thomas Polakowski
Ulrich Reineke
Friedrich Scheiflinger
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of AU2013235741A1 publication Critical patent/AU2013235741A1/en
Assigned to Baxalta GmbH, BAXALTA INCORPORATED reassignment Baxalta GmbH Request for Assignment Assignors: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.
Application granted granted Critical
Publication of AU2013235741B2 publication Critical patent/AU2013235741B2/en
Priority to AU2017221855A priority Critical patent/AU2017221855B2/en
Publication of AU2013235741C1 publication Critical patent/AU2013235741C1/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: Baxalta GmbH, BAXALTA INCORPORATED
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013235741A 2012-03-21 2013-01-31 TFPI inhibitors and methods of use Active AU2013235741C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017221855A AU2017221855B2 (en) 2012-03-21 2017-09-01 Tfpi inhibitors and methods of use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261613865P 2012-03-21 2012-03-21
US61/613,865 2012-03-21
PCT/US2013/024167 WO2013141965A1 (en) 2012-03-21 2013-01-31 Tfpi inhibitors and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017221855A Division AU2017221855B2 (en) 2012-03-21 2017-09-01 Tfpi inhibitors and methods of use

Publications (3)

Publication Number Publication Date
AU2013235741A1 AU2013235741A1 (en) 2014-09-18
AU2013235741B2 AU2013235741B2 (en) 2017-06-15
AU2013235741C1 true AU2013235741C1 (en) 2017-12-21

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013235741A Active AU2013235741C1 (en) 2012-03-21 2013-01-31 TFPI inhibitors and methods of use
AU2017221855A Active AU2017221855B2 (en) 2012-03-21 2017-09-01 Tfpi inhibitors and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017221855A Active AU2017221855B2 (en) 2012-03-21 2017-09-01 Tfpi inhibitors and methods of use

Country Status (16)

Country Link
US (3) US8962563B2 (enExample)
EP (1) EP2827883B1 (enExample)
JP (2) JP2015514070A (enExample)
KR (2) KR20140143191A (enExample)
CN (3) CN104302306B (enExample)
AU (2) AU2013235741C1 (enExample)
BR (1) BR112014022435B1 (enExample)
CA (1) CA2867363C (enExample)
DK (1) DK2827883T3 (enExample)
ES (1) ES2733958T3 (enExample)
HR (1) HRP20191160T1 (enExample)
HU (1) HUE046572T2 (enExample)
LT (1) LT2827883T (enExample)
NZ (3) NZ629130A (enExample)
SI (1) SI2827883T1 (enExample)
WO (1) WO2013141965A1 (enExample)

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US9580758B2 (en) 2013-11-12 2017-02-28 Luc Montagnier System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
BR112016019484A2 (pt) 2014-02-28 2017-10-24 3B Pharmaceuticals Gmbh peptídeos e métodos de uso
ES2905085T3 (es) 2014-09-17 2022-04-07 Novo Nordisk As Anticuerpos que pueden unirse a dos epítopos en el inhibidor de la vía del factor tisular (1-161)
ES2959277T3 (es) * 2016-05-13 2024-02-22 Scripps Research Inst Composiciones y métodos para terapias antitrombóticas y hemostáticas
EP3997104A1 (en) * 2019-07-08 2022-05-18 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
IL289675B1 (en) 2019-07-08 2025-09-01 3B Pharmaceuticals Gmbh Compounds comprising a protein ligand for fibroblast activation and their use
JPWO2021167107A1 (enExample) * 2020-02-22 2021-08-26
US20240199703A1 (en) * 2021-04-18 2024-06-20 Rambam Med-Tech Ltd. Procoagulant peptides and use thereof
CA3244889A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM
US20240216504A1 (en) * 2022-12-30 2024-07-04 Dong Kyu Jin Method for preventing or treating of hemathrosis

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WO2012135671A2 (en) * 2011-04-01 2012-10-04 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)

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