JP2015512644A5 - - Google Patents
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- Publication number
- JP2015512644A5 JP2015512644A5 JP2015504687A JP2015504687A JP2015512644A5 JP 2015512644 A5 JP2015512644 A5 JP 2015512644A5 JP 2015504687 A JP2015504687 A JP 2015504687A JP 2015504687 A JP2015504687 A JP 2015504687A JP 2015512644 A5 JP2015512644 A5 JP 2015512644A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- acid derivative
- cell culture
- host cell
- recombinant host
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 235000014113 dietary fatty acids Nutrition 0.000 claims description 45
- 229930195729 fatty acid Natural products 0.000 claims description 45
- 239000000194 fatty acid Substances 0.000 claims description 45
- 150000004665 fatty acids Chemical class 0.000 claims description 45
- 238000004113 cell culture Methods 0.000 claims description 37
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
- 108091033319 polynucleotide Proteins 0.000 claims description 16
- 239000002157 polynucleotide Substances 0.000 claims description 16
- 102000040430 polynucleotide Human genes 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims description 6
- 150000001336 alkenes Chemical group 0.000 claims description 5
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 4
- 150000002192 fatty aldehydes Chemical class 0.000 claims description 4
- 150000002194 fatty esters Chemical class 0.000 claims description 4
- 150000002576 ketones Chemical group 0.000 claims description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 4
- GGQQNYXPYWCUHG-RMTFUQJTSA-N (3e,6e)-deca-3,6-diene Chemical group CCC\C=C\C\C=C\CC GGQQNYXPYWCUHG-RMTFUQJTSA-N 0.000 claims description 3
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 3
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims description 2
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 claims description 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 17
- 101710146995 Acyl carrier protein Proteins 0.000 description 5
- 101150084526 eptC gene Proteins 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 108050003185 3-oxoacyl-[acyl-carrier-protein] synthase 2 Proteins 0.000 description 3
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 description 3
- 108090001042 Hydro-Lyases Proteins 0.000 description 3
- 102000004867 Hydro-Lyases Human genes 0.000 description 3
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 3
- 101150026389 fabF gene Proteins 0.000 description 3
- 108010093803 3-ketoacyl-acyl carrier protein synthase III Proteins 0.000 description 2
- 241000588625 Acinetobacter sp. Species 0.000 description 2
- 102000006488 Acyl-Carrier Protein S-Malonyltransferase Human genes 0.000 description 2
- 108010058912 Acyl-Carrier Protein S-Malonyltransferase Proteins 0.000 description 2
- 101100012355 Bacillus anthracis fabH1 gene Proteins 0.000 description 2
- 101100012357 Bacillus subtilis (strain 168) fabHA gene Proteins 0.000 description 2
- 101100280474 Bacillus subtilis (strain 168) fabL gene Proteins 0.000 description 2
- 101100296146 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) pab1 gene Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 2
- 108090000769 Isomerases Proteins 0.000 description 2
- 102000004195 Isomerases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 101150070497 accC gene Proteins 0.000 description 2
- 108010055956 beta-ketoacyl-acyl carrier protein synthase I Proteins 0.000 description 2
- 101150015067 fabB gene Proteins 0.000 description 2
- 101150090981 fabG gene Proteins 0.000 description 2
- 101150035981 fabH gene Proteins 0.000 description 2
- 101150100150 fabI gene Proteins 0.000 description 2
- 101150104461 fabM gene Proteins 0.000 description 2
- 101150072202 fabV gene Proteins 0.000 description 2
- 101150084167 fabZ gene Proteins 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 101150068528 mabA gene Proteins 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 102000000157 3-oxoacyl-(acyl-carrier-protein) reductase Human genes 0.000 description 1
- 108010055468 3-oxoacyl-(acyl-carrier-protein) reductase Proteins 0.000 description 1
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 description 1
- 241000897241 Acinetobacter sp. ADP1 Species 0.000 description 1
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 1
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 1
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 1
- 101100388296 Arabidopsis thaliana DTX51 gene Proteins 0.000 description 1
- 241000370685 Arge Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 101100351124 Bacillus subtilis (strain 168) pckA gene Proteins 0.000 description 1
- 101100173127 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) fabZ gene Proteins 0.000 description 1
- 241000193401 Clostridium acetobutylicum Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101100138523 Escherichia coli (strain K12) frwD gene Proteins 0.000 description 1
- 101100083051 Escherichia coli (strain K12) pflC gene Proteins 0.000 description 1
- 101100432378 Escherichia coli (strain K12) yijO gene Proteins 0.000 description 1
- 241000206589 Marinobacter Species 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 1
- 241001113889 Rhodococcus opacus B4 Species 0.000 description 1
- 101100215626 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADP1 gene Proteins 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 101100083037 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) act gene Proteins 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 101150078207 fabA gene Proteins 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 101150049339 pflA gene Proteins 0.000 description 1
- 101150013042 pflD gene Proteins 0.000 description 1
- 108010001814 phosphopantetheinyl transferase Proteins 0.000 description 1
- 101150023641 ppc gene Proteins 0.000 description 1
- 101150056746 sfp gene Proteins 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619324P | 2012-04-02 | 2012-04-02 | |
| US61/619,324 | 2012-04-02 | ||
| PCT/US2013/035037 WO2013152051A2 (en) | 2012-04-02 | 2013-04-02 | Improved production of fatty acid derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072000A Division JP6738852B2 (ja) | 2012-04-02 | 2018-04-04 | 改良された脂肪酸誘導体産生方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512644A JP2015512644A (ja) | 2015-04-30 |
| JP2015512644A5 true JP2015512644A5 (cg-RX-API-DMAC7.html) | 2016-05-26 |
| JP6381518B2 JP6381518B2 (ja) | 2018-08-29 |
Family
ID=48087775
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504687A Expired - Fee Related JP6381518B2 (ja) | 2012-04-02 | 2013-04-02 | 改良された脂肪酸誘導体産生方法 |
| JP2018072000A Expired - Fee Related JP6738852B2 (ja) | 2012-04-02 | 2018-04-04 | 改良された脂肪酸誘導体産生方法 |
| JP2020081804A Active JP7366836B2 (ja) | 2012-04-02 | 2020-05-07 | 改良された脂肪酸誘導体産生方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072000A Expired - Fee Related JP6738852B2 (ja) | 2012-04-02 | 2018-04-04 | 改良された脂肪酸誘導体産生方法 |
| JP2020081804A Active JP7366836B2 (ja) | 2012-04-02 | 2020-05-07 | 改良された脂肪酸誘導体産生方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20150064782A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2834352B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6381518B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102166271B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114456996A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013243601B2 (cg-RX-API-DMAC7.html) |
| BR (3) | BR112014024675B1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2883968C (cg-RX-API-DMAC7.html) |
| CO (1) | CO7170149A2 (cg-RX-API-DMAC7.html) |
| MX (2) | MX379251B (cg-RX-API-DMAC7.html) |
| MY (1) | MY181688A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013152051A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX379251B (es) | 2012-04-02 | 2025-03-11 | Genomatica Inc | Producción mejorada de derivados de ácidos grasos. |
| WO2014026162A1 (en) | 2012-08-10 | 2014-02-13 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US10047383B2 (en) | 2013-03-15 | 2018-08-14 | Cargill, Incorporated | Bioproduction of chemicals |
| BR112015023473B1 (pt) * | 2013-03-15 | 2023-04-11 | Cargill, Incorporated | Microrganismo geneticamente modificado e método de produzir um produto |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN106795483A (zh) | 2013-07-19 | 2017-05-31 | 嘉吉公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| WO2015054138A1 (en) * | 2013-10-10 | 2015-04-16 | William Marsh Rice University | Improved fatty acid productivity |
| WO2015095240A2 (en) * | 2013-12-20 | 2015-06-25 | The Regents Of The University Of California | Biosynthesis of 1-undecence and related terminal olefins |
| WO2015200335A1 (en) * | 2014-06-23 | 2015-12-30 | Joule Unlimited Technologies, Inc. | Engineered photosynthetic microbes and recombinant synthesis of carbon-based products |
| BR112017001105A2 (pt) | 2014-07-18 | 2018-07-24 | REG Life Sciences, LLC | produção microbiana de dióis graxos |
| EP2993228B1 (en) * | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN105985987B (zh) * | 2015-03-02 | 2020-01-31 | 苏州安捷生物科技有限公司 | 一种生物法制备脂肪醇的方法 |
| JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞 |
| JP6934303B2 (ja) | 2017-02-08 | 2021-09-15 | 花王株式会社 | 脂肪族アルコールの生産方法 |
| KR102677413B1 (ko) | 2017-04-03 | 2024-06-24 | 게노마티카 인코포레이티드 | 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체 |
| EP3775182A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Materials and methods for biosynthetic manufacture of pimelic acid and utilization of synthetic polypeptides |
| EP3775241A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Methods for controlling oxygen concentration during aerobic biosynthesis |
| WO2019191767A1 (en) | 2018-03-30 | 2019-10-03 | Invista Textiles (U.K.) Limited | High hydrogen utilization and gas recycle |
| CN111836898B (zh) | 2018-03-30 | 2024-02-23 | 英威达纺织（英国）有限公司 | 用于在连续有氧发酵中控制溶解氧浓度的方法 |
| US11203771B2 (en) | 2018-03-30 | 2021-12-21 | Inv Nylon Chemicals Americas, Llc | Materials and methods for biosynthetic manufacture of carbon-based chemicals |
| WO2019213019A1 (en) | 2018-05-02 | 2019-11-07 | Invista North America S.A.R.L. | Materials and methods for differential biosynthesis in species of the genera ralstonia and cupriavidus and organisms related thereto |
| US11788055B2 (en) | 2018-05-02 | 2023-10-17 | Inv Nylon Chemicals Americas, Llc | Materials and methods for controlling oxidation and reduction in biosynthetic pathways of species of the genera ralstonia and cupriavidus and organisms related thereto |
| EP3788156A1 (en) | 2018-05-02 | 2021-03-10 | INVISTA Textiles (U.K.) Limited | Methods for controlling limitation conditions in product biosynthesis for non-phb generating cupriavidus or ralstonia |
| WO2019213033A1 (en) | 2018-05-02 | 2019-11-07 | Invista North America S.A.R.L. | Materials and methods for maximizing biosynthesis through alteration of pyruvate-acetyl-coa-tca balance in species of the genera ralstonia and cupriavidus and organisms related thereto |
| US11098381B2 (en) | 2018-05-02 | 2021-08-24 | Inv Nylon Chemicals Americas, Llc | Materials and methods for controlling regulation in biosynthesis in species of the genera Ralstonia or Cupriavidus and organisms related thereto |
| KR102117828B1 (ko) | 2018-07-19 | 2020-06-02 | 서울대학교산학협력단 | 레귤론 변이를 통한 지방산 및 지방산 유도체 생산에서 불포화도 감소 |
| EP3844179A4 (en) | 2018-08-31 | 2022-08-31 | Genomatica, Inc. | XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE |
| WO2020181091A1 (en) | 2019-03-05 | 2020-09-10 | Bp Corporation North America Inc. | Fatty acyl-acp reductases and their uses |
| CN118382700A (zh) * | 2021-12-06 | 2024-07-23 | 能源与材料国家研究中心 | 嵌合酶和生产末端烯烃的方法 |
| CN114634917A (zh) * | 2022-03-25 | 2022-06-17 | 湖南农业大学 | accD突变蛋白在提高植物种子脂肪酸含量中的应用 |
| WO2024119298A1 (en) | 2022-12-05 | 2024-06-13 | The Procter & Gamble Company | Fabric and home care composition comprising a polyalkylenecarbonate compound |
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| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
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| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
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| KR101831331B1 (ko) * | 2012-04-02 | 2018-02-23 | 알이지 라이프 사이언시스, 엘엘씨 | Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 |
-
2013
- 2013-04-02 MX MX2019004568A patent/MX379251B/es unknown
- 2013-04-02 CA CA2883968A patent/CA2883968C/en active Active
- 2013-04-02 CA CA3162104A patent/CA3162104A1/en active Pending
- 2013-04-02 MX MX2014011905A patent/MX366939B/es active IP Right Grant
- 2013-04-02 EP EP13715879.6A patent/EP2834352B1/en active Active
- 2013-04-02 US US14/390,378 patent/US20150064782A1/en not_active Abandoned
- 2013-04-02 BR BR112014024675-0A patent/BR112014024675B1/pt not_active IP Right Cessation
- 2013-04-02 KR KR1020147030467A patent/KR102166271B1/ko not_active Expired - Fee Related
- 2013-04-02 WO PCT/US2013/035037 patent/WO2013152051A2/en not_active Ceased
- 2013-04-02 KR KR1020207015194A patent/KR102353113B1/ko active Active
- 2013-04-02 JP JP2015504687A patent/JP6381518B2/ja not_active Expired - Fee Related
- 2013-04-02 EP EP19211601.0A patent/EP3674400A1/en not_active Withdrawn
- 2013-04-02 BR BR122019026142-3A patent/BR122019026142B1/pt active IP Right Grant
- 2013-04-02 BR BR122019026127-0A patent/BR122019026127B1/pt active IP Right Grant
- 2013-04-02 CN CN202210135822.5A patent/CN114456996A/zh active Pending
- 2013-04-02 CN CN201380026304.9A patent/CN104395464B/zh not_active Expired - Fee Related
- 2013-04-02 AU AU2013243601A patent/AU2013243601B2/en not_active Ceased
- 2013-04-02 MY MYPI2014002773A patent/MY181688A/en unknown
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2014
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2017
- 2017-07-14 US US15/650,285 patent/US11060099B2/en not_active Expired - Fee Related
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2018
- 2018-04-04 JP JP2018072000A patent/JP6738852B2/ja not_active Expired - Fee Related
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- 2020-05-07 JP JP2020081804A patent/JP7366836B2/ja active Active
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2021
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2023
- 2023-06-29 US US18/344,219 patent/US20240150774A1/en active Pending
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