JP2015511598A - Ｐａｋ１阻害剤を用いて黒色腫を治療する方法 - Google Patents

Ｐａｋ１阻害剤を用いて黒色腫を治療する方法 Download PDF

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Publication number
JP2015511598A
JP2015511598A JP2014561427A JP2014561427A JP2015511598A JP 2015511598 A JP2015511598 A JP 2015511598A JP 2014561427 A JP2014561427 A JP 2014561427A JP 2014561427 A JP2014561427 A JP 2014561427A JP 2015511598 A JP2015511598 A JP 2015511598A
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JP
Japan
Prior art keywords
melanoma
pak1
inhibitor
braf
treatment
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Pending
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JP2014561427A
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English (en)
Japanese (ja)
Inventor
クラウス ピー． ホーフリッチ，
クラウス ピー． ホーフリッチ，
エイドリアン エム． ジュッブ，
エイドリアン エム． ジュッブ，
ハルトムート ケッペン，
ハルトムート ケッペン，
クリスティー シー． オング，
クリスティー シー． オング，
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エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト
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Publication of JP2015511598A publication Critical patent/JP2015511598A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014561427A 2012-03-16 2013-03-13 Ｐａｋ１阻害剤を用いて黒色腫を治療する方法 Pending JP2015511598A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612202P 2012-03-16 2012-03-16
US61/612,202 2012-03-16
PCT/EP2013/055085 WO2013135745A1 (en) 2012-03-16 2013-03-13 Methods of treating melanoma with pak1 inhibitors

Publications (1)

Publication Number Publication Date
JP2015511598A true JP2015511598A (ja) 2015-04-20

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ID=47846052

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014561427A Pending JP2015511598A (ja) 2012-03-16 2013-03-13 Ｐａｋ１阻害剤を用いて黒色腫を治療する方法

Country Status (10)

Country Link
EP (1) EP2844248A1 (pt)
JP (1) JP2015511598A (pt)
KR (1) KR20140135198A (pt)
CN (1) CN104168898A (pt)
BR (1) BR112014020173A8 (pt)
CA (1) CA2860994A1 (pt)
HK (1) HK1200093A1 (pt)
MX (1) MX2014010953A (pt)
RU (1) RU2014141018A (pt)
WO (1) WO2013135745A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016139331A1 (en) * 2015-03-05 2016-09-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of melanoma
KR101730595B1 (ko) 2015-03-18 2017-05-11 충북대학교 산학협력단 Pak4 억제제를 유효성분으로 포함하는 미백 및 멜라닌 색소 과다 침착 질환의 치료용 조성물

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Also Published As

Publication number Publication date
BR112014020173A8 (pt) 2017-07-11
BR112014020173A2 (pt) 2017-06-20
WO2013135745A1 (en) 2013-09-19
HK1200093A1 (en) 2015-07-31
KR20140135198A (ko) 2014-11-25
MX2014010953A (es) 2014-10-13
RU2014141018A (ru) 2016-05-10
CA2860994A1 (en) 2013-09-19
EP2844248A1 (en) 2015-03-11
CN104168898A (zh) 2014-11-26

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