KR20140135198A - Pak1 억제제로 흑색종을 치료하는 방법 - Google Patents

Pak1 억제제로 흑색종을 치료하는 방법 Download PDF

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Publication number
KR20140135198A
KR20140135198A KR20147025466A KR20147025466A KR20140135198A KR 20140135198 A KR20140135198 A KR 20140135198A KR 20147025466 A KR20147025466 A KR 20147025466A KR 20147025466 A KR20147025466 A KR 20147025466A KR 20140135198 A KR20140135198 A KR 20140135198A
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KR
South Korea
Prior art keywords
melanoma
pak1
inhibitor
braf
patient
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KR20147025466A
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English (en)
Korean (ko)
Inventor
클라우스 피 회프리치
애드리안 엠 저브
하르트무트 코에펜
크리스티 씨 옹
Original Assignee
에프. 호프만-라 로슈 아게
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Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20140135198A publication Critical patent/KR20140135198A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR20147025466A 2012-03-16 2013-03-13 Pak1 억제제로 흑색종을 치료하는 방법 KR20140135198A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612202P 2012-03-16 2012-03-16
US61/612,202 2012-03-16
PCT/EP2013/055085 WO2013135745A1 (en) 2012-03-16 2013-03-13 Methods of treating melanoma with pak1 inhibitors

Publications (1)

Publication Number Publication Date
KR20140135198A true KR20140135198A (ko) 2014-11-25

Family

ID=47846052

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20147025466A KR20140135198A (ko) 2012-03-16 2013-03-13 Pak1 억제제로 흑색종을 치료하는 방법

Country Status (10)

Country Link
EP (1) EP2844248A1 (pt)
JP (1) JP2015511598A (pt)
KR (1) KR20140135198A (pt)
CN (1) CN104168898A (pt)
BR (1) BR112014020173A8 (pt)
CA (1) CA2860994A1 (pt)
HK (1) HK1200093A1 (pt)
MX (1) MX2014010953A (pt)
RU (1) RU2014141018A (pt)
WO (1) WO2013135745A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016139331A1 (en) * 2015-03-05 2016-09-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of melanoma
KR101730595B1 (ko) 2015-03-18 2017-05-11 충북대학교 산학협력단 Pak4 억제제를 유효성분으로 포함하는 미백 및 멜라닌 색소 과다 침착 질환의 치료용 조성물

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Also Published As

Publication number Publication date
BR112014020173A8 (pt) 2017-07-11
BR112014020173A2 (pt) 2017-06-20
WO2013135745A1 (en) 2013-09-19
HK1200093A1 (en) 2015-07-31
MX2014010953A (es) 2014-10-13
RU2014141018A (ru) 2016-05-10
CA2860994A1 (en) 2013-09-19
JP2015511598A (ja) 2015-04-20
EP2844248A1 (en) 2015-03-11
CN104168898A (zh) 2014-11-26

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