JP2015509962A5 - - Google Patents
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- Publication number
- JP2015509962A5 JP2015509962A5 JP2014560093A JP2014560093A JP2015509962A5 JP 2015509962 A5 JP2015509962 A5 JP 2015509962A5 JP 2014560093 A JP2014560093 A JP 2014560093A JP 2014560093 A JP2014560093 A JP 2014560093A JP 2015509962 A5 JP2015509962 A5 JP 2015509962A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- clostridium difficile
- acid sequence
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 110
- 241000193163 Clostridioides difficile Species 0.000 claims description 88
- 239000000427 antigen Substances 0.000 claims description 67
- 108091007433 antigens Proteins 0.000 claims description 67
- 102000036639 antigens Human genes 0.000 claims description 67
- 239000012634 fragment Substances 0.000 claims description 66
- 208000024891 symptom Diseases 0.000 claims description 57
- 201000010099 disease Diseases 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 45
- 239000008194 pharmaceutical composition Substances 0.000 claims description 43
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims description 35
- 101710182532 Toxin a Proteins 0.000 claims description 35
- 101710182223 Toxin B Proteins 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- 229940124597 therapeutic agent Drugs 0.000 claims description 11
- 210000000056 organ Anatomy 0.000 claims description 10
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims description 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 108700022831 Clostridium difficile toxB Proteins 0.000 claims description 7
- 230000007774 longterm Effects 0.000 claims description 7
- 206010052779 Transplant rejections Diseases 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 102000005962 receptors Human genes 0.000 claims description 6
- 208000037384 Clostridium Infections Diseases 0.000 claims description 5
- 206010054236 Clostridium difficile infection Diseases 0.000 claims description 5
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 5
- 206010061598 Immunodeficiency Diseases 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229940088710 antibiotic agent Drugs 0.000 claims description 5
- 230000001506 immunosuppresive effect Effects 0.000 claims description 5
- 239000003112 inhibitor Substances 0.000 claims description 5
- 229940126409 proton pump inhibitor Drugs 0.000 claims description 5
- 239000000612 proton pump inhibitor Substances 0.000 claims description 5
- 102100021324 5-azacytidine-induced protein 2 Human genes 0.000 claims description 4
- 208000004998 Abdominal Pain Diseases 0.000 claims description 4
- 206010000060 Abdominal distension Diseases 0.000 claims description 4
- 208000005156 Dehydration Diseases 0.000 claims description 4
- 206010012735 Diarrhoea Diseases 0.000 claims description 4
- 208000032843 Hemorrhage Diseases 0.000 claims description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 4
- 108090001007 Interleukin-8 Proteins 0.000 claims description 4
- 208000002720 Malnutrition Diseases 0.000 claims description 4
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims description 4
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims description 4
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 206010040047 Sepsis Diseases 0.000 claims description 4
- 208000022531 anorexia Diseases 0.000 claims description 4
- 208000034158 bleeding Diseases 0.000 claims description 4
- 230000000740 bleeding effect Effects 0.000 claims description 4
- 238000012321 colectomy Methods 0.000 claims description 4
- 206010061428 decreased appetite Diseases 0.000 claims description 4
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 230000001071 malnutrition Effects 0.000 claims description 4
- 235000000824 malnutrition Nutrition 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 208000015380 nutritional deficiency disease Diseases 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 230000001668 ameliorated effect Effects 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 229940041181 antineoplastic drug Drugs 0.000 claims description 3
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 239000003018 immunosuppressive agent Substances 0.000 claims description 3
- 229940124589 immunosuppressive drug Drugs 0.000 claims description 3
- 238000009116 palliative therapy Methods 0.000 claims description 3
- 238000001959 radiotherapy Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 229960005486 vaccine Drugs 0.000 claims description 3
- 206010017943 Gastrointestinal conditions Diseases 0.000 claims description 2
- 101150056637 Hrh2 gene Proteins 0.000 claims description 2
- 206010022714 Intestinal ulcer Diseases 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 201000006549 dyspepsia Diseases 0.000 claims description 2
- 208000024798 heartburn Diseases 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 229960001340 histamine Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims 1
- 230000002554 disease preventive effect Effects 0.000 claims 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261605914P | 2012-03-02 | 2012-03-02 | |
| US61/605,914 | 2012-03-02 | ||
| US201261608255P | 2012-03-08 | 2012-03-08 | |
| US61/608,255 | 2012-03-08 | ||
| US201261717404P | 2012-10-23 | 2012-10-23 | |
| US61/717,404 | 2012-10-23 | ||
| PCT/US2013/028630 WO2013130981A1 (en) | 2012-03-02 | 2013-03-01 | Human antibodies to clostridium difficile toxins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017231934A Division JP2018029625A (ja) | 2012-03-02 | 2017-12-01 | Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ毒素に対するヒト抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509962A JP2015509962A (ja) | 2015-04-02 |
| JP2015509962A5 true JP2015509962A5 (https=) | 2016-04-07 |
Family
ID=47844536
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560093A Pending JP2015509962A (ja) | 2012-03-02 | 2013-03-01 | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素に対するヒト抗体 |
| JP2017231934A Pending JP2018029625A (ja) | 2012-03-02 | 2017-12-01 | Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ毒素に対するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017231934A Pending JP2018029625A (ja) | 2012-03-02 | 2017-12-01 | Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ毒素に対するヒト抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9399674B2 (https=) |
| EP (1) | EP2820044A1 (https=) |
| JP (2) | JP2015509962A (https=) |
| KR (1) | KR20140130709A (https=) |
| CN (2) | CN108101983A (https=) |
| AR (1) | AR090219A1 (https=) |
| AU (1) | AU2016203511A1 (https=) |
| BR (1) | BR112014021251A2 (https=) |
| CA (1) | CA2863536A1 (https=) |
| HK (1) | HK1200463A1 (https=) |
| IL (1) | IL233884A0 (https=) |
| MX (1) | MX2014010527A (https=) |
| NZ (2) | NZ628943A (https=) |
| RU (2) | RU2628305C2 (https=) |
| SG (2) | SG11201405087PA (https=) |
| TW (1) | TWI592422B (https=) |
| UY (1) | UY34652A (https=) |
| WO (1) | WO2013130981A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US9181632B1 (en) | 2013-09-09 | 2015-11-10 | Merck Sharp & Dohme Corp. | C.difficile toxin B CROP domain peptides, antibodies and complexes thereof |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| CA2976976C (en) | 2015-02-19 | 2023-02-28 | Immune Biosolutions Inc. | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| US20180085458A1 (en) * | 2015-04-15 | 2018-03-29 | Medimmune, Llc | Methods for treating clostridium difficile infection and associated disease |
| US12297266B2 (en) | 2016-04-18 | 2025-05-13 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human CD40 and uses thereof |
| US11299751B2 (en) * | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3753952A4 (en) * | 2017-12-13 | 2022-04-13 | XDCExplorer (Shanghai) Co., Ltd. | EGFRVIII ANTIBODY AND CONJUGATE, AND METHODS FOR ITS PRODUCTION AND USE |
| US11992520B2 (en) | 2018-09-18 | 2024-05-28 | Vanderbilt University | Human monoclonal antibodies to Staphylococcal aureus Isd proteins and uses thereof |
| US20200148762A1 (en) * | 2018-11-09 | 2020-05-14 | Avamab Pharma Inc. | Methods for regulating endogenous production of antibodies against infectious diseases |
| CN111793130B (zh) * | 2019-03-20 | 2021-09-14 | 华中农业大学 | 一株副猪嗜血杆菌CdtB杂交瘤细胞及单克隆抗体应用 |
| KR102376876B1 (ko) | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
| WO2021219786A1 (en) | 2020-04-30 | 2021-11-04 | Gottfried Himmler | Anti-toxin secretory iga2 preparation |
| WO2025029561A2 (en) * | 2023-07-28 | 2025-02-06 | University Of South Florida | Vaccine containing rbd2 of cdtb component from binary toxin cdt of clostridioides difficile |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US5358868A (en) | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5244657A (en) | 1987-11-24 | 1993-09-14 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5221618A (en) | 1987-11-24 | 1993-06-22 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5332583A (en) | 1987-11-24 | 1994-07-26 | Connaught Laboratories Limited | Vaccine containing genetically-detoxified pertussis holotoxin |
| GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| US5224657A (en) | 1989-05-23 | 1993-07-06 | Kabushiki Kaisha Toshiba | Cryogenic refrigerator |
| WO1996033735A1 (en) * | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5231003A (en) * | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
| DE19739685A1 (de) * | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
| EP2305303A3 (en) | 1997-10-20 | 2013-11-13 | Sanofi Pasteur Biologics Co. | Immunization against Clostridium difficile disease |
| EP1568378B1 (en) | 1997-10-20 | 2016-03-16 | Sanofi Pasteur Biologics, LLC | Immunization against Clostridium difficile disease |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| CN1809591A (zh) * | 2003-05-21 | 2006-07-26 | 米德列斯公司 | 针对炭疽芽孢杆菌保护性抗原的人单克隆抗体 |
| DK2270045T3 (en) | 2004-02-06 | 2015-04-07 | Univ Massachusetts | ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINES AND APPLICATIONS THEREOF |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| WO2006071877A2 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| BRPI0711572A2 (pt) * | 2006-04-17 | 2011-11-16 | Schering Plough Ltd | organismos recombinantes atenuados de clostridium e vacinas |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| US20090311258A1 (en) * | 2006-08-02 | 2009-12-17 | Johannes Gutenberg-Universitaet Mainz | Medicament for lct poisoning |
| US8035027B2 (en) | 2006-10-09 | 2011-10-11 | Solexel, Inc. | Solar module structures and assembly methods for pyramidal three-dimensional thin-film solar cells |
| US20110020356A1 (en) | 2007-12-07 | 2011-01-27 | Lin Fang | Therapeutic clostridium difficile antibody compositions |
| BRPI0906060A2 (pt) | 2008-02-28 | 2015-12-01 | 3M Innovative Properties Co | anticorpos isolados, métodos de preparo de um anticorpo anti-clostridium difficile, composição e método para a detecção da presença de um esporo de clostridium difficile em uma amostra |
| AU2010215275B2 (en) | 2009-02-20 | 2016-03-31 | Micropharm Limited | Antibodies to Clostridium difficile toxins |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| PL2480255T3 (pl) * | 2009-09-23 | 2018-07-31 | Thomas Julius Borody | Terapia przewlekłych zakażeń jelitowych |
| US20120282274A1 (en) | 2009-11-20 | 2012-11-08 | Northshore University Health System Research Institute | Targeting of the c-terminal segment of c.difficile toxin b for improved clinical diagnosis, prevention, and treatment |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US8986697B2 (en) | 2010-04-15 | 2015-03-24 | Progenics Pharmaceuticals, Inc. | Antibodies for the treatment of Clostridium difficile-associated infection and disease |
-
2013
- 2013-03-01 AR ARP130100670A patent/AR090219A1/es unknown
- 2013-03-01 CA CA2863536A patent/CA2863536A1/en not_active Abandoned
- 2013-03-01 TW TW102107190A patent/TWI592422B/zh not_active IP Right Cessation
- 2013-03-01 KR KR1020147026227A patent/KR20140130709A/ko not_active Withdrawn
- 2013-03-01 HK HK15100241.0A patent/HK1200463A1/xx unknown
- 2013-03-01 NZ NZ628943A patent/NZ628943A/en not_active IP Right Cessation
- 2013-03-01 JP JP2014560093A patent/JP2015509962A/ja active Pending
- 2013-03-01 BR BR112014021251A patent/BR112014021251A2/pt not_active IP Right Cessation
- 2013-03-01 SG SG11201405087PA patent/SG11201405087PA/en unknown
- 2013-03-01 US US13/782,444 patent/US9399674B2/en active Active
- 2013-03-01 CN CN201711446090.7A patent/CN108101983A/zh active Pending
- 2013-03-01 CN CN201380012035.0A patent/CN104203976A/zh active Pending
- 2013-03-01 NZ NZ714516A patent/NZ714516A/en not_active IP Right Cessation
- 2013-03-01 UY UY0001034652A patent/UY34652A/es unknown
- 2013-03-01 RU RU2014139552A patent/RU2628305C2/ru not_active IP Right Cessation
- 2013-03-01 EP EP13708641.9A patent/EP2820044A1/en not_active Withdrawn
- 2013-03-01 SG SG10201610123UA patent/SG10201610123UA/en unknown
- 2013-03-01 MX MX2014010527A patent/MX2014010527A/es unknown
- 2013-03-01 RU RU2017127772A patent/RU2017127772A/ru not_active Application Discontinuation
- 2013-03-01 WO PCT/US2013/028630 patent/WO2013130981A1/en not_active Ceased
-
2014
- 2014-07-30 IL IL233884A patent/IL233884A0/en unknown
-
2016
- 2016-05-27 AU AU2016203511A patent/AU2016203511A1/en not_active Abandoned
- 2016-06-01 US US15/170,602 patent/US20160264650A1/en not_active Abandoned
-
2017
- 2017-12-01 JP JP2017231934A patent/JP2018029625A/ja active Pending
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