JP2015509111A5 - - Google Patents
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- Publication number
- JP2015509111A5 JP2015509111A5 JP2014555364A JP2014555364A JP2015509111A5 JP 2015509111 A5 JP2015509111 A5 JP 2015509111A5 JP 2014555364 A JP2014555364 A JP 2014555364A JP 2014555364 A JP2014555364 A JP 2014555364A JP 2015509111 A5 JP2015509111 A5 JP 2015509111A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- saccharide
- group
- conjugate
- meningococcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 230000002163 immunogen Effects 0.000 claims 28
- 150000001720 carbohydrates Chemical class 0.000 claims 27
- 150000004676 glycans Chemical class 0.000 claims 12
- 229920001282 polysaccharide Polymers 0.000 claims 12
- 239000005017 polysaccharide Substances 0.000 claims 12
- 238000004513 sizing Methods 0.000 claims 12
- 102000014914 Carrier Proteins Human genes 0.000 claims 8
- 108010078791 Carrier Proteins Proteins 0.000 claims 8
- 238000009739 binding Methods 0.000 claims 8
- 229960000814 tetanus toxoid Drugs 0.000 claims 8
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 7
- 238000011534 incubation Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 4
- 241000588650 Neisseria meningitidis Species 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- JPUHPGALPBINPO-UHFFFAOYSA-N benzotriazole-1-carbonitrile Chemical compound C1=CC=C2N(C#N)N=NC2=C1 JPUHPGALPBINPO-UHFFFAOYSA-N 0.000 claims 4
- SLPWXZZHNSOZPX-UHFFFAOYSA-N imidazole-1-carbonitrile Chemical compound N#CN1C=CN=C1 SLPWXZZHNSOZPX-UHFFFAOYSA-N 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 3
- -1 1-cyano-4-pyrrolidinopyrrolidinium tetrafluoroborate Chemical compound 0.000 claims 2
- 239000007987 MES buffer Substances 0.000 claims 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 235000017281 sodium acetate Nutrition 0.000 claims 2
- 239000001632 sodium acetate Substances 0.000 claims 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 101710183389 Pneumolysin Proteins 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN281/MUM/2012 | 2012-01-30 | ||
| IN281MU2012 | 2012-01-30 | ||
| PCT/IB2013/050739 WO2013114268A1 (en) | 2012-01-30 | 2013-01-29 | Immunogenic composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509111A JP2015509111A (ja) | 2015-03-26 |
| JP2015509111A5 true JP2015509111A5 (enExample) | 2016-02-25 |
| JP6042455B2 JP6042455B2 (ja) | 2016-12-14 |
Family
ID=54259032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555364A Active JP6042455B2 (ja) | 2012-01-30 | 2013-01-29 | 免疫原性組成物の調製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9198977B2 (enExample) |
| EP (1) | EP2809349B1 (enExample) |
| JP (1) | JP6042455B2 (enExample) |
| KR (1) | KR101897317B1 (enExample) |
| CN (1) | CN104302315B (enExample) |
| BR (1) | BR112014018815B1 (enExample) |
| CA (1) | CA2863178C (enExample) |
| DK (1) | DK2809349T3 (enExample) |
| ES (1) | ES2707294T3 (enExample) |
| HU (1) | HUE040914T4 (enExample) |
| MX (1) | MX354103B (enExample) |
| PT (1) | PT2809349T (enExample) |
| RU (1) | RU2634405C2 (enExample) |
| SG (1) | SG11201404447WA (enExample) |
| SI (1) | SI2809349T1 (enExample) |
| TR (1) | TR201900778T4 (enExample) |
| WO (1) | WO2013114268A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20110072A1 (es) * | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| WO2014080423A2 (en) * | 2012-11-21 | 2014-05-30 | Serum Institute Of India Ltd. | Production of high yields of bacterial polysaccharides |
| KR102447303B1 (ko) * | 2013-08-24 | 2022-09-23 | 브하라트 바이오테크 인터내셔날 리미티드 | 박테리아성 백신 및 그의 제조방법 |
| EP2921856B1 (en) | 2014-03-18 | 2016-09-14 | Serum Institute Of India Private Limited | A quantitative assay for 4-pyrrolidinopyridine (4-ppy) in polysaccharide-protein conjugate vaccines |
| EA201792470A1 (ru) * | 2015-06-08 | 2018-10-31 | Серум Инститьют Оф Индия Прайват Лтд. | Способы улучшения адсорбции полисахарид-белковых конъюгатов и полученная из них композиция поливалентной вакцины |
| WO2017006349A1 (en) * | 2015-07-04 | 2017-01-12 | Bharat Biotech International Limited | Polysaccharide vaccine formulations and processes for industrial production of bacterial polysaccharides |
| JP2019508468A (ja) * | 2016-03-15 | 2019-03-28 | エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． | 新規の多糖体−タンパク質コンジュゲート及びそれを得る方法 |
| CN106110316A (zh) * | 2016-06-27 | 2016-11-16 | 北京智飞绿竹生物制药有限公司 | 一种肺炎球菌结合物组合疫苗的制备方法 |
| BR112019003992A2 (pt) * | 2016-09-02 | 2019-05-28 | Sanofi Pasteur Inc | vacina contra neisseria meningitidis |
| CN106397537B (zh) * | 2016-10-13 | 2020-01-07 | 李红臣 | 一种高效快速的多糖蛋白结合疫苗纯化分析方法 |
| US11739356B2 (en) | 2017-05-05 | 2023-08-29 | Serum Institute Of India Private Limited | Method for removal of impurities from bacterial capsular polysaccharide based preparations |
| JP2020525495A (ja) * | 2017-06-27 | 2020-08-27 | エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． | 新規の多価多糖類・タンパク質のコンジュゲートワクチン組成物及びその製剤 |
| US20200353064A1 (en) * | 2018-01-29 | 2020-11-12 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel meningococcal vaccine composition and process thereof |
| WO2019198096A1 (en) * | 2018-04-11 | 2019-10-17 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Tetravalent meningococcal vaccine composition and process to prepare thereof |
| JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| CN118078981A (zh) * | 2024-04-26 | 2024-05-28 | 成都康华生物制品股份有限公司 | 一种基于双蛋白载体的五价脑膜炎球菌多糖结合疫苗的制备方法及其产品 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| CZ20024224A3 (cs) * | 2000-06-29 | 2003-05-14 | Glaxosmithkline Biologicals S. A. | Farmaceutický prostředek |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0130215D0 (en) * | 2001-12-18 | 2002-02-06 | Glaxosmithkline Biolog Sa | Vaccine |
| NZ546430A (en) * | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| PE20110072A1 (es) * | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| GB0513069D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| JP5135220B2 (ja) * | 2005-09-01 | 2013-02-06 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 血清群ｃ髄膜炎菌を含む複数ワクチン接種 |
| KR101515078B1 (ko) * | 2005-12-22 | 2015-04-24 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| GB0703369D0 (en) * | 2007-02-21 | 2007-03-28 | Health Prot Agency | Compositions Comprising Capsular Polysaccharides and Their Use as Vaccines |
| CA2836153C (en) * | 2009-12-17 | 2016-06-21 | Fina Biosolutions, Llc | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
| RU2014151567A (ru) * | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
-
2013
- 2013-01-29 MX MX2014009250A patent/MX354103B/es active IP Right Grant
- 2013-01-29 JP JP2014555364A patent/JP6042455B2/ja active Active
- 2013-01-29 KR KR1020147024348A patent/KR101897317B1/ko active Active
- 2013-01-29 RU RU2014134288A patent/RU2634405C2/ru active
- 2013-01-29 PT PT13743463T patent/PT2809349T/pt unknown
- 2013-01-29 BR BR112014018815-7A patent/BR112014018815B1/pt active IP Right Grant
- 2013-01-29 WO PCT/IB2013/050739 patent/WO2013114268A1/en not_active Ceased
- 2013-01-29 DK DK13743463.5T patent/DK2809349T3/da active
- 2013-01-29 SG SG11201404447WA patent/SG11201404447WA/en unknown
- 2013-01-29 US US14/375,385 patent/US9198977B2/en active Active
- 2013-01-29 CA CA2863178A patent/CA2863178C/en active Active
- 2013-01-29 SI SI201331329T patent/SI2809349T1/sl unknown
- 2013-01-29 TR TR2019/00778T patent/TR201900778T4/tr unknown
- 2013-01-29 HU HUE13743463A patent/HUE040914T4/hu unknown
- 2013-01-29 CN CN201380017781.9A patent/CN104302315B/zh active Active
- 2013-01-29 EP EP13743463.5A patent/EP2809349B1/en active Active
- 2013-01-29 ES ES13743463T patent/ES2707294T3/es active Active
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