JP2015509111A5 - - Google Patents
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- Publication number
- JP2015509111A5 JP2015509111A5 JP2014555364A JP2014555364A JP2015509111A5 JP 2015509111 A5 JP2015509111 A5 JP 2015509111A5 JP 2014555364 A JP2014555364 A JP 2014555364A JP 2014555364 A JP2014555364 A JP 2014555364A JP 2015509111 A5 JP2015509111 A5 JP 2015509111A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- saccharide
- group
- conjugate
- meningococcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 230000002163 immunogen Effects 0.000 claims 28
- 150000001720 carbohydrates Chemical class 0.000 claims 27
- 150000004676 glycans Chemical class 0.000 claims 12
- 229920001282 polysaccharide Polymers 0.000 claims 12
- 239000005017 polysaccharide Substances 0.000 claims 12
- 238000004513 sizing Methods 0.000 claims 12
- 102000014914 Carrier Proteins Human genes 0.000 claims 8
- 108010078791 Carrier Proteins Proteins 0.000 claims 8
- 238000009739 binding Methods 0.000 claims 8
- 229960000814 tetanus toxoid Drugs 0.000 claims 8
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 7
- 238000011534 incubation Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 4
- 241000588650 Neisseria meningitidis Species 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- JPUHPGALPBINPO-UHFFFAOYSA-N benzotriazole-1-carbonitrile Chemical compound C1=CC=C2N(C#N)N=NC2=C1 JPUHPGALPBINPO-UHFFFAOYSA-N 0.000 claims 4
- SLPWXZZHNSOZPX-UHFFFAOYSA-N imidazole-1-carbonitrile Chemical compound N#CN1C=CN=C1 SLPWXZZHNSOZPX-UHFFFAOYSA-N 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 3
- -1 1-cyano-4-pyrrolidinopyrrolidinium tetrafluoroborate Chemical compound 0.000 claims 2
- 239000007987 MES buffer Substances 0.000 claims 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 235000017281 sodium acetate Nutrition 0.000 claims 2
- 239000001632 sodium acetate Substances 0.000 claims 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 101710183389 Pneumolysin Proteins 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN281/MUM/2012 | 2012-01-30 | ||
| IN281MU2012 | 2012-01-30 | ||
| PCT/IB2013/050739 WO2013114268A1 (en) | 2012-01-30 | 2013-01-29 | Immunogenic composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509111A JP2015509111A (ja) | 2015-03-26 |
| JP2015509111A5 true JP2015509111A5 (enExample) | 2016-02-25 |
| JP6042455B2 JP6042455B2 (ja) | 2016-12-14 |
Family
ID=54259032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555364A Active JP6042455B2 (ja) | 2012-01-30 | 2013-01-29 | 免疫原性組成物の調製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9198977B2 (enExample) |
| EP (1) | EP2809349B1 (enExample) |
| JP (1) | JP6042455B2 (enExample) |
| KR (1) | KR101897317B1 (enExample) |
| CN (1) | CN104302315B (enExample) |
| BR (1) | BR112014018815B1 (enExample) |
| CA (1) | CA2863178C (enExample) |
| DK (1) | DK2809349T3 (enExample) |
| ES (1) | ES2707294T3 (enExample) |
| HU (1) | HUE040914T4 (enExample) |
| MX (1) | MX354103B (enExample) |
| PT (1) | PT2809349T (enExample) |
| RU (1) | RU2634405C2 (enExample) |
| SG (1) | SG11201404447WA (enExample) |
| SI (1) | SI2809349T1 (enExample) |
| TR (1) | TR201900778T4 (enExample) |
| WO (1) | WO2013114268A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2878307T3 (pl) | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| CN104936615B (zh) * | 2012-11-21 | 2017-03-29 | 印度血清研究所私人有限公司 | 高产量的细菌多糖的制备 |
| WO2015029056A1 (en) | 2013-08-24 | 2015-03-05 | Bharat Biotech International Limited | A bacterial vaccine and methods for manufacture thereof |
| EP2921856B1 (en) | 2014-03-18 | 2016-09-14 | Serum Institute Of India Private Limited | A quantitative assay for 4-pyrrolidinopyridine (4-ppy) in polysaccharide-protein conjugate vaccines |
| MX2017015985A (es) * | 2015-06-08 | 2018-08-15 | Serum Inst Of India Private Ltd | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y formulacion de vacuna multivalente obtenida con los mismos. |
| AU2016290233A1 (en) * | 2015-07-04 | 2018-01-25 | Bharat Biotech International Limited | Polysaccharide vaccine formulations and processes for industrial production of bacterial polysaccharides |
| BR112018068523A2 (pt) * | 2016-03-15 | 2019-01-22 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | novos conjugados de polissacarídeo-proteína e processo para obter os mesmos |
| CN106110316A (zh) * | 2016-06-27 | 2016-11-16 | 北京智飞绿竹生物制药有限公司 | 一种肺炎球菌结合物组合疫苗的制备方法 |
| KR20190044663A (ko) | 2016-09-02 | 2019-04-30 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
| CN106397537B (zh) * | 2016-10-13 | 2020-01-07 | 李红臣 | 一种高效快速的多糖蛋白结合疫苗纯化分析方法 |
| AU2018262438B2 (en) * | 2017-05-05 | 2022-07-14 | Serum Institute Of India Private Limited | Method for removal of impurities from bacterial capsular polysaccharide based preparations |
| BR112019027182A2 (pt) * | 2017-06-27 | 2020-06-30 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | nova composição de vacina conjugada de proteína - polissacarídeo multivalente e formulação da mesma |
| US20200353064A1 (en) * | 2018-01-29 | 2020-11-12 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel meningococcal vaccine composition and process thereof |
| WO2019198096A1 (en) * | 2018-04-11 | 2019-10-17 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Tetravalent meningococcal vaccine composition and process to prepare thereof |
| JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP4192499A4 (en) | 2020-08-10 | 2024-09-25 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| CN118078981A (zh) * | 2024-04-26 | 2024-05-28 | 成都康华生物制品股份有限公司 | 一种基于双蛋白载体的五价脑膜炎球菌多糖结合疫苗的制备方法及其产品 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| CZ20024224A3 (cs) * | 2000-06-29 | 2003-05-14 | Glaxosmithkline Biologicals S. A. | Farmaceutický prostředek |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0130215D0 (en) * | 2001-12-18 | 2002-02-06 | Glaxosmithkline Biolog Sa | Vaccine |
| ATE506963T1 (de) * | 2003-10-02 | 2011-05-15 | Novartis Vaccines & Diagnostic | Kombinationsimpfstoffe gegen meningitis |
| PL2878307T3 (pl) * | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| GB0513069D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CN101287488B (zh) * | 2005-09-01 | 2013-01-30 | 诺华疫苗和诊断有限两合公司 | 含血清群c脑膜炎球菌的多价疫苗 |
| PL3017827T3 (pl) * | 2005-12-22 | 2019-04-30 | Glaxosmithkline Biologicals Sa | Szczepionka z koniugatem polisacharydu pneumokokowego |
| GB0703369D0 (en) * | 2007-02-21 | 2007-03-28 | Health Prot Agency | Compositions Comprising Capsular Polysaccharides and Their Use as Vaccines |
| KR101635795B1 (ko) * | 2009-12-17 | 2016-07-04 | 피나 바이오솔루션스, 엘엘씨 | 다당류/단백질 접합체 백신의 제조에 있어서 시안화제인 1-시아노벤조트리아졸 (1-cbt)을 통한 다당류의 활성화 |
| AU2013265336A1 (en) * | 2012-05-22 | 2014-12-04 | Novartis Ag | Meningococcus serogroup X conjugate |
-
2013
- 2013-01-29 CA CA2863178A patent/CA2863178C/en active Active
- 2013-01-29 HU HUE13743463A patent/HUE040914T4/hu unknown
- 2013-01-29 SI SI201331329T patent/SI2809349T1/sl unknown
- 2013-01-29 WO PCT/IB2013/050739 patent/WO2013114268A1/en not_active Ceased
- 2013-01-29 SG SG11201404447WA patent/SG11201404447WA/en unknown
- 2013-01-29 DK DK13743463.5T patent/DK2809349T3/da active
- 2013-01-29 CN CN201380017781.9A patent/CN104302315B/zh active Active
- 2013-01-29 PT PT13743463T patent/PT2809349T/pt unknown
- 2013-01-29 KR KR1020147024348A patent/KR101897317B1/ko active Active
- 2013-01-29 ES ES13743463T patent/ES2707294T3/es active Active
- 2013-01-29 MX MX2014009250A patent/MX354103B/es active IP Right Grant
- 2013-01-29 BR BR112014018815-7A patent/BR112014018815B1/pt active IP Right Grant
- 2013-01-29 US US14/375,385 patent/US9198977B2/en active Active
- 2013-01-29 RU RU2014134288A patent/RU2634405C2/ru active
- 2013-01-29 JP JP2014555364A patent/JP6042455B2/ja active Active
- 2013-01-29 EP EP13743463.5A patent/EP2809349B1/en active Active
- 2013-01-29 TR TR2019/00778T patent/TR201900778T4/tr unknown
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