JP2015509107A5 - - Google Patents
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- JP2015509107A5 JP2015509107A5 JP2014555045A JP2014555045A JP2015509107A5 JP 2015509107 A5 JP2015509107 A5 JP 2015509107A5 JP 2014555045 A JP2014555045 A JP 2014555045A JP 2014555045 A JP2014555045 A JP 2014555045A JP 2015509107 A5 JP2015509107 A5 JP 2015509107A5
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- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 9
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 206010025323 Lymphomas Diseases 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000003950 B-cell lymphoma Diseases 0.000 claims 4
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
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- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
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- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000001718 Immediate Hypersensitivity Diseases 0.000 claims 2
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- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
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- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 206010065857 Primary Effusion Lymphoma Diseases 0.000 claims 2
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- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims 2
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- QPWWALBJROMWHE-UHFFFAOYSA-N 1-[2-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CC3(C2)CCN(CC3)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 QPWWALBJROMWHE-UHFFFAOYSA-N 0.000 claims 1
- MDOOZFHNLMQRHG-UHFFFAOYSA-N 1-[6-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CC3(C2)CN(C3)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 MDOOZFHNLMQRHG-UHFFFAOYSA-N 0.000 claims 1
- ISDIBDPXVWNENH-UHFFFAOYSA-N 1-[7-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-azaspiro[3.5]nonan-2-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CCC3(CN(C3)C(=O)C=C)CC2)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 ISDIBDPXVWNENH-UHFFFAOYSA-N 0.000 claims 1
- -1 2- (4-Amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl) -6-azaspiro [3.5] nonan-6-yl Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
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- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261632781P | 2012-01-31 | 2012-01-31 | |
| US61/632,781 | 2012-01-31 | ||
| PCT/CA2013/000085 WO2013113097A1 (en) | 2012-01-31 | 2013-01-30 | Cyclic molecules as bruton's tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509107A JP2015509107A (ja) | 2015-03-26 |
| JP2015509107A5 true JP2015509107A5 (https=) | 2015-07-02 |
| JP5985658B2 JP5985658B2 (ja) | 2016-09-06 |
Family
ID=48904331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555045A Expired - Fee Related JP5985658B2 (ja) | 2012-01-31 | 2013-01-30 | ブルトンチロシンキナーゼ阻害薬としての環状分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9458162B2 (https=) |
| EP (1) | EP2809673B1 (https=) |
| JP (1) | JP5985658B2 (https=) |
| CN (1) | CN104080789B (https=) |
| CA (1) | CA2863239C (https=) |
| WO (1) | WO2013113097A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| JP6403751B2 (ja) | 2013-03-14 | 2018-10-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用 |
| WO2014152114A1 (en) * | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| WO2015116485A1 (en) * | 2014-01-29 | 2015-08-06 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as btk inhibitors |
| MX2016009403A (es) * | 2014-02-03 | 2016-09-16 | Cadila Healthcare Ltd | Compuestos heterociclicos. |
| EP3166608B1 (en) * | 2014-07-07 | 2018-12-12 | Jiangsu Hengrui Medicine Co., Ltd. | Aminopyridazinone compounds as protein kinase inhibitors |
| TWI578574B (zh) * | 2014-07-14 | 2017-04-11 | 新世紀光電股份有限公司 | 發光元件結構 |
| WO2016106629A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| WO2017031138A1 (en) * | 2015-08-17 | 2017-02-23 | Infinite Arthroscopy Inc, Limited | Light source |
| EP3414234B1 (en) * | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| CN106588914B (zh) * | 2015-10-16 | 2018-11-02 | 陈剑 | 具有取代吡啶并咪唑类衍生物，其制备及其在医药上的应用 |
| US9975882B2 (en) * | 2015-12-16 | 2018-05-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as BTK inhibitors |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| US10793566B2 (en) | 2016-01-21 | 2020-10-06 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| US10662187B2 (en) | 2016-01-21 | 2020-05-26 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
| KR102416971B1 (ko) | 2016-03-11 | 2022-07-04 | 엔젤 파마슈티칼 컴퍼니, 리미티드 | 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법 |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| CA2939286A1 (en) * | 2016-08-17 | 2018-02-17 | Pharmascience Inc. | Spirocyclic containing compounds and pharmaceutical uses thereof |
| US11186578B2 (en) | 2016-08-17 | 2021-11-30 | Shenzhen Targetrx, Inc. | Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| CN106831787B (zh) * | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
| KR102627756B1 (ko) * | 2017-03-22 | 2024-01-23 | 쑤저우 바이지부공 파마수티컬 테크널러지 컴퍼니 리미티드 | 브루톤 타이로신 키나제 억제제 |
| JP7166331B2 (ja) | 2017-08-01 | 2022-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中間体化合物及び方法 |
| WO2020015735A1 (zh) * | 2018-07-20 | 2020-01-23 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| TWI767148B (zh) * | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| CN117377675A (zh) * | 2021-06-01 | 2024-01-09 | 正大天晴药业集团股份有限公司 | 含有并环或螺环的布鲁顿酪氨酸激酶降解剂 |
| WO2025240240A1 (en) * | 2024-05-14 | 2025-11-20 | Dana-Farber Cancer Institute, Inc. | Novel spirocycle derivatives as inhibitors of hck |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2344249A1 (en) * | 1998-09-18 | 2000-03-30 | Basf Aktiengesellschaft | Pyrrolopyrimidines as protein kinase inhibitors |
| US6713474B2 (en) * | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
| BRPI0622054B8 (pt) * | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| US8129371B2 (en) * | 2007-10-16 | 2012-03-06 | Wyeth Llc | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors |
| CA2730606A1 (en) | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| ES2660418T3 (es) * | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| WO2011029915A1 (en) * | 2009-09-10 | 2011-03-17 | Novartis Ag | Ether derivatives of bicyclic heteroaryls |
| WO2011064211A1 (en) * | 2009-11-25 | 2011-06-03 | Novartis Ag | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls |
| PE20140570A1 (es) * | 2011-07-01 | 2014-04-28 | Bayer Ip Gmbh | Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
-
2013
- 2013-01-30 JP JP2014555045A patent/JP5985658B2/ja not_active Expired - Fee Related
- 2013-01-30 CN CN201380007581.5A patent/CN104080789B/zh active Active
- 2013-01-30 US US14/375,539 patent/US9458162B2/en not_active Expired - Fee Related
- 2013-01-30 CA CA2863239A patent/CA2863239C/en not_active Expired - Fee Related
- 2013-01-30 EP EP13743950.1A patent/EP2809673B1/en not_active Not-in-force
- 2013-01-30 WO PCT/CA2013/000085 patent/WO2013113097A1/en not_active Ceased
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