JP2015503618A5 - - Google Patents

Download PDF

Info

Publication number
JP2015503618A5
JP2015503618A5 JP2014552290A JP2014552290A JP2015503618A5 JP 2015503618 A5 JP2015503618 A5 JP 2015503618A5 JP 2014552290 A JP2014552290 A JP 2014552290A JP 2014552290 A JP2014552290 A JP 2014552290A JP 2015503618 A5 JP2015503618 A5 JP 2015503618A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
disease
formula
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014552290A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015503618A (ja
JP6126131B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/020981 external-priority patent/WO2013106535A1/en
Publication of JP2015503618A publication Critical patent/JP2015503618A/ja
Publication of JP2015503618A5 publication Critical patent/JP2015503618A5/ja
Application granted granted Critical
Publication of JP6126131B2 publication Critical patent/JP6126131B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014552290A 2012-01-10 2013-01-10 Irak阻害剤およびその使用 Active JP6126131B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261585194P 2012-01-10 2012-01-10
US61/585,194 2012-01-10
US201261663227P 2012-06-22 2012-06-22
US61/663,227 2012-06-22
US201261682637P 2012-08-13 2012-08-13
US61/682,637 2012-08-13
US201261724695P 2012-11-09 2012-11-09
US61/724,695 2012-11-09
US201261734133P 2012-12-06 2012-12-06
US61/734,133 2012-12-06
PCT/US2013/020981 WO2013106535A1 (en) 2012-01-10 2013-01-10 Irak inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016203006A Division JP2017008110A (ja) 2012-01-10 2016-10-14 Irak阻害剤およびその使用

Publications (3)

Publication Number Publication Date
JP2015503618A JP2015503618A (ja) 2015-02-02
JP2015503618A5 true JP2015503618A5 (https=) 2016-02-18
JP6126131B2 JP6126131B2 (ja) 2017-05-10

Family

ID=48781892

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014552290A Active JP6126131B2 (ja) 2012-01-10 2013-01-10 Irak阻害剤およびその使用
JP2016203006A Pending JP2017008110A (ja) 2012-01-10 2016-10-14 Irak阻害剤およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016203006A Pending JP2017008110A (ja) 2012-01-10 2016-10-14 Irak阻害剤およびその使用

Country Status (10)

Country Link
US (2) US9212190B2 (https=)
EP (1) EP2802330A4 (https=)
JP (2) JP6126131B2 (https=)
CN (1) CN104582705A (https=)
AU (2) AU2013207972B2 (https=)
BR (1) BR112014017021A8 (https=)
CA (1) CA2863259A1 (https=)
HK (1) HK1209632A1 (https=)
TW (2) TW201728592A (https=)
WO (1) WO2013106535A1 (https=)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
AU2011281015B2 (en) 2010-07-23 2015-09-24 President And Fellows Of Harvard College Tricyclic proteasome activity enhancing compounds
US8703941B2 (en) 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
CN104582705A (zh) 2012-01-10 2015-04-29 林伯士艾瑞斯公司 白介素-1受体相关激酶(irak)抑制剂和其用途
WO2013112699A2 (en) * 2012-01-25 2013-08-01 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
CA2861464C (en) 2012-01-25 2018-03-06 Proteostasis Therapeutics, Inc. Proteasome activity modulating tricyclic compounds
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2014011906A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
JP2016505012A (ja) * 2013-01-10 2016-02-18 ニンバス アイリス, インコーポレイテッド Irak阻害剤およびその使用
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
EP2951187A1 (en) 2013-02-01 2015-12-09 Bayer Pharma Aktiengesellschaft Substituted thienopyrimidines and pharmaceutical use thereof
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
WO2014194242A2 (en) * 2013-05-31 2014-12-04 Nimbus Iris, Inc. Flt3 inhibitors and uses thereof
WO2014194245A2 (en) * 2013-05-31 2014-12-04 Nimbus Iris, Inc. Cdk8 inhibitors and uses thereof
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
BR112016006319A2 (pt) 2013-09-27 2017-08-01 Nimbus Iris Inc inibidores de irak e usos dos mesmos
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
TW201605867A (zh) * 2013-11-20 2016-02-16 拜耳製藥公司 噻吩并嘧啶
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
WO2015143400A1 (en) 2014-03-20 2015-09-24 Pharmacyclics, Inc. Phospholipase c gamma 2 and resistance associated mutations
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
US20160008366A1 (en) * 2014-07-14 2016-01-14 Pharmacyclics Llc Btk inhibitors for the treatment of cns malignancies
SI3209651T1 (sl) 2014-10-24 2019-12-31 Bristol-Myers Squibb Company Derivati karbazola
JP2016124791A (ja) * 2014-12-26 2016-07-11 国立大学法人 千葉大学 新規化合物及びこれを有効成分とする抗ウイルス剤
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法
EA039043B1 (ru) 2015-04-22 2021-11-25 Райджел Фармасьютикалз, Инк. Пиразольные соединения и способ получения и применения данных соединений
JP6994454B2 (ja) 2015-08-04 2022-01-14 ライジェル ファーマシューティカルズ, インコーポレイテッド ベンズアゾール化合物ならびに該化合物の作製方法および使用方法
SG10201508795XA (en) * 2015-10-23 2017-05-30 Agency Science Tech & Res Method for treating cancer
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
EP3532164A4 (en) * 2016-10-28 2020-10-07 Children's Hospital Medical Center TREATMENT OF IRAQ ASSOCIATED DISEASES ACTIVATED
TW202340194A (zh) 2017-02-16 2023-10-16 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
WO2019001461A1 (zh) * 2017-06-27 2019-01-03 南京明德新药研发股份有限公司 Irak4抑制剂
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
MX2020003190A (es) 2017-09-22 2020-11-11 Kymera Therapeutics Inc Degradadores de proteinas y usos de los mismos.
US11065231B2 (en) 2017-11-17 2021-07-20 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CN108033931B (zh) * 2017-12-28 2020-03-10 山东铂源药业有限公司 一种N-Boc哌嗪的合成方法
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
MX2021000094A (es) * 2018-07-20 2021-03-25 Merck Patent Gmbh Compuesto de amino-pirimidina sustituido para usarse en un metodo para tratamiento y prevencion de esclerosis multiple.
EP3841100A1 (en) 2018-08-20 2021-06-30 Arvinas Operations, Inc. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases
JP7623943B2 (ja) 2018-11-30 2025-01-29 カイメラ セラピューティクス, インコーポレイテッド Irak分解剤およびそれらの使用
AU2019395201A1 (en) 2018-12-06 2021-05-20 Daiichi Sankyo Company, Limited Cycloalkane-1,3-diamine derivative
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
BR112021026517A2 (pt) 2019-06-28 2022-05-10 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
WO2021011868A1 (en) 2019-07-17 2021-01-21 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CN121159524A (zh) 2019-08-30 2025-12-19 里格尔药品股份有限公司 吡唑化合物,其配制品以及使用所述化合物和/或配制品的方法
US12551564B2 (en) 2019-12-10 2026-02-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021127190A1 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
CA3200608A1 (en) * 2020-12-09 2022-06-16 Xiaozhang Zheng Irak degraders and uses thereof
PH12023500015A1 (en) 2020-12-30 2024-03-11 Kymera Therapeutics Inc Irak degraders and uses thereof
CN116867494A (zh) 2021-02-15 2023-10-10 凯麦拉医疗公司 Irak4降解剂和其用途
WO2022174268A1 (en) 2021-02-15 2022-08-18 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
WO2022187303A1 (en) 2021-03-03 2022-09-09 Rigel Pharmaceuticals, Inc. A method for treating a disease or condition using a pyrazole compound or formulation thereof
AU2022271290A1 (en) 2021-05-07 2023-11-23 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
US12187744B2 (en) 2021-10-29 2025-01-07 Kymera Therapeutics, Inc. IRAK4 degraders and synthesis thereof
EP4472967A4 (en) 2022-01-31 2026-04-15 Kymera Therapeutics Inc Iraqi Degradation Agents and Their Uses
JP2025513716A (ja) 2022-03-23 2025-04-30 ライジェル・ファーマシューティカルズ・インコーポレイテッド Irak阻害剤としてのピリミド-2-イル-ピラゾール化合物
CN118978528A (zh) * 2024-08-02 2024-11-19 上海信诺维生物医药有限公司 一种irak4激酶抑制剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937459A1 (de) * 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
EP1167367A4 (en) * 1999-03-30 2002-04-24 Nippon Soda Co THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
US6297238B1 (en) 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
US6849638B2 (en) 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
WO2003057149A2 (en) 2001-12-28 2003-07-17 Bayer Corporation 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
JP2006512313A (ja) 2002-10-31 2006-04-13 アムジェン インコーポレイテッド 抗炎症剤
WO2004092154A1 (en) * 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
DE502005008916D1 (de) 2004-07-23 2010-03-11 Medicines Co Leipzig Gmbh Substituierte pyridoä3',2':4,5üthienoä3,2-düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü-pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung
EP1899353A1 (en) * 2005-06-22 2008-03-19 DeveloGen Aktiengesellschaft Thienopyrimidines for pharmaceutical compositions
EP2132211A4 (en) 2006-11-09 2011-12-07 Ardea Biosciences Inc 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER
US20100227853A1 (en) * 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
WO2009140200A1 (en) * 2008-05-12 2009-11-19 Amnestix, Inc. Compounds for improving learning and memory
AU2009291783A1 (en) 2008-09-10 2010-03-18 Alcon Research, Ltd Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
EP2473054B1 (en) 2009-09-04 2017-06-14 The Regents of the University of Michigan Compositions and methods for treatment of leukemia
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
EP2509597A4 (en) * 2009-12-10 2013-04-10 Univ North Carolina SELECTIVE BETA-GLUCURONIDASE INHIBITORS FOR THE TREATMENT OF SIDE EFFECTS OF ANTINEOPLASTIC CAMPTOTHECIN MEDICAMENTS
JP5985473B2 (ja) 2010-07-13 2016-09-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft IRAK4モジュレーターとしてのピラゾロ[1,5a]ピリミジン及びチエノ[3,2b]ピリミジン誘導体
AU2011281015B2 (en) 2010-07-23 2015-09-24 President And Fellows Of Harvard College Tricyclic proteasome activity enhancing compounds
US8703941B2 (en) 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
ES2575143T3 (es) * 2011-11-23 2016-06-24 Cancer Research Technology Limited Inhibidores de tienopiridina de la proteína quinasa C atípica
CN104582705A (zh) 2012-01-10 2015-04-29 林伯士艾瑞斯公司 白介素-1受体相关激酶(irak)抑制剂和其用途
US20140018361A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2014011906A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Similar Documents

Publication Publication Date Title
JP2015503618A5 (https=)
JP2015528801A5 (https=)
JP2016531870A5 (https=)
RU2016140870A (ru) Ингибиторы irak и их применения
RU2016110852A (ru) Ингибиторы irak и их применения
ES2975436T3 (es) Enantiómeros (R) y (S) de n-(5-(3-hidroxipirrolidin-1-il)-2-morfolinooxazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4- il)oxazol-carboxamida como inhibidores de IRAK4 para el tratamiento del cáncer
IL303987A (en) IRAK joints and their uses
JPWO2020113233A5 (https=)
JP2017505337A5 (https=)
AU2019364336B2 (en) TYK2 inhibitors and uses thereof
JP2017502088A5 (https=)
TWI827016B (zh) 吡啶衍生物及其在醫藥上的應用
ES2930585T3 (es) Inhibidores de TYK2 y usos de los mismos
CA3086763A1 (en) Irak degraders and uses thereof
JP2017518348A5 (https=)
AU2011241420B2 (en) Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders
SA515360627B1 (ar) مشتقات بيرازولو - بيريميدين نشطة علاجيا
JP2013504325A5 (https=)
AU2014205577A1 (en) IRAK inhibitors and uses thereof
PT2099797E (pt) Compostos e composições como inibidores de proteína-quinase
AU2007321923A1 (en) Heterobicyclic matrix metalloprotease inhibitors
AU2011241420A1 (en) Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders
CN108218838B (zh) 嘧啶基吲哚衍生物及其制备方法和在制备抗肿瘤药物中的应用
AU2015274285C1 (en) Pyrimidine compounds and methods using the same
US20130090327A1 (en) Inhibitors of Protein Tyrosine Kinase Activity