CN104080789B - 作为布鲁顿酪氨酸激酶抑制剂的环状分子 - Google Patents

作为布鲁顿酪氨酸激酶抑制剂的环状分子 Download PDF

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CN104080789B
CN104080789B CN201380007581.5A CN201380007581A CN104080789B CN 104080789 B CN104080789 B CN 104080789B CN 201380007581 A CN201380007581 A CN 201380007581A CN 104080789 B CN104080789 B CN 104080789B
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cancer
disease
lymphoma
syndrome
phenoxyphenyl
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CN104080789A (zh
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王召印
李连海
王志刚
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Hamde Ningbo Intelligent Medical Technology Co ltd
Shanghai Xinqibo Biotechnology Co ltd
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Beta Pharma Canada Inc
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  • Diabetes (AREA)
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CN201380007581.5A 2012-01-31 2013-01-30 作为布鲁顿酪氨酸激酶抑制剂的环状分子 Active CN104080789B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261632781P 2012-01-31 2012-01-31
US61/632,781 2012-01-31
PCT/CA2013/000085 WO2013113097A1 (en) 2012-01-31 2013-01-30 Cyclic molecules as bruton's tyrosine kinase inhibitors

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CN104080789A CN104080789A (zh) 2014-10-01
CN104080789B true CN104080789B (zh) 2016-05-11

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US (1) US9458162B2 (https=)
EP (1) EP2809673B1 (https=)
JP (1) JP5985658B2 (https=)
CN (1) CN104080789B (https=)
CA (1) CA2863239C (https=)
WO (1) WO2013113097A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201500499TA (en) 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
JP6403751B2 (ja) 2013-03-14 2018-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用
WO2014152114A1 (en) * 2013-03-15 2014-09-25 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as btk inhibitors
WO2015116485A1 (en) * 2014-01-29 2015-08-06 Boehringer Ingelheim International Gmbh Pyrazole compounds as btk inhibitors
MX2016009403A (es) * 2014-02-03 2016-09-16 Cadila Healthcare Ltd Compuestos heterociclicos.
EP3166608B1 (en) * 2014-07-07 2018-12-12 Jiangsu Hengrui Medicine Co., Ltd. Aminopyridazinone compounds as protein kinase inhibitors
TWI578574B (zh) * 2014-07-14 2017-04-11 新世紀光電股份有限公司 發光元件結構
WO2016106629A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Btk inhibitors
WO2016106652A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Biarylether imidazopyrazine btk inhibitors
WO2017031138A1 (en) * 2015-08-17 2017-02-23 Infinite Arthroscopy Inc, Limited Light source
EP3414234B1 (en) * 2015-10-14 2022-06-29 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
CN106588914B (zh) * 2015-10-16 2018-11-02 陈剑 具有取代吡啶并咪唑类衍生物，其制备及其在医药上的应用
US9975882B2 (en) * 2015-12-16 2018-05-22 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as BTK inhibitors
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
US10793566B2 (en) 2016-01-21 2020-10-06 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
US10662187B2 (en) 2016-01-21 2020-05-26 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
CN107021963A (zh) 2016-01-29 2017-08-08 北京诺诚健华医药科技有限公司 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用
KR102416971B1 (ko) 2016-03-11 2022-07-04 엔젤 파마슈티칼 컴퍼니, 리미티드 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법
MD3436461T2 (ro) 2016-03-28 2024-05-31 Incyte Corp Compuși pirolotriazină ca inhibitori TAM
CA2939286A1 (en) * 2016-08-17 2018-02-17 Pharmascience Inc. Spirocyclic containing compounds and pharmaceutical uses thereof
US11186578B2 (en) 2016-08-17 2021-11-30 Shenzhen Targetrx, Inc. Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
MA46995A (fr) 2016-12-03 2019-10-09 Acerta Pharma Bv Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase
CN106831787B (zh) * 2017-01-20 2018-10-23 成都倍特药业有限公司 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用
KR102627756B1 (ko) * 2017-03-22 2024-01-23 쑤저우 바이지부공 파마수티컬 테크널러지 컴퍼니 리미티드 브루톤 타이로신 키나제 억제제
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WO2020015735A1 (zh) * 2018-07-20 2020-01-23 正大天晴药业集团股份有限公司 布鲁顿酪氨酸激酶抑制剂
TWI767148B (zh) * 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN111454268B (zh) * 2019-01-18 2023-09-08 明慧医药（上海）有限公司 作为布鲁顿酪氨酸激酶抑制剂的环状分子
CN117377675A (zh) * 2021-06-01 2024-01-09 正大天晴药业集团股份有限公司 含有并环或螺环的布鲁顿酪氨酸激酶降解剂
WO2025240240A1 (en) * 2024-05-14 2025-11-20 Dana-Farber Cancer Institute, Inc. Novel spirocycle derivatives as inhibitors of hck

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153752A1 (en) * 1998-09-18 2003-08-14 Hirst Gavin C. Pyrrolopyrimidines as therapeutic agents
CN101610676A (zh) * 2006-09-22 2009-12-23 药品循环公司 布鲁顿酪氨酸激酶的抑制剂
CN101883774A (zh) * 2007-10-16 2010-11-10 惠氏有限责任公司 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途
CN102159214A (zh) * 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344249A1 (en) * 1998-09-18 2000-03-30 Basf Aktiengesellschaft Pyrrolopyrimidines as protein kinase inhibitors
US6921763B2 (en) * 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
JP2007520559A (ja) * 2004-02-03 2007-07-26 アボット・ラボラトリーズ 治療薬としてのアミノベンゾオキサゾール類
CA2730606A1 (en) 2008-07-16 2010-01-21 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
WO2011029915A1 (en) * 2009-09-10 2011-03-17 Novartis Ag Ether derivatives of bicyclic heteroaryls
WO2011064211A1 (en) * 2009-11-25 2011-06-03 Novartis Ag Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
PE20140570A1 (es) * 2011-07-01 2014-04-28 Bayer Ip Gmbh Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153752A1 (en) * 1998-09-18 2003-08-14 Hirst Gavin C. Pyrrolopyrimidines as therapeutic agents
CN101610676A (zh) * 2006-09-22 2009-12-23 药品循环公司 布鲁顿酪氨酸激酶的抑制剂
CN101883774A (zh) * 2007-10-16 2010-11-10 惠氏有限责任公司 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途
CN102159214A (zh) * 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂

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