CN104080789B - 作为布鲁顿酪氨酸激酶抑制剂的环状分子 - Google Patents

作为布鲁顿酪氨酸激酶抑制剂的环状分子 Download PDF

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CN104080789B
CN104080789B CN201380007581.5A CN201380007581A CN104080789B CN 104080789 B CN104080789 B CN 104080789B CN 201380007581 A CN201380007581 A CN 201380007581A CN 104080789 B CN104080789 B CN 104080789B
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cancer
disease
lymphoma
syndrome
phenoxyphenyl
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CN104080789A (zh
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王召印
李连海
王志刚
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Hamde Ningbo Intelligent Medical Technology Co ltd
Shanghai Xinqibo Biotechnology Co ltd
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Beta Pharma Canada Inc
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CN201380007581.5A 2012-01-31 2013-01-30 作为布鲁顿酪氨酸激酶抑制剂的环状分子 Active CN104080789B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261632781P 2012-01-31 2012-01-31
US61/632,781 2012-01-31
PCT/CA2013/000085 WO2013113097A1 (en) 2012-01-31 2013-01-30 Cyclic molecules as bruton's tyrosine kinase inhibitors

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CN104080789A CN104080789A (zh) 2014-10-01
CN104080789B true CN104080789B (zh) 2016-05-11

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US (1) US9458162B2 (https=)
EP (1) EP2809673B1 (https=)
JP (1) JP5985658B2 (https=)
CN (1) CN104080789B (https=)
CA (1) CA2863239C (https=)
WO (1) WO2013113097A1 (https=)

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SG11201500499TA (en) 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
JP6403751B2 (ja) 2013-03-14 2018-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用
JP6495886B2 (ja) * 2013-03-15 2019-04-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としての複素環式芳香族化合物
JP6486954B2 (ja) * 2014-01-29 2019-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのピラゾール化合物
WO2015132799A2 (en) * 2014-02-03 2015-09-11 Cadila Healthcare Limited Novel heterocyclic compounds
CN106573001B (zh) * 2014-07-07 2019-01-29 江苏恒瑞医药股份有限公司 作为蛋白激酶抑制剂的氨基哒嗪酮化合物
TWI578574B (zh) * 2014-07-14 2017-04-11 新世紀光電股份有限公司 發光元件結構
WO2016106652A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Biarylether imidazopyrazine btk inhibitors
WO2016106629A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Btk inhibitors
JP6680868B2 (ja) * 2015-08-17 2020-04-15 インフィニット アースロスコピー インコーポレーテッド， リミテッド 光源
EP3414234B1 (en) * 2015-10-14 2022-06-29 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
CN106588914B (zh) * 2015-10-16 2018-11-02 陈剑 具有取代吡啶并咪唑类衍生物，其制备及其在医药上的应用
LT3390390T (lt) * 2015-12-16 2021-11-25 Boehringer Ingelheim International Gmbh Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
KR102699906B1 (ko) 2016-01-21 2024-08-29 즈보 바이오폴라 창쉥 파마수티컬 컴퍼니 리미티드 브루톤 티로신 키나제 억제제
US10793566B2 (en) 2016-01-21 2020-10-06 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
CN107021963A (zh) 2016-01-29 2017-08-08 北京诺诚健华医药科技有限公司 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用
CN109071455B (zh) 2016-03-11 2022-08-02 嘉兴和剂药业有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法
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