JP2015508156A - バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法 - Google Patents

バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法 Download PDF

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JP2015508156A
JP2015508156A JP2014554887A JP2014554887A JP2015508156A JP 2015508156 A JP2015508156 A JP 2015508156A JP 2014554887 A JP2014554887 A JP 2014554887A JP 2014554887 A JP2014554887 A JP 2014554887A JP 2015508156 A JP2015508156 A JP 2015508156A
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virus
biomarkers
patient
tumor
cancer
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JP2015508156A5 (OSRAM
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フランク トゥファロ
フランク トゥファロ
チャールズ コンラド
チャールズ コンラド
ジュアン フエヨ−マーガレット
ジュアン フエヨ−マーガレット
フレデリック ジュニア ラング
フレデリック ジュニア ラング
キャンデラリア ゴメッツ−マンザノ
キャンデラリア ゴメッツ−マンザノ
ダブリュ.ケイ. アルフレッド ヤング
ダブリュ.ケイ. アルフレッド ヤング
エイミー ヘイムバーガー
エイミー ヘイムバーガー
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University of Texas System
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JP2014554887A 2012-01-25 2013-01-25 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法 Pending JP2015508156A (ja)

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US201261590441P 2012-01-25 2012-01-25
US61/590,441 2012-01-25
US201261637191P 2012-04-23 2012-04-23
US61/637,191 2012-04-23
PCT/US2013/023304 WO2013112942A1 (en) 2012-01-25 2013-01-25 Biomarkers and combination therapies using oncolytic virus and immunomodulation

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JP2018211406A Division JP2019066482A (ja) 2012-01-25 2018-11-09 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法

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JP2015508156A true JP2015508156A (ja) 2015-03-16
JP2015508156A5 JP2015508156A5 (OSRAM) 2016-03-10

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JP2014554887A Pending JP2015508156A (ja) 2012-01-25 2013-01-25 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法
JP2018211406A Pending JP2019066482A (ja) 2012-01-25 2018-11-09 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法
JP2021035972A Pending JP2021103174A (ja) 2012-01-25 2021-03-08 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法

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JP2021035972A Pending JP2021103174A (ja) 2012-01-25 2021-03-08 バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法

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US (3) US10238698B2 (OSRAM)
EP (2) EP3578198A1 (OSRAM)
JP (3) JP2015508156A (OSRAM)
KR (1) KR102081567B1 (OSRAM)
CN (1) CN104427992B (OSRAM)
AU (2) AU2013211871B2 (OSRAM)
BR (1) BR112014018331A8 (OSRAM)
CA (1) CA2862390A1 (OSRAM)
DK (1) DK2806883T3 (OSRAM)
SG (3) SG11201404313YA (OSRAM)
WO (1) WO2013112942A1 (OSRAM)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018530584A (ja) * 2015-10-15 2018-10-18 デューク ユニバーシティー 併用療法
JP2019501670A (ja) * 2016-01-08 2019-01-24 レプリミュン リミテッド 改変された腫瘍溶解性ウイルス
JP2019506400A (ja) * 2016-01-21 2019-03-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫調節剤を併用するがんの治療
JP2019513005A (ja) * 2016-02-19 2019-05-23 イマティクス バイオテクノロジーズ ゲーエムベーハー Nhlおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
JP2021035361A (ja) * 2016-02-19 2021-03-04 イマティクス バイオテクノロジーズ ゲーエムベーハー Nhlおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
JP2022545191A (ja) * 2019-08-29 2022-10-26 バイオノックス インコーポレイテッド 活性成分としてワクシニアウイルス及び顆粒球生成阻害剤を含む、がん治療用医薬組成物
US12059444B2 (en) 2017-01-09 2024-08-13 Replimune Limited Altered virus

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016217B1 (ru) 2005-12-02 2012-03-30 Маунт Синай Скул Оф Медсин Химерные вирусы, представляющие неприродные поверхностные белки, и их применение
HRP20170908T1 (hr) 2008-12-09 2017-09-22 F. Hoffmann - La Roche Ag Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice
EP2987856B1 (en) 2009-02-05 2018-07-25 Icahn School of Medicine at Mount Sinai Chimeric newcastle disease viruses and uses thereof
EP4663241A2 (en) 2010-10-08 2025-12-17 Mesoblast International Sàrl Enhanced msc preparations
AU2013214776B2 (en) 2012-02-02 2017-11-09 Board Of Regents, The University Of Texas System Adenoviruses expressing heterologous tumor-associated antigens
WO2013131050A1 (en) * 2012-03-02 2013-09-06 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for differential treatment of cancer
US20150118244A1 (en) * 2012-05-10 2015-04-30 Bristol-Myers Squibb Company Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
KR20210008155A (ko) * 2012-08-30 2021-01-20 암젠 인크 단순 헤르페스 바이러스 및 면역 체크포인트 억제제를 사용한 흑색종의 치료방법
WO2014158811A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Newcastle disease viruses and uses thereof
US9945870B2 (en) 2013-05-17 2018-04-17 The Board Of Trustees Of The Leland Stanford Junior University Methods for determining responsiveness to an anti-CD47 agent
CN104415335A (zh) * 2013-09-02 2015-03-18 北京中康万达医药科技有限公司 体内个体化系统免疫治疗方法和装置
CN106029889A (zh) * 2013-11-22 2016-10-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
SG11201607130RA (en) 2014-02-27 2016-09-29 Viralytics Ltd Combination method for treatment of cancer
EP2942629A1 (en) * 2014-05-08 2015-11-11 Universität Würzburg Predictive markers for successful cancer immunotherapy
US20170115291A1 (en) * 2014-05-28 2017-04-27 Dana-Farber Cancer Institute, Inc. Activating JAK Kinase Biomarkers Predictive of Anti-Immune Checkpoint Inhibitor Response
ES2841075T3 (es) * 2014-10-24 2021-07-07 Calidi Biotherapeutics Inc Enfoque de inmunoterapia de combinación para el tratamiento del cáncer
ES2883249T3 (es) 2015-03-17 2021-12-07 Mayo Found Medical Education & Res Métodos y materiales para evaluar y tratar el cáncer
PH12017502013B1 (en) 2015-05-07 2022-07-22 Agenus Inc Anti-ox40 antibodies and methods of use thereof
EP4015652B1 (en) 2015-06-03 2025-08-06 Aelan Cell Technologies, Inc. Companion methods or il-2-based therapies and mesenchymal stem cell-based therapies
WO2017013421A1 (en) 2015-07-20 2017-01-26 Virttu Biologics Limited Treatment of cancer by infusion of oncolytic herpes simplex virus to the blood
JP6452266B2 (ja) * 2015-07-22 2019-01-16 国立大学法人鳥取大学 ワクシニアウイルスの増殖・伝搬を増強する宿主制御因子
JP6788663B2 (ja) 2015-08-11 2020-11-25 カリディ・バイオセラピューティクス・インコーポレイテッドCalidi Biotherapeutics,Inc. 癌処置のための天然痘ワクチン
WO2017037298A1 (en) 2015-09-04 2017-03-09 Aslan Pharmaceuticals Pte Limited A combination therapy comprising varlitinib and an anticancer agent
WO2017062615A2 (en) * 2015-10-08 2017-04-13 Macrogenics, Inc. Combination therapy for the treatment of cancer
CN106591361A (zh) * 2015-10-20 2017-04-26 钱文斌 一种重组痘溶瘤病毒及其构建方法和应用
WO2017079520A1 (en) * 2015-11-04 2017-05-11 Duke University Combination therapy of immunotoxin and checkpoint inhibitor
SG11201804265XA (en) 2015-12-02 2018-06-28 Agenus Inc Antibodies and methods of use thereof
EP3193173A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Serological autoantibodies as biomarker for colorectal cancer
FI127460B (en) * 2016-01-15 2018-06-29 Targovax Oy Combining adenovirus and chemotherapeutic agents for treating cancer
CN105603085B (zh) * 2016-01-29 2019-01-29 北京泱深生物信息技术有限公司 椎间盘退行性病变的诊治靶标
US20170224796A1 (en) 2016-02-05 2017-08-10 Xeme Biopharma Inc. Therapeutic Cancer Vaccine Containing Tumor-Associated Neoantigens and Immunostimulants in a Delivery System
CN108778301A (zh) * 2016-03-10 2018-11-09 永恒生物科技股份有限公司 通过联合疗法来治疗实体瘤或淋巴瘤的方法
WO2017176289A1 (en) * 2016-04-08 2017-10-12 Celgene Corporation Uses of lenalidomide and car t-cells
GB201608918D0 (en) * 2016-05-20 2016-07-06 Aslan Pharmaceuticals Pte Ltd Method
CN109789177A (zh) * 2016-05-27 2019-05-21 德那翠丝有限公司 腺病毒和免疫调节剂组合治疗
WO2017218757A1 (en) * 2016-06-17 2017-12-21 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
CA3029426A1 (en) 2016-06-30 2018-01-04 Oncorus, Inc. Pseudotyped oncolytic viral delivery of therapeutic polypeptides
US20190185571A1 (en) * 2016-07-28 2019-06-20 Musc Foundation For Research Development Methods and compositions for the treatment of cancer combining an anti-smic antibody and immune checkpoint inhibitors
CA3040194A1 (en) * 2016-10-13 2018-04-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for predicting response and resistance to ctla4 blockade in melanoma using a gene expression signature
EP3534923A4 (en) 2016-11-01 2020-05-27 DNAtrix, Inc. COMBINATION THERAPY FOR THE TREATMENT OF BRAIN CARCINOMAS
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
KR20190112263A (ko) * 2016-12-12 2019-10-04 멀티비르 인코포레이티드 암 및 감염성 질환의 치료 및 예방을 위한 바이러스 유전자 치료요법 및 면역 체크포인트 억제제를 포함하는 방법 및 조성물
CN110650745A (zh) 2016-12-21 2020-01-03 曼珍有限责任公司 武装复制型溶瘤腺病毒
EP4628895A3 (en) 2017-01-13 2025-12-17 Mayo Foundation for Medical Education and Research Materials and methods for treating cancer
CN108341818A (zh) * 2017-01-21 2018-07-31 南京华威医药科技开发有限公司 巴瑞克替尼及其磷酸盐的新晶型及其制备方法
CN108338994A (zh) 2017-01-25 2018-07-31 杭州康万达医药科技有限公司 溶瘤病毒作为用于治疗肿瘤和/或癌症的免疫刺激剂的应用
WO2018148334A1 (en) * 2017-02-08 2018-08-16 Mitra Rxdx, Inc. Method of predicting clinical outcome of anticancer agents
WO2018152095A1 (en) * 2017-02-14 2018-08-23 Celgene Corporation Treatment of cancer with smg1-inhibitors
US11338003B2 (en) 2017-04-14 2022-05-24 Cg Oncology, Inc. Methods of treating bladder cancer with an oncolytic virus
BR112019022488A2 (pt) 2017-04-28 2020-06-16 Merck Sharp & Dohme Corp. Biomarcadores para terapêutica do câncer
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
WO2019102268A1 (en) 2017-11-22 2019-05-31 Mesoblast International Sarl Cellular compositions and methods of treatment i
JP2021508477A (ja) 2017-12-29 2021-03-11 オンコラス, インコーポレイテッド 治療用ポリペプチドの腫瘍溶解性ウイルス送達
WO2019143585A1 (en) * 2018-01-17 2019-07-25 Eli Lilly And Company Compounds and methods targeting interleukin-19
CN108414660B (zh) * 2018-03-08 2020-03-20 中国药科大学 一组与肺癌早期诊断相关的血浆代谢小分子标志物的应用
US12454561B2 (en) 2018-03-19 2025-10-28 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer
CN110527696A (zh) * 2018-06-13 2019-12-03 中山大学 一种IFNβ和FerritinH基因联合修饰的骨髓间充质干细胞及其制备方法和应用
KR102091567B1 (ko) * 2018-06-15 2020-03-20 인하대학교 산학협력단 오스테오폰틴 단백질 단편을 유효성분으로 함유하는 뇌손상 예방 또는 치료용 약학 조성물
CN110755619A (zh) * 2018-07-27 2020-02-07 复旦大学 一种人疱疹病毒裂解复制激活的宿主标志物及其用途
US12391957B2 (en) 2018-08-17 2025-08-19 Icahn School Of Medicine At Mount Sinai Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease
CN108998529A (zh) * 2018-08-30 2018-12-14 上海交通大学医学院附属上海儿童医学中心 肺腺癌检测试剂盒及检测tulp2基因甲基化水平的方法
WO2020047345A1 (en) 2018-08-31 2020-03-05 Yale University Compositions and methods of using cell-penetrating antibodies in combination with immune checkpoint modulators
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CA3116192C (en) * 2018-11-06 2025-09-23 Calidi Biotherapeutics (Nevada), Inc. IMPROVED SYSTEMS FOR CELL-MEDIATED ONCOLYTIC VIRAL THERAPY
CN113906298B (zh) * 2019-03-27 2024-12-20 新加坡保健服务集团有限公司 对腹膜癌扩散具有治疗意义的生物标志物
KR102868516B1 (ko) * 2019-03-28 2025-10-02 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Vsv-ifn베타-nis 종양용해 치료법에서 약역학적 마커로서의 ifn베타
KR102199141B1 (ko) * 2019-05-03 2021-01-06 사회복지법인 삼성생명공익재단 대장암 진단 마커 및 대장암 진단에 필요한 정보를 제공하는 방법
CN114245874A (zh) * 2019-05-24 2022-03-25 艾迪菲斯健康有限公司 用于癌症免疫疗法的精准医学方法
KR20220038485A (ko) 2019-08-05 2022-03-28 메조블라스트 인터내셔널 에스에이알엘 바이러스 벡터를 포함하는 세포 조성물 및 치료 방법
CN110687281B (zh) * 2019-08-26 2023-05-23 中国医学科学院肿瘤医院 Pd-l1自身抗体在肿瘤预后评估中的应用
WO2021061775A1 (en) * 2019-09-23 2021-04-01 Sillajen, Inc. Immune assay for monitoring response to oncolytic vaccinia virus and uses thereof
CN111337678B (zh) * 2020-02-21 2023-06-06 杭州凯保罗生物科技有限公司 与肿瘤免疫治疗效果相关的生物标志物及其应用
WO2021206766A1 (en) 2020-04-09 2021-10-14 Children's Hospital Medical Center Sars-cov-2 infection biomarkers and uses thereof
US11324750B2 (en) 2020-04-09 2022-05-10 Children's Hospital Medical Center Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
KR102628046B1 (ko) * 2020-05-08 2024-01-23 주식회사 루닛 면역 항암제에 대한 반응을 예측하는 방법 및 시스템
WO2021225422A1 (ko) * 2020-05-08 2021-11-11 주식회사 루닛 병리 슬라이드 이미지에 대한 면역 표현형과 연관된 정보를 제공하는 방법 및 장치
JP7730487B2 (ja) 2020-05-08 2025-08-28 ルニット インコーポレイテッド 免疫抗癌剤に対する反応を予測する方法及びシステム
CN111579788A (zh) * 2020-05-29 2020-08-25 郑州大学 一种高灵敏肿瘤标志物EPHA2的Simoa试剂盒及其应用
US20230293590A1 (en) 2020-08-10 2023-09-21 Mesoblast International Sárl Cellular compositions and methods of treatment
CN116322728A (zh) * 2020-08-14 2023-06-23 上海行深生物科技有限公司 水疱性口炎病毒及其治疗用途
CN112345755B (zh) * 2020-09-23 2023-06-16 杭州凯保罗生物科技有限公司 乳腺癌的生物标志物及其应用
KR102710867B1 (ko) * 2020-12-18 2024-09-27 (주)인비보텍 Oligodendrocyte transcription factor 2 억제제를 유효성분으로 포함하는 흑색종 치료 효과 증진용 약학적 조성물
WO2022140576A1 (en) * 2020-12-22 2022-06-30 The Brigham And Women's Hospital, Inc. Blood-based protein biomarker panel for early and accurate detection of cancer
CN114764101B (zh) * 2021-01-25 2025-08-08 武汉大学中南医院 一种确定具有gbm预后价值的血液炎症标志物的方法及gbm生存率计算系统
EP4444873A1 (en) * 2021-12-06 2024-10-16 ElevateBio Technologies, Inc. Compositions and methods of seneca valley virus (svv) related cancer therapy
AU2023361162A1 (en) 2022-10-11 2025-05-29 Yale University Compositions and methods of using cell-penetrating antibodies
CN115948557B (zh) * 2023-01-04 2025-09-02 陕西师范大学 一种nlrp2作为靶点在卵巢癌疾病诊断和/或治疗中的应用
WO2025067288A1 (en) * 2023-09-28 2025-04-03 Huashan Hospital, Fudan University Combination for treating glioma

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501445A (ja) * 1999-06-08 2003-01-14 ユーエイビー リサーチ ファンデーション 外来遺伝子を発現するヘルペス単純ウイルスおよびそれによる癌の治療方法
WO2005094867A1 (ja) * 2004-03-31 2005-10-13 Tomoki Todo ウイルス療法の抗癌作用増強剤、癌の予防または治療方法
JP2009504687A (ja) * 2005-08-31 2009-02-05 オンコリティクス バイオテク,インコーポレーテッド 新生物に関する免疫系による認識のインビボでの増強のための、腫瘍崩壊ウイルスおよび免疫賦活剤による処置
WO2010072900A1 (en) * 2008-12-22 2010-07-01 Oncos Therapeutics Oncolytic adenoviral vectors and methods and uses related thereto
WO2010135242A1 (en) * 2009-05-19 2010-11-25 Eden Pharmaceuticals, Inc. Combinations of immunostimulatory agents, oncolytic virus, and additional anticancer therapy
WO2011134670A2 (en) * 2010-04-30 2011-11-03 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechtes Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5981725A (en) 1989-09-08 1999-11-09 The Johns Hopkins Univiersity Structural alterations of the EGF receptor gene in human tumors
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
WO1996017053A1 (en) 1994-11-28 1996-06-06 Genetic Therapy, Inc. Vectors for tissue-specific replication
JPH11503910A (ja) 1995-04-17 1999-04-06 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム アデノウイルスヘルパーウイルスシステム
US20030026789A1 (en) 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
US6080578A (en) 1996-12-31 2000-06-27 Onyx Pharmaceuticals, Inc. Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia
US6403370B1 (en) 1997-02-10 2002-06-11 Genstar Therapeutics Corporation Oncolytic/immunogenic complementary-adenoviral vector system
JP2002514075A (ja) 1997-03-03 2002-05-14 セル ジェネシス,インコーポレイティド 癌胎児性抗原を発現する細胞に特異的なアデノウイルスベクターおよびその使用方法
US6096718A (en) 1997-06-05 2000-08-01 Gene Targeting Corp. Tissue specific adenovirus vectors for breast cancer treatment
EP1131458A1 (en) 1998-11-18 2001-09-12 CANJI, Inc. Viral vectors with late transgene expression
GB9906815D0 (en) 1999-03-24 1999-05-19 Isrec Anti-neoplastic viral agents
AU767904B2 (en) 1999-05-12 2003-11-27 Uab Research Foundation, The Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
US20040175362A1 (en) 1999-05-12 2004-09-09 Curiel David T. Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
WO2001023004A1 (en) 1999-09-30 2001-04-05 The Trustees Of The University Of Pennsylvania Replication selective adenoviruses for use in cancer therapy
CA2386626A1 (en) 1999-10-15 2001-04-26 Richard Murphy Targeted vectors
US6756044B1 (en) 2000-02-09 2004-06-29 Genvec, Inc. Antigenic complexes and methods
WO2001058940A2 (en) 2000-02-09 2001-08-16 Genvec, Inc. Adenoviral capsid containing chimeric protein ix
US20030138405A1 (en) 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways
US20030211477A1 (en) 2002-04-05 2003-11-13 Holmes Kathryn V. Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) structure and uses thereof in drug identification and screening
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
EP3679951A1 (en) 2003-06-27 2020-07-15 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
US20070134202A1 (en) 2003-10-15 2007-06-14 The New Industry Reserch Organization Cancer gene therapeutic drug
AU2005262164A1 (en) 2004-07-13 2006-01-19 The University Of British Columbia Indoleamine 2,3-dioxygenase (IDO) inhibitors
CA2606809C (en) 2005-05-06 2016-01-05 Providence Health System Trimeric ox40-immunoglobulin fusion protein and methods of use
RS54271B1 (sr) * 2005-07-01 2016-02-29 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1)
WO2007103825A2 (en) * 2006-03-02 2007-09-13 The Board Of Regents Of The University Of Texas System Combination therapy with oncolytic adenovirus
WO2009117656A2 (en) 2008-03-21 2009-09-24 Vectorlogics,Inc. Capsid-incorporated antigen for novel adenovirus vaccine
CN102203132A (zh) * 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂的组合物和使用方法
CN101607985B (zh) 2008-12-24 2013-03-27 中国科学院生物物理研究所 抗人cea的单克隆抗体,包含其的组合物,及其用途
PL2429574T3 (pl) 2009-05-15 2015-12-31 Univ Health Network Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie SIRP-CD47
EP2266588A1 (en) * 2009-06-04 2010-12-29 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Method for cancer therapy based on co-administration of a parovirus and a cytokine
PL2482849T3 (pl) * 2009-09-30 2018-11-30 Memorial Sloan-Kettering Cancer Center Skojarzona immunoterapia w leczeniu nowotworu
JP2013512251A (ja) * 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Pd−l1/pd−l2の同時阻害
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
EP2407177A1 (en) 2010-07-13 2012-01-18 Institut Gustave Roussy Adenovirus vaccine vectors
WO2011140284A2 (en) 2010-05-04 2011-11-10 Fred Hutchinson Cancer Research Center Conditional superagonist ctl ligands for the promotion of tumor-specific ctl responses
AU2012290121B2 (en) 2011-08-01 2015-11-26 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
WO2013043569A1 (en) * 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
AU2013214776B2 (en) 2012-02-02 2017-11-09 Board Of Regents, The University Of Texas System Adenoviruses expressing heterologous tumor-associated antigens
PL3010519T3 (pl) 2013-06-18 2021-09-27 Dnatrix, Inc. Adenowirus onkolityczny do zastosowania w leczeniu nowotworu mózgu

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501445A (ja) * 1999-06-08 2003-01-14 ユーエイビー リサーチ ファンデーション 外来遺伝子を発現するヘルペス単純ウイルスおよびそれによる癌の治療方法
WO2005094867A1 (ja) * 2004-03-31 2005-10-13 Tomoki Todo ウイルス療法の抗癌作用増強剤、癌の予防または治療方法
JP2009504687A (ja) * 2005-08-31 2009-02-05 オンコリティクス バイオテク,インコーポレーテッド 新生物に関する免疫系による認識のインビボでの増強のための、腫瘍崩壊ウイルスおよび免疫賦活剤による処置
WO2010072900A1 (en) * 2008-12-22 2010-07-01 Oncos Therapeutics Oncolytic adenoviral vectors and methods and uses related thereto
WO2010135242A1 (en) * 2009-05-19 2010-11-25 Eden Pharmaceuticals, Inc. Combinations of immunostimulatory agents, oncolytic virus, and additional anticancer therapy
WO2011134670A2 (en) * 2010-04-30 2011-11-03 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechtes Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CANCER RES., vol. 67, no. 24, JPN6016049678, 2007, pages 11499 - 11504, ISSN: 0003652225 *
CLINICAL BIOCHEMISTRY, vol. Vol.42, No.10-11, JPN6016049692, 2009, pages 1144 - 1157, ISSN: 0003652224 *
CURRENT GENE THERAPY, vol. 9, no. 5, JPN6016049681, 2009, pages 422 - 427, ISSN: 0003836745 *
INT. J. CANCER, vol. 121, no. 1, JPN6016049688, 2007, pages 95 - 105, ISSN: 0003652229 *
MOLECULAR THERAPY, vol. 19, no. 9, JPN6016049685, 2011, pages 1737 - 1746, ISSN: 0003652228 *
MURPHY K.ほか著, 笹月健彦 監訳, 免疫生物学(原書第7版), JPN6016049682, 2010, pages 427 - 429, ISSN: 0003652227 *
NEURO ONCOLOGY, vol. 13, JPN6016049694, 2011, pages 30 - 33, ISSN: 0003652226 *
REVUE NEUROLOGIQUE, vol. 167, no. 10, JPN6016049690, 2011, pages 668 - 672, ISSN: 0003652230 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10744170B2 (en) 2015-10-15 2020-08-18 Duke University Combination treatment
JP2018530584A (ja) * 2015-10-15 2018-10-18 デューク ユニバーシティー 併用療法
JP2022183342A (ja) * 2015-10-15 2022-12-08 デューク ユニバーシティー 併用療法
JP2020183447A (ja) * 2015-10-15 2020-11-12 デューク ユニバーシティー 併用療法
US12024724B2 (en) 2016-01-08 2024-07-02 Replimune Limited Oncolytic virus strain
JP7295192B2 (ja) 2016-01-08 2023-06-20 レプリミュン リミテッド 改変された腫瘍溶解性ウイルス
US12465639B2 (en) 2016-01-08 2025-11-11 Replimune Limited GB Modified oncolytic virus
US12458696B2 (en) 2016-01-08 2025-11-04 Replimune Limited Modified oncolytic virus
JP2022002531A (ja) * 2016-01-08 2022-01-11 レプリミュン リミテッド 改変された腫瘍溶解性ウイルス
US12397053B2 (en) 2016-01-08 2025-08-26 Replimune Limited Engineered virus
US12049647B2 (en) 2016-01-08 2024-07-30 Replimune Limited Engineered virus
US11427810B2 (en) 2016-01-08 2022-08-30 Replimune Limited Modified oncolytic virus
US11473063B2 (en) 2016-01-08 2022-10-18 Replimune Limited Oncolytic virus strain
JP2019501670A (ja) * 2016-01-08 2019-01-24 レプリミュン リミテッド 改変された腫瘍溶解性ウイルス
JP2023113885A (ja) * 2016-01-08 2023-08-16 レプリミュン リミテッド 改変された腫瘍溶解性ウイルス
JP7026047B2 (ja) 2016-01-21 2022-02-25 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫調節剤を併用するがんの治療
JP2023085370A (ja) * 2016-01-21 2023-06-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫調節剤を併用するがんの治療
JP2019506400A (ja) * 2016-01-21 2019-03-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫調節剤を併用するがんの治療
JP2022033899A (ja) * 2016-01-21 2022-03-02 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 免疫調節剤を併用するがんの治療
JP2019513005A (ja) * 2016-02-19 2019-05-23 イマティクス バイオテクノロジーズ ゲーエムベーハー Nhlおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
JP2021040627A (ja) * 2016-02-19 2021-03-18 イマティクス バイオテクノロジーズ ゲーエムベーハー Nhlおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
JP2021035361A (ja) * 2016-02-19 2021-03-04 イマティクス バイオテクノロジーズ ゲーエムベーハー Nhlおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
US12059444B2 (en) 2017-01-09 2024-08-13 Replimune Limited Altered virus
JP2022545191A (ja) * 2019-08-29 2022-10-26 バイオノックス インコーポレイテッド 活性成分としてワクシニアウイルス及び顆粒球生成阻害剤を含む、がん治療用医薬組成物

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