JP2015505245A - 川崎病のためのバイオマーカー - Google Patents

川崎病のためのバイオマーカー Download PDF

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JP2015505245A
JP2015505245A JP2014550413A JP2014550413A JP2015505245A JP 2015505245 A JP2015505245 A JP 2015505245A JP 2014550413 A JP2014550413 A JP 2014550413A JP 2014550413 A JP2014550413 A JP 2014550413A JP 2015505245 A JP2015505245 A JP 2015505245A
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pdgfc
expression
subject
rna
sample
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JP2015505245A5 (enExample
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バージニア エム. パスクアル
バージニア エム. パスクアル
チャオホイ スー
チャオホイ スー
オクタビオ ラミーロ
オクタビオ ラミーロ
ローランド チマズ
ローランド チマズ
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Baylor Research Institute
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C12Q2600/158Expression markers
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/49Platelet-derived growth factor [PDGF]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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JP2014550413A 2011-12-29 2012-12-21 川崎病のためのバイオマーカー Pending JP2015505245A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161581199P 2011-12-29 2011-12-29
US61/581,199 2011-12-29
PCT/US2012/071360 WO2013101758A1 (en) 2011-12-29 2012-12-21 Biomarkers for kawasaki disease

Publications (2)

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JP2015505245A true JP2015505245A (ja) 2015-02-19
JP2015505245A5 JP2015505245A5 (enExample) 2016-02-12

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JP2014550413A Pending JP2015505245A (ja) 2011-12-29 2012-12-21 川崎病のためのバイオマーカー

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US (1) US20140348818A1 (enExample)
EP (1) EP2798081A1 (enExample)
JP (1) JP2015505245A (enExample)
KR (1) KR20140108718A (enExample)
CN (1) CN104160039B (enExample)
CA (1) CA2862270A1 (enExample)
WO (1) WO2013101758A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020502541A (ja) * 2016-11-11 2020-01-23 アセンダント ディーエックス, エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3137907A4 (en) * 2014-05-02 2018-02-28 Momenta Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of kawasaki disease
CN104450901B (zh) * 2014-11-27 2016-09-21 广州赛哲生物科技股份有限公司 快速诊断川崎病的核酸标记物及其试剂盒
JP6153239B2 (ja) * 2015-02-10 2017-06-28 公立大学法人横浜市立大学 川崎病の検査方法およびキット
CN105112552B (zh) * 2015-09-28 2018-02-27 北京泱深生物信息技术有限公司 Ift52基因在骨质疏松症诊断中的应用
CN106636413B (zh) * 2016-12-28 2019-07-16 常州市第二人民医院 一种用于诊断哮喘的分子标志物
CN106701962B (zh) * 2016-12-28 2020-07-28 广州赛哲生物科技股份有限公司 用于川崎病检测的引物组、探针及试剂盒
CN110824173B (zh) * 2019-11-27 2022-09-02 中国人民解放军陆军军医大学第一附属医院 促血管生成因子pdgfc在作为诊断和治疗肝肺综合征的标志物中的应用
WO2025077406A1 (zh) * 2023-10-11 2025-04-17 中国医学科学院北京协和医院 一种新生物标志物在诊断或辅助诊断spn中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US7192584B2 (en) * 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US5286623A (en) * 1991-11-26 1994-02-15 National Jewish Center For Immunology And Respiratory Medicine Method for screening for Kawasaki disease
US5279721A (en) 1993-04-22 1994-01-18 Peter Schmid Apparatus and method for an automated electrophoresis system
ATE507240T1 (de) * 2004-03-05 2011-05-15 Vegenics Pty Ltd Materialien und verfahren für wachstumsfaktorbindende konstrukte
SG157299A1 (en) * 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
WO2010025393A2 (en) 2008-08-28 2010-03-04 The Regents Of The University Of California Protein biomarkers and methods for diagnosing kawasaki disease
CA2766403A1 (en) * 2009-07-13 2011-01-20 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6016037913; 日本臨床免疫学会会誌 Vol.25, No.5, 2002, p.412 *
JPN6016037915; Experimental Cell Research Vol.314, No.14, 2008, pp.2529-2543 *
JPN6016037917; 小児科臨床 Vol.44, No.7, 1991, pp.2041-2043 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020502541A (ja) * 2016-11-11 2020-01-23 アセンダント ディーエックス, エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
JP2022110148A (ja) * 2016-11-11 2022-07-28 アセンダント ディーエックス, エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
JP7132233B2 (ja) 2016-11-11 2022-09-06 アセンダント ディーエックス, エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
US11448648B2 (en) 2016-11-11 2022-09-20 Ascendant Diagnostics, LLC Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and Kawasaki disease

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Publication number Publication date
WO2013101758A1 (en) 2013-07-04
US20140348818A1 (en) 2014-11-27
KR20140108718A (ko) 2014-09-12
CN104160039B (zh) 2021-08-03
CN104160039A (zh) 2014-11-19
EP2798081A1 (en) 2014-11-05
CA2862270A1 (en) 2013-07-04

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