JP2015505245A5 - - Google Patents
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- JP2015505245A5 JP2015505245A5 JP2014550413A JP2014550413A JP2015505245A5 JP 2015505245 A5 JP2015505245 A5 JP 2015505245A5 JP 2014550413 A JP2014550413 A JP 2014550413A JP 2014550413 A JP2014550413 A JP 2014550413A JP 2015505245 A5 JP2015505245 A5 JP 2015505245A5
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- 102100040681 Platelet-derived growth factor C Human genes 0.000 claims description 71
- 108010017992 platelet-derived growth factor C Proteins 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 55
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- 101000683584 Homo sapiens Ribosome-binding protein 1 Proteins 0.000 claims description 7
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- 102100024643 ATP-binding cassette sub-family D member 1 Human genes 0.000 claims description 6
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- 102000013601 Fanconi Anemia Complementation Group D2 protein Human genes 0.000 claims description 6
- 108010026653 Fanconi Anemia Complementation Group D2 protein Proteins 0.000 claims description 6
- 102100035340 Guanine nucleotide-binding protein subunit beta-4 Human genes 0.000 claims description 6
- 102100022191 Hemogen Human genes 0.000 claims description 6
- 102100028902 Hermansky-Pudlak syndrome 1 protein Human genes 0.000 claims description 6
- 101000929319 Homo sapiens Actin, aortic smooth muscle Proteins 0.000 claims description 6
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- 101000595802 Homo sapiens Phospholipase A and acyltransferase 2 Proteins 0.000 claims description 6
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- 101000933542 Homo sapiens Transcription factor BTF3 Proteins 0.000 claims description 6
- 101000663031 Homo sapiens Transmembrane and coiled-coil domains protein 1 Proteins 0.000 claims description 6
- 102100036480 Interferon-related developmental regulator 2 Human genes 0.000 claims description 6
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- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims description 6
- 108010050345 Microphthalmia-Associated Transcription Factor Proteins 0.000 claims description 6
- 102000013760 Microphthalmia-Associated Transcription Factor Human genes 0.000 claims description 6
- 102100039840 Mitochondrial inner membrane protease subunit 2 Human genes 0.000 claims description 6
- 102100036067 Phospholipase A and acyltransferase 2 Human genes 0.000 claims description 6
- 102100030432 Polyubiquitin-B Human genes 0.000 claims description 6
- 102100035542 Regulator of cell cycle RGCC Human genes 0.000 claims description 6
- 108091006702 SLC24A4 Proteins 0.000 claims description 6
- 102100029289 Serine/arginine-rich splicing factor 8 Human genes 0.000 claims description 6
- 102100029946 Sialic acid-binding Ig-like lectin 7 Human genes 0.000 claims description 6
- 102100032003 Sodium/potassium/calcium exchanger 4 Human genes 0.000 claims description 6
- 101710113279 Solute carrier family 49 member A3 Proteins 0.000 claims description 6
- 102100021482 Solute carrier family 49 member A3 Human genes 0.000 claims description 6
- 102100037718 Transmembrane and coiled-coil domains protein 1 Human genes 0.000 claims description 6
- 108010035632 ornithine decarboxylase antizyme inhibitor Proteins 0.000 claims description 6
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims description 5
- 208000006820 Arthralgia Diseases 0.000 claims description 5
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 claims description 5
- 206010049047 Chapped lips Diseases 0.000 claims description 5
- 102100032396 Coiled-coil domain-containing protein 24 Human genes 0.000 claims description 5
- 102100025849 Complement C1q subcomponent subunit C Human genes 0.000 claims description 5
- 102100028572 Disabled homolog 2 Human genes 0.000 claims description 5
- 208000010201 Exanthema Diseases 0.000 claims description 5
- 102100040130 FH1/FH2 domain-containing protein 1 Human genes 0.000 claims description 5
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims description 5
- 101000610215 Homo sapiens Adenylyl-sulfate kinase Proteins 0.000 claims description 5
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims description 5
- 101000868756 Homo sapiens Coiled-coil domain-containing protein 24 Proteins 0.000 claims description 5
- 101000933636 Homo sapiens Complement C1q subcomponent subunit C Proteins 0.000 claims description 5
- 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 claims description 5
- 101000890761 Homo sapiens FH1/FH2 domain-containing protein 1 Proteins 0.000 claims description 5
- 101001120760 Homo sapiens Olfactomedin-4 Proteins 0.000 claims description 5
- 101001072881 Homo sapiens Phosphoglucomutase-like protein 5 Proteins 0.000 claims description 5
- 101000830710 Homo sapiens Torsin-4A Proteins 0.000 claims description 5
- 206010024570 Lip swelling Diseases 0.000 claims description 5
- 102100026071 Olfactomedin-4 Human genes 0.000 claims description 5
- 102100036635 Phosphoglucomutase-like protein 5 Human genes 0.000 claims description 5
- 206010037660 Pyrexia Diseases 0.000 claims description 5
- 102100024605 Torsin-4A Human genes 0.000 claims description 5
- 206010046851 Uveitis Diseases 0.000 claims description 5
- 206010047115 Vasculitis Diseases 0.000 claims description 5
- 208000006331 coronary aneurysm Diseases 0.000 claims description 5
- 231100000321 erythema Toxicity 0.000 claims description 5
- 201000005884 exanthem Diseases 0.000 claims description 5
- 210000004013 groin Anatomy 0.000 claims description 5
- 201000003265 lymphadenitis Diseases 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 206010037844 rash Diseases 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- 102100040529 CKLF-like MARVEL transmembrane domain-containing protein 4 Human genes 0.000 claims description 4
- 101000749431 Homo sapiens CKLF-like MARVEL transmembrane domain-containing protein 4 Proteins 0.000 claims description 4
- 208000011200 Kawasaki disease Diseases 0.000 claims description 4
- 210000004904 fingernail bed Anatomy 0.000 claims description 4
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims description 4
- 201000005111 ocular hyperemia Diseases 0.000 claims description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 3
- 102100031351 Galectin-9 Human genes 0.000 claims description 3
- 102100033636 Histone H3.2 Human genes 0.000 claims description 3
- 101001130151 Homo sapiens Galectin-9 Proteins 0.000 claims description 3
- 101000871895 Homo sapiens Histone H3.2 Proteins 0.000 claims description 3
- 101000609261 Homo sapiens Plasminogen activator inhibitor 2 Proteins 0.000 claims description 3
- 101000814373 Homo sapiens Protein wntless homolog Proteins 0.000 claims description 3
- 101000759241 Homo sapiens Zinc finger protein 138 Proteins 0.000 claims description 3
- 102100039419 Plasminogen activator inhibitor 2 Human genes 0.000 claims description 3
- 102100039471 Protein wntless homolog Human genes 0.000 claims description 3
- 102100023394 Zinc finger protein 138 Human genes 0.000 claims description 3
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 3
- 239000003246 corticosteroid Substances 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 208000006740 Aseptic Meningitis Diseases 0.000 claims description 2
- 101001082584 Homo sapiens Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 Proteins 0.000 claims description 2
- 206010027201 Meningitis aseptic Diseases 0.000 claims description 2
- 102100030480 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 Human genes 0.000 claims description 2
- 206010040844 Skin exfoliation Diseases 0.000 claims description 2
- 238000007899 nucleic acid hybridization Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 238000003757 reverse transcription PCR Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100030695 Electron transfer flavoprotein subunit alpha, mitochondrial Human genes 0.000 claims 3
- 101001010541 Homo sapiens Electron transfer flavoprotein subunit alpha, mitochondrial Proteins 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100022033 Presenilin-1 Human genes 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 description 11
- 206010023232 Joint swelling Diseases 0.000 description 3
- 201000009906 Meningitis Diseases 0.000 description 2
- 238000013500 data storage Methods 0.000 description 2
- 108010054404 Adenylyl-sulfate kinase Proteins 0.000 description 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161581199P | 2011-12-29 | 2011-12-29 | |
| US61/581,199 | 2011-12-29 | ||
| PCT/US2012/071360 WO2013101758A1 (en) | 2011-12-29 | 2012-12-21 | Biomarkers for kawasaki disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015505245A JP2015505245A (ja) | 2015-02-19 |
| JP2015505245A5 true JP2015505245A5 (enExample) | 2016-02-12 |
Family
ID=47459205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550413A Pending JP2015505245A (ja) | 2011-12-29 | 2012-12-21 | 川崎病のためのバイオマーカー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140348818A1 (enExample) |
| EP (1) | EP2798081A1 (enExample) |
| JP (1) | JP2015505245A (enExample) |
| KR (1) | KR20140108718A (enExample) |
| CN (1) | CN104160039B (enExample) |
| CA (1) | CA2862270A1 (enExample) |
| WO (1) | WO2013101758A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015168602A2 (en) * | 2014-05-02 | 2015-11-05 | Momenta Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of kawasaki disease |
| CN104450901B (zh) * | 2014-11-27 | 2016-09-21 | 广州赛哲生物科技股份有限公司 | 快速诊断川崎病的核酸标记物及其试剂盒 |
| WO2016129631A1 (ja) * | 2015-02-10 | 2016-08-18 | 公立大学法人横浜市立大学 | 川崎病の検査方法およびキット |
| CN105112552B (zh) * | 2015-09-28 | 2018-02-27 | 北京泱深生物信息技术有限公司 | Ift52基因在骨质疏松症诊断中的应用 |
| US11448648B2 (en) | 2016-11-11 | 2022-09-20 | Ascendant Diagnostics, LLC | Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and Kawasaki disease |
| CN106636413B (zh) * | 2016-12-28 | 2019-07-16 | 常州市第二人民医院 | 一种用于诊断哮喘的分子标志物 |
| CN106701962B (zh) * | 2016-12-28 | 2020-07-28 | 广州赛哲生物科技股份有限公司 | 用于川崎病检测的引物组、探针及试剂盒 |
| CN110824173B (zh) * | 2019-11-27 | 2022-09-02 | 中国人民解放军陆军军医大学第一附属医院 | 促血管生成因子pdgfc在作为诊断和治疗肝肺综合征的标志物中的应用 |
| WO2025077407A1 (zh) * | 2023-10-11 | 2025-04-17 | 中国医学科学院北京协和医院 | 一种诊断或辅助诊断spn试剂盒的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US5286623A (en) * | 1991-11-26 | 1994-02-15 | National Jewish Center For Immunology And Respiratory Medicine | Method for screening for Kawasaki disease |
| US5279721A (en) | 1993-04-22 | 1994-01-18 | Peter Schmid | Apparatus and method for an automated electrophoresis system |
| US7422741B2 (en) * | 2004-03-05 | 2008-09-09 | Vegenics Limited | VEGFR-3 fusion proteins |
| SG157299A1 (en) * | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| WO2010025393A2 (en) | 2008-08-28 | 2010-03-04 | The Regents Of The University Of California | Protein biomarkers and methods for diagnosing kawasaki disease |
| SG177640A1 (en) * | 2009-07-13 | 2012-02-28 | Genentech Inc | Diagnostic methods and compositions for treatment of cancer |
-
2012
- 2012-12-21 WO PCT/US2012/071360 patent/WO2013101758A1/en not_active Ceased
- 2012-12-21 CA CA2862270A patent/CA2862270A1/en not_active Abandoned
- 2012-12-21 EP EP12808661.8A patent/EP2798081A1/en not_active Withdrawn
- 2012-12-21 CN CN201280070975.0A patent/CN104160039B/zh active Active
- 2012-12-21 US US14/362,857 patent/US20140348818A1/en not_active Abandoned
- 2012-12-21 JP JP2014550413A patent/JP2015505245A/ja active Pending
- 2012-12-21 KR KR1020147021229A patent/KR20140108718A/ko not_active Withdrawn
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