JP2015502991A5 - - Google Patents
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- JP2015502991A5 JP2015502991A5 JP2014539909A JP2014539909A JP2015502991A5 JP 2015502991 A5 JP2015502991 A5 JP 2015502991A5 JP 2014539909 A JP2014539909 A JP 2014539909A JP 2014539909 A JP2014539909 A JP 2014539909A JP 2015502991 A5 JP2015502991 A5 JP 2015502991A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composite hydrogel
- hydrogel according
- bioactive agent
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000017 hydrogel Substances 0.000 claims 33
- 239000002131 composite material Substances 0.000 claims 32
- 229920000642 polymer Polymers 0.000 claims 17
- 239000012867 bioactive agent Substances 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- -1 aliphatic amino acid Chemical class 0.000 claims 4
- 150000003862 amino acid derivatives Chemical class 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 229920006318 anionic polymer Polymers 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- BEWCSNDRHAIGAY-BYPYZUCNSA-N (2s)-2-amino-4-methyltellanylbutanoic acid Chemical compound C[Te]CC[C@H](N)C(O)=O BEWCSNDRHAIGAY-BYPYZUCNSA-N 0.000 claims 1
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 claims 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- NPSWHDAHNWWMEG-UHFFFAOYSA-N 2-aminohex-5-enoic acid Chemical compound OC(=O)C(N)CCC=C NPSWHDAHNWWMEG-UHFFFAOYSA-N 0.000 claims 1
- SCGJGNWMYSYORS-UHFFFAOYSA-N 2-azaniumylhex-5-ynoate Chemical compound OC(=O)C(N)CCC#C SCGJGNWMYSYORS-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 claims 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 claims 1
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- NUXSIDPKKIEIMI-LURJTMIESA-N N(6)-carboxymethyl-L-lysine Chemical compound OC(=O)[C@@H](N)CCCCNCC(O)=O NUXSIDPKKIEIMI-LURJTMIESA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- BKGWACHYAMTLAF-BYPYZUCNSA-N l-thiocitrulline Chemical compound OC(=O)[C@@H](N)CCC\N=C(/N)S BKGWACHYAMTLAF-BYPYZUCNSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 229960002718 selenomethionine Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229940026510 theanine Drugs 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2011081783 | 2011-11-04 | ||
| SG201108178-3 | 2011-11-04 | ||
| PCT/SG2012/000421 WO2013066274A1 (en) | 2011-11-04 | 2012-11-05 | Self-assembled composite ultrasmall peptide-polymer hydrogels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502991A JP2015502991A (ja) | 2015-01-29 |
| JP2015502991A5 true JP2015502991A5 (https=) | 2015-12-24 |
| JP6143269B2 JP6143269B2 (ja) | 2017-06-07 |
Family
ID=54256948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539909A Expired - Fee Related JP6143269B2 (ja) | 2011-11-04 | 2012-11-05 | 自己組織化複合超小型ペプチドポリマーヒドロゲル |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10449257B2 (https=) |
| EP (1) | EP2773696B1 (https=) |
| JP (1) | JP6143269B2 (https=) |
| SG (1) | SG11201401964TA (https=) |
| WO (1) | WO2013066274A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8999916B2 (en) | 2010-03-31 | 2015-04-07 | Agency For Science, Technology And Research | Crosslinked peptide hydrogels |
| US9687591B2 (en) * | 2010-03-31 | 2017-06-27 | Agency For Science, Technology And Research | Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes |
| SG184345A1 (en) | 2010-03-31 | 2012-11-29 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| WO2013066274A1 (en) | 2011-11-04 | 2013-05-10 | Agency For Science, Technology And Research | Self-assembled composite ultrasmall peptide-polymer hydrogels |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| SG2012096699A (en) | 2012-12-31 | 2014-07-30 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| EP2958933B1 (en) * | 2013-01-28 | 2018-08-22 | Agency For Science, Technology And Research | Crosslinked peptide hydrogels |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| EP3057617B1 (en) * | 2013-10-18 | 2020-04-01 | Agency For Science, Technology And Research | Nanoparticle-containing hydrogels |
| BR112016012230A2 (pt) * | 2013-11-30 | 2017-08-08 | Agency Science Tech & Res | Peptídeo hidrofóbico e/ou peptídeo-mimético, capaz de formar um hidrogel; composição ou mistura; hidrogel; uso do hidrogel; método para preparar um hidrogel; curativo de ferida ou agente cicatrizante de ferida; implante cirúrgico; composição cosmética e/ou farmacêutica e/ou um dispositivo biomédico e/ou dispositivo eletrônico; kit de peças; método in vitro ou in vivo de regeneração de tecido; método de tratamento de uma ferida e para cicatrização de ferida; dispositivo de bioimagem; e; substrato de cultura da célula 2d ou 3d |
| HK1225745A1 (zh) * | 2013-11-30 | 2017-09-15 | 新加坡科技研究局 | 自组装肽、肽模拟物和肽缀合物作为构件用於生物制造和打印 |
| JP6301136B2 (ja) * | 2014-01-22 | 2018-03-28 | コンビ株式会社 | ポリアミンを有効成分とする、軟骨組織の再生を促進するための組成物 |
| EP3167277A4 (en) * | 2014-07-08 | 2018-03-07 | Agency For Science, Technology And Research | Ultrashort peptides as exogenous second harmonic probes for bioimaging applications |
| FR3038318B1 (fr) * | 2015-07-02 | 2017-08-04 | Univ De Lille 1 Sciences Et Technologies | Procede de fabrication d'hydrogel a base de chitosan et de polyelectrolytes charges negativement et materiau poreux alveolaire issu dudit hydrogel |
| KR101912826B1 (ko) * | 2016-10-25 | 2018-10-30 | 한국생산기술연구원 | 특정분자 친화력을 갖는 하이드로겔 및 이를 이용한 하이드로겔의 부피 조절 방법 |
| US20180214476A1 (en) * | 2017-02-01 | 2018-08-02 | North Carolina State University | Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation |
| KR102418307B1 (ko) * | 2017-05-11 | 2022-07-06 | 킹 압둘라 유니버시티 오브 사이언스 앤드 테크놀로지 | 미세유체공학-기반 3d 바이오프린팅용 장치 및 방법 |
| JP7326161B2 (ja) | 2017-05-11 | 2023-08-15 | キング アブドラ ユニバーシティ オブ サイエンス アンド テクノロジー | 組織エンジニアリングおよびバイオプリンティングにおける使用のためのゲルを形成し得るペプチド |
| CN107043467B (zh) * | 2017-06-02 | 2020-06-19 | 东华大学 | 一种可光交联水凝胶及其制备方法 |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| US11839661B2 (en) | 2017-08-15 | 2023-12-12 | Brandeis University | Rapid formation of supramolecular hydrogels by short peptide and bioactive small molecules |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| CN109554331B (zh) * | 2017-09-27 | 2022-09-27 | 清华大学 | L-核酸水凝胶 |
| CN108992670B (zh) * | 2018-07-24 | 2021-06-08 | 武汉理工大学 | 一种近红外光聚合可注射水凝胶的制备与应用 |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| CN109294142B (zh) * | 2018-11-15 | 2021-03-30 | 湖北大学 | 一种水凝胶、油水分离器及其制备方法和应用 |
| CN109646711A (zh) * | 2019-01-29 | 2019-04-19 | 青岛中腾生物技术有限公司 | 一种医用止血封闭防黏连材料 |
| CN110204593A (zh) * | 2019-05-17 | 2019-09-06 | 高邮市宇航化工机械厂 | 一种生物制药用多肽化合物的制备工艺 |
| US12109327B2 (en) | 2020-08-20 | 2024-10-08 | King Abdullah University Of Science And Technology | Scaffolds from self-assembling tetrapeptides support 3D spreading, osteogenic differentiation and angiogenesis of mesenchymal stem cells |
| US12590121B2 (en) | 2020-08-20 | 2026-03-31 | King Abdullah University Of Science And Technology | Peptide compound with repetitive sequences |
| US11673324B2 (en) | 2020-08-20 | 2023-06-13 | King Abdullah University Of Science And Technology | Nozzle for 3D bioprinting |
| CN113121642A (zh) * | 2020-09-22 | 2021-07-16 | 中国药科大学 | 自组装多肽、氧化还原响应多肽水凝胶及其制备方法和应用 |
| CN112138208A (zh) * | 2020-09-28 | 2020-12-29 | 深圳清华大学研究院 | 促血管化组织再生的支架材料及其制备方法 |
| CN112807483B (zh) * | 2021-02-03 | 2022-10-21 | 中国药科大学 | 一种抗炎、抗菌、止血的双网络水凝胶及其制备方法和应用 |
| CN115429929B (zh) * | 2021-06-04 | 2024-08-13 | 中国科学院上海硅酸盐研究所 | 一种可注射自组装水凝胶及其制备方法和应用 |
| CN113384743A (zh) * | 2021-07-09 | 2021-09-14 | 吉林省国大生物工程有限公司 | 一种具有促进组织修复及抗菌的温敏敷料的制备方法 |
| CN116003826B (zh) * | 2021-10-22 | 2024-12-20 | 中山大学附属第三医院（中山大学肝脏病医院） | 一种可注射改性透明质酸/功能性短肽复合水凝胶及其制备方法和应用 |
| CN114381015A (zh) * | 2021-12-24 | 2022-04-22 | 中山大学附属第三医院（中山大学肝脏病医院） | 一种可注射和自修复的水凝胶及其制备方法和应用 |
| US12582767B2 (en) | 2021-12-30 | 2026-03-24 | Taiyo Weber | Compressible, minimally invasive implants and related systems and methods |
| CN114904057B (zh) * | 2022-04-20 | 2023-06-09 | 华中科技大学同济医学院附属协和医院 | 一种抑制神经长入的复合纤维环凝胶制备方法及应用 |
| CN116212098B (zh) * | 2023-03-14 | 2024-08-13 | 四川大学 | 一种酸性环境快速响应型多肽粘合剂的制备方法 |
| CN120818235B (zh) * | 2025-09-19 | 2025-12-05 | 中南大学湘雅医院 | 一种高分子复合水凝胶及其制备方法 |
| CN121758556A (zh) * | 2026-03-04 | 2026-03-31 | 成都安可兴科技有限公司 | 一款适配髓核力学性能的可注射抗氧化水凝胶及其制备方法与应用 |
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|---|---|---|---|---|
| CA2721045A1 (en) * | 2008-04-09 | 2009-10-15 | Mcmaster University | Hydrogel with covalently crosslinked core |
| US20110081398A1 (en) | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
| SG184345A1 (en) | 2010-03-31 | 2012-11-29 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| WO2013066274A1 (en) | 2011-11-04 | 2013-05-10 | Agency For Science, Technology And Research | Self-assembled composite ultrasmall peptide-polymer hydrogels |
-
2012
- 2012-11-05 WO PCT/SG2012/000421 patent/WO2013066274A1/en not_active Ceased
- 2012-11-05 US US14/356,116 patent/US10449257B2/en not_active Expired - Fee Related
- 2012-11-05 SG SG11201401964TA patent/SG11201401964TA/en unknown
- 2012-11-05 JP JP2014539909A patent/JP6143269B2/ja not_active Expired - Fee Related
- 2012-11-05 EP EP12846222.3A patent/EP2773696B1/en not_active Not-in-force
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