JP2015502134A5 - - Google Patents
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- JP2015502134A5 JP2015502134A5 JP2014528740A JP2014528740A JP2015502134A5 JP 2015502134 A5 JP2015502134 A5 JP 2015502134A5 JP 2014528740 A JP2014528740 A JP 2014528740A JP 2014528740 A JP2014528740 A JP 2014528740A JP 2015502134 A5 JP2015502134 A5 JP 2015502134A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- pharmaceutical composition
- acid strand
- nucleotides
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003729 nucleotide group Chemical group 0.000 claims 145
- 239000008194 pharmaceutical composition Substances 0.000 claims 101
- 150000007523 nucleic acids Chemical class 0.000 claims 100
- 108020004707 nucleic acids Proteins 0.000 claims 94
- 102000039446 nucleic acids Human genes 0.000 claims 94
- 239000002773 nucleotide Substances 0.000 claims 86
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 15
- 102100034343 Integrase Human genes 0.000 claims 13
- 101710203526 Integrase Proteins 0.000 claims 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 238000002372 labelling Methods 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 2
- 108091028664 Ribonucleotide Proteins 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000002336 ribonucleotide Substances 0.000 claims 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims 1
- 229930186217 Glycolipid Natural products 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 229930003802 tocotrienol Natural products 0.000 claims 1
- 239000011731 tocotrienol Substances 0.000 claims 1
- 235000019148 tocotrienols Nutrition 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014528740A JP6112569B2 (ja) | 2011-12-16 | 2012-12-17 | キメラ２重鎖核酸 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011275488 | 2011-12-16 | ||
| JP2011275488 | 2011-12-16 | ||
| JP2014528740A JP6112569B2 (ja) | 2011-12-16 | 2012-12-17 | キメラ２重鎖核酸 |
| PCT/JP2012/083180 WO2013089283A1 (en) | 2011-12-16 | 2012-12-17 | Chimeric double-stranded nucleic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044034A Division JP6416301B2 (ja) | 2011-12-16 | 2017-03-08 | キメラ２重鎖核酸 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502134A JP2015502134A (ja) | 2015-01-22 |
| JP2015502134A5 true JP2015502134A5 (enExample) | 2016-03-31 |
| JP6112569B2 JP6112569B2 (ja) | 2017-04-12 |
Family
ID=47559626
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528740A Active JP6112569B2 (ja) | 2011-12-16 | 2012-12-17 | キメラ２重鎖核酸 |
| JP2017044034A Active JP6416301B2 (ja) | 2011-12-16 | 2017-03-08 | キメラ２重鎖核酸 |
| JP2018188022A Active JP6638923B2 (ja) | 2011-12-16 | 2018-10-03 | キメラ２重鎖核酸 |
| JP2019224279A Active JP6960123B2 (ja) | 2011-12-16 | 2019-12-12 | キメラ２重鎖核酸 |
| JP2020179738A Active JP7174384B2 (ja) | 2011-12-16 | 2020-10-27 | キメラ２重鎖核酸 |
| JP2021136038A Pending JP2022000426A (ja) | 2011-12-16 | 2021-08-24 | キメラ２重鎖核酸 |
| JP2022146970A Active JP7423015B2 (ja) | 2011-12-16 | 2022-09-15 | キメラ２重鎖核酸 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044034A Active JP6416301B2 (ja) | 2011-12-16 | 2017-03-08 | キメラ２重鎖核酸 |
| JP2018188022A Active JP6638923B2 (ja) | 2011-12-16 | 2018-10-03 | キメラ２重鎖核酸 |
| JP2019224279A Active JP6960123B2 (ja) | 2011-12-16 | 2019-12-12 | キメラ２重鎖核酸 |
| JP2020179738A Active JP7174384B2 (ja) | 2011-12-16 | 2020-10-27 | キメラ２重鎖核酸 |
| JP2021136038A Pending JP2022000426A (ja) | 2011-12-16 | 2021-08-24 | キメラ２重鎖核酸 |
| JP2022146970A Active JP7423015B2 (ja) | 2011-12-16 | 2022-09-15 | キメラ２重鎖核酸 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US9816089B2 (enExample) |
| EP (1) | EP2791335B1 (enExample) |
| JP (7) | JP6112569B2 (enExample) |
| CN (2) | CN104126010B (enExample) |
| AU (1) | AU2012353330B2 (enExample) |
| CA (2) | CA2859581C (enExample) |
| ES (1) | ES2707232T3 (enExample) |
| IN (1) | IN2014CN04590A (enExample) |
| WO (1) | WO2013089283A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| CN104126010B (zh) * | 2011-12-16 | 2021-04-06 | 国立大学法人东京医科齿科大学 | 嵌合的双链核酸 |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| WO2014132671A1 (en) * | 2013-03-01 | 2014-09-04 | National University Corporation Tokyo Medical And Dental University | Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent |
| JP6300212B2 (ja) * | 2013-03-21 | 2018-03-28 | 国立大学法人 東京医科歯科大学 | 二重鎖核酸結合剤、当該結合剤−二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法 |
| CN105324119A (zh) * | 2013-06-16 | 2016-02-10 | 国立大学法人东京医科齿科大学 | 具有外显子跳跃效应的双链反义核酸 |
| WO2015105083A1 (ja) * | 2014-01-07 | 2015-07-16 | 塩野義製薬株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| US9714288B2 (en) | 2014-09-30 | 2017-07-25 | The Regents Of The University Of California | Antisense compounds and uses thereof |
| EP3929293A3 (en) | 2015-04-03 | 2022-03-16 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| EP3353306A4 (en) | 2015-09-25 | 2019-06-05 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| WO2017068791A1 (ja) * | 2015-10-23 | 2017-04-27 | レナセラピューティクス株式会社 | 少なくとも１つのバルジ構造を有する核酸複合体 |
| JPWO2017068790A1 (ja) * | 2015-10-23 | 2018-08-09 | レナセラピューティクス株式会社 | 核酸複合体 |
| WO2017094745A1 (ja) * | 2015-12-01 | 2017-06-08 | 国立大学法人大阪大学 | 核酸を含む経腸投与用組成物 |
| EP3409779A4 (en) * | 2016-01-26 | 2019-07-03 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| KR102775461B1 (ko) * | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| US11433089B2 (en) | 2016-09-23 | 2022-09-06 | National University Corporation Tokyo Medical And Dental University | Blood-brain barrier permeable heteroduplex nucleic acid |
| US11260134B2 (en) | 2016-09-29 | 2022-03-01 | National University Corporation Tokyo Medical And Dental University | Double-stranded nucleic acid complex having overhang |
| JP7188087B2 (ja) * | 2017-02-06 | 2022-12-13 | 日産化学株式会社 | 一本鎖オリゴヌクレオチド |
| EP3603648B1 (en) | 2017-03-29 | 2025-09-17 | Shionogi & Co., Ltd | Complex of nucleic acid medicine and multibranched lipid |
| WO2018180005A1 (ja) * | 2017-03-31 | 2018-10-04 | 国立研究開発法人日本医療研究開発機構 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| JP6974872B2 (ja) * | 2017-06-30 | 2021-12-01 | 国立大学法人 東京医科歯科大学 | ヘテロ二本鎖型ａｎｔｉｍｉＲ |
| US11555188B2 (en) | 2017-07-26 | 2023-01-17 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| WO2019118916A1 (en) | 2017-12-14 | 2019-06-20 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US11674141B2 (en) | 2018-02-28 | 2023-06-13 | National University Corporation Tokyo Medical And Dental University | Ischemic-lesion-site-specific gene therapy |
| KR20190110043A (ko) * | 2018-03-19 | 2019-09-27 | 주식회사 케이티 | 비디오 신호 처리 방법 및 장치 |
| US11851654B2 (en) | 2018-03-19 | 2023-12-26 | National University Corporation Tokyo Medical And Dental University | Nucleic acid with reduced toxicity |
| EP3770256A4 (en) | 2018-03-20 | 2021-12-22 | Tokyo Institute of Technology | ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY |
| JP7262816B2 (ja) * | 2018-03-22 | 2023-04-24 | 国立大学法人 東京医科歯科大学 | ヘテロ核酸のｂｂｂ通過脂質リガンド |
| CN113614232A (zh) * | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| CN113677374A (zh) * | 2019-04-08 | 2021-11-19 | 国立大学法人东京医科齿科大学 | 肌疾病治疗用药物组合物 |
| JP7692829B2 (ja) | 2019-07-30 | 2025-06-16 | 塩野義製薬株式会社 | Ｍｕｒｆ１を標的とする核酸医薬 |
| EP4043565A4 (en) * | 2019-10-11 | 2024-01-24 | National University Corporation Tokyo Medical and Dental University | MODIFIED HETERONUCLEIC ACID |
| EP4090744A4 (en) * | 2020-01-17 | 2024-04-10 | Anastasia Khvorova | UNIVERSAL DYNAMIC PHARMACOKINETIC MODIFYING ANCHORS |
| CN114929876A (zh) | 2020-01-31 | 2022-08-19 | 株式会社三和化学研究所 | Atn1的反义寡核苷酸 |
| WO2021177418A1 (ja) | 2020-03-04 | 2021-09-10 | 日産化学株式会社 | Ｃａｌｍ２のアンチセンスオリゴヌクレオチド |
| EP4123023A4 (en) * | 2020-03-16 | 2024-07-17 | National University Corporation Tokyo Medical and Dental University | Heteronucleic acid containing morpholino nucleic acid |
| CA3174079A1 (en) | 2020-05-26 | 2021-12-02 | Anastasia Khvorova | Synthetic oligonucleotides having regions of block and cluster modifications |
| EP4166563A4 (en) | 2020-06-15 | 2023-12-27 | LIID Pharmaceuticals, Inc. | Bridged nucleoside and nucleotide |
| AU2021382146A1 (en) | 2020-11-23 | 2022-05-27 | Alpha Anomeric Sas | Nucleic acid duplexes |
| US20240141414A1 (en) * | 2021-02-26 | 2024-05-02 | Northwestern University | Cell-free biosensors with dna strand displacement circuits |
| CA3221584A1 (en) | 2021-05-25 | 2022-12-01 | National University Corporation Tokyo Medical And Dental University | Heteronucleic acid containing scpbna or amna |
| EP4353266A4 (en) | 2021-05-31 | 2026-04-29 | Rena Therapeutics Inc | LIGAND-BOND NUCLEIC ACID COMPLEX |
| EP4389891A4 (en) * | 2021-08-19 | 2025-10-29 | Univ Nat Corp Tokyo Medical & Dental | MODIFIED HETERONUCLEIC ACID CONTAINING MORPHOLINO NUCLEIC ACID |
| WO2023026994A1 (ja) | 2021-08-21 | 2023-03-02 | 武田薬品工業株式会社 | ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート |
| US20250179486A1 (en) * | 2021-09-15 | 2025-06-05 | National University Corporation Tokyo Medical And Dental University | Heteronucleic acid including 2'-modified nucleoside |
| US20250000892A1 (en) * | 2021-10-14 | 2025-01-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Programmable delivery platforms for rna structures |
| US20260185102A1 (en) | 2021-11-02 | 2026-07-02 | Rena Therapeutics Inc. | Ligand-binding nucleic acid complex |
| WO2023105898A1 (ja) | 2021-12-07 | 2023-06-15 | リードファーマ株式会社 | アンチセンスオリゴヌクレオチド複合体 |
| WO2024071099A1 (ja) | 2022-09-29 | 2024-04-04 | 国立大学法人東京医科歯科大学 | ５'－シクロプロピレン修飾を含む核酸分子 |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| WO2024228398A1 (ja) * | 2023-05-02 | 2024-11-07 | 国立大学法人東京医科歯科大学 | グアニン四重鎖構造を誘導するための核酸剤 |
| WO2025047953A1 (ja) | 2023-08-30 | 2025-03-06 | 株式会社Stratoimmune | ＲａｓＧＲＰ４のアンチセンスオリゴヌクレオチド |
| EP4782540A1 (en) | 2023-09-19 | 2026-07-29 | National University Corporation Tokai National Higher Education And Research System | Single-stranded polynucleotide |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09110894A (ja) * | 1995-10-17 | 1997-04-28 | Soyaku Gijutsu Kenkyusho:Kk | ハイブリッドｄｎａ／ｒｎａオリゴヌクレオチド及び抗ウイルス剤 |
| US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| JP3781879B2 (ja) | 1996-11-18 | 2006-05-31 | 武 今西 | 新規ヌクレオチド類縁体 |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| EP1015469B2 (en) | 1997-09-12 | 2015-11-18 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues |
| US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
| FR2832154B1 (fr) * | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
| US20030104401A1 (en) | 2001-11-12 | 2003-06-05 | Epiclone, Inc. | Gene silencing using sense DNA and antisense RNA hybrid constructs |
| WO2004003134A2 (en) * | 2002-06-26 | 2004-01-08 | Isis Pharmaceuticals, Inc. | Antisense inhibition via rnase h-independent reduction in mrna |
| DE10240417A1 (de) * | 2002-09-02 | 2004-03-11 | Avontec Gmbh | Decoy-Oligonukleotid-Hemmung der CD40-Expression |
| EP1546344A4 (en) * | 2002-09-18 | 2007-10-03 | Isis Pharmaceuticals Inc | EFFICIENT PRODUCTION OF TARGET RNAS USING SINGLE AND DOUBLE-STRONG OLIGOMER COMPOUNDS |
| AU2003294281B2 (en) | 2002-11-13 | 2010-05-20 | Kastle Therapeutics, Llc | Antisense modulation of apolipoprotein B expression |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
| EP2182063A3 (en) * | 2003-09-18 | 2012-07-18 | Isis Pharmaceuticals, Inc. | Modulation of EIF4E expression |
| US20050244869A1 (en) * | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
| AU2011204898A1 (en) * | 2004-04-09 | 2011-08-11 | Biodelivery Sciences International, Inc | Nucleotide-cochleate compositions and methods of use |
| WO2005113571A2 (en) * | 2004-05-13 | 2005-12-01 | The University Of North Carolina At Chapel Hill | Methods for the delivery of oligomeric compounds |
| JP2008526213A (ja) | 2004-12-30 | 2008-07-24 | トッド エム． ハウザー， | 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法 |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| JP5339291B2 (ja) * | 2006-08-10 | 2013-11-13 | オンコセラピー・サイエンス株式会社 | 乳癌に関連する遺伝子およびポリペプチド |
| WO2008029619A1 (fr) | 2006-09-07 | 2008-03-13 | Daiichi Sankyo Company, Limited | Oligonucléotide antisens ena ayant une action spécifique de la séquence |
| EP2076597A2 (en) | 2006-10-09 | 2009-07-08 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of pcsk9 |
| US8093222B2 (en) * | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| US7858592B2 (en) * | 2007-02-26 | 2010-12-28 | The Board Of Regents Of The University Of Texas System | Interfering RNAs against the promoter region of P53 |
| WO2008111908A1 (en) * | 2007-03-15 | 2008-09-18 | Jyoti Chattopadhyaya | Five- and six-membered conformationally locked 2',4'- carbocyclic ribo-thymidines for the treatment of infections and cancer |
| JP2011510678A (ja) * | 2008-02-08 | 2011-04-07 | プロセンサ ホールディング ビーブイ | Ｄｎａ反復不安定性関連遺伝性障害を治療するための方法及び手段 |
| EP2133425A1 (en) * | 2008-06-13 | 2009-12-16 | Karin Mölling | Method and compound for antiviral (HIV) therapy |
| US8541569B2 (en) * | 2008-09-06 | 2013-09-24 | Chemgenes Corporation | Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA |
| AU2010306940A1 (en) * | 2009-10-12 | 2012-06-07 | Smith, Larry | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| CN104126010B (zh) * | 2011-12-16 | 2021-04-06 | 国立大学法人东京医科齿科大学 | 嵌合的双链核酸 |
| WO2014132671A1 (en) * | 2013-03-01 | 2014-09-04 | National University Corporation Tokyo Medical And Dental University | Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent |
| JP6472087B2 (ja) * | 2013-05-30 | 2019-02-27 | 国立大学法人 東京医科歯科大学 | 治療用オリゴヌクレオチドを送達するための二本鎖剤 |
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