JP2015501822A5 - - Google Patents

Info

Publication number

JP2015501822A5

JP2015501822A5 JP2014546468A JP2014546468A JP2015501822A5 JP 2015501822 A5 JP2015501822 A5 JP 2015501822A5 JP 2014546468 A JP2014546468 A JP 2014546468A JP 2014546468 A JP2014546468 A JP 2014546468A JP 2015501822 A5 JP2015501822 A5 JP 2015501822A5

Authority

JP

Japan

Prior art keywords

lipocalin mutein

pharmaceutical composition

mutein

composition according

fragment

Prior art date

2012-12-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000019298 Lipocalin Human genes 0.000 claims 21
• 108050006654 Lipocalin Proteins 0.000 claims 21
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 239000012634 fragment Substances 0.000 claims 8
• 229910052742 iron Inorganic materials 0.000 claims 8
• 208000007502 anemia Diseases 0.000 claims 7
• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 5
• 102000018511 hepcidin Human genes 0.000 claims 5
• 108060003558 hepcidin Proteins 0.000 claims 5
• 229940066919 hepcidin Drugs 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 208000035475 disorder Diseases 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 108060003951 Immunoglobulin Proteins 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 238000009472 formulation Methods 0.000 claims 3
• 102000018358 immunoglobulin Human genes 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 229920001515 polyalkylene glycol Polymers 0.000 claims 3
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
• 239000004698 Polyethylene Substances 0.000 claims 2
• 208000020832 chronic kidney disease Diseases 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• -1 polyethylene Polymers 0.000 claims 2
• 229920000573 polyethylene Polymers 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• 208000020459 Anaemia of malignant disease Diseases 0.000 claims 1
• 102000014914 Carrier Proteins Human genes 0.000 claims 1
• 208000033981 Hereditary haemochromatosis Diseases 0.000 claims 1
• 108010003272 Hyaluronate lyase Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 108091008324 binding proteins Proteins 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000010255 intramuscular injection Methods 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 239000002736 nonionic surfactant Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108020001580 protein domains Proteins 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 238000010254 subcutaneous injection Methods 0.000 claims 1