JP2015500648A5 - - Google Patents
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- JP2015500648A5 JP2015500648A5 JP2014546733A JP2014546733A JP2015500648A5 JP 2015500648 A5 JP2015500648 A5 JP 2015500648A5 JP 2014546733 A JP2014546733 A JP 2014546733A JP 2014546733 A JP2014546733 A JP 2014546733A JP 2015500648 A5 JP2015500648 A5 JP 2015500648A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- scna
- polypeptide
- target
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical group 0.000 claims 21
- 238000000034 method Methods 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 230000027455 binding Effects 0.000 claims 6
- 238000009739 binding Methods 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 102000011931 Nucleoproteins Human genes 0.000 claims 3
- 108010061100 Nucleoproteins Proteins 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108010013043 Acetylesterase Proteins 0.000 claims 1
- 108010077544 Chromatin Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 230000004568 DNA-binding Effects 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 108010061833 Integrases Proteins 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 101710183280 Topoisomerase Proteins 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000037429 base substitution Effects 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000003763 chloroplast Anatomy 0.000 claims 1
- 210000003483 chromatin Anatomy 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- -1 deacetylase Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000000368 destabilizing effect Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 230000005782 double-strand break Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000004940 nucleus Anatomy 0.000 claims 1
- 210000002706 plastid Anatomy 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576423P | 2011-12-16 | 2011-12-16 | |
| US61/576,423 | 2011-12-16 | ||
| PCT/IL2012/050528 WO2013088446A1 (en) | 2011-12-16 | 2012-12-16 | Compositions and methods for modifying a predetermined target nucleic acid sequence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500648A JP2015500648A (ja) | 2015-01-08 |
| JP2015500648A5 true JP2015500648A5 (enExample) | 2016-02-04 |
Family
ID=48611953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546733A Pending JP2015500648A (ja) | 2011-12-16 | 2012-12-16 | 所定の標的核酸配列を修飾するための組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US11458157B2 (enExample) |
| EP (1) | EP2790708B1 (enExample) |
| JP (1) | JP2015500648A (enExample) |
| CN (1) | CN104080462B (enExample) |
| AU (2) | AU2012354062B2 (enExample) |
| BR (1) | BR112014014105B1 (enExample) |
| CA (2) | CA2858801C (enExample) |
| IL (2) | IL253372B (enExample) |
| IN (1) | IN2014MN00974A (enExample) |
| PH (1) | PH12014501360B1 (enExample) |
| RU (1) | RU2663354C2 (enExample) |
| UA (1) | UA115772C2 (enExample) |
| WO (1) | WO2013088446A1 (enExample) |
| ZA (1) | ZA201403785B (enExample) |
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| JP2013511979A (ja) * | 2009-11-27 | 2013-04-11 | ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー | キメラエンドヌクレアーゼおよびその使用 |
| EP3456826B1 (en) * | 2009-12-10 | 2023-06-28 | Regents of the University of Minnesota | Tal effector-mediated dna modification |
| JP6208580B2 (ja) | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| EP2392208B1 (en) | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| JP5725864B2 (ja) | 2010-08-06 | 2015-05-27 | 株式会社 資生堂 | エラスターゼ阻害剤 |
| BR112013024337A2 (pt) | 2011-03-23 | 2017-09-26 | Du Pont | locus de traço transgênico complexo em uma planta, planta ou semente, método para produzir em uma planta um locus de traço transgênico complexo e construto de expressão |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| PL4289948T3 (pl) * | 2012-05-25 | 2025-06-02 | The Regents Of The University Of California | Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US9340800B2 (en) * | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
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2012
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