JP2015187156A5 - - Google Patents

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JP2015187156A5
JP2015187156A5 JP2015125342A JP2015125342A JP2015187156A5 JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5 JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5
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JP2015187156A (ja
JP6194335B2 (ja
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JP2015125342A 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物 Expired - Lifetime JP6194335B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38084202P 2002-05-17 2002-05-17
US60/380,842 2002-05-17
US42460002P 2002-11-06 2002-11-06
US60/424,600 2002-11-06

Related Parent Applications (1)

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JP2009116367A Division JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Related Child Applications (1)

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JP2017095838A Division JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Publications (3)

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JP2015187156A JP2015187156A (ja) 2015-10-29
JP2015187156A5 true JP2015187156A5 (OSRAM) 2016-02-04
JP6194335B2 JP6194335B2 (ja) 2017-09-06

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ID=29553516

Family Applications (8)

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JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2015125342A Expired - Lifetime JP6194335B2 (ja) 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications Before (6)

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JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Country Status (19)

Country Link
EP (9) EP2915533B1 (OSRAM)
JP (8) JP2005530784A (OSRAM)
KR (2) KR100822149B1 (OSRAM)
CN (13) CN104606193A (OSRAM)
AT (1) ATE459357T1 (OSRAM)
AU (1) AU2003234626B2 (OSRAM)
CA (10) CA2672000C (OSRAM)
CY (3) CY1110013T1 (OSRAM)
DE (1) DE60331537D1 (OSRAM)
DK (1) DK1505973T3 (OSRAM)
ES (2) ES2340027T3 (OSRAM)
IL (9) IL165254A0 (OSRAM)
LU (1) LU92642I2 (OSRAM)
MX (1) MXPA04011311A (OSRAM)
NZ (5) NZ549175A (OSRAM)
PT (2) PT1505973E (OSRAM)
SI (1) SI1505973T1 (OSRAM)
WO (1) WO2003097052A2 (OSRAM)
ZA (3) ZA200503656B (OSRAM)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
ATE450529T1 (de) 2001-02-27 2009-12-15 Governement Of The United Stat Analoga von thalidomid als angiogeneseinhibitoren
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
EP2915533B1 (en) * 2002-05-17 2017-09-13 Celgene Corporation Pharmaceutical compositions for treating cancer
US7393862B2 (en) * 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
NZ540186A (en) * 2002-10-31 2008-03-28 Celgene Corp Composition for the treatment of macular degeneration
US7785601B2 (en) * 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
UA83504C2 (en) 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
JP4943845B2 (ja) 2003-09-17 2012-05-30 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ サリドマイド類似体
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
BRPI0417186A (pt) * 2003-12-02 2007-03-06 Celgene Corp método de tratamento de um indivìduo tendo uma hemoglobinopatia ou uma anemia, de modulação da diferenciação de uma célula-tronco ou precursora de cd34+ para uma linhagem de eritróides, e, composição farmacêutica
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
JP2007529434A (ja) 2004-03-17 2007-10-25 ラース マイケル ラーセン, 視覚サイクルの阻害による網膜症の予防
NZ550026A (en) * 2004-03-22 2009-10-30 Celgene Corp Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders
MXPA06011798A (es) * 2004-04-14 2007-01-16 Celgene Corp Metodos de uso y composiciones que comprenden compuestos inmunomoduladores para el tratamiento y manejo de sindromes mielodisplasticos.
EP1814543A2 (en) * 2004-11-12 2007-08-08 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
CA2588597A1 (en) * 2004-11-23 2006-06-01 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
HRP20110348T1 (hr) * 2005-09-01 2011-07-31 Celgene Corporation Imunološke primjene imunomodulatornih spojeva za cjepivo i za liječenje infektivnih bolesti
EP1960551A2 (en) * 2005-12-01 2008-08-27 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
WO2007120669A1 (en) 2006-04-13 2007-10-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
ZA200809956B (en) * 2006-05-26 2010-07-28 Celgene Corp Methods and compositions using Immunomodulatory compounds in combination therapy
CL2007002218A1 (es) * 2006-08-03 2008-03-14 Celgene Corp Soc Organizada Ba Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
PL2068874T3 (pl) * 2006-08-07 2015-06-30 Abbvie Biotherapeutics Inc Sposoby leczenia szpiczaka mnogiego z użyciem terapii skojarzonych opartych na przeciwciałach anty-cs1
CN101557806A (zh) * 2006-10-19 2009-10-14 细胞基因公司 使用免疫调节化合物治疗和控制螺旋体和其它专性胞内菌疾病的方法和组合物
RU2348420C2 (ru) * 2007-04-17 2009-03-10 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ лечения местно-распространенного рака легкого
RS53841B1 (sr) * 2007-09-28 2015-06-30 Anthrogenesis Corporation Supresija tumora korišćenjem humanog placentalnog perfuzata i intermedijernih ćelija ubica poreklom iz humane placente
UA104579C2 (uk) * 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
CN101977603A (zh) * 2008-01-29 2011-02-16 细胞基因公司 使用免疫调节化合物来调节cd59水平的方法
RU2398525C1 (ru) * 2009-03-25 2010-09-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ лечения рака легкого
CN101696205B (zh) 2009-11-02 2011-10-19 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
JP2013512195A (ja) * 2009-11-24 2013-04-11 セルジーン コーポレイション ビタミンd耐性腫瘍細胞においてビタミンd感受性を回復させるための免疫調節性化合物
LT3202460T (lt) 2010-02-11 2019-10-10 Celgene Corporation Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus
MX2012010367A (es) * 2010-03-12 2012-11-23 Celgene Corp Metodos para el tratamiento de linfomas no hodgkin que usan lenalidomida y biomarcadores de genes y proteinas como un predictor.
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
RU2645069C2 (ru) * 2010-08-18 2018-02-15 Авм Байотекнолоджи, Ллс Композиции и способы для ингибирования связывания стволовых клеток и клеток-предшественников с лимфоидной тканью и для регенерации зародышевых центров в лимфатических тканях
EP2637653B1 (en) * 2010-11-11 2018-01-10 Ingo Schmidt-Wolf Compositions comprising ethacrynic acid and lenalidomide and/or thalidomide for use in treating myeloma
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
KR20150054962A (ko) * 2012-09-10 2015-05-20 셀진 코포레이션 국소 진행성 유방암의 치료방법
CA2907908A1 (en) * 2013-04-02 2014-10-09 Celgene Corporation Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
CN104231068A (zh) * 2014-01-27 2014-12-24 苏州发士达生物科技有限公司 人白细胞介素ii突变体及其应用
JP6616934B2 (ja) * 2014-05-22 2019-12-04 株式会社 資生堂 レナリドミドの光学分割方法
PT3182996T (pt) 2014-08-22 2023-03-21 Celgene Corp Métodos de tratamento de mieloma múltiplo com compostos imunomoduladores em combinação com anticorpos
EP3198035B1 (en) 2014-09-26 2022-11-02 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
US20180014914A1 (en) * 2015-01-20 2018-01-18 Sreevatsan Raghavan Self-illuminating cheek retractor
US11000536B2 (en) 2015-04-30 2021-05-11 Nant Holdings Ip, Llc Patient treatment via teratogenic pharmaceutical compounds
WO2017003990A1 (en) * 2015-06-29 2017-01-05 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens comprising pomalidomide and an anti-cs1 antibody for treating cancer
AU2016342039B2 (en) * 2015-10-21 2023-03-09 Teclison, Inc. Compositions and methods for immune-mediated cancer therapy
CN105388237B (zh) * 2015-12-28 2017-02-01 成都百裕金阁莱药业有限公司 阿普斯特中3‑乙酰氨基邻苯二甲酸的检测方法
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
CN110612294B (zh) 2017-01-31 2024-01-16 阿尔维纳斯运营股份有限公司 人小脑蛋白配体和包含其的双官能化合物
KR102509006B1 (ko) 2017-04-01 2023-03-13 에이브이엠 바이오테크놀로지, 엘엘씨 세포 면역치료요법 전 세포독성 사전컨디셔닝의 대체
PE20251254A1 (es) 2017-05-24 2025-05-06 Novartis Ag Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer
EP3700508A1 (en) * 2017-10-26 2020-09-02 Synbias Pharma AG Lenalidomide immediate release formulations
MX2020011183A (es) 2018-04-23 2020-11-12 Celgene Corp Compuestos de 4-aminoisoindolina-1,3-diona sustituidos y su uso para el tratamiento de linfoma.
US10969381B2 (en) * 2018-05-23 2021-04-06 Celgene Corporation Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
KR20210056397A (ko) * 2018-09-07 2021-05-18 메드샤인 디스커버리 아이엔씨. 삼환식 치환 피페리딘 디온계 화합물
EP3488851A1 (en) 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
CN114502176A (zh) * 2019-10-04 2022-05-13 达纳-法伯癌症研究所股份有限公司 作为zeta链相关蛋白激酶70(zap70)激动剂的免疫调节性酰亚胺药物及其用途
EP4048278B1 (en) * 2019-10-21 2023-11-01 Celgene Corporation Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benz yl)amino)isoindoline-1,3-dione
EP4048668A4 (en) * 2019-10-21 2024-03-13 Celgene Corporation Methods for treating a hematological cancer and the use of companion biomarkers for 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione
CN115175901B (zh) 2019-12-19 2024-03-22 阿尔维纳斯运营股份有限公司 用于雄激素受体的靶向降解的化合物和方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228601A (en) 1964-02-20 1966-01-11 Monarch Marking Systems Inc Controls for marking machine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするdna
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5360352A (en) 1992-12-24 1994-11-01 The Whitaker Corporation Wire retainer for current mode coupler
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6114355A (en) 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
ATE530542T1 (de) 1996-07-24 2011-11-15 Celgene Corp Amino substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide zur verringerung der tnf-alpha-stufen
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
CA2262906C (en) 1996-08-12 2006-10-31 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
DK1920773T3 (da) * 1996-11-05 2011-03-28 Childrens Medical Center Thalidomid og dexamethason til behandling af tumorer
US5874448A (en) 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
AU777572B2 (en) * 1999-04-01 2004-10-21 Board Of Regents, The University Of Texas System Compositions and methods for treating lymphoma
SI21172A (sl) * 2000-03-17 2003-10-31 Cell Therapeutics, Inc. Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo
NZ522767A (en) * 2000-05-15 2004-07-30 Celgene Corp Thalidomide and a topoisomerase inhibitor for the treatment of cancer
US6458810B1 (en) * 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
US7812169B2 (en) * 2000-11-30 2010-10-12 The Children's Medical Center Corporation Method of synthesis of 4-amino-thalidomide enantiomers
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
EP2915533B1 (en) * 2002-05-17 2017-09-13 Celgene Corporation Pharmaceutical compositions for treating cancer

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