JP2015165823A5 - - Google Patents
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- Publication number
- JP2015165823A5 JP2015165823A5 JP2015131234A JP2015131234A JP2015165823A5 JP 2015165823 A5 JP2015165823 A5 JP 2015165823A5 JP 2015131234 A JP2015131234 A JP 2015131234A JP 2015131234 A JP2015131234 A JP 2015131234A JP 2015165823 A5 JP2015165823 A5 JP 2015165823A5
- Authority
- JP
- Japan
- Prior art keywords
- culture
- cell mass
- wnt signal
- signal activator
- culture solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 6
- DDLZLOKCJHBUHD-WAVHTBQISA-N 6-bromoindirubin-3'-oxime Chemical group O=C/1NC2=CC(Br)=CC=C2C\1=C\1/C(=N/O)/C2=CC=CC=C2N/1 DDLZLOKCJHBUHD-WAVHTBQISA-N 0.000 claims 4
- 210000003780 hair follicle Anatomy 0.000 claims 4
- 230000002500 effect on skin Effects 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 2
- 238000012136 culture method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 210000004209 hair Anatomy 0.000 claims 2
- 238000012835 hanging drop method Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000000392 somatic effect Effects 0.000 claims 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 1
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims 1
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002488 outer root sheath cell Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000004918 root sheath Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015131234A JP5976172B2 (ja) | 2006-06-27 | 2015-06-30 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006176763 | 2006-06-27 | ||
| JP2006176763 | 2006-06-27 | ||
| JP2015131234A JP5976172B2 (ja) | 2006-06-27 | 2015-06-30 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248660A Division JP2013059337A (ja) | 2006-06-27 | 2012-11-12 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015165823A JP2015165823A (ja) | 2015-09-24 |
| JP2015165823A5 true JP2015165823A5 (https=) | 2016-06-23 |
| JP5976172B2 JP5976172B2 (ja) | 2016-08-23 |
Family
ID=38845692
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248660A Pending JP2013059337A (ja) | 2006-06-27 | 2012-11-12 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
| JP2013019652A Pending JP2013078344A (ja) | 2006-06-27 | 2013-02-04 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
| JP2015131234A Active JP5976172B2 (ja) | 2006-06-27 | 2015-06-30 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248660A Pending JP2013059337A (ja) | 2006-06-27 | 2012-11-12 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
| JP2013019652A Pending JP2013078344A (ja) | 2006-06-27 | 2013-02-04 | 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8563309B2 (https=) |
| EP (2) | EP2034011B1 (https=) |
| JP (3) | JP2013059337A (https=) |
| KR (1) | KR101472594B1 (https=) |
| CN (1) | CN101479376A (https=) |
| ES (2) | ES2641528T3 (https=) |
| WO (1) | WO2008001938A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100291580A1 (en) * | 2007-12-19 | 2010-11-18 | Aderans Research Institute, Inc | Biomarkers for trichogenicity |
| CN101658518B (zh) * | 2009-08-19 | 2011-06-08 | 新疆奥斯曼生物化妆品有限公司 | 靛玉红用作制备育毛发的药物中的用途 |
| GB201112922D0 (en) * | 2011-07-27 | 2011-09-14 | Univ Durham | Micro-organ |
| EP2991692B1 (en) * | 2013-05-03 | 2019-08-21 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Skin substitutes and methods for hair follicle neogenesis |
| CA2945263A1 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| JP6218238B2 (ja) * | 2014-07-10 | 2017-10-25 | 国立大学法人大阪大学 | 人工皮膚及びその製造方法 |
| US20170296595A1 (en) | 2014-09-18 | 2017-10-19 | North Carolina State University | Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof |
| EP3351621B1 (en) | 2015-10-30 | 2023-11-22 | National University Corporation Yokohama National University | Regenerated hair follicle primordium aggregation manufacturing method, hair follicle tissue-containing sheet, and method for manufacturing hair follicle tissue-containing sheet |
| WO2017132494A1 (en) * | 2016-01-28 | 2017-08-03 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for serum-free synthesis |
| FR3061207B1 (fr) * | 2016-12-23 | 2023-03-10 | Oreal | Utilisation des cellules germinales pour la preparation d’un microfollicule pileux |
| KR101948396B1 (ko) | 2016-12-26 | 2019-02-14 | 동국대학교 산학협력단 | 특정 전자기파 처리를 통한 효율적 3d 중뇌 유사 오가노이드 제조 방법 |
| EP3562827A1 (en) | 2016-12-30 | 2019-11-06 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| WO2018191350A1 (en) * | 2017-04-11 | 2018-10-18 | Frequency Therapeutics, Inc. | Methods for hair follicle stem cell proliferation |
| WO2019092667A1 (en) * | 2017-11-10 | 2019-05-16 | Vitroscreen S.R.L. | Method for preparing three-dimensional scaffold-free microtissues for use in the preclinical screening of active substances |
| CN108486035B (zh) * | 2018-03-26 | 2021-11-26 | 西北大学 | 一种三维类器官的液滴培养方法 |
| JP7142840B2 (ja) | 2018-05-16 | 2022-09-28 | 国立大学法人横浜国立大学 | 細胞含有ハイドロゲル体及びその製造方法 |
| JP7246595B2 (ja) * | 2018-11-08 | 2023-03-28 | 国立大学法人横浜国立大学 | 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 |
| JP7702229B2 (ja) * | 2018-11-19 | 2025-07-03 | 株式会社 資生堂 | 毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法 |
| KR102636511B1 (ko) * | 2020-03-20 | 2024-02-14 | 주식회사 에이엔케이 | 기판 상에 형성된 모낭 세포 스페로이드 및 이의 제조방법 |
| KR102636512B1 (ko) * | 2020-03-20 | 2024-02-14 | 주식회사 에이엔케이 | 모유두 세포의 반복 시딩 및 배양을 통한 모유두 스페로이드의 제조방법 |
| WO2022039165A1 (ja) | 2020-08-18 | 2022-02-24 | 東ソー株式会社 | 多能性幹細胞の外胚葉、中胚葉及び内胚葉系細胞への分化誘導方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE369144T1 (de) * | 2000-03-31 | 2007-08-15 | Gen Hospital Corp | Verfahren zur steigerung des haarwuchses durch wnt polypeptid |
| EP1488776A4 (en) * | 2002-03-28 | 2005-09-07 | Shiseido Co Ltd | PHENYLACETONITRIL DERIVATIVES AND HAIR TONIC AND THE DERIVATIVES OF TOPICAL SKIN PREPARATIONS |
| JP2004248632A (ja) * | 2003-02-21 | 2004-09-09 | Osaka Industrial Promotion Organization | 男性型脱毛症治療薬のスクリーニング方法、男性型脱毛症治療薬の製造方法および男性型脱毛症治療薬。 |
| JP2005237273A (ja) * | 2004-02-26 | 2005-09-08 | Shiseido Co Ltd | 育毛剤の評価方法 |
| WO2005095585A1 (en) * | 2004-03-31 | 2005-10-13 | Reliance Life Sciences Pvt Ltd | Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture |
| JP4565112B2 (ja) * | 2004-09-15 | 2010-10-20 | 独立行政法人産業技術総合研究所 | 毛髪成長促進剤、発毛促進剤及び脱毛症治療剤 |
| JP2005021171A (ja) * | 2004-10-04 | 2005-01-27 | Shiseido Co Ltd | ヒト毛芽の活性化作用の検出方法 |
-
2007
- 2007-06-27 WO PCT/JP2007/063333 patent/WO2008001938A1/ja not_active Ceased
- 2007-06-27 ES ES12155498.4T patent/ES2641528T3/es active Active
- 2007-06-27 ES ES07768103T patent/ES2419232T3/es active Active
- 2007-06-27 EP EP07768103.9A patent/EP2034011B1/en not_active Not-in-force
- 2007-06-27 US US12/306,649 patent/US8563309B2/en not_active Expired - Fee Related
- 2007-06-27 CN CNA2007800242047A patent/CN101479376A/zh active Pending
- 2007-06-27 EP EP12155498.4A patent/EP2455111B1/en not_active Not-in-force
-
2008
- 2008-11-25 KR KR1020087028837A patent/KR101472594B1/ko active Active
-
2012
- 2012-11-12 JP JP2012248660A patent/JP2013059337A/ja active Pending
-
2013
- 2013-02-04 JP JP2013019652A patent/JP2013078344A/ja active Pending
- 2013-09-18 US US14/030,449 patent/US20140106432A1/en not_active Abandoned
-
2015
- 2015-06-30 JP JP2015131234A patent/JP5976172B2/ja active Active
- 2015-07-01 US US14/788,925 patent/US10344266B2/en active Active
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