JP2015091822A5 - - Google Patents
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- Publication number
- JP2015091822A5 JP2015091822A5 JP2014246066A JP2014246066A JP2015091822A5 JP 2015091822 A5 JP2015091822 A5 JP 2015091822A5 JP 2014246066 A JP2014246066 A JP 2014246066A JP 2014246066 A JP2014246066 A JP 2014246066A JP 2015091822 A5 JP2015091822 A5 JP 2015091822A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- excipient
- sodium
- final formulation
- hpmc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97948207P | 2007-10-12 | 2007-10-12 | |
| US60/979,482 | 2007-10-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Division JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015091822A JP2015091822A (ja) | 2015-05-14 |
| JP2015091822A5 true JP2015091822A5 (enExample) | 2016-07-28 |
Family
ID=40032615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Active JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
| JP2014246066A Pending JP2015091822A (ja) | 2007-10-12 | 2014-12-04 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Active JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Country Status (32)
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2278960T (pt) | 2008-03-17 | 2017-03-09 | Actelion Pharmaceuticals Ltd | Regime de dosagem para um agonista seletivo do recetor s1p1 |
| CA2733508A1 (en) | 2008-08-18 | 2010-02-25 | David Leppert | Compounds for the treatment of peripheral neuropathies |
| IL294658A (en) | 2008-12-22 | 2022-09-01 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
| SG171404A1 (en) * | 2008-12-22 | 2011-07-28 | Novartis Ag | Dosage regimen for a s1p receptor agonist |
| WO2011131370A1 (en) * | 2010-04-22 | 2011-10-27 | Ratiopharm Gmbh | Melt-granulated fingolimod |
| WO2011131369A1 (en) * | 2010-04-22 | 2011-10-27 | Ratiopharm Gmbh | Fingolimod in the form of a solid solution |
| CN101973898B (zh) * | 2010-09-09 | 2013-06-19 | 南京明生医药技术有限公司 | 2-对辛基苯乙基-2-氨基丙二醇衍生物及其应用 |
| JO3619B1 (ar) * | 2011-01-07 | 2020-08-27 | Novartis Ag | صياغات مثبطة للمناعة |
| WO2012095853A1 (en) | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
| ES2388273B1 (es) * | 2011-03-16 | 2013-10-01 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de inhibidores de receptores de s1p para el tratamiento de la estenosis aórtica calcificada |
| AR085749A1 (es) * | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| EA028950B1 (ru) | 2011-08-01 | 2018-01-31 | Тева Фармасьютикал Индастриз Лтд. | Способ получения фармацевтических композиций, содержащих финголимод |
| SG11201401065RA (en) * | 2011-10-21 | 2014-09-26 | Novartis Ag | Dosage regimen for an s1p receptor modulator or agonist |
| WO2013091704A1 (en) | 2011-12-22 | 2013-06-27 | Synthon Bv | Pharmaceutical composition comprising fingolimod |
| RU2482842C1 (ru) * | 2012-04-26 | 2013-05-27 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения |
| RU2506949C1 (ru) * | 2012-06-13 | 2014-02-20 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
| RU2496486C1 (ru) * | 2012-07-11 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение |
| JP2014129238A (ja) * | 2012-12-28 | 2014-07-10 | Lion Corp | エトドラク含有固形製剤 |
| WO2014141298A2 (en) * | 2013-03-11 | 2014-09-18 | Astron Research Limited | Stable pharmaceutical composition of fingolimod |
| EP2996681B1 (en) * | 2013-05-13 | 2019-12-18 | Synthon B.V. | Pharmaceutical composition comprising fingolimod |
| WO2015015254A1 (en) | 2013-07-29 | 2015-02-05 | Aizant Drug Research Solutions Pvt Ltd | Pharmaceutical compositions of fingolimod |
| US20150141520A1 (en) * | 2013-11-18 | 2015-05-21 | Chandrasekhar Kandi | Stabilized pharmaceutical compositions of fingolimod and process for preparation thereof |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| US9493442B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| KR102421235B1 (ko) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Lsd1 저해제로서 사이클로프로필아민 |
| TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
| EP3129006B1 (en) * | 2014-04-10 | 2021-01-27 | Novartis AG | Immunosuppressant formulation |
| TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為lsd1抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| US20170231928A1 (en) * | 2014-08-22 | 2017-08-17 | Sunshine Lake Pharma Co., Ltd. | Solid composition of fingolimod and preparation thereof |
| WO2016042493A1 (en) | 2014-09-19 | 2016-03-24 | Aizant Drug Research Pvt. Ltd | Pharmaceutical compositions of fingolimod |
| MX391191B (es) * | 2014-11-17 | 2025-03-21 | Context Biopharma Inc | Composiciones de liberación extendida de onapristona y métodos. |
| US9925138B2 (en) | 2015-01-20 | 2018-03-27 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
| WO2016118515A1 (en) * | 2015-01-20 | 2016-07-28 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
| SG11201708047UA (en) | 2015-04-03 | 2017-10-30 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
| MX2017013896A (es) * | 2015-04-28 | 2018-03-15 | Astellas Pharma Inc | Composicion farmaceutica para administracion oral. |
| CN110402244B (zh) | 2015-08-12 | 2023-02-03 | 因赛特公司 | Lsd1抑制剂的盐 |
| RU2639424C2 (ru) * | 2015-09-15 | 2017-12-21 | Закрытое Акционерное Общество "Биокад" | Твердая пероральная фармацевтическая композиция S1P-агониста или его фармацевтически приемлемой соли, способы ее получения и способы лечения и снижения частоты клинических обострений рассеянного склероза |
| US20180280322A1 (en) * | 2015-10-02 | 2018-10-04 | Mylan Inc. | Stable formulations of fingolimod |
| SG10202010414QA (en) * | 2016-04-22 | 2020-11-27 | Incyte Corp | Formulations of an lsd1 inhibitor |
| US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| WO2018178744A1 (en) | 2017-03-29 | 2018-10-04 | Deva Holding Anonim Sirketi | Stable formulations of fingolimod |
| EP3813789A1 (en) | 2018-06-28 | 2021-05-05 | Arx, LLC | Dispensing method for producing dissolvable unit dose film constructs |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| EP3862318A4 (en) | 2018-10-05 | 2022-06-15 | Fuji Chemical Industry Co., Ltd. | Porous silica particle composition |
| WO2022220593A1 (ko) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제를 포함하는 직접 타정용 약제학적 조성물 |
| EP4633611A1 (en) | 2022-12-12 | 2025-10-22 | Synthon B.V. | Pharmaceutical composition of siponimod |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0627406T3 (da) * | 1992-10-21 | 1999-07-12 | Taito Co | 2-Amino-1,3-propandiolforbindelser og immunundertrykkende midler |
| ATE211726T1 (de) | 1994-08-22 | 2002-01-15 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| US5616621A (en) * | 1995-01-30 | 1997-04-01 | American Home Products Corporation | Taste masking liquids |
| RU2156127C2 (ru) | 1995-12-28 | 2000-09-20 | Еситоми Фармасьютикал Индустриз, Лтд. | Препарат местного применения для иммуносупрессии и лечения аутоиммунных или аллергических заболеваний |
| ES2317663T3 (es) | 1997-02-27 | 2009-04-16 | Novartis Ag | Composicion farmaceutica que comprende 2-amino-2-(2-(4-octilfenil)etil)propano-1,3-diol, una lecitina y un sacarido. |
| DK1319651T3 (da) | 1997-04-04 | 2005-08-01 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diolforbindelser, medicinsk anvendelse deraf og mellemprodukter til syntese af disse |
| JP4627356B2 (ja) | 1999-06-30 | 2011-02-09 | 昭 松森 | ウイルス性心筋炎の予防または治療薬剤 |
| SK152003A3 (en) | 2000-07-13 | 2004-07-07 | Sankyo Co | Amino alcohol derivatives |
| JP2004507552A (ja) | 2000-08-31 | 2004-03-11 | メルク エンド カムパニー インコーポレーテッド | 免疫調節剤としてのリン酸誘導体 |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| CA2460640C (en) | 2001-09-27 | 2011-03-29 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same |
| JP4217620B2 (ja) | 2001-09-27 | 2009-02-04 | 杏林製薬株式会社 | ジアリールスルフィド誘導体とその付加塩及び免疫抑制剤 |
| AU2003207567B2 (en) | 2002-01-18 | 2008-01-24 | Merck Sharp & Dohme Corp. | Edg receptor agonists |
| DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
| JP4571497B2 (ja) | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| AU2004213297B2 (en) | 2003-02-18 | 2009-03-19 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators |
| GB2400318B (en) * | 2003-04-08 | 2005-08-10 | Novartis Ag | Pharmaceutical composition comprising an S1P receptor agonist |
| TW200503783A (en) | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| FR2854549B1 (fr) | 2003-05-06 | 2005-06-24 | Actis Ets | Tete pour l'equipement d'un bras de robot destine a realiser une operation d'ebavurage ou de cardage |
| EP2644195A1 (en) | 2003-05-19 | 2013-10-02 | Irm Llc | Immunosuppressant Compounds and Compositions |
| MY150088A (en) * | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| AU2004253473B2 (en) | 2003-06-24 | 2010-03-04 | University Of Connecticut | Methods of inhibiting vascular permeability and apoptosis |
| EP1660449B1 (en) | 2003-08-28 | 2009-11-18 | Novartis AG | Aminopropanol derivatives |
| US20050090520A1 (en) | 2003-09-12 | 2005-04-28 | Per Lindquist | Treatment of disease or injury of the nervous system with FTY720 |
| UA74941C2 (en) | 2004-04-26 | 2006-02-15 | Fos Internat S A | A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same |
| WO2005113330A1 (en) | 2004-05-05 | 2005-12-01 | Adler, Richard, S. | Systems and methods for protecting ship from attack on the surface or under water |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| WO2006102611A2 (en) | 2005-03-24 | 2006-09-28 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of leukemia |
| CN1891212B (zh) * | 2005-07-07 | 2010-10-13 | 马启明 | 一种口服制剂及其制备方法 |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| PT3103448T (pt) * | 2006-09-26 | 2019-07-12 | Novartis Ag | Composições farmacêuticas que compreendem um modulador de s1p |
-
2008
- 2008-10-09 AR ARP080104420A patent/AR068986A1/es not_active Application Discontinuation
- 2008-10-09 PL PL15173766T patent/PL2952177T3/pl unknown
- 2008-10-09 JO JOP/2008/0436A patent/JOP20080436B1/ar active
- 2008-10-09 EP EP13177175.0A patent/EP2653154A1/en not_active Withdrawn
- 2008-10-09 CN CN200880111160A patent/CN101820916A/zh active Pending
- 2008-10-09 SG SG10201800085XA patent/SG10201800085XA/en unknown
- 2008-10-09 BR BRPI0818161A patent/BRPI0818161B8/pt active IP Right Grant
- 2008-10-09 KR KR1020177004540A patent/KR20170021904A/ko not_active Withdrawn
- 2008-10-09 US US12/682,343 patent/US8673918B2/en not_active Expired - Fee Related
- 2008-10-09 EP EP20176935.3A patent/EP3733162A1/en not_active Withdrawn
- 2008-10-09 SI SI200832164T patent/SI2952177T1/sl unknown
- 2008-10-09 HU HUE15173766A patent/HUE053835T2/hu unknown
- 2008-10-09 PT PT151737665T patent/PT2952177T/pt unknown
- 2008-10-09 ES ES12155251.7T patent/ES2545361T3/es active Active
- 2008-10-09 KR KR1020167004264A patent/KR101710845B1/ko active Active
- 2008-10-09 DK DK15173766.5T patent/DK2952177T3/da active
- 2008-10-09 EP EP08838495A patent/EP2209493A2/en not_active Withdrawn
- 2008-10-09 PT PT121552517T patent/PT2465492E/pt unknown
- 2008-10-09 AU AU2008310846A patent/AU2008310846C1/en active Active
- 2008-10-09 EP EP15173766.5A patent/EP2952177B1/en active Active
- 2008-10-09 RU RU2010118457/15A patent/RU2010118457A/ru unknown
- 2008-10-09 TW TW097139107A patent/TW200927142A/zh unknown
- 2008-10-09 EP EP12155251.7A patent/EP2465492B1/en not_active Revoked
- 2008-10-09 EP EP16182588.0A patent/EP3120833A1/en not_active Withdrawn
- 2008-10-09 SI SI200831476T patent/SI2465492T1/sl unknown
- 2008-10-09 WO PCT/US2008/079264 patent/WO2009048993A2/en not_active Ceased
- 2008-10-09 MX MX2010003925A patent/MX337152B/es active IP Right Grant
- 2008-10-09 PL PL12155251T patent/PL2465492T3/pl unknown
- 2008-10-09 HU HUE12155251A patent/HUE027696T2/en unknown
- 2008-10-09 NZ NZ600355A patent/NZ600355A/xx not_active IP Right Cessation
- 2008-10-09 ES ES15173766T patent/ES2864671T3/es active Active
- 2008-10-09 KR KR1020107010336A patent/KR101600098B1/ko active Active
- 2008-10-09 MY MYPI2010001202A patent/MY159358A/en unknown
- 2008-10-09 EP EP20176933.8A patent/EP3733161A1/en not_active Withdrawn
- 2008-10-09 CA CA2925175A patent/CA2925175A1/en not_active Abandoned
- 2008-10-09 JP JP2010529013A patent/JP6034000B2/ja active Active
- 2008-10-09 SG SG2013002415A patent/SG187458A1/en unknown
- 2008-10-09 CA CA2699788A patent/CA2699788C/en active Active
- 2008-10-10 PE PE2012002520A patent/PE20130309A1/es not_active Application Discontinuation
- 2008-10-10 PE PE2008001756A patent/PE20090799A1/es not_active Application Discontinuation
- 2008-10-10 CL CL2008003003A patent/CL2008003003A1/es unknown
-
2010
- 2010-03-15 IL IL204514A patent/IL204514B/en active IP Right Grant
- 2010-03-15 ZA ZA2010/01819A patent/ZA201001819B/en unknown
- 2010-03-26 TN TNP2010000136A patent/TN2010000136A1/fr unknown
- 2010-04-28 CO CO10050315A patent/CO6270342A2/es not_active Application Discontinuation
- 2010-04-30 MA MA32805A patent/MA31799B1/fr unknown
- 2010-05-11 EC EC2010010169A patent/ECSP10010169A/es unknown
-
2014
- 2014-01-27 US US14/164,623 patent/US20140142192A1/en not_active Abandoned
- 2014-12-04 JP JP2014246066A patent/JP2015091822A/ja active Pending
-
2015
- 2015-02-25 US US14/631,102 patent/US9399066B2/en not_active Expired - Fee Related
- 2015-08-06 HR HRP20150838TT patent/HRP20150838T1/hr unknown
-
2016
- 2016-06-15 US US15/183,523 patent/US20160296481A1/en not_active Abandoned
-
2017
- 2017-02-14 US US15/432,628 patent/US20170151195A1/en not_active Abandoned
- 2017-09-08 US US15/698,742 patent/US20170368001A1/en not_active Abandoned
- 2017-11-19 IL IL255737A patent/IL255737B/en active IP Right Grant
-
2020
- 2020-10-13 IL IL277999A patent/IL277999A/en unknown
-
2021
- 2021-07-08 JO JOP/2021/0187A patent/JOP20210187A1/ar unknown
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