JP2015091822A5 - - Google Patents
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- JP2015091822A5 JP2015091822A5 JP2014246066A JP2014246066A JP2015091822A5 JP 2015091822 A5 JP2015091822 A5 JP 2015091822A5 JP 2014246066 A JP2014246066 A JP 2014246066A JP 2014246066 A JP2014246066 A JP 2014246066A JP 2015091822 A5 JP2015091822 A5 JP 2015091822A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- excipient
- sodium
- final formulation
- hpmc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97948207P | 2007-10-12 | 2007-10-12 | |
| US60/979,482 | 2007-10-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Division JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015091822A JP2015091822A (ja) | 2015-05-14 |
| JP2015091822A5 true JP2015091822A5 (enExample) | 2016-07-28 |
Family
ID=40032615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Active JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
| JP2014246066A Pending JP2015091822A (ja) | 2007-10-12 | 2014-12-04 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529013A Active JP6034000B2 (ja) | 2007-10-12 | 2008-10-09 | スフィンゴシン−1−リン酸(s1p)受容体モジュレーターを含む組成物 |
Country Status (32)
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2716448A1 (en) | 2008-03-17 | 2009-09-24 | Patrick Brossard | Dosing regimen for a selective s1p1 receptor agonist |
| CA2733508A1 (en) * | 2008-08-18 | 2010-02-25 | David Leppert | Compounds for the treatment of peripheral neuropathies |
| MX367667B (es) | 2008-12-22 | 2019-08-30 | Novartis Ag | Régimen de dosificación de un agonista de los receptores de s1p. |
| US20100160259A1 (en) * | 2008-12-22 | 2010-06-24 | Robert Schmouder | Dosage regimen for a s1p receptor agonist |
| EP2560621A1 (en) * | 2010-04-22 | 2013-02-27 | Ratiopharm GmbH | Fingolimod in the form of a solid solution |
| US20130102683A1 (en) * | 2010-04-22 | 2013-04-25 | Ratiopharm Gmbh | Melt-granulated fingolimod |
| CN101973898B (zh) * | 2010-09-09 | 2013-06-19 | 南京明生医药技术有限公司 | 2-对辛基苯乙基-2-氨基丙二醇衍生物及其应用 |
| SG191286A1 (en) | 2011-01-07 | 2013-07-31 | Novartis Ag | Immunosuppressant formulations |
| WO2012095853A1 (en) | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
| ES2388273B1 (es) * | 2011-03-16 | 2013-10-01 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de inhibidores de receptores de s1p para el tratamiento de la estenosis aórtica calcificada |
| AR085749A1 (es) * | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| WO2013019872A1 (en) | 2011-08-01 | 2013-02-07 | Teva Pharmaceutical Industries Ltd. | Process for preparing pharmaceutical compositions comprising fingolimod |
| CA2852142A1 (en) * | 2011-10-21 | 2013-04-25 | Novartis Ag | Dosage regimen for an s1p receptor modulator or agonist |
| WO2013091704A1 (en) | 2011-12-22 | 2013-06-27 | Synthon Bv | Pharmaceutical composition comprising fingolimod |
| RU2482842C1 (ru) * | 2012-04-26 | 2013-05-27 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения |
| RU2506949C1 (ru) * | 2012-06-13 | 2014-02-20 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
| RU2496486C1 (ru) | 2012-07-11 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение |
| JP2014129238A (ja) * | 2012-12-28 | 2014-07-10 | Lion Corp | エトドラク含有固形製剤 |
| WO2014141298A2 (en) * | 2013-03-11 | 2014-09-18 | Astron Research Limited | Stable pharmaceutical composition of fingolimod |
| EP2996681B1 (en) * | 2013-05-13 | 2019-12-18 | Synthon B.V. | Pharmaceutical composition comprising fingolimod |
| EP3027174B1 (en) | 2013-07-29 | 2019-07-24 | Aizant Drug Research Solutions Private Limited | Pharmaceutical compositions of fingolimod |
| US20150141520A1 (en) * | 2013-11-18 | 2015-05-21 | Chandrasekhar Kandi | Stabilized pharmaceutical compositions of fingolimod and process for preparation thereof |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| WO2015123424A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| EP3392244A1 (en) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| LT3105218T (lt) | 2014-02-13 | 2019-12-10 | Incyte Corp | Ciklopropilaminai kaip lsd1 inhibitoriai |
| KR102466348B1 (ko) * | 2014-04-10 | 2022-11-10 | 노파르티스 아게 | 면역억제제 제제 |
| WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
| WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| US20170231928A1 (en) * | 2014-08-22 | 2017-08-17 | Sunshine Lake Pharma Co., Ltd. | Solid composition of fingolimod and preparation thereof |
| WO2016042493A1 (en) | 2014-09-19 | 2016-03-24 | Aizant Drug Research Pvt. Ltd | Pharmaceutical compositions of fingolimod |
| RU2017112748A (ru) * | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | Композиции онапристона пролонгированного действия и способы |
| WO2016118515A1 (en) | 2015-01-20 | 2016-07-28 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
| EA201792205A1 (ru) | 2015-04-03 | 2018-02-28 | Инсайт Корпорейшн | Гетероциклические соединения как ингибиторы lsd1 |
| EP3290037A4 (en) * | 2015-04-28 | 2019-01-23 | Astellas Pharma Inc. | PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION |
| DK3334709T3 (da) | 2015-08-12 | 2025-02-03 | Incyte Holdings Corp | Salte af en lsd1-hæmmer |
| RU2639424C2 (ru) * | 2015-09-15 | 2017-12-21 | Закрытое Акционерное Общество "Биокад" | Твердая пероральная фармацевтическая композиция S1P-агониста или его фармацевтически приемлемой соли, способы ее получения и способы лечения и снижения частоты клинических обострений рассеянного склероза |
| WO2017058364A1 (en) * | 2015-10-02 | 2017-04-06 | Mylan Inc. | Stable formulations of fingolimod |
| CA3021678A1 (en) * | 2016-04-22 | 2017-10-26 | Incyte Corporation | Formulations of an lsd1 inhibitor |
| US11434200B2 (en) | 2017-03-09 | 2022-09-06 | Novartis Ag | Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof |
| US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| EP3419607B1 (en) | 2017-03-29 | 2019-11-20 | Deva Holding Anonim Sirketi | Stable formulations of fingolimod |
| CA3105187A1 (en) | 2018-06-28 | 2020-01-02 | Arx, Llc | Dispensing method for producing dissolvable unit dose film constructs |
| US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
| WO2020071539A1 (ja) | 2018-10-05 | 2020-04-09 | 富士化学工業株式会社 | 多孔性シリカ粒子組成物 |
| KR102885760B1 (ko) * | 2021-04-14 | 2025-11-13 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제를 포함하는 고형 제제의 제조 방법 |
| CN117202893A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物 |
| CN117120037A (zh) * | 2021-04-14 | 2023-11-24 | 株式会社Lg化学 | 包含具有受控粒度的鞘氨醇-1-磷酸酯受体激动剂的药物组合物 |
| US20260207513A1 (en) | 2022-12-12 | 2026-07-23 | Synthon B.V. | Pharmaceutical composition of siponimod |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0155015B1 (ko) | 1992-10-21 | 1998-12-01 | 고우야 마사시 | 2-아미노-1,3-프로판디올 화합물 및 면역 억제제 |
| DE69524962T4 (de) | 1994-08-22 | 2003-08-28 | Mitsubishi Pharma Corp., Osaka | Benzolderivate und deren medizinische verwendung |
| US5616621A (en) * | 1995-01-30 | 1997-04-01 | American Home Products Corporation | Taste masking liquids |
| WO1997024112A1 (en) | 1995-12-28 | 1997-07-10 | Yoshitomi Pharmaceutical Industries, Ltd. | External preparation |
| EP2030614A1 (en) | 1997-02-27 | 2009-03-04 | Novartis AG | Pharmaceutical Composition comprising 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol and a lecithin |
| ES2240868T3 (es) | 1997-04-04 | 2005-10-16 | Mitsubishi Pharma Corporation | Compuesto de 2-aminopropano -1,3-diol, su uso farmaceutico e intermedios en su sintesis. |
| JP4627356B2 (ja) | 1999-06-30 | 2011-02-09 | 昭 松森 | ウイルス性心筋炎の予防または治療薬剤 |
| CZ200350A3 (cs) | 2000-07-13 | 2003-05-14 | Sankyo Company Limited | Aminoalkoholové deriváty |
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| JP4152884B2 (ja) | 2001-09-27 | 2008-09-17 | 杏林製薬株式会社 | ジアリールエーテル誘導体とその付加塩及び免疫抑制剤 |
| KR100913269B1 (ko) | 2001-09-27 | 2009-08-21 | 교린 세이야꾸 가부시키 가이샤 | 디아릴 황화물 유도체, 그의 염 및 이를 이용한 면역억제제 |
| DE60329073D1 (de) | 2002-01-18 | 2009-10-15 | Merck & Co Inc | Edg-rezeptoragonisten |
| ATE448193T1 (de) | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| JP4571497B2 (ja) | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| DK1602660T3 (da) | 2003-02-18 | 2011-05-23 | Kyorin Seiyaku Kk | Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer |
| CA2707750A1 (en) * | 2003-04-08 | 2004-10-21 | Novartis Ag | Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol |
| TW200503783A (en) | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| FR2854549B1 (fr) | 2003-05-06 | 2005-06-24 | Actis Ets | Tete pour l'equipement d'un bras de robot destine a realiser une operation d'ebavurage ou de cardage |
| EP1628967B1 (en) | 2003-05-19 | 2014-04-09 | Irm Llc | Immunosuppressant compounds and compositions |
| MY150088A (en) * | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| US7838562B2 (en) | 2003-06-24 | 2010-11-23 | University Of Connecticut | Methods of inhibiting vascular permeability and apoptosis |
| EP1660449B1 (en) | 2003-08-28 | 2009-11-18 | Novartis AG | Aminopropanol derivatives |
| WO2005025553A2 (en) * | 2003-09-12 | 2005-03-24 | Neuronova Ab | Treatment of disorders of nervous systemsystem with fty720 |
| UA74941C2 (en) | 2004-04-26 | 2006-02-15 | Fos Internat S A | A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same |
| WO2005113330A1 (en) | 2004-05-05 | 2005-12-01 | Adler, Richard, S. | Systems and methods for protecting ship from attack on the surface or under water |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| US8633161B2 (en) | 2005-03-24 | 2014-01-21 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of leukemia |
| CN1891212B (zh) * | 2005-07-07 | 2010-10-13 | 马启明 | 一种口服制剂及其制备方法 |
| GT200600350A (es) | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| RU2487703C2 (ru) | 2006-09-26 | 2013-07-20 | Новартис Аг | Фармацевтические композиции, включающие модулятор s1р |
-
2008
- 2008-10-09 WO PCT/US2008/079264 patent/WO2009048993A2/en not_active Ceased
- 2008-10-09 HU HUE12155251A patent/HUE027696T2/en unknown
- 2008-10-09 CA CA2925175A patent/CA2925175A1/en not_active Abandoned
- 2008-10-09 HU HUE15173766A patent/HUE053835T2/hu unknown
- 2008-10-09 ES ES12155251.7T patent/ES2545361T3/es active Active
- 2008-10-09 BR BRPI0818161A patent/BRPI0818161B8/pt active IP Right Grant
- 2008-10-09 PT PT121552517T patent/PT2465492E/pt unknown
- 2008-10-09 CA CA2699788A patent/CA2699788C/en active Active
- 2008-10-09 TW TW097139107A patent/TW200927142A/zh unknown
- 2008-10-09 AR ARP080104420A patent/AR068986A1/es not_active Application Discontinuation
- 2008-10-09 MX MX2010003925A patent/MX337152B/es active IP Right Grant
- 2008-10-09 EP EP13177175.0A patent/EP2653154A1/en not_active Withdrawn
- 2008-10-09 EP EP16182588.0A patent/EP3120833A1/en not_active Withdrawn
- 2008-10-09 PL PL15173766T patent/PL2952177T3/pl unknown
- 2008-10-09 PT PT151737665T patent/PT2952177T/pt unknown
- 2008-10-09 US US12/682,343 patent/US8673918B2/en not_active Expired - Fee Related
- 2008-10-09 KR KR1020107010336A patent/KR101600098B1/ko active Active
- 2008-10-09 JO JOP/2008/0436A patent/JOP20080436B1/ar active
- 2008-10-09 JP JP2010529013A patent/JP6034000B2/ja active Active
- 2008-10-09 SI SI200831476T patent/SI2465492T1/sl unknown
- 2008-10-09 KR KR1020167004264A patent/KR101710845B1/ko active Active
- 2008-10-09 DK DK15173766.5T patent/DK2952177T3/da active
- 2008-10-09 AU AU2008310846A patent/AU2008310846C1/en active Active
- 2008-10-09 CN CN200880111160A patent/CN101820916A/zh active Pending
- 2008-10-09 EP EP08838495A patent/EP2209493A2/en not_active Withdrawn
- 2008-10-09 PL PL12155251T patent/PL2465492T3/pl unknown
- 2008-10-09 SI SI200832164T patent/SI2952177T1/sl unknown
- 2008-10-09 SG SG10201800085XA patent/SG10201800085XA/en unknown
- 2008-10-09 SG SG2013002415A patent/SG187458A1/en unknown
- 2008-10-09 EP EP15173766.5A patent/EP2952177B1/en active Active
- 2008-10-09 EP EP20176935.3A patent/EP3733162A1/en not_active Withdrawn
- 2008-10-09 MY MYPI2010001202A patent/MY159358A/en unknown
- 2008-10-09 ES ES15173766T patent/ES2864671T3/es active Active
- 2008-10-09 EP EP20176933.8A patent/EP3733161A1/en not_active Withdrawn
- 2008-10-09 RU RU2010118457/15A patent/RU2010118457A/ru unknown
- 2008-10-09 EP EP12155251.7A patent/EP2465492B1/en not_active Revoked
- 2008-10-09 KR KR1020177004540A patent/KR20170021904A/ko not_active Withdrawn
- 2008-10-09 NZ NZ600355A patent/NZ600355A/xx not_active IP Right Cessation
- 2008-10-10 PE PE2008001756A patent/PE20090799A1/es not_active Application Discontinuation
- 2008-10-10 CL CL2008003003A patent/CL2008003003A1/es unknown
- 2008-10-10 PE PE2012002520A patent/PE20130309A1/es not_active Application Discontinuation
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2010
- 2010-03-15 ZA ZA2010/01819A patent/ZA201001819B/en unknown
- 2010-03-15 IL IL204514A patent/IL204514B/en active IP Right Grant
- 2010-03-26 TN TNP2010000136A patent/TN2010000136A1/fr unknown
- 2010-04-28 CO CO10050315A patent/CO6270342A2/es not_active Application Discontinuation
- 2010-04-30 MA MA32805A patent/MA31799B1/fr unknown
- 2010-05-11 EC EC2010010169A patent/ECSP10010169A/es unknown
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2014
- 2014-01-27 US US14/164,623 patent/US20140142192A1/en not_active Abandoned
- 2014-12-04 JP JP2014246066A patent/JP2015091822A/ja active Pending
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2015
- 2015-02-25 US US14/631,102 patent/US9399066B2/en not_active Expired - Fee Related
- 2015-08-06 HR HRP20150838TT patent/HRP20150838T1/hr unknown
-
2016
- 2016-06-15 US US15/183,523 patent/US20160296481A1/en not_active Abandoned
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2017
- 2017-02-14 US US15/432,628 patent/US20170151195A1/en not_active Abandoned
- 2017-09-08 US US15/698,742 patent/US20170368001A1/en not_active Abandoned
- 2017-11-19 IL IL255737A patent/IL255737B/en active IP Right Grant
-
2020
- 2020-10-13 IL IL277999A patent/IL277999A/en unknown
-
2021
- 2021-07-08 JO JOP/2021/0187A patent/JOP20210187A1/ar unknown
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